Reactome | si:ch73-109i22.2 [cytosol]

si:ch73-109i22.2 [cytosol]

Stable Identifier

R-DRE-4420125

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

cytosol

Synonyms

SH2D2A, E7FFT4

Locations in the PathwayBrowser

Expand all

Signal Transduction (Danio rerio)

- Signaling by Receptor Tyrosine Kinases (Danio rerio)
  - Signaling by VEGF (Danio rerio)
    - VEGFA-VEGFR2 Pathway (Danio rerio)
      - AXL autophosphorylates on Y779 and Y821 (Danio rerio)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:AXL [plasma membrane] (Danio rerio)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1 [plasma membrane] (Danio rerio)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Danio rerio)
        
        Homologues of SH2D2A [cytosol] (Danio rerio)
        
        si:ch73-109i22.2 [cytosol] (Danio rerio)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXL [plasma membrane] (Danio rerio)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1 [plasma membrane] (Danio rerio)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Danio rerio)
        
        Homologues of SH2D2A [cytosol] (Danio rerio)
        
        si:ch73-109i22.2 [cytosol] (Danio rerio)
      - Phosphorylation of SRC-1 (Danio rerio)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A:SRC-1 [plasma membrane] (Danio rerio)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Danio rerio)
        
        Homologues of SH2D2A [cytosol] (Danio rerio)
        
        si:ch73-109i22.2 [cytosol] (Danio rerio)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1 [plasma membrane] (Danio rerio)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Danio rerio)
        
        Homologues of SH2D2A [cytosol] (Danio rerio)
        
        si:ch73-109i22.2 [cytosol] (Danio rerio)
      - SRC1-1 binds SH2D2A and is recruited to VEGFR2 (Danio rerio)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Danio rerio)
        
        Homologues of SH2D2A [cytosol] (Danio rerio)
        
        si:ch73-109i22.2 [cytosol] (Danio rerio)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A:SRC-1 [plasma membrane] (Danio rerio)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Danio rerio)
        
        Homologues of SH2D2A [cytosol] (Danio rerio)
        
        si:ch73-109i22.2 [cytosol] (Danio rerio)
      - VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K/VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y772,Y814-AXL:PI3K [plasma membrane] (Danio rerio)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXL:PI3K [plasma membrane] (Danio rerio)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXL [plasma membrane] (Danio rerio)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1 [plasma membrane] (Danio rerio)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Danio rerio)
        
        Homologues of SH2D2A [cytosol] (Danio rerio)
        
        si:ch73-109i22.2 [cytosol] (Danio rerio)
      - p-6Y-VEGFR2 binds SH2D2A (Danio rerio)
        
        Homologues of SH2D2A [cytosol] (Danio rerio)
        
        si:ch73-109i22.2 [cytosol] (Danio rerio)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Danio rerio)
        
        Homologues of SH2D2A [cytosol] (Danio rerio)
        
        si:ch73-109i22.2 [cytosol] (Danio rerio)
      - p-AXL binds PI3K (Danio rerio)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXL [plasma membrane] (Danio rerio)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1 [plasma membrane] (Danio rerio)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Danio rerio)
        
        Homologues of SH2D2A [cytosol] (Danio rerio)
        
        si:ch73-109i22.2 [cytosol] (Danio rerio)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXL:PI3K [plasma membrane] (Danio rerio)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXL [plasma membrane] (Danio rerio)
        
        VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1 [plasma membrane] (Danio rerio)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane] (Danio rerio)
        
        Homologues of SH2D2A [cytosol] (Danio rerio)
        
        si:ch73-109i22.2 [cytosol] (Danio rerio)

External Reference Information

External Reference

UniProt:E7FFT4

Gene Names

si:ch73-109i22.2

Reference Genes

BioGPS Gene:570350 si:ch73-109i22.2

ENSEMBL:ENSDARG00000089983

KEGG:dre:570350 si:ch73-109i22.2

Monarch:570350 si:ch73-109i22.2

NCBI Gene:570350 si:ch73-109i22.2

UCSC:E7FFT4 si:ch73-109i22.2

Reference Transcript

RefSeq:XM_693824.9 si:ch73-109i22.2

Other Identifiers

13067815

13067824

570350

A_15_P241361

A_15_P482395

CUST_15445_PI428451953

DRER28107

GT_Spec_XM_693824.6_423925

XM_693824

Participates

as a member of

Homologues of SH2D2A [cytosol] (Danio rerio)

Inferred From

SH2D2A [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_698916.2

ENSEMBL

ENSDARP00000105578, ENSDART00000127362, ENSDARG00000089983

ZFIN

ZDB-GENE-141211-57