Reactome | pafah1b1a [cytosol]

pafah1b1a [cytosol]

Stable Identifier

R-DRE-376249

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

cytosol

Synonyms

PAFAH1B1, Q7T394

Locations in the PathwayBrowser

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Cell Cycle (Danio rerio)

- Cell Cycle Checkpoints (Danio rerio)
  - Mitotic Spindle Checkpoint (Danio rerio)
    - Amplification of signal from the kinetochores (Danio rerio)
      - Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (Danio rerio)
        
        MAD2 associates with the Mad1 kinetochore complex (Danio rerio)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Danio rerio)
        
        Mad1:kinetochore complex [cytosol] (Danio rerio)
        
        Kinetochore [cytosol] (Danio rerio)
        
        pafah1b1a [cytosol] (Danio rerio)
        
        Mad1:kinetochore complex [cytosol] (Danio rerio)
        
        Kinetochore [cytosol] (Danio rerio)
        
        pafah1b1a [cytosol] (Danio rerio)
        
        MAD2 converted to an inhibitory state via interaction with Mad1 (Danio rerio)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Danio rerio)
        
        Mad1:kinetochore complex [cytosol] (Danio rerio)
        
        Kinetochore [cytosol] (Danio rerio)
        
        pafah1b1a [cytosol] (Danio rerio)
        
        Mad1 binds kinetochore (Danio rerio)
        
        Kinetochore [cytosol] (Danio rerio)
        
        pafah1b1a [cytosol] (Danio rerio)
        
        Mad1:kinetochore complex [cytosol] (Danio rerio)
        
        Kinetochore [cytosol] (Danio rerio)
        
        pafah1b1a [cytosol] (Danio rerio)
        
        Release of activated MAD2 from kinetochores (Danio rerio)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Danio rerio)
        
        Mad1:kinetochore complex [cytosol] (Danio rerio)
        
        Kinetochore [cytosol] (Danio rerio)
        
        pafah1b1a [cytosol] (Danio rerio)
        
        Mad1:kinetochore complex [cytosol] (Danio rerio)
        
        Kinetochore [cytosol] (Danio rerio)
        
        pafah1b1a [cytosol] (Danio rerio)
- Cell Cycle, Mitotic (Danio rerio)
  - M Phase (Danio rerio)
    - Mitotic Metaphase and Anaphase (Danio rerio)
      - Mitotic Anaphase (Danio rerio)
        
        Separation of Sister Chromatids (Danio rerio)
        
        ESPL1 (Separase) cleaves centromeric cohesin (Danio rerio)
        
        Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Danio rerio)
        
        Kinetochore [cytosol] (Danio rerio)
        
        pafah1b1a [cytosol] (Danio rerio)
        
        p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Danio rerio)
        
        Microtubule-bound kinetochore [cytosol] (Danio rerio)
        
        Kinetochore [cytosol] (Danio rerio)
        
        pafah1b1a [cytosol] (Danio rerio)
        
        Separation of sister chromatids (Danio rerio)
        
        Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Danio rerio)
        
        Kinetochore [cytosol] (Danio rerio)
        
        pafah1b1a [cytosol] (Danio rerio)
        
        Sister Centromere:Kinetochore:Microtubules [cytosol] (Danio rerio)
        
        Kinetochore [cytosol] (Danio rerio)
        
        pafah1b1a [cytosol] (Danio rerio)
    - Mitotic Prometaphase (Danio rerio)
      - Recruitment of NuMA to mitotic centrosomes (Danio rerio)
        
        Translocation of NuMA to the centrosomes (Danio rerio)
        
        Mature centrosome enriched in gamma-TURC:p-T2055-NUMA1 homodimer [cytosol] (Danio rerio)
        
        Mature centrosomes enriched in gamma-TURC complexes [cytosol] (Danio rerio)
        
        centrosome [cytosol] (Danio rerio)
        
        pafah1b1a [cytosol] (Danio rerio)
        
        Mature centrosomes enriched in gamma-TURC complexes [cytosol] (Danio rerio)
        
        centrosome [cytosol] (Danio rerio)
        
        pafah1b1a [cytosol] (Danio rerio)
      - Resolution of Sister Chromatid Cohesion (Danio rerio)
        
        CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Danio rerio)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Danio rerio)
        
        Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Danio rerio)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Danio rerio)
        
        Kinetochore [cytosol] (Danio rerio)
        
        pafah1b1a [cytosol] (Danio rerio)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Danio rerio)
        
        Kinetochore [cytosol] (Danio rerio)
        
        pafah1b1a [cytosol] (Danio rerio)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Danio rerio)
        
