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map3k8 [cytosol]
Stable Identifier
R-DRE-389388
Type
Protein [EntityWithAccessionedSequence]
Species
Danio rerio
Compartment
cytosol
Synonyms
MAP3K8, A0A8N7T7L4
Locations in the PathwayBrowser
Expand all
Immune System (Danio rerio)
Adaptive Immune System (Danio rerio)
Regulation of T cell activation by CD28 family (Danio rerio)
Co-stimulation by CD28 (Danio rerio)
CD28 dependent PI3K/Akt signaling (Danio rerio)
AKT interacts and phosphorylates Cot (Danio rerio)
map3k8 [cytosol] (Danio rerio)
p-S400-Cot phosphorylates NIK (Danio rerio)
map3k8 [cytosol] (Danio rerio)
Cytokine Signaling in Immune system (Danio rerio)
Signaling by Interleukins (Danio rerio)
Interleukin-1 family signaling (Danio rerio)
Interleukin-1 signaling (Danio rerio)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Danio rerio)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Danio rerio)
NFKB1:MAP3K8:TNIP2 [cytosol] (Danio rerio)
map3k8 [cytosol] (Danio rerio)
p-S927,S932-NFKB1(1-968):MAP3K8:TNIP2 [cytosol] (Danio rerio)
map3k8 [cytosol] (Danio rerio)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Danio rerio)
NFKB1:MAP3K8:TNIP2 [cytosol] (Danio rerio)
map3k8 [cytosol] (Danio rerio)
MAP3K8 is phosphorylated (Danio rerio)
NFKB1:MAP3K8:TNIP2 [cytosol] (Danio rerio)
map3k8 [cytosol] (Danio rerio)
NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Danio rerio)
NFKB1:MAP3K8:TNIP2 [cytosol] (Danio rerio)
map3k8 [cytosol] (Danio rerio)
map3k8 [cytosol] (Danio rerio)
Interleukin-17 signaling (Danio rerio)
MAP kinase activation (Danio rerio)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Danio rerio)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Danio rerio)
NFKB1:MAP3K8:TNIP2 [cytosol] (Danio rerio)
map3k8 [cytosol] (Danio rerio)
p-S927,S932-NFKB1(1-968):MAP3K8:TNIP2 [cytosol] (Danio rerio)
map3k8 [cytosol] (Danio rerio)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Danio rerio)
NFKB1:MAP3K8:TNIP2 [cytosol] (Danio rerio)
map3k8 [cytosol] (Danio rerio)
MAP3K8 is phosphorylated (Danio rerio)
NFKB1:MAP3K8:TNIP2 [cytosol] (Danio rerio)
map3k8 [cytosol] (Danio rerio)
NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Danio rerio)
NFKB1:MAP3K8:TNIP2 [cytosol] (Danio rerio)
map3k8 [cytosol] (Danio rerio)
map3k8 [cytosol] (Danio rerio)
Innate Immune System (Danio rerio)
Toll-like Receptor Cascades (Danio rerio)
Toll Like Receptor 10 (TLR10) Cascade (Danio rerio)
MyD88 cascade initiated on plasma membrane (Danio rerio)
MAP kinase activation (Danio rerio)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Danio rerio)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Danio rerio)
NFKB1:MAP3K8:TNIP2 [cytosol] (Danio rerio)
map3k8 [cytosol] (Danio rerio)
p-S927,S932-NFKB1(1-968):MAP3K8:TNIP2 [cytosol] (Danio rerio)
map3k8 [cytosol] (Danio rerio)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Danio rerio)
NFKB1:MAP3K8:TNIP2 [cytosol] (Danio rerio)
map3k8 [cytosol] (Danio rerio)
MAP3K8 is phosphorylated (Danio rerio)
NFKB1:MAP3K8:TNIP2 [cytosol] (Danio rerio)
map3k8 [cytosol] (Danio rerio)
NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Danio rerio)
NFKB1:MAP3K8:TNIP2 [cytosol] (Danio rerio)
map3k8 [cytosol] (Danio rerio)
map3k8 [cytosol] (Danio rerio)
Toll Like Receptor 2 (TLR2) Cascade (Danio rerio)
Toll Like Receptor TLR1:TLR2 Cascade (Danio rerio)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Danio rerio)
MAP kinase activation (Danio rerio)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Danio rerio)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Danio rerio)
NFKB1:MAP3K8:TNIP2 [cytosol] (Danio rerio)
map3k8 [cytosol] (Danio rerio)
p-S927,S932-NFKB1(1-968):MAP3K8:TNIP2 [cytosol] (Danio rerio)
map3k8 [cytosol] (Danio rerio)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Danio rerio)
