Reactome | tab2 [endosome membrane]

tab2 [endosome membrane]

Stable Identifier

R-DRE-450279

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

endosome membrane

Synonyms

TAB2, Q5RFW2

Locations in the PathwayBrowser

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Immune System (Danio rerio)

- Innate Immune System (Danio rerio)
  - Toll-like Receptor Cascades (Danio rerio)
    - Toll Like Receptor 7/8 (TLR7/8) Cascade (Danio rerio)
      - MyD88 dependent cascade initiated on endosome (Danio rerio)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Danio rerio)
        
        IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation (Danio rerio)
        
        Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 upon TLR7/8 or 9 activation (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63 pUb:TAK1 complex [endosome membrane] (Danio rerio)
        
        TAK1 complex [endosome membrane] (Danio rerio)
        
        TAB2/3 [endosome membrane] (Danio rerio)
        
        tab2 [endosome membrane] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [endosome membrane] (Danio rerio)
        
        TAB2/3 [endosome membrane] (Danio rerio)
        
        tab2 [endosome membrane] (Danio rerio)
    - Toll Like Receptor 9 (TLR9) Cascade (Danio rerio)
      - MyD88 dependent cascade initiated on endosome (Danio rerio)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Danio rerio)
        
        IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation (Danio rerio)
        
        Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 upon TLR7/8 or 9 activation (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63 pUb:TAK1 complex [endosome membrane] (Danio rerio)
        
        TAK1 complex [endosome membrane] (Danio rerio)
        
        TAB2/3 [endosome membrane] (Danio rerio)
        
        tab2 [endosome membrane] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [endosome membrane] (Danio rerio)
        
        TAB2/3 [endosome membrane] (Danio rerio)
        
        tab2 [endosome membrane] (Danio rerio)

External Reference Information

External Reference

UniProt:Q5RFW2

Gene Names

tab2

Reference Genes

BioGPS Gene:494163 tab2

ENSEMBL:ENSDARG00000021509

Monarch:494163 tab2

NCBI Gene:494163 tab2

UCSC:Q5RFW2 tab2

Other Identifiers

13093787

13282218

494163

A_15_P101399

A_15_P102867

A_15_P108433

A_15_P191526

A_15_P191531

A_15_P605777

A_15_P624156

A_15_P720061

CJ013780

CJ014358

CJ014498

CUST_6981_PI428451958

CUST_7720_PI428451953

CUST_7721_PI428451953

CUST_7722_PI428451953

DRER02187

DRER09041

DRER35903

Dr.10125.1.S1_at

ENSDART00000017791

ENSDART00000017791_1

ENSDART00000017791_2

ENSDART00000064436

GO:0043130

GT_Spec_NM_001009900.1_235575

LOL00054

LOL00055

LOL01054

LOL01055

LOL01595

LOL01596

LOL02430

LOL02431

LOL02432

LOL02433

LOL02434

LOL02435

LOL02436

LOL02437

LOL02438

LOL02440

LOL02441

LOL02442

LOL02443

LOL02444

LOL02445

LOL04903

LOL04904

MADDr01009141

NM_001009900

OTTDART00000012702

OTTDART00000012703

Participates

as a member of

TAB2/3 [endosome membrane] (Danio rerio)

Other forms of this molecule

tab2 [plasma membrane]

tab2 [cytosol]

Inferred From

TAB2 [endosome membrane] (Homo sapiens)

Cross References

ENSEMBL

ENSDARP00000019647, ENSDARG00000021509, ENSDART00000017791

ZFIN

ZDB-GENE-040426-933

PRO

Q5RFW2

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