Reactome | ARF4 [cytosol]

ARF4 [cytosol]

Stable Identifier

R-DRE-5618178

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

cytosol

Synonyms

Q6DC20

Locations in the PathwayBrowser

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Metabolism of proteins (Danio rerio)

- Post-translational protein modification (Danio rerio)
  - Asparagine N-linked glycosylation (Danio rerio)
    - Transport to the Golgi and subsequent modification (Danio rerio)
      - ER to Golgi Anterograde Transport (Danio rerio)
        
        COPI-mediated anterograde transport (Danio rerio)
        
        ARFGAPs stimulate ARF GTPase activity (Danio rerio)
        
        ARF:GDP [cytosol] (Danio rerio)
        
        ARFs [cytosol] (Danio rerio)
        
        ARF4 [cytosol] (Danio rerio)
        
        ARFs [cytosol] (Danio rerio)
        
        ARF4 [cytosol] (Danio rerio)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane] (Danio rerio)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Danio rerio)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP [endoplasmic reticulum-Golgi intermediate compartment membrane] (Danio rerio)
        
        ARF:GTP [cytosol] (Danio rerio)
        
        ARFs [cytosol] (Danio rerio)
        
        ARF4 [cytosol] (Danio rerio)
        
        Active ARF recruits coatomer (Danio rerio)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP [endoplasmic reticulum-Golgi intermediate compartment membrane] (Danio rerio)
        
        ARF:GTP [cytosol] (Danio rerio)
        
        ARFs [cytosol] (Danio rerio)
        
        ARF4 [cytosol] (Danio rerio)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Danio rerio)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP [endoplasmic reticulum-Golgi intermediate compartment membrane] (Danio rerio)
        
        ARF:GTP [cytosol] (Danio rerio)
        
        ARFs [cytosol] (Danio rerio)
        
        ARF4 [cytosol] (Danio rerio)
        
        GBF1 recruits ARF:GDP to the ERGIC (Danio rerio)
        
        ARF:GDP [cytosol] (Danio rerio)
        
        ARFs [cytosol] (Danio rerio)
        
        ARF4 [cytosol] (Danio rerio)
        
        RAB1:GTP:GBF1:USO1:ARF:GDP [endoplasmic reticulum-Golgi intermediate compartment membrane] (Danio rerio)
        
        ARF:GDP [cytosol] (Danio rerio)
        
        ARFs [cytosol] (Danio rerio)
        
        ARF4 [cytosol] (Danio rerio)
        
        GBF1 stimulates ARF nucleotide exchange (Danio rerio)
        
        RAB1:GTP:GBF1:USO1:ARF:GDP [endoplasmic reticulum-Golgi intermediate compartment membrane] (Danio rerio)
        
        ARF:GDP [cytosol] (Danio rerio)
        
        ARFs [cytosol] (Danio rerio)
        
        ARF4 [cytosol] (Danio rerio)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP [endoplasmic reticulum-Golgi intermediate compartment membrane] (Danio rerio)
        
        ARF:GTP [cytosol] (Danio rerio)
        
        ARFs [cytosol] (Danio rerio)
        
        ARF4 [cytosol] (Danio rerio)

Vesicle-mediated transport (Danio rerio)

- Membrane Trafficking (Danio rerio)
  - ER to Golgi Anterograde Transport (Danio rerio)
    - COPI-mediated anterograde transport (Danio rerio)
      - ARFGAPs stimulate ARF GTPase activity (Danio rerio)
        
        ARF:GDP [cytosol] (Danio rerio)
        
        ARFs [cytosol] (Danio rerio)
        
        ARF4 [cytosol] (Danio rerio)
        
        ARFs [cytosol] (Danio rerio)
        
        ARF4 [cytosol] (Danio rerio)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane] (Danio rerio)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Danio rerio)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP [endoplasmic reticulum-Golgi intermediate compartment membrane] (Danio rerio)
        
        ARF:GTP [cytosol] (Danio rerio)
        
        ARFs [cytosol] (Danio rerio)
        
        ARF4 [cytosol] (Danio rerio)
      - Active ARF recruits coatomer (Danio rerio)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP [endoplasmic reticulum-Golgi intermediate compartment membrane] (Danio rerio)
        
        ARF:GTP [cytosol] (Danio rerio)
        
        ARFs [cytosol] (Danio rerio)
        
        ARF4 [cytosol] (Danio rerio)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Danio rerio)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP [endoplasmic reticulum-Golgi intermediate compartment membrane] (Danio rerio)
        
        ARF:GTP [cytosol] (Danio rerio)
        
        ARFs [cytosol] (Danio rerio)
        
        ARF4 [cytosol] (Danio rerio)
      - GBF1 recruits ARF:GDP to the ERGIC (Danio rerio)
        
        ARF:GDP [cytosol] (Danio rerio)
        
        ARFs [cytosol] (Danio rerio)
        
        ARF4 [cytosol] (Danio rerio)
        
        RAB1:GTP:GBF1:USO1:ARF:GDP [endoplasmic reticulum-Golgi intermediate compartment membrane] (Danio rerio)
        
        ARF:GDP [cytosol] (Danio rerio)
        
        ARFs [cytosol] (Danio rerio)
        
        ARF4 [cytosol] (Danio rerio)
      - GBF1 stimulates ARF nucleotide exchange (Danio rerio)
        
