Reactome | phospho-jak1 [cytosol]

phospho-jak1 [cytosol]

Stable Identifier

R-DRE-451921

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

cytosol

Synonyms

p-Y-JAK1, O12990

Locations in the PathwayBrowser

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Immune System (Danio rerio)

- Cytokine Signaling in Immune system (Danio rerio)
  - Interferon Signaling (Danio rerio)
    - Interferon alpha/beta signaling (Danio rerio)
      - Activation of JAK kinases (Danio rerio)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:IFNAR1:p-TYK2 [plasma membrane] (Danio rerio)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Danio rerio)
        
        IFNAR2:p-JAK1:STAT2 [plasma membrane] (Danio rerio)
        
        phospho-jak1 [cytosol] (Danio rerio)
        
        p-TYK2:p-IFNAR1:SOCS-1/SOCS-3:IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Danio rerio)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Danio rerio)
        
        IFNAR2:p-JAK1:STAT2 [plasma membrane] (Danio rerio)
        
        phospho-jak1 [cytosol] (Danio rerio)
      - Formation of p-STAT1 homodimer (Danio rerio)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:p-STAT2 [plasma membrane] (Danio rerio)
        
        IFNAR2:p-JAK1:STAT2 [plasma membrane] (Danio rerio)
        
        phospho-jak1 [cytosol] (Danio rerio)
        
        phospho-jak1 [cytosol] (Danio rerio)
      - Phosphorylation of INFAR1 by TYK2 (Danio rerio)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:IFNAR1:p-TYK2 [plasma membrane] (Danio rerio)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Danio rerio)
        
        IFNAR2:p-JAK1:STAT2 [plasma membrane] (Danio rerio)
        
        phospho-jak1 [cytosol] (Danio rerio)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2 [plasma membrane] (Danio rerio)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Danio rerio)
        
        IFNAR2:p-JAK1:STAT2 [plasma membrane] (Danio rerio)
        
        phospho-jak1 [cytosol] (Danio rerio)
      - Phosphorylation of STAT1 (Danio rerio)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:p-STAT2 [plasma membrane] (Danio rerio)
        
        IFNAR2:p-JAK1:STAT2 [plasma membrane] (Danio rerio)
        
        phospho-jak1 [cytosol] (Danio rerio)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:p-STAT2:p-STAT1 [plasma membrane] (Danio rerio)
        
        IFNAR2:p-JAK1:STAT2 [plasma membrane] (Danio rerio)
        
        phospho-jak1 [cytosol] (Danio rerio)
        
        phospho-jak1 [cytosol] (Danio rerio)
      - Phosphorylation of STAT2 (Danio rerio)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:STAT2 [plasma membrane] (Danio rerio)
        
        IFNAR2:p-JAK1:STAT2 [plasma membrane] (Danio rerio)
        
        phospho-jak1 [cytosol] (Danio rerio)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:p-STAT2 [plasma membrane] (Danio rerio)
        
        IFNAR2:p-JAK1:STAT2 [plasma membrane] (Danio rerio)
        
        phospho-jak1 [cytosol] (Danio rerio)
      - Recruitment of STAT2 to p-IFNAR1 (Danio rerio)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2 [plasma membrane] (Danio rerio)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Danio rerio)
        
        IFNAR2:p-JAK1:STAT2 [plasma membrane] (Danio rerio)
        
        phospho-jak1 [cytosol] (Danio rerio)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:STAT2 [plasma membrane] (Danio rerio)
        
        IFNAR2:p-JAK1:STAT2 [plasma membrane] (Danio rerio)
        
        phospho-jak1 [cytosol] (Danio rerio)
      - Regulation of IFNA signaling (Danio rerio)
        
        Dephosphorylation of JAK1 by SHP1 (Danio rerio)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:IFNAR1:TYK2 [plasma membrane] (Danio rerio)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Danio rerio)
        
