Reactome | clasp2 [cytosol]

clasp2 [cytosol]

Stable Identifier

R-DRE-376252

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

cytosol

Synonyms

CLASP2, Q6NYW6

Locations in the PathwayBrowser

Expand all

Cell Cycle (Danio rerio)

- Cell Cycle Checkpoints (Danio rerio)
  - Mitotic Spindle Checkpoint (Danio rerio)
    - Amplification of signal from the kinetochores (Danio rerio)
      - Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (Danio rerio)
        
        MAD2 associates with the Mad1 kinetochore complex (Danio rerio)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Danio rerio)
        
        Mad1:kinetochore complex [cytosol] (Danio rerio)
        
        Kinetochore [cytosol] (Danio rerio)
        
        clasp2 [cytosol] (Danio rerio)
        
        Mad1:kinetochore complex [cytosol] (Danio rerio)
        
        Kinetochore [cytosol] (Danio rerio)
        
        clasp2 [cytosol] (Danio rerio)
        
        MAD2 converted to an inhibitory state via interaction with Mad1 (Danio rerio)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Danio rerio)
        
        Mad1:kinetochore complex [cytosol] (Danio rerio)
        
        Kinetochore [cytosol] (Danio rerio)
        
        clasp2 [cytosol] (Danio rerio)
        
        Mad1 binds kinetochore (Danio rerio)
        
        Kinetochore [cytosol] (Danio rerio)
        
        clasp2 [cytosol] (Danio rerio)
        
        Mad1:kinetochore complex [cytosol] (Danio rerio)
        
        Kinetochore [cytosol] (Danio rerio)
        
        clasp2 [cytosol] (Danio rerio)
        
        Release of activated MAD2 from kinetochores (Danio rerio)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Danio rerio)
        
        Mad1:kinetochore complex [cytosol] (Danio rerio)
        
        Kinetochore [cytosol] (Danio rerio)
        
        clasp2 [cytosol] (Danio rerio)
        
        Mad1:kinetochore complex [cytosol] (Danio rerio)
        
        Kinetochore [cytosol] (Danio rerio)
        
        clasp2 [cytosol] (Danio rerio)
- Cell Cycle, Mitotic (Danio rerio)
  - M Phase (Danio rerio)
    - Mitotic Metaphase and Anaphase (Danio rerio)
      - Mitotic Anaphase (Danio rerio)
        
        Separation of Sister Chromatids (Danio rerio)
        
        ESPL1 (Separase) cleaves centromeric cohesin (Danio rerio)
        
        Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Danio rerio)
        
        Kinetochore [cytosol] (Danio rerio)
        
        clasp2 [cytosol] (Danio rerio)
        
        p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Danio rerio)
        
        Microtubule-bound kinetochore [cytosol] (Danio rerio)
        
        Kinetochore [cytosol] (Danio rerio)
        
        clasp2 [cytosol] (Danio rerio)
        
        Separation of sister chromatids (Danio rerio)
        
        Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Danio rerio)
        
        Kinetochore [cytosol] (Danio rerio)
        
        clasp2 [cytosol] (Danio rerio)
        
        Sister Centromere:Kinetochore:Microtubules [cytosol] (Danio rerio)
        
        Kinetochore [cytosol] (Danio rerio)
        
        clasp2 [cytosol] (Danio rerio)
    - Mitotic Prometaphase (Danio rerio)
      - Resolution of Sister Chromatid Cohesion (Danio rerio)
        
        CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Danio rerio)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Danio rerio)
        
        Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Danio rerio)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Danio rerio)
        
        Kinetochore [cytosol] (Danio rerio)
        
        clasp2 [cytosol] (Danio rerio)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Danio rerio)
        
        Kinetochore [cytosol] (Danio rerio)
        
        clasp2 [cytosol] (Danio rerio)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Danio rerio)
        
        Microtubule-bound kinetochore [cytosol] (Danio rerio)
        
        Kinetochore [cytosol] (Danio rerio)
        
        clasp2 [cytosol] (Danio rerio)
        
        Kinetochore assembly (Danio rerio)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Danio rerio)
        
        Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Danio rerio)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Danio rerio)
        
        Kinetochore [cytosol] (Danio rerio)
        
        clasp2 [cytosol] (Danio rerio)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Danio rerio)
        
        Kinetochore [cytosol] (Danio rerio)
        
        clasp2 [cytosol] (Danio rerio)
        
        Microtubule-bound kinetochore [cytosol] (Danio rerio)
        
        Kinetochore [cytosol] (Danio rerio)
        
        clasp2 [cytosol] (Danio rerio)
        
        PP2A-B56 dephosphorylates centromeric cohesin (Danio rerio)
        
        p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Danio rerio)
        
        Microtubule-bound kinetochore [cytosol] (Danio rerio)
        
        Kinetochore [cytosol] (Danio rerio)
        
        clasp2 [cytosol] (Danio rerio)
        
        p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Danio rerio)
        
        Microtubule-bound kinetochore [cytosol] (Danio rerio)
        
        Kinetochore [cytosol] (Danio rerio)
        
        clasp2 [cytosol] (Danio rerio)
        
        Phosphorylation of cohesin by PLK1 at centromeres (Danio rerio)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Danio rerio)
        
        Microtubule-bound kinetochore [cytosol] (Danio rerio)
        
        Kinetochore [cytosol] (Danio rerio)
        
        clasp2 [cytosol] (Danio rerio)
        
        p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Danio rerio)
        
        Microtubule-bound kinetochore [cytosol] (Danio rerio)
        
        Kinetochore [cytosol] (Danio rerio)
        
        clasp2 [cytosol] (Danio rerio)

Signal Transduction (Danio rerio)

- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Danio rerio)
  - Signaling by Rho GTPases (Danio rerio)
    - RHO GTPase Effectors (Danio rerio)
      - RHO GTPases Activate Formins (Danio rerio)
        
        AURKB phosphorylates DIAPH2-2 at kinetochores (Danio rerio)
        
        Kinetochore:CDC42:GTP:DIAPH2-2 [cytosol] (Danio rerio)
        
        Kinetochore [cytosol] (Danio rerio)
        
        clasp2 [cytosol] (Danio rerio)
        
        Kinetochore:CDC42:GTP:p-S196-DIAPH2-2 [cytosol] (Danio rerio)
        
        Kinetochore [cytosol] (Danio rerio)
        
        clasp2 [cytosol] (Danio rerio)

External Reference Information

External Reference

UniProt:Q6NYW6

Gene Names

clasp2

Reference Genes

BioGPS Gene:404604 clasp2

ENSEMBL:ENSDARG00000020345

KEGG:dre:404604 clasp2

Monarch:404604 clasp2

NCBI Gene:404604 clasp2

UCSC:Q6NYW6 clasp2

Reference Transcript

RefSeq:NM_207072.2 clasp2

Other Identifiers

13070852

13278008

13278020

404604

A_15_P100068

A_15_P109131

A_15_P182871

A_15_P280651

CUST_25235_PI428451953

CUST_25236_PI428451953

CUST_25237_PI428451953

CUST_25238_PI428451953

CUST_25239_PI428451953

CUST_25240_PI428451953

CUST_25241_PI428451953

CUST_5626_PI428451958

DRER04776

DRER10666

DRER16082

DRER33224

DRER36086

DRER37750

DRER38091

DRER43050

DRER48928

DRER49016

DRER49077

DRER49363

Dr.14760.1.A1_at

ENSDART00000039871

ENSDART00000039871_1

ENSDART00000039871_2

GO:0008092

GO:0015631

GT_Xhyb_NM_207072.1_151876

GT_Xhyb_XM_005159729.1_294155

LOLS02397

MADDr01008851

NM_207072

OTTDART00000018852

OTTDART00000018853

OTTDART00000018855

Participates

as a component of

Kinetochore [cytosol] (Danio rerio)

Inferred From

CLASP2 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_996955.1

ENSEMBL

ENSDART00000144557, ENSDARG00000020345, ENSDARP00000113962

ZFIN

ZDB-GENE-040426-2343

PRO

Q6NYW6

Cite Us!