Reactome | kbtbd7 [cytosol]

kbtbd7 [cytosol]

Stable Identifier

R-DRE-5658415

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

cytosol

Synonyms

KBTBD7, A0A8M1PRY0

Locations in the PathwayBrowser

Expand all

Immune System (Danio rerio)

- Adaptive Immune System (Danio rerio)
  - Class I MHC mediated antigen processing & presentation (Danio rerio)
    - Antigen processing: Ubiquitination & Proteasome degradation (Danio rerio)
      - Interaction of E3 with substrate and E2-Ub complex (Danio rerio)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Danio rerio)
        
        E3 ligases in proteasomal degradation [cytosol] (Danio rerio)
        
        RBX1:CUL3:BTB [cytosol] (Danio rerio)
        
        BTB proteins [cytosol] (Danio rerio)
        
        kbtbd7 [cytosol] (Danio rerio)
        
        E3 ligases in proteasomal degradation [cytosol] (Danio rerio)
        
        RBX1:CUL3:BTB [cytosol] (Danio rerio)
        
        BTB proteins [cytosol] (Danio rerio)
        
        kbtbd7 [cytosol] (Danio rerio)
      - Polyubiquitination of substrate (Danio rerio)
        
        E3 ligases in proteasomal degradation [cytosol] (Danio rerio)
        
        RBX1:CUL3:BTB [cytosol] (Danio rerio)
        
        BTB proteins [cytosol] (Danio rerio)
        
        kbtbd7 [cytosol] (Danio rerio)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Danio rerio)
        
        E3 ligases in proteasomal degradation [cytosol] (Danio rerio)
        
        RBX1:CUL3:BTB [cytosol] (Danio rerio)
        
        BTB proteins [cytosol] (Danio rerio)
        
        kbtbd7 [cytosol] (Danio rerio)
        
        E3:Ub:substrate [cytosol] (Danio rerio)
        
        E3 ligases in proteasomal degradation [cytosol] (Danio rerio)
        
        RBX1:CUL3:BTB [cytosol] (Danio rerio)
        
        BTB proteins [cytosol] (Danio rerio)
        
        kbtbd7 [cytosol] (Danio rerio)
      - Release of E3 from polyubiquitinated substrate (Danio rerio)
        
        E3 ligases in proteasomal degradation [cytosol] (Danio rerio)
        
        RBX1:CUL3:BTB [cytosol] (Danio rerio)
        
        BTB proteins [cytosol] (Danio rerio)
        
        kbtbd7 [cytosol] (Danio rerio)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Danio rerio)
        
        E3 ligases in proteasomal degradation [cytosol] (Danio rerio)
        
        RBX1:CUL3:BTB [cytosol] (Danio rerio)
        
        BTB proteins [cytosol] (Danio rerio)
        
        kbtbd7 [cytosol] (Danio rerio)
      - Transfer of Ub from E2 to substrate and release of E2 (Danio rerio)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Danio rerio)
        
        E3 ligases in proteasomal degradation [cytosol] (Danio rerio)
        
        RBX1:CUL3:BTB [cytosol] (Danio rerio)
        
        BTB proteins [cytosol] (Danio rerio)
        
        kbtbd7 [cytosol] (Danio rerio)
        
        E3 ligases in proteasomal degradation [cytosol] (Danio rerio)
        
        RBX1:CUL3:BTB [cytosol] (Danio rerio)
        
        BTB proteins [cytosol] (Danio rerio)
        
        kbtbd7 [cytosol] (Danio rerio)
        
        E3:Ub:substrate [cytosol] (Danio rerio)
        
        E3 ligases in proteasomal degradation [cytosol] (Danio rerio)
        
        RBX1:CUL3:BTB [cytosol] (Danio rerio)
        
        BTB proteins [cytosol] (Danio rerio)
        
        kbtbd7 [cytosol] (Danio rerio)

Metabolism of proteins (Danio rerio)

- Post-translational protein modification (Danio rerio)
  - Neddylation (Danio rerio)
    - AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex (Danio rerio)
      - NEDD8-AcM-UBE2M:CRL3 E3 ubiquitin ligase :DCUN1D1,2,4,5 [cytosol] (Danio rerio)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Danio rerio)
        
        RBX1:CUL3:BTB [cytosol] (Danio rerio)
        
        BTB proteins [cytosol] (Danio rerio)
        
        kbtbd7 [cytosol] (Danio rerio)
      - NEDD8-CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Danio rerio)
        
        NEDD8-CUL3:RBX1:BTB [cytosol] (Danio rerio)
        