        IFNAR2:p-JAK1:STAT2 [plasma membrane] (Danio rerio)
        
        phospho-jak1 [cytosol] (Danio rerio)
        
        Dephosphorylation of TYK2 by PTP1B (Danio rerio)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:IFNAR1:TYK2 [plasma membrane] (Danio rerio)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Danio rerio)
        
        IFNAR2:p-JAK1:STAT2 [plasma membrane] (Danio rerio)
        
        phospho-jak1 [cytosol] (Danio rerio)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:IFNAR1:p-TYK2 [plasma membrane] (Danio rerio)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Danio rerio)
        
        IFNAR2:p-JAK1:STAT2 [plasma membrane] (Danio rerio)
        
        phospho-jak1 [cytosol] (Danio rerio)
      - Release of p-STAT2:p-STAT1 dimer (Danio rerio)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2 [plasma membrane] (Danio rerio)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Danio rerio)
        
        IFNAR2:p-JAK1:STAT2 [plasma membrane] (Danio rerio)
        
        phospho-jak1 [cytosol] (Danio rerio)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:p-STAT2:p-STAT1 [plasma membrane] (Danio rerio)
        
        IFNAR2:p-JAK1:STAT2 [plasma membrane] (Danio rerio)
        
        phospho-jak1 [cytosol] (Danio rerio)
    - Interferon gamma signaling (Danio rerio)
      - Binding of STAT1 to p-IFNGR1 (Danio rerio)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Danio rerio)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Danio rerio)
        
        p-IFNGR1:p-JAK1 [plasma membrane] (Danio rerio)
        
        phospho-jak1 [cytosol] (Danio rerio)
        
        STAT1 bound to p-IFNGR1 [plasma membrane] (Danio rerio)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Danio rerio)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Danio rerio)
        
        p-IFNGR1:p-JAK1 [plasma membrane] (Danio rerio)
        
        phospho-jak1 [cytosol] (Danio rerio)
      - Phosphorylation of IFNGR1 by JAK kinases (Danio rerio)
        
        IFNG:IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Danio rerio)
        
        IFNGR complex with p-JAK [plasma membrane] (Danio rerio)
        
        IFNGR1:p-JAK1 [plasma membrane] (Danio rerio)
        
        phospho-jak1 [cytosol] (Danio rerio)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Danio rerio)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Danio rerio)
        
        p-IFNGR1:p-JAK1 [plasma membrane] (Danio rerio)
        
        phospho-jak1 [cytosol] (Danio rerio)
        
        phospho-jak1 [cytosol] (Danio rerio)
      - Phosphorylation of STAT1 at Ser727 (Danio rerio)
        
        p-STAT1 dimer bound to p-IFNGR1 [plasma membrane] (Danio rerio)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Danio rerio)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Danio rerio)
        
        p-IFNGR1:p-JAK1 [plasma membrane] (Danio rerio)
        
        phospho-jak1 [cytosol] (Danio rerio)
        
        p-STAT1(Y701) bound to p-IFNGR1 [plasma membrane] (Danio rerio)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Danio rerio)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Danio rerio)
        
        p-IFNGR1:p-JAK1 [plasma membrane] (Danio rerio)
        
        phospho-jak1 [cytosol] (Danio rerio)
      - Phosphorylation of STAT1 by JAK kinases (Danio rerio)
        
        STAT1 bound to p-IFNGR1 [plasma membrane] (Danio rerio)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Danio rerio)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Danio rerio)
        
        p-IFNGR1:p-JAK1 [plasma membrane] (Danio rerio)
        
        phospho-jak1 [cytosol] (Danio rerio)
        
        p-STAT1(Y701) bound to p-IFNGR1 [plasma membrane] (Danio rerio)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Danio rerio)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Danio rerio)
        
        p-IFNGR1:p-JAK1 [plasma membrane] (Danio rerio)
        
        phospho-jak1 [cytosol] (Danio rerio)
      - Release of STAT1 dimer from active receptor unit (Danio rerio)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Danio rerio)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Danio rerio)
        
        p-IFNGR1:p-JAK1 [plasma membrane] (Danio rerio)
        
        phospho-jak1 [cytosol] (Danio rerio)
        
        p-STAT1 dimer bound to p-IFNGR1 [plasma membrane] (Danio rerio)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Danio rerio)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Danio rerio)
        
        p-IFNGR1:p-JAK1 [plasma membrane] (Danio rerio)
        
        phospho-jak1 [cytosol] (Danio rerio)
      - Transphosphorylation of JAK1 (Danio rerio)
        