NFKB1:MAP3K8:TNIP2 [cytosol] (Danio rerio)
map3k8 [cytosol] (Danio rerio)
MAP3K8 is phosphorylated (Danio rerio)
NFKB1:MAP3K8:TNIP2 [cytosol] (Danio rerio)
map3k8 [cytosol] (Danio rerio)
NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Danio rerio)
NFKB1:MAP3K8:TNIP2 [cytosol] (Danio rerio)
map3k8 [cytosol] (Danio rerio)
map3k8 [cytosol] (Danio rerio)
Toll Like Receptor TLR6:TLR2 Cascade (Danio rerio)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Danio rerio)
MAP kinase activation (Danio rerio)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Danio rerio)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Danio rerio)
NFKB1:MAP3K8:TNIP2 [cytosol] (Danio rerio)
map3k8 [cytosol] (Danio rerio)
p-S927,S932-NFKB1(1-968):MAP3K8:TNIP2 [cytosol] (Danio rerio)
map3k8 [cytosol] (Danio rerio)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Danio rerio)
NFKB1:MAP3K8:TNIP2 [cytosol] (Danio rerio)
map3k8 [cytosol] (Danio rerio)
MAP3K8 is phosphorylated (Danio rerio)
NFKB1:MAP3K8:TNIP2 [cytosol] (Danio rerio)
map3k8 [cytosol] (Danio rerio)
NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Danio rerio)
NFKB1:MAP3K8:TNIP2 [cytosol] (Danio rerio)
map3k8 [cytosol] (Danio rerio)
map3k8 [cytosol] (Danio rerio)
Toll Like Receptor 3 (TLR3) Cascade (Danio rerio)
MAP kinase activation (Danio rerio)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Danio rerio)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Danio rerio)
NFKB1:MAP3K8:TNIP2 [cytosol] (Danio rerio)
map3k8 [cytosol] (Danio rerio)
p-S927,S932-NFKB1(1-968):MAP3K8:TNIP2 [cytosol] (Danio rerio)
map3k8 [cytosol] (Danio rerio)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Danio rerio)
NFKB1:MAP3K8:TNIP2 [cytosol] (Danio rerio)
map3k8 [cytosol] (Danio rerio)
MAP3K8 is phosphorylated (Danio rerio)
NFKB1:MAP3K8:TNIP2 [cytosol] (Danio rerio)
map3k8 [cytosol] (Danio rerio)
NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Danio rerio)
NFKB1:MAP3K8:TNIP2 [cytosol] (Danio rerio)
map3k8 [cytosol] (Danio rerio)
map3k8 [cytosol] (Danio rerio)
Toll Like Receptor 4 (TLR4) Cascade (Danio rerio)
MyD88-independent TLR4 cascade (Danio rerio)
TRIF (TICAM1)-mediated TLR4 signaling (Danio rerio)
MAP kinase activation (Danio rerio)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Danio rerio)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Danio rerio)
NFKB1:MAP3K8:TNIP2 [cytosol] (Danio rerio)
map3k8 [cytosol] (Danio rerio)
p-S927,S932-NFKB1(1-968):MAP3K8:TNIP2 [cytosol] (Danio rerio)
map3k8 [cytosol] (Danio rerio)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Danio rerio)
NFKB1:MAP3K8:TNIP2 [cytosol] (Danio rerio)
map3k8 [cytosol] (Danio rerio)
MAP3K8 is phosphorylated (Danio rerio)
NFKB1:MAP3K8:TNIP2 [cytosol] (Danio rerio)
map3k8 [cytosol] (Danio rerio)
NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Danio rerio)
NFKB1:MAP3K8:TNIP2 [cytosol] (Danio rerio)
map3k8 [cytosol] (Danio rerio)
map3k8 [cytosol] (Danio rerio)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Danio rerio)
MAP kinase activation (Danio rerio)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Danio rerio)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Danio rerio)
NFKB1:MAP3K8:TNIP2 [cytosol] (Danio rerio)
map3k8 [cytosol] (Danio rerio)
p-S927,S932-NFKB1(1-968):MAP3K8:TNIP2 [cytosol] (Danio rerio)
map3k8 [cytosol] (Danio rerio)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Danio rerio)
NFKB1:MAP3K8:TNIP2 [cytosol] (Danio rerio)
map3k8 [cytosol] (Danio rerio)
MAP3K8 is phosphorylated (Danio rerio)
NFKB1:MAP3K8:TNIP2 [cytosol] (Danio rerio)
map3k8 [cytosol] (Danio rerio)
NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Danio rerio)
NFKB1:MAP3K8:TNIP2 [cytosol] (Danio rerio)
map3k8 [cytosol] (Danio rerio)
map3k8 [cytosol] (Danio rerio)
Toll Like Receptor 5 (TLR5) Cascade (Danio rerio)