        BTB proteins [cytosol] (Danio rerio)
        
        kbtbd7 [cytosol] (Danio rerio)
    - CAND1 binds cytosolic CRL E3 ubiquitin ligases (Danio rerio)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Danio rerio)
        
        CRL E3 ubiquitin ligases [cytosol] (Danio rerio)
        
        RBX1:CUL3:BTB [cytosol] (Danio rerio)
        
        BTB proteins [cytosol] (Danio rerio)
        
        kbtbd7 [cytosol] (Danio rerio)
      - CRL E3 ubiquitin ligases [cytosol] (Danio rerio)
        
        RBX1:CUL3:BTB [cytosol] (Danio rerio)
        
        BTB proteins [cytosol] (Danio rerio)
        
        kbtbd7 [cytosol] (Danio rerio)
    - COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Danio rerio)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Danio rerio)
        
        CRL E3 ubiquitin ligases [cytosol] (Danio rerio)
        
        RBX1:CUL3:BTB [cytosol] (Danio rerio)
        
        BTB proteins [cytosol] (Danio rerio)
        
        kbtbd7 [cytosol] (Danio rerio)
      - CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Danio rerio)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Danio rerio)
        
        RBX1:CUL3:BTB [cytosol] (Danio rerio)
        
        BTB proteins [cytosol] (Danio rerio)
        
        kbtbd7 [cytosol] (Danio rerio)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Danio rerio)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Danio rerio)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Danio rerio)
        
        RBX1:CUL3:BTB [cytosol] (Danio rerio)
        
        BTB proteins [cytosol] (Danio rerio)
        
        kbtbd7 [cytosol] (Danio rerio)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Danio rerio)
        
        NEDD8-CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Danio rerio)
        
        NEDD8-CUL3:RBX1:BTB [cytosol] (Danio rerio)
        
        BTB proteins [cytosol] (Danio rerio)
        
        kbtbd7 [cytosol] (Danio rerio)
    - NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex (Danio rerio)
      - CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Danio rerio)
        
        RBX1:CUL3:BTB [cytosol] (Danio rerio)
        
        BTB proteins [cytosol] (Danio rerio)
        
        kbtbd7 [cytosol] (Danio rerio)
      - NEDD8-AcM-UBE2M:CRL3 E3 ubiquitin ligase :DCUN1D1,2,4,5 [cytosol] (Danio rerio)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Danio rerio)
        
        RBX1:CUL3:BTB [cytosol] (Danio rerio)
        
        BTB proteins [cytosol] (Danio rerio)
        
        kbtbd7 [cytosol] (Danio rerio)

Signal Transduction (Danio rerio)

- MAPK family signaling cascades (Danio rerio)
  - MAPK1/MAPK3 signaling (Danio rerio)
    - RAF/MAP kinase cascade (Danio rerio)
      - Regulation of RAS by GAPs (Danio rerio)
        
        KBTBD7:CUL3:RBX1 ubiquitinates NF1 (Danio rerio)
        
        KBTBD7:CUL3:RBX1 [cytosol] (Danio rerio)
        
        kbtbd7 [cytosol] (Danio rerio)

External Reference Information

External Reference

UniProt:A0A8M1PRY0

Gene Names

kbtbd7

Reference Genes

BioGPS Gene:794299 kbtbd7

ENSEMBL:ENSDARG00000078001

Monarch:794299 kbtbd7

NCBI Gene:794299 kbtbd7

UCSC:A0A8M1PRY0 kbtbd7

Reference Transcript

Other Identifiers

13258973

794299

A_15_P260836

A_15_P491672

CUST_15155_PI428451953

CUST_6417_PI424165604

CUST_6418_PI424165604

CUST_6419_PI424165604

CUST_6420_PI424165604

CUST_6421_PI424165604

CUST_6422_PI424165604

CUST_6423_PI424165604

CUST_6424_PI424165604

DRER19908

DRER53168

ENSDART00000112884

GO:0005515

GT_Spec_XM_001334195.3_420725

MADDr01013530

Participates

as a component of

KBTBD7:CUL3:RBX1 [cytosol] (Danio rerio)

as a member of

BTB proteins [cytosol] (Danio rerio)

Other forms of this molecule

kbtbd7 [cytosol]

Inferred From

KBTBD7 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_021330297.1, XP_001334231.1, XP_021329827.1, XP_021334550.1, XP_073768686.1

ENSEMBL

ENSDARP00000128961, ENSDARG00000078001, ENSDART00000155233

ZFIN

ZDB-GENE-070912-204

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