        IFNG:IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Danio rerio)
        
        IFNGR complex with p-JAK [plasma membrane] (Danio rerio)
        
        IFNGR1:p-JAK1 [plasma membrane] (Danio rerio)
        
        phospho-jak1 [cytosol] (Danio rerio)
  - Signaling by Interleukins (Danio rerio)
    - Interleukin-10 signaling (Danio rerio)
      - IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3 (Danio rerio)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Danio rerio)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Danio rerio)
        
        p-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Danio rerio)
        
        phospho-jak1 [cytosol] (Danio rerio)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:STAT3 [plasma membrane] (Danio rerio)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Danio rerio)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Danio rerio)
        
        p-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Danio rerio)
        
        phospho-jak1 [cytosol] (Danio rerio)
      - JAK1,TYK2 phosphorylate JAK1,TYK2 (Danio rerio)
        
        IL10 dimer:2xIL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Danio rerio)
        
        IL10 dimer:2xIL10RA:p-Y-JAK1 [plasma membrane] (Danio rerio)
        
        IL10RA:p-Y-JAK1 [plasma membrane] (Danio rerio)
        
        phospho-jak1 [cytosol] (Danio rerio)
      - STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2 (Danio rerio)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:STAT3 [plasma membrane] (Danio rerio)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Danio rerio)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Danio rerio)
        
        p-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Danio rerio)
        
        phospho-jak1 [cytosol] (Danio rerio)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 [plasma membrane] (Danio rerio)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Danio rerio)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Danio rerio)
        
        p-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Danio rerio)
        
        phospho-jak1 [cytosol] (Danio rerio)
      - p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA (Danio rerio)
        
        IL10 dimer:2xIL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Danio rerio)
        
        IL10 dimer:2xIL10RA:p-Y-JAK1 [plasma membrane] (Danio rerio)
        
        IL10RA:p-Y-JAK1 [plasma membrane] (Danio rerio)
        
        phospho-jak1 [cytosol] (Danio rerio)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Danio rerio)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Danio rerio)
        
        p-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Danio rerio)
        
        phospho-jak1 [cytosol] (Danio rerio)
      - p-Y705-STAT3 dissociates from IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 (Danio rerio)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Danio rerio)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Danio rerio)
        
        p-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Danio rerio)
        
        phospho-jak1 [cytosol] (Danio rerio)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 [plasma membrane] (Danio rerio)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Danio rerio)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Danio rerio)
        
        p-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Danio rerio)
        
        phospho-jak1 [cytosol] (Danio rerio)
    - Interleukin-2 family signaling (Danio rerio)
      - Interleukin receptor SHC signaling (Danio rerio)
        
        Gab2 binds the p85 subunit of Class 1A PI3 kinases (Danio rerio)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Danio rerio)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Danio rerio)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Danio rerio)
        
        phospho-jak1 [cytosol] (Danio rerio)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Danio rerio)
        
        IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Danio rerio)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Danio rerio)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Danio rerio)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Danio rerio)
        
        phospho-jak1 [cytosol] (Danio rerio)
        