        RAB1:GTP:GBF1:USO1:ARF:GDP [endoplasmic reticulum-Golgi intermediate compartment membrane] (Danio rerio)
        
        ARF:GDP [cytosol] (Danio rerio)
        
        ARFs [cytosol] (Danio rerio)
        
        ARF4 [cytosol] (Danio rerio)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP [endoplasmic reticulum-Golgi intermediate compartment membrane] (Danio rerio)
        
        ARF:GTP [cytosol] (Danio rerio)
        
        ARFs [cytosol] (Danio rerio)
        
        ARF4 [cytosol] (Danio rerio)
  - Intra-Golgi and retrograde Golgi-to-ER traffic (Danio rerio)
    - Golgi-to-ER retrograde transport (Danio rerio)
      - COPI-dependent Golgi-to-ER retrograde traffic (Danio rerio)
        
        ARFGAPs stimulate ARF GTPase activity at the Golgi membrane (Danio rerio)
        
        ARF:GDP [cytosol] (Danio rerio)
        
        ARFs [cytosol] (Danio rerio)
        
        ARF4 [cytosol] (Danio rerio)
        
        ARFs [cytosol] (Danio rerio)
        
        ARF4 [cytosol] (Danio rerio)
        
        RAB1:GTP:GBF1:ARF:GTP:coatomer:p24 dimers:ARFGAPs:SEC22B:cargo [Golgi membrane] (Danio rerio)
        
        RAB1:GTP:GBF1:ARF:GTP:coatomer [Golgi membrane] (Danio rerio)
        
        RAB1:GTP:GBF1:ARF:GTP [Golgi membrane] (Danio rerio)
        
        ARF:GTP [cytosol] (Danio rerio)
        
        ARFs [cytosol] (Danio rerio)
        
        ARF4 [cytosol] (Danio rerio)
        
        Active ARF recruits coatomer to the Golgi (Danio rerio)
        
        RAB1:GTP:GBF1:ARF:GTP [Golgi membrane] (Danio rerio)
        
        ARF:GTP [cytosol] (Danio rerio)
        
        ARFs [cytosol] (Danio rerio)
        
        ARF4 [cytosol] (Danio rerio)
        
        RAB1:GTP:GBF1:ARF:GTP:coatomer [Golgi membrane] (Danio rerio)
        
        RAB1:GTP:GBF1:ARF:GTP [Golgi membrane] (Danio rerio)
        
        ARF:GTP [cytosol] (Danio rerio)
        
        ARFs [cytosol] (Danio rerio)
        
        ARF4 [cytosol] (Danio rerio)
        
        GBF1 recruits ARF:GDP to the Golgi (Danio rerio)
        
        ARF:GDP [cytosol] (Danio rerio)
        
        ARFs [cytosol] (Danio rerio)
        
        ARF4 [cytosol] (Danio rerio)
        
        RAB1:GTP:GBF1:ARF:GDP [Golgi membrane] (Danio rerio)
        
        ARF:GDP [cytosol] (Danio rerio)
        
        ARFs [cytosol] (Danio rerio)
        
        ARF4 [cytosol] (Danio rerio)
        
        GBF1 stimulates nucleotide exchange on ARF (Danio rerio)
        
        ARFs [cytosol] (Danio rerio)
        
        ARF4 [cytosol] (Danio rerio)
        
        RAB1:GTP:GBF1:ARF:GDP [Golgi membrane] (Danio rerio)
        
        ARF:GDP [cytosol] (Danio rerio)
        
        ARFs [cytosol] (Danio rerio)
        
        ARF4 [cytosol] (Danio rerio)
        
        RAB1:GTP:GBF1:ARF:GTP [Golgi membrane] (Danio rerio)
        
        ARF:GTP [cytosol] (Danio rerio)
        
        ARFs [cytosol] (Danio rerio)
        
        ARF4 [cytosol] (Danio rerio)

External Reference Information

External Reference

UniProt:Q6DC20

Reference Genes

BioGPS Gene:445196

CTD Gene:445196

ENSEMBL:ENSDARG00000045989

KEGG:dre:445196

Monarch:445196

NCBI Gene:445196

UCSC:Q6DC20

Reference Transcript

RefSeq:NM_001003590.1

Other Identifiers

13282486

13283758

445196

A_15_P150491

A_15_P562232

CUST_1882_PI428451953

DRER09760

DRER09761

DRER10136

ENSDART00000067607

ENSDART00000067607_1

ENSDART00000067607_2

GO:0003924

GO:0005525

GO:0016787

LOLS12143

MADDr01003143

NM_001003590

Participates

as a component of

as a member of

ARFs [cytosol] (Danio rerio)

Other forms of this molecule

ARF5 [cytosol]

Inferred From

ARF4 [cytosol] (Homo sapiens)

Modified Residues

Name

N-myristoylglycine at 2 (in Homo sapiens)

Coordinate

PsiMod Name

N-myristoylglycine [MOD:00068]

PsiMod Definition

A protein modification that effectively converts a glycine residue to N-myristoylglycine.

Cross References

RefSeq

NP_001003590.1

ENSEMBL

ENSDART00000067604, ENSDARG00000045989, ENSDARP00000067603

ZFIN

ZDB-GENE-040801-109

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