        Microtubule-bound kinetochore [cytosol] (Danio rerio)
        
        Kinetochore [cytosol] (Danio rerio)
        
        pafah1b1a [cytosol] (Danio rerio)
        
        Kinetochore assembly (Danio rerio)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Danio rerio)
        
        Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Danio rerio)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Danio rerio)
        
        Kinetochore [cytosol] (Danio rerio)
        
        pafah1b1a [cytosol] (Danio rerio)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Danio rerio)
        
        Kinetochore [cytosol] (Danio rerio)
        
        pafah1b1a [cytosol] (Danio rerio)
        
        Microtubule-bound kinetochore [cytosol] (Danio rerio)
        
        Kinetochore [cytosol] (Danio rerio)
        
        pafah1b1a [cytosol] (Danio rerio)
        
        PP2A-B56 dephosphorylates centromeric cohesin (Danio rerio)
        
        p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Danio rerio)
        
        Microtubule-bound kinetochore [cytosol] (Danio rerio)
        
        Kinetochore [cytosol] (Danio rerio)
        
        pafah1b1a [cytosol] (Danio rerio)
        
        p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Danio rerio)
        
        Microtubule-bound kinetochore [cytosol] (Danio rerio)
        
        Kinetochore [cytosol] (Danio rerio)
        
        pafah1b1a [cytosol] (Danio rerio)
        
        Phosphorylation of cohesin by PLK1 at centromeres (Danio rerio)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Danio rerio)
        
        Microtubule-bound kinetochore [cytosol] (Danio rerio)
        
        Kinetochore [cytosol] (Danio rerio)
        
        pafah1b1a [cytosol] (Danio rerio)
        
        p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Danio rerio)
        
        Microtubule-bound kinetochore [cytosol] (Danio rerio)
        
        Kinetochore [cytosol] (Danio rerio)
        
        pafah1b1a [cytosol] (Danio rerio)

Signal Transduction (Danio rerio)

- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Danio rerio)
  - Signaling by Rho GTPases (Danio rerio)
    - RHO GTPase Effectors (Danio rerio)
      - RHO GTPases Activate Formins (Danio rerio)
        
        AURKB phosphorylates DIAPH2-2 at kinetochores (Danio rerio)
        
        Kinetochore:CDC42:GTP:DIAPH2-2 [cytosol] (Danio rerio)
        
        Kinetochore [cytosol] (Danio rerio)
        
        pafah1b1a [cytosol] (Danio rerio)
        
        Kinetochore:CDC42:GTP:p-S196-DIAPH2-2 [cytosol] (Danio rerio)
        
        Kinetochore [cytosol] (Danio rerio)
        
        pafah1b1a [cytosol] (Danio rerio)

Vesicle-mediated transport (Danio rerio)

- Membrane Trafficking (Danio rerio)
  - Intra-Golgi and retrograde Golgi-to-ER traffic (Danio rerio)
    - Golgi-to-ER retrograde transport (Danio rerio)
      - COPI-independent Golgi-to-ER retrograde traffic (Danio rerio)
        
        PLA2s hydrolyze phospholipids at the Golgi membrane (Danio rerio)
        
        cPLA2s [cytosol] (Danio rerio)
        
        PAFAH Ib [cytosol] (Danio rerio)
        
        pafah1b1a [cytosol] (Danio rerio)

External Reference Information

External Reference

UniProt:Q7T394

Gene Names

pafah1b1a

Reference Genes

BioGPS Gene:394246 pafah1b1a

CTD Gene:394246 pafah1b1a

ENSEMBL:ENSDARG00000032013

KEGG:dre:394246 pafah1b1a

Monarch:394246 pafah1b1a

NCBI Gene:394246 pafah1b1a

UCSC:Q7T394 pafah1b1a

Reference Transcript

Other Identifiers

13025924

13025926

394246

A_15_P104481

A_15_P281691

DRER05098

DRER30419

Dr.15832.1.S1_at

Dr.16144.1.A1_at

ENSDART00000042218

ENSDART00000042218_1

ENSDART00000042218_2

GO:0005515

MADDr01008290

NM_201345

OTTDART00000026082

Participates

as a component of

Other forms of this molecule

pafah1b1a [nucleoplasm]

pafah1b1a [cytosol]

Inferred From

PAFAH1B1 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_005157632.1, NP_958502.1

ENSEMBL

ENSDART00000190690, ENSDARG00000032013, ENSDARP00000156578, ENSDARP00000042217, ENSDART00000042218

ZFIN

ZDB-GENE-040116-2

PRO

Q7T394

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