        SHC1 mediates cytokine-induced phosphorylation of GAB2 (Danio rerio)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:GAB2 [plasma membrane] (Danio rerio)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Danio rerio)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Danio rerio)
        
        phospho-jak1 [cytosol] (Danio rerio)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Danio rerio)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Danio rerio)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Danio rerio)
        
        phospho-jak1 [cytosol] (Danio rerio)
      - Interleukin-15 signaling (Danio rerio)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds STAT3 and STAT5 (Danio rerio)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Danio rerio)
        
        phospho-jak1 [cytosol] (Danio rerio)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:STAT3,STAT5,(STAT3:STAT5) [plasma membrane] (Danio rerio)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Danio rerio)
        
        phospho-jak1 [cytosol] (Danio rerio)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5 (Danio rerio)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:STAT3,STAT5,(STAT3:STAT5) [plasma membrane] (Danio rerio)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Danio rerio)
        
        phospho-jak1 [cytosol] (Danio rerio)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-STAT3,p-STAT5,(p-Y-STAT3:p-STAT5) [plasma membrane] (Danio rerio)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Danio rerio)
        
        phospho-jak1 [cytosol] (Danio rerio)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 binds SOS1,SOS2 (Danio rerio)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 [plasma membrane] (Danio rerio)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 [plasma membrane] (Danio rerio)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Danio rerio)
        
        phospho-jak1 [cytosol] (Danio rerio)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2:SOS [plasma membrane] (Danio rerio)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 [plasma membrane] (Danio rerio)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 [plasma membrane] (Danio rerio)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Danio rerio)
        
        phospho-jak1 [cytosol] (Danio rerio)
        
        p-Y-STAT3 and p-STAT5 dissociates from IL15:IL15RA:IL2RB:p-JAK1:IL2RG:p-JAK3:p-Y-STAT3:p-STAT5 (Danio rerio)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Danio rerio)
        
        phospho-jak1 [cytosol] (Danio rerio)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-STAT3,p-STAT5,(p-Y-STAT3:p-STAT5) [plasma membrane] (Danio rerio)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Danio rerio)
        
        phospho-jak1 [cytosol] (Danio rerio)
      - Interleukin-21 signaling (Danio rerio)
        
        IL21 receptor JAK phosphorylation (Danio rerio)
        
        IL21:IL21R:p-Y-JAK1:IL2RG:p-Y-JAK3 [plasma membrane] (Danio rerio)
        
        IL21:IL21R:p-Y-JAK1 [plasma membrane] (Danio rerio)
        
        IL21R:p-Y-JAK1 [plasma membrane] (Danio rerio)
        
        phospho-jak1 [cytosol] (Danio rerio)
        
        IL21 receptor STAT binding (Danio rerio)
        
        IL21:IL21R:p-Y-JAK1:IL2RG:p-Y-JAK3 [plasma membrane] (Danio rerio)
        
        IL21:IL21R:p-Y-JAK1 [plasma membrane] (Danio rerio)
        
        IL21R:p-Y-JAK1 [plasma membrane] (Danio rerio)
        
        phospho-jak1 [cytosol] (Danio rerio)
        
        IL21:IL21R:p-Y-JAK1:IL2RG:p-Y-JAK3:STAT1,STAT3,STAT4,STAT5 [plasma membrane] (Danio rerio)
        
        IL21:IL21R:p-Y-JAK1:IL2RG:p-Y-JAK3 [plasma membrane] (Danio rerio)
        
        IL21:IL21R:p-Y-JAK1 [plasma membrane] (Danio rerio)
        
        IL21R:p-Y-JAK1 [plasma membrane] (Danio rerio)
        
        phospho-jak1 [cytosol] (Danio rerio)
        
        IL21 receptor STAT phosphorylation (Danio rerio)
        
        IL21:IL21R:p-Y-JAK1:IL2RG:p-Y-JAK3:STAT1,STAT3,STAT4,STAT5 [plasma membrane] (Danio rerio)
        
        IL21:IL21R:p-Y-JAK1:IL2RG:p-Y-JAK3 [plasma membrane] (Danio rerio)
        
        IL21:IL21R:p-Y-JAK1 [plasma membrane] (Danio rerio)
        
