Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
vcla [cytosol]
Stable Identifier
R-DRE-350753
Type
Protein [EntityWithAccessionedSequence]
Species
Danio rerio
Compartment
cytosol
Synonyms
VCL, B3DI32
Locations in the PathwayBrowser
Expand all
Cell-Cell communication (Danio rerio)
Cell junction organization (Danio rerio)
Cell-cell junction organization (Danio rerio)
Adherens junctions interactions (Danio rerio)
Activation of STAT3 by cadherin engagement (Danio rerio)
CDH1 forms homotypic trans-dimers (Danio rerio)
Homotypic CDH1 cis-cluster:F-actin:VCL [plasma membrane] (Danio rerio)
vcla [cytosol] (Danio rerio)
Homotypic CDH1 trans-dimer cluster [plasma membrane] (Danio rerio)
Homotypic CDH1 trans-dimer [plasma membrane] (Danio rerio)
Man,Man9GlucNAc2,p-3S-CDH1:CTNNB1,JUP:CTNNA1:CTNND1:F-actin:VCL [plasma membrane] (Danio rerio)
vcla [cytosol] (Danio rerio)
trans-homotypic CDH1 cluster:F-actin:VCL [plasma membrane] (Danio rerio)
vcla [cytosol] (Danio rerio)
CDH1-associated CTNNA1 binds VCL (Danio rerio)
Homotypic CDH1 cis-cluster:F-actin:VCL [plasma membrane] (Danio rerio)
vcla [cytosol] (Danio rerio)
vcla [cytosol] (Danio rerio)
Cell-to-cell contact through homophilic cadherin interactions inhibits RAC1/CDC42 ubiquitination (Danio rerio)
Engaged CDH1,(CDH11) [plasma membrane] (Danio rerio)
Homotypic CDH1 trans-dimer cluster [plasma membrane] (Danio rerio)
Homotypic CDH1 trans-dimer [plasma membrane] (Danio rerio)
Man,Man9GlucNAc2,p-3S-CDH1:CTNNB1,JUP:CTNNA1:CTNND1:F-actin:VCL [plasma membrane] (Danio rerio)
vcla [cytosol] (Danio rerio)
Regulation of Homotypic Cell-Cell Adhesion (Danio rerio)
Regulation of Expression and Function of Type I Classical Cadherins (Danio rerio)
Regulation of CDH1 Expression and Function (Danio rerio)
Regulation of CDH1 Function (Danio rerio)
CDH1 forms homotypic trans-dimers (Danio rerio)
Homotypic CDH1 cis-cluster:F-actin:VCL [plasma membrane] (Danio rerio)
vcla [cytosol] (Danio rerio)
Homotypic CDH1 trans-dimer cluster [plasma membrane] (Danio rerio)
Homotypic CDH1 trans-dimer [plasma membrane] (Danio rerio)
Man,Man9GlucNAc2,p-3S-CDH1:CTNNB1,JUP:CTNNA1:CTNND1:F-actin:VCL [plasma membrane] (Danio rerio)
vcla [cytosol] (Danio rerio)
trans-homotypic CDH1 cluster:F-actin:VCL [plasma membrane] (Danio rerio)
vcla [cytosol] (Danio rerio)
CDH1-associated CTNNA1 binds VCL (Danio rerio)
Homotypic CDH1 cis-cluster:F-actin:VCL [plasma membrane] (Danio rerio)
vcla [cytosol] (Danio rerio)
vcla [cytosol] (Danio rerio)
Cellular responses to stimuli (Danio rerio)
Cellular responses to mechanical stimuli (Danio rerio)
Response of endothelial cells to shear stress (Danio rerio)
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells (Danio rerio)
Calpain2 (m-Calpain, CAPN2:CAPNS:Ca2+) cleaves VCL (Vinculin) (Danio rerio)
vcla [cytosol] (Danio rerio)
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells (Danio rerio)
Calpain2 (m-Calpain, CAPN2:CAPNS:Ca2+) cleaves VCL (Vinculin) (Danio rerio)
vcla [cytosol] (Danio rerio)
Hemostasis (Danio rerio)
Platelet activation, signaling and aggregation (Danio rerio)
Response to elevated platelet cytosolic Ca2+ (Danio rerio)
Platelet degranulation (Danio rerio)
Release of platelet cytosolic components (Danio rerio)
Platelet releasate cytosolic proteins [cytosol] (Danio rerio)
vcla [cytosol] (Danio rerio)
Signal Transduction (Danio rerio)
MAPK family signaling cascades (Danio rerio)
MAPK1/MAPK3 signaling (Danio rerio)
RAF/MAP kinase cascade (Danio rerio)
MAP2K and MAPK activation (Danio rerio)
Dual mechanism MAP2K inhibitors bind MAP2Ks (Danio rerio)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Danio rerio)
RAF/MAPK scaffolds [cytosol] (Danio rerio)
Focal Adhesion/Focal contacts [plasma membrane] (Danio rerio)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Danio rerio)
Vinculin bound to PIP2 [plasma membrane] (Danio rerio)
