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phospho-mdm2 [nucleoplasm]
Stable Identifier
R-DRE-6793669
Type
Protein [EntityWithAccessionedSequence]
Species
Danio rerio
Compartment
nucleoplasm
Synonyms
p-S166,S188-MDM2, O42354
Locations in the PathwayBrowser
Expand all
Cell Cycle (Danio rerio)
Cell Cycle Checkpoints (Danio rerio)
G1/S DNA Damage Checkpoints (Danio rerio)
p53-Dependent G1/S DNA damage checkpoint (Danio rerio)
p53-Dependent G1 DNA Damage Response (Danio rerio)
Stabilization of p53 (Danio rerio)
MDM2 binds TP53 (Danio rerio)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53 [nucleoplasm] (Danio rerio)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Danio rerio)
p-S166,S188-MDM2 dimer [nucleoplasm] (Danio rerio)
phospho-mdm2 [nucleoplasm] (Danio rerio)
p-S166,S188-MDM2:MDM4 [nucleoplasm] (Danio rerio)
phospho-mdm2 [nucleoplasm] (Danio rerio)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Danio rerio)
p-S166,S188-MDM2 dimer [nucleoplasm] (Danio rerio)
phospho-mdm2 [nucleoplasm] (Danio rerio)
p-S166,S188-MDM2:MDM4 [nucleoplasm] (Danio rerio)
phospho-mdm2 [nucleoplasm] (Danio rerio)
MDM2 forms homo- or heterodimers (Danio rerio)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Danio rerio)
p-S166,S188-MDM2 dimer [nucleoplasm] (Danio rerio)
phospho-mdm2 [nucleoplasm] (Danio rerio)
p-S166,S188-MDM2:MDM4 [nucleoplasm] (Danio rerio)
phospho-mdm2 [nucleoplasm] (Danio rerio)
p-S166,S188-MDM2,MDM4 [nucleoplasm] (Danio rerio)
phospho-mdm2 [nucleoplasm] (Danio rerio)
phospho-mdm2 [nucleoplasm] (Danio rerio)
MDM2 ubiquitinates TP53 (Danio rerio)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53 [nucleoplasm] (Danio rerio)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Danio rerio)
p-S166,S188-MDM2 dimer [nucleoplasm] (Danio rerio)
phospho-mdm2 [nucleoplasm] (Danio rerio)
p-S166,S188-MDM2:MDM4 [nucleoplasm] (Danio rerio)
phospho-mdm2 [nucleoplasm] (Danio rerio)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Danio rerio)
p-S166,S188-MDM2 dimer [nucleoplasm] (Danio rerio)
phospho-mdm2 [nucleoplasm] (Danio rerio)
p-S166,S188-MDM2:MDM4 [nucleoplasm] (Danio rerio)
phospho-mdm2 [nucleoplasm] (Danio rerio)
MDM2 ubiquitinates phosphorylated MDM4 (Danio rerio)
p-S166,S188-MDM2:p-S346,S367,S403-MDM4 [nucleoplasm] (Danio rerio)
phospho-mdm2 [nucleoplasm] (Danio rerio)
Cellular responses to stimuli (Danio rerio)
Cellular responses to stress (Danio rerio)
Cellular Senescence (Danio rerio)
Oncogene Induced Senescence (Danio rerio)
MDM2 ubiquitinates TP53 (Danio rerio)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53 [nucleoplasm] (Danio rerio)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Danio rerio)
p-S166,S188-MDM2 dimer [nucleoplasm] (Danio rerio)
phospho-mdm2 [nucleoplasm] (Danio rerio)
p-S166,S188-MDM2:MDM4 [nucleoplasm] (Danio rerio)
phospho-mdm2 [nucleoplasm] (Danio rerio)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Danio rerio)
p-S166,S188-MDM2 dimer [nucleoplasm] (Danio rerio)
phospho-mdm2 [nucleoplasm] (Danio rerio)
p-S166,S188-MDM2:MDM4 [nucleoplasm] (Danio rerio)
phospho-mdm2 [nucleoplasm] (Danio rerio)
Oxidative Stress Induced Senescence (Danio rerio)
MDM2 ubiquitinates TP53 (Danio rerio)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53 [nucleoplasm] (Danio rerio)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Danio rerio)
p-S166,S188-MDM2 dimer [nucleoplasm] (Danio rerio)
phospho-mdm2 [nucleoplasm] (Danio rerio)
p-S166,S188-MDM2:MDM4 [nucleoplasm] (Danio rerio)
phospho-mdm2 [nucleoplasm] (Danio rerio)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Danio rerio)
p-S166,S188-MDM2 dimer [nucleoplasm] (Danio rerio)
phospho-mdm2 [nucleoplasm] (Danio rerio)
p-S166,S188-MDM2:MDM4 [nucleoplasm] (Danio rerio)
phospho-mdm2 [nucleoplasm] (Danio rerio)
Gene expression (Transcription) (Danio rerio)
RNA Polymerase II Transcription (Danio rerio)
Generic Transcription Pathway (Danio rerio)
Transcriptional Regulation by TP53 (Danio rerio)
Regulation of TP53 Activity (Danio rerio)
Regulation of TP53 Expression and Degradation (Danio rerio)