        IL21R:p-Y-JAK1 [plasma membrane] (Danio rerio)
        
        phospho-jak1 [cytosol] (Danio rerio)
        
        IL21:IL21R:p-Y-JAK1:IL2RG:p-Y-JAK3:p-Y701-STAT1,p-Y705-STAT3,p-Y693-STAT4,(p-Y694-STAT5A,p-Y699-STAT5B) [plasma membrane] (Danio rerio)
        
        IL21:IL21R:p-Y-JAK1:IL2RG:p-Y-JAK3 [plasma membrane] (Danio rerio)
        
        IL21:IL21R:p-Y-JAK1 [plasma membrane] (Danio rerio)
        
        IL21R:p-Y-JAK1 [plasma membrane] (Danio rerio)
        
        phospho-jak1 [cytosol] (Danio rerio)
    - Interleukin-3, Interleukin-5 and GM-CSF signaling (Danio rerio)
      - Interleukin receptor SHC signaling (Danio rerio)
        
        Gab2 binds the p85 subunit of Class 1A PI3 kinases (Danio rerio)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Danio rerio)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Danio rerio)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Danio rerio)
        
        phospho-jak1 [cytosol] (Danio rerio)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Danio rerio)
        
        IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Danio rerio)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Danio rerio)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Danio rerio)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Danio rerio)
        
        phospho-jak1 [cytosol] (Danio rerio)
        
        SHC1 mediates cytokine-induced phosphorylation of GAB2 (Danio rerio)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:GAB2 [plasma membrane] (Danio rerio)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Danio rerio)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Danio rerio)
        
        phospho-jak1 [cytosol] (Danio rerio)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Danio rerio)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Danio rerio)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Danio rerio)
        
        phospho-jak1 [cytosol] (Danio rerio)
    - Interleukin-4 and Interleukin-13 signaling (Danio rerio)
      - IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated (Danio rerio)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1 [plasma membrane] (Danio rerio)
        
        phospho-jak1 [cytosol] (Danio rerio)
      - JAK1 phosphorylates STAT3,STAT6 (Danio rerio)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1:STAT3,STAT6 [plasma membrane] (Danio rerio)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1 [plasma membrane] (Danio rerio)
        
        phospho-jak1 [cytosol] (Danio rerio)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1:p-Y705-STAT3,p-Y641-STAT6 [plasma membrane] (Danio rerio)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1 [plasma membrane] (Danio rerio)
        
        phospho-jak1 [cytosol] (Danio rerio)
        
        phospho-jak1 [cytosol] (Danio rerio)
      - STAT3,STAT6 bind p-Y-IL4R (Danio rerio)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1 [plasma membrane] (Danio rerio)
        
        phospho-jak1 [cytosol] (Danio rerio)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1:STAT3,STAT6 [plasma membrane] (Danio rerio)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1 [plasma membrane] (Danio rerio)
        
        phospho-jak1 [cytosol] (Danio rerio)
      - p-Y705-STAT3,p-Y641-STAT6 dissociate (Danio rerio)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1 [plasma membrane] (Danio rerio)
        
        phospho-jak1 [cytosol] (Danio rerio)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1:p-Y705-STAT3,p-Y641-STAT6 [plasma membrane] (Danio rerio)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1 [plasma membrane] (Danio rerio)
        
        phospho-jak1 [cytosol] (Danio rerio)

External Reference Information

External Reference

UniProt:O12990

Gene Names

jak1

Reference Genes

ENSEMBL:ENSDARG00000020625

Participant Of

hasComponent

Other forms of this molecule

phospho-jak1 [cytosol]

jak1 [endosome]

phospho-jak1 [cytosol]

jak1 [cytosol]

phospho-jak1 [cytosol]

Inferred From

p-Y-JAK1 [cytosol] (Homo sapiens)

Modified Residues

Name

O4'-phospho-L-tyrosine at unknown position

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

IntEnz

2.7.10.2

PRO

O12990

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