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p-2S MAP2K homo/heterodimers [cytosol]
Stable Identifier
R-DRE-5672721
Type
Set [DefinedSet]
Species
Danio rerio
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Signal Transduction (Danio rerio)
MAPK family signaling cascades (Danio rerio)
MAPK1/MAPK3 signaling (Danio rerio)
RAF/MAP kinase cascade (Danio rerio)
MAP2K and MAPK activation (Danio rerio)
Dual mechanism MAPK inhibitors bind MAPKs (Danio rerio)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Danio rerio)
p-2S MAP2K homo/heterodimers [cytosol] (Danio rerio)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Danio rerio)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Danio rerio)
p-2S MAP2K homo/heterodimers [cytosol] (Danio rerio)
IL17RD binds p-2S MAP2Ks and MAPKs (Danio rerio)
IL17RD:p-2S MAP2Ks:MAPKs [Golgi membrane] (Danio rerio)
p-2S MAP2K homo/heterodimers [cytosol] (Danio rerio)
p-2S MAP2K homo/heterodimers [cytosol] (Danio rerio)
MAP2Ks and MAPKs are phosphorylated at the endosome membrane (Danio rerio)
WDR83:LAMTOR2:LAMTOR3:activated RAF:p-2S MAP2K:p-T,Y MAPK complex [endosome membrane] (Danio rerio)
p-2S MAP2K homo/heterodimers [cytosol] (Danio rerio)
MAP2Ks phosphorylate MAPK at the Golgi membrane (Danio rerio)
IL17RD:p-2S MAP2Ks:MAPKs [Golgi membrane] (Danio rerio)
p-2S MAP2K homo/heterodimers [cytosol] (Danio rerio)
IL17RD:p-2S MAP2Ks:p-T,Y MAPKs [Golgi membrane] (Danio rerio)
p-2S MAP2K homo/heterodimers [cytosol] (Danio rerio)
p-2S MAP2K homo/heterodimers [cytosol] (Danio rerio)
MAP2Ks phosphorylate MAPKs (Danio rerio)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Danio rerio)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Danio rerio)
p-2S MAP2K homo/heterodimers [cytosol] (Danio rerio)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Danio rerio)
p-2S MAP2K homo/heterodimers [cytosol] (Danio rerio)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Danio rerio)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Danio rerio)
p-2S MAP2K homo/heterodimers [cytosol] (Danio rerio)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Danio rerio)
p-2S MAP2K homo/heterodimers [cytosol] (Danio rerio)
p-2S MAP2K homo/heterodimers [cytosol] (Danio rerio)
RAF phosphorylates MAP2K dimer (Danio rerio)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Danio rerio)
p-2S MAP2K homo/heterodimers [cytosol] (Danio rerio)
Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Danio rerio)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Danio rerio)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Danio rerio)
p-2S MAP2K homo/heterodimers [cytosol] (Danio rerio)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Danio rerio)
p-2S MAP2K homo/heterodimers [cytosol] (Danio rerio)
Single mechanism MAPK inhibitors bind phosphorylated MAPK (Danio rerio)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Danio rerio)
p-2S MAP2K homo/heterodimers [cytosol] (Danio rerio)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Danio rerio)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Danio rerio)
p-2S MAP2K homo/heterodimers [cytosol] (Danio rerio)
RAF activation (Danio rerio)
Phosphorylation of RAF (Danio rerio)
RAF activating kinases [plasma membrane] (Danio rerio)
p-2S MAP2K homo/heterodimers [cytosol] (Danio rerio)
Signaling by Receptor Tyrosine Kinases (Danio rerio)
Signaling by NTRKs (Danio rerio)
Signaling by NTRK1 (TRKA) (Danio rerio)
Signalling to ERKs (Danio rerio)
Prolonged ERK activation events (Danio rerio)
Frs2-mediated activation (Danio rerio)
Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF (Danio rerio)
RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:MAPK complex [endosome membrane] (Danio rerio)
p-2S MAP2K homo/heterodimers [cytosol] (Danio rerio)
Dissociation of phosphorylated MAP2Ks and MAPKs (Danio rerio)
RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:p-T,Y MAPK complex [endosome membrane] (Danio rerio)
p-2S MAP2K homo/heterodimers [cytosol] (Danio rerio)
p-2S MAP2K homo/heterodimers [cytosol] (Danio rerio)
MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF (Danio rerio)
RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:MAPK complex [endosome membrane] (Danio rerio)
p-2S MAP2K homo/heterodimers [cytosol] (Danio rerio)
RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:p-T,Y MAPK complex [endosome membrane] (Danio rerio)
p-2S MAP2K homo/heterodimers [cytosol] (Danio rerio)
Participants
members
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol]
(Danio rerio)
p-S218,S222 MAP2K1 dimer [cytosol]
(Danio rerio)
p-S222,S226 MAP2K2 dimer [cytosol]
(Danio rerio)
Participates
as a component of
WDR83:LAMTOR2:LAMTOR3:activated RAF:p-2S MAP2K:p-T,Y MAPK complex [endosome membrane] (Danio rerio)
IL17RD:p-2S MAP2Ks:p-T,Y MAPKs [Golgi membrane] (Danio rerio)
IL17RD:p-2S MAP2Ks:MAPKs [Golgi membrane] (Danio rerio)
RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:MAPK complex [endosome membrane] (Danio rerio)
RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:p-T,Y MAPK complex [endosome membrane] (Danio rerio)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Danio rerio)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Danio rerio)
as an input of
IL17RD binds p-2S MAP2Ks and MAPKs (Danio rerio)
as an output of
Dissociation of phosphorylated MAP2Ks and MAPKs (Danio rerio)
as a candidate of
RAF activating kinases [plasma membrane] (Danio rerio)
Inferred From
p-2S MAP2K homo/heterodimers [cytosol]
(Homo sapiens)
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