Reactome | phospho-p-Y-JAK1 [cytosol]

phospho-p-Y-JAK1 [cytosol]

Stable Identifier

R-DRE-451921

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

cytosol

Synonyms

O12990

Locations in the PathwayBrowser

Expand all

Immune System (Danio rerio)

- Cytokine Signaling in Immune system (Danio rerio)
  - Interferon Signaling (Danio rerio)
    - Interferon gamma signaling (Danio rerio)
      - Binding of STAT1 to p-IFNGR1 (Danio rerio)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Danio rerio)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Danio rerio)
        
        p-IFNGR1:p-JAK1 [plasma membrane] (Danio rerio)
        
        phospho-p-Y-JAK1 [cytosol] (Danio rerio)
        
        STAT1 bound to p-IFNGR1 [plasma membrane] (Danio rerio)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Danio rerio)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Danio rerio)
        
        p-IFNGR1:p-JAK1 [plasma membrane] (Danio rerio)
        
        phospho-p-Y-JAK1 [cytosol] (Danio rerio)
      - JAK2-activated MAPKs phosphorylate YBX1 (Danio rerio)
        
        IFNG:IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Danio rerio)
        
        IFNGR complex with p-JAK [plasma membrane] (Danio rerio)
        
        IFNGR1:p-JAK1 [plasma membrane] (Danio rerio)
        
        phospho-p-Y-JAK1 [cytosol] (Danio rerio)
      - Phosphorylation of IFNGR1 by JAK kinases (Danio rerio)
        
        IFNG:IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Danio rerio)
        
        IFNGR complex with p-JAK [plasma membrane] (Danio rerio)
        
        IFNGR1:p-JAK1 [plasma membrane] (Danio rerio)
        
        phospho-p-Y-JAK1 [cytosol] (Danio rerio)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Danio rerio)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Danio rerio)
        
        p-IFNGR1:p-JAK1 [plasma membrane] (Danio rerio)
        
        phospho-p-Y-JAK1 [cytosol] (Danio rerio)
        
        phospho-p-Y-JAK1 [cytosol] (Danio rerio)
      - Phosphorylation of STAT1 at Ser727 (Danio rerio)
        
        p-STAT1 dimer bound to p-IFNGR1 [plasma membrane] (Danio rerio)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Danio rerio)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Danio rerio)
        
        p-IFNGR1:p-JAK1 [plasma membrane] (Danio rerio)
        
        phospho-p-Y-JAK1 [cytosol] (Danio rerio)
        
        p-STAT1(Y701) bound to p-IFNGR1 [plasma membrane] (Danio rerio)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Danio rerio)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Danio rerio)
        
        p-IFNGR1:p-JAK1 [plasma membrane] (Danio rerio)
        
        phospho-p-Y-JAK1 [cytosol] (Danio rerio)
      - Phosphorylation of STAT1 by JAK kinases (Danio rerio)
        
        STAT1 bound to p-IFNGR1 [plasma membrane] (Danio rerio)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Danio rerio)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Danio rerio)
        
        p-IFNGR1:p-JAK1 [plasma membrane] (Danio rerio)
        
        phospho-p-Y-JAK1 [cytosol] (Danio rerio)
        
        p-STAT1(Y701) bound to p-IFNGR1 [plasma membrane] (Danio rerio)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Danio rerio)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Danio rerio)
        
        p-IFNGR1:p-JAK1 [plasma membrane] (Danio rerio)
        
        phospho-p-Y-JAK1 [cytosol] (Danio rerio)
      - Release of STAT1 dimer from active receptor unit (Danio rerio)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Danio rerio)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Danio rerio)
        
        p-IFNGR1:p-JAK1 [plasma membrane] (Danio rerio)
        
        phospho-p-Y-JAK1 [cytosol] (Danio rerio)
        
        p-STAT1 dimer bound to p-IFNGR1 [plasma membrane] (Danio rerio)
        
        IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Danio rerio)
        
        p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Danio rerio)
        
        p-IFNGR1:p-JAK1 [plasma membrane] (Danio rerio)
        
        phospho-p-Y-JAK1 [cytosol] (Danio rerio)
      - Transphosphorylation of JAK1 (Danio rerio)
        
        IFNG:IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Danio rerio)
        
        IFNGR complex with p-JAK [plasma membrane] (Danio rerio)
        
        IFNGR1:p-JAK1 [plasma membrane] (Danio rerio)
        
        phospho-p-Y-JAK1 [cytosol] (Danio rerio)
  - Signaling by Interleukins (Danio rerio)
    - Interleukin-10 signaling (Danio rerio)
      - JAK1,TYK2 phosphorylate JAK1,TYK2 (Danio rerio)
        