MyD88 cascade initiated on plasma membrane (Danio rerio)
MAP kinase activation (Danio rerio)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Danio rerio)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Danio rerio)
NFKB1:MAP3K8:TNIP2 [cytosol] (Danio rerio)
map3k8 [cytosol] (Danio rerio)
p-S927,S932-NFKB1(1-968):MAP3K8:TNIP2 [cytosol] (Danio rerio)
map3k8 [cytosol] (Danio rerio)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Danio rerio)
NFKB1:MAP3K8:TNIP2 [cytosol] (Danio rerio)
map3k8 [cytosol] (Danio rerio)
MAP3K8 is phosphorylated (Danio rerio)
NFKB1:MAP3K8:TNIP2 [cytosol] (Danio rerio)
map3k8 [cytosol] (Danio rerio)
NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Danio rerio)
NFKB1:MAP3K8:TNIP2 [cytosol] (Danio rerio)
map3k8 [cytosol] (Danio rerio)
map3k8 [cytosol] (Danio rerio)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Danio rerio)
MyD88 dependent cascade initiated on endosome (Danio rerio)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Danio rerio)
MAP kinase activation (Danio rerio)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Danio rerio)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Danio rerio)
NFKB1:MAP3K8:TNIP2 [cytosol] (Danio rerio)
map3k8 [cytosol] (Danio rerio)
p-S927,S932-NFKB1(1-968):MAP3K8:TNIP2 [cytosol] (Danio rerio)
map3k8 [cytosol] (Danio rerio)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Danio rerio)
NFKB1:MAP3K8:TNIP2 [cytosol] (Danio rerio)
map3k8 [cytosol] (Danio rerio)
MAP3K8 is phosphorylated (Danio rerio)
NFKB1:MAP3K8:TNIP2 [cytosol] (Danio rerio)
map3k8 [cytosol] (Danio rerio)
NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Danio rerio)
NFKB1:MAP3K8:TNIP2 [cytosol] (Danio rerio)
map3k8 [cytosol] (Danio rerio)
map3k8 [cytosol] (Danio rerio)
Toll Like Receptor 9 (TLR9) Cascade (Danio rerio)
MyD88 dependent cascade initiated on endosome (Danio rerio)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Danio rerio)
MAP kinase activation (Danio rerio)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Danio rerio)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Danio rerio)
NFKB1:MAP3K8:TNIP2 [cytosol] (Danio rerio)
map3k8 [cytosol] (Danio rerio)
p-S927,S932-NFKB1(1-968):MAP3K8:TNIP2 [cytosol] (Danio rerio)
map3k8 [cytosol] (Danio rerio)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Danio rerio)
NFKB1:MAP3K8:TNIP2 [cytosol] (Danio rerio)
map3k8 [cytosol] (Danio rerio)
MAP3K8 is phosphorylated (Danio rerio)
NFKB1:MAP3K8:TNIP2 [cytosol] (Danio rerio)
map3k8 [cytosol] (Danio rerio)
NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Danio rerio)
NFKB1:MAP3K8:TNIP2 [cytosol] (Danio rerio)
map3k8 [cytosol] (Danio rerio)
map3k8 [cytosol] (Danio rerio)
External Reference Information
External Reference
UniProt:A0A8N7T7L4
Gene Names
map3k8
Reference Genes
ENSEMBL:ENSDARG00000061710
KEGG:dre:563727 map3k8
UCSC:A0A8N7T7L4 map3k8
Other Identifiers
12991460
563727
A_15_P166686
CJ009620
CJ010474
CJ010836
CJ012920
CJ013818
CJ014407
CJ014472
CUST_9137_PI428451953
DRER13377
ENSDART00000088319
ENSDART00000088319_1
ENSDART00000088319_2
GO:0003824
GO:0004672
GO:0005524
GO:0006468
GO:0016740
GO:0140096
GT_Spec_XM_687085.4_260557
JP010018
JP010872
JP011234
LOL04465
LOL04467
LOL04468
XM_687085
Participates
as an input of
AKT interacts and phosphorylates Cot (Danio rerio)
NFKB p105, TPL2 (COT) and ABIN2 form a stable complex (Danio rerio)
as a component of
p-S927,S932-NFKB1(1-968):MAP3K8:TNIP2 [cytosol] (Danio rerio)
NFKB1:MAP3K8:TNIP2 [cytosol] (Danio rerio)
Other forms of this molecule
phospho-map3k8 [cytosol]
phospho-map3k8 [cytosol]
Inferred From
MAP3K8 [cytosol]
(Homo sapiens)
Cross References
ENSEMBL
ENSDART00000088319
,
ENSDARG00000061710
,
ENSDARP00000082752
ZFIN
ZDB-GENE-100316-8
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