Regulation of TP53 Degradation (Danio rerio)
(CDK1,CDK2):CCNA phosphorylates MDM2 at T218 (Danio rerio)
phospho-mdm2 [nucleoplasm] (Danio rerio)
MDM2 binds TP53 (Danio rerio)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53 [nucleoplasm] (Danio rerio)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Danio rerio)
p-S166,S188-MDM2 dimer [nucleoplasm] (Danio rerio)
phospho-mdm2 [nucleoplasm] (Danio rerio)
p-S166,S188-MDM2:MDM4 [nucleoplasm] (Danio rerio)
phospho-mdm2 [nucleoplasm] (Danio rerio)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Danio rerio)
p-S166,S188-MDM2 dimer [nucleoplasm] (Danio rerio)
phospho-mdm2 [nucleoplasm] (Danio rerio)
p-S166,S188-MDM2:MDM4 [nucleoplasm] (Danio rerio)
phospho-mdm2 [nucleoplasm] (Danio rerio)
MDM2 forms homo- or heterodimers (Danio rerio)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Danio rerio)
p-S166,S188-MDM2 dimer [nucleoplasm] (Danio rerio)
phospho-mdm2 [nucleoplasm] (Danio rerio)
p-S166,S188-MDM2:MDM4 [nucleoplasm] (Danio rerio)
phospho-mdm2 [nucleoplasm] (Danio rerio)
p-S166,S188-MDM2,MDM4 [nucleoplasm] (Danio rerio)
phospho-mdm2 [nucleoplasm] (Danio rerio)
phospho-mdm2 [nucleoplasm] (Danio rerio)
MDM2 homodimers auto-ubiquitinate (Danio rerio)
p-S166,S188-MDM2 dimer [nucleoplasm] (Danio rerio)
phospho-mdm2 [nucleoplasm] (Danio rerio)
MDM2 translocates to the nucleus (Danio rerio)
phospho-mdm2 [nucleoplasm] (Danio rerio)
MDM2 ubiquitinates TP53 (Danio rerio)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53 [nucleoplasm] (Danio rerio)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Danio rerio)
p-S166,S188-MDM2 dimer [nucleoplasm] (Danio rerio)
phospho-mdm2 [nucleoplasm] (Danio rerio)
p-S166,S188-MDM2:MDM4 [nucleoplasm] (Danio rerio)
phospho-mdm2 [nucleoplasm] (Danio rerio)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] (Danio rerio)
p-S166,S188-MDM2 dimer [nucleoplasm] (Danio rerio)
phospho-mdm2 [nucleoplasm] (Danio rerio)
p-S166,S188-MDM2:MDM4 [nucleoplasm] (Danio rerio)
phospho-mdm2 [nucleoplasm] (Danio rerio)
MDM2 ubiquitinates phosphorylated MDM4 (Danio rerio)
p-S166,S188-MDM2:p-S346,S367,S403-MDM4 [nucleoplasm] (Danio rerio)
phospho-mdm2 [nucleoplasm] (Danio rerio)
Transcriptional regulation by RUNX3 (Danio rerio)
Regulation of RUNX3 expression and activity (Danio rerio)
MDM2 binds RUNX3 (Danio rerio)
RUNX3:p-S166,S188-MDM2 dimer [nucleoplasm] (Danio rerio)
p-S166,S188-MDM2 dimer [nucleoplasm] (Danio rerio)
phospho-mdm2 [nucleoplasm] (Danio rerio)
p-S166,S188-MDM2 dimer [nucleoplasm] (Danio rerio)
phospho-mdm2 [nucleoplasm] (Danio rerio)
MDM2 polyubiquitinates RUNX3 (Danio rerio)
RUNX3:p-S166,S188-MDM2 dimer [nucleoplasm] (Danio rerio)
p-S166,S188-MDM2 dimer [nucleoplasm] (Danio rerio)
phospho-mdm2 [nucleoplasm] (Danio rerio)
p-S166,S188-MDM2 dimer [nucleoplasm] (Danio rerio)
phospho-mdm2 [nucleoplasm] (Danio rerio)
External Reference Information
External Reference
UniProt:O42354
Gene Names
mdm2
Reference Genes
ENSEMBL:ENSDARG00000033443
Participates
as a component of
p-S166,S188-MDM2:p-S403-MDM4 [nucleoplasm] (Danio rerio)
p-S166,S188-MDM2:p-S346,S367,S403-MDM4 [nucleoplasm] (Danio rerio)
p-S166,S188-MDM2:MDM4 [nucleoplasm] (Danio rerio)
p-S166,S188-MDM2 dimer [nucleoplasm] (Danio rerio)
as an input of
(CDK1,CDK2):CCNA phosphorylates MDM2 at T218 (Danio rerio)
MDM2 forms homo- or heterodimers (Danio rerio)
as an output of
MDM2 translocates to the nucleus (Danio rerio)
as a member of
p-S166,S188-MDM2,MDM4 [nucleoplasm] (Danio rerio)
Other forms of this molecule
mdm2 [nucleoplasm]
phospho-mdm2 [nucleoplasm]
phospho-mdm2 [nucleoplasm]
phospho-mdm2 [nucleoplasm]
mdm2 [nucleoplasm]
mdm2 [cytosol]
phospho-mdm2 [cytosol]
Inferred From
p-S166,S188-MDM2 [nucleoplasm]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-serine at 166 (in Homo sapiens)
Coordinate
166
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 188 (in Homo sapiens)
Coordinate
188
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
ZFIN
ZDB-GENE-990415-153
PRO
O42354
PDB
7AH2
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