        IL10 dimer:2xIL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Danio rerio)
        
        IL10 dimer:2xIL10RA:p-Y-JAK1 [plasma membrane] (Danio rerio)
        
        IL10RA:p-Y-JAK1 [plasma membrane] (Danio rerio)
        
        phospho-p-Y-JAK1 [cytosol] (Danio rerio)
      - p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA (Danio rerio)
        
        IL10 dimer:2xIL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Danio rerio)
        
        IL10 dimer:2xIL10RA:p-Y-JAK1 [plasma membrane] (Danio rerio)
        
        IL10RA:p-Y-JAK1 [plasma membrane] (Danio rerio)
        
        phospho-p-Y-JAK1 [cytosol] (Danio rerio)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Danio rerio)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Danio rerio)
        
        p-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Danio rerio)
        
        phospho-p-Y-JAK1 [cytosol] (Danio rerio)
    - Interleukin-2 family signaling (Danio rerio)
      - Interleukin-21 signaling (Danio rerio)
        
        IL21 receptor JAK phosphorylation (Danio rerio)
        
        IL21:IL21R:p-Y-JAK1:IL2RG:p-Y-JAK3 [plasma membrane] (Danio rerio)
        
        IL21:IL21R:p-Y-JAK1 [plasma membrane] (Danio rerio)
        
        IL21R:p-Y-JAK1 [plasma membrane] (Danio rerio)
        
        phospho-p-Y-JAK1 [cytosol] (Danio rerio)
        
        IL21 receptor STAT binding (Danio rerio)
        
        IL21:IL21R:p-Y-JAK1:IL2RG:p-Y-JAK3 [plasma membrane] (Danio rerio)
        
        IL21:IL21R:p-Y-JAK1 [plasma membrane] (Danio rerio)
        
        IL21R:p-Y-JAK1 [plasma membrane] (Danio rerio)
        
        phospho-p-Y-JAK1 [cytosol] (Danio rerio)
        
        IL21:IL21R:p-Y-JAK1:IL2RG:p-Y-JAK3:STAT1,STAT3,STAT4,STAT5 [plasma membrane] (Danio rerio)
        
        IL21:IL21R:p-Y-JAK1:IL2RG:p-Y-JAK3 [plasma membrane] (Danio rerio)
        
        IL21:IL21R:p-Y-JAK1 [plasma membrane] (Danio rerio)
        
        IL21R:p-Y-JAK1 [plasma membrane] (Danio rerio)
        
        phospho-p-Y-JAK1 [cytosol] (Danio rerio)
        
        IL21 receptor STAT phosphorylation (Danio rerio)
        
        IL21:IL21R:p-Y-JAK1:IL2RG:p-Y-JAK3:STAT1,STAT3,STAT4,STAT5 [plasma membrane] (Danio rerio)
        
        IL21:IL21R:p-Y-JAK1:IL2RG:p-Y-JAK3 [plasma membrane] (Danio rerio)
        
        IL21:IL21R:p-Y-JAK1 [plasma membrane] (Danio rerio)
        
        IL21R:p-Y-JAK1 [plasma membrane] (Danio rerio)
        
        phospho-p-Y-JAK1 [cytosol] (Danio rerio)
        
        IL21:IL21R:p-Y-JAK1:IL2RG:p-Y-JAK3:p-Y701-STAT1,p-Y705-STAT3,p-Y693-STAT4,(p-Y694-STAT5A,p-Y699-STAT5B) [plasma membrane] (Danio rerio)
        
        IL21:IL21R:p-Y-JAK1:IL2RG:p-Y-JAK3 [plasma membrane] (Danio rerio)
        
        IL21:IL21R:p-Y-JAK1 [plasma membrane] (Danio rerio)
        
        IL21R:p-Y-JAK1 [plasma membrane] (Danio rerio)
        
        phospho-p-Y-JAK1 [cytosol] (Danio rerio)

External Reference Information

External Reference

UniProt:O12990

Reference Genes

ENSEMBL:ENSDARG00000020625

UCSC:O12990

Participates

as a component of

Other forms of this molecule

phospho-p-Y1034,Y1035-JAK1 [cytosol]

phospho-p-JAK1 [cytosol]

phospho-p-Y1034-JAK1 [cytosol]

JAK1 [cytosol]

Inferred From

p-Y-JAK1 [cytosol] (Homo sapiens)

Modified Residues

Name

O4'-phospho-L-tyrosine at unknown position

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

ZFIN

ZDB-GENE-980526-142

PRO

O12990

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