vcla [cytosol] (Danio rerio)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Danio rerio)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Danio rerio)
RAF/MAPK scaffolds [cytosol] (Danio rerio)
Focal Adhesion/Focal contacts [plasma membrane] (Danio rerio)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Danio rerio)
Vinculin bound to PIP2 [plasma membrane] (Danio rerio)
vcla [cytosol] (Danio rerio)
Dual mechanism MAPK inhibitors bind MAPKs (Danio rerio)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Danio rerio)
RAF/MAPK scaffolds [cytosol] (Danio rerio)
Focal Adhesion/Focal contacts [plasma membrane] (Danio rerio)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Danio rerio)
Vinculin bound to PIP2 [plasma membrane] (Danio rerio)
vcla [cytosol] (Danio rerio)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Danio rerio)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Danio rerio)
RAF/MAPK scaffolds [cytosol] (Danio rerio)
Focal Adhesion/Focal contacts [plasma membrane] (Danio rerio)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Danio rerio)
Vinculin bound to PIP2 [plasma membrane] (Danio rerio)
vcla [cytosol] (Danio rerio)
MAP2Ks phosphorylate MAPKs (Danio rerio)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Danio rerio)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Danio rerio)
RAF/MAPK scaffolds [cytosol] (Danio rerio)
Focal Adhesion/Focal contacts [plasma membrane] (Danio rerio)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Danio rerio)
Vinculin bound to PIP2 [plasma membrane] (Danio rerio)
vcla [cytosol] (Danio rerio)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Danio rerio)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Danio rerio)
RAF/MAPK scaffolds [cytosol] (Danio rerio)
Focal Adhesion/Focal contacts [plasma membrane] (Danio rerio)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Danio rerio)
Vinculin bound to PIP2 [plasma membrane] (Danio rerio)
vcla [cytosol] (Danio rerio)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Danio rerio)
RAF/MAPK scaffolds [cytosol] (Danio rerio)
Focal Adhesion/Focal contacts [plasma membrane] (Danio rerio)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Danio rerio)
Vinculin bound to PIP2 [plasma membrane] (Danio rerio)
vcla [cytosol] (Danio rerio)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Danio rerio)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Danio rerio)
RAF/MAPK scaffolds [cytosol] (Danio rerio)
Focal Adhesion/Focal contacts [plasma membrane] (Danio rerio)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Danio rerio)
Vinculin bound to PIP2 [plasma membrane] (Danio rerio)
vcla [cytosol] (Danio rerio)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Danio rerio)
RAF/MAPK scaffolds [cytosol] (Danio rerio)
Focal Adhesion/Focal contacts [plasma membrane] (Danio rerio)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Danio rerio)
Vinculin bound to PIP2 [plasma membrane] (Danio rerio)
vcla [cytosol] (Danio rerio)
RAF phosphorylates MAP2K dimer (Danio rerio)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Danio rerio)
RAF/MAPK scaffolds [cytosol] (Danio rerio)
Focal Adhesion/Focal contacts [plasma membrane] (Danio rerio)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Danio rerio)
Vinculin bound to PIP2 [plasma membrane] (Danio rerio)
vcla [cytosol] (Danio rerio)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Danio rerio)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Danio rerio)
RAF/MAPK scaffolds [cytosol] (Danio rerio)
Focal Adhesion/Focal contacts [plasma membrane] (Danio rerio)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Danio rerio)
Vinculin bound to PIP2 [plasma membrane] (Danio rerio)
vcla [cytosol] (Danio rerio)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Danio rerio)
RAF/MAPK scaffolds [cytosol] (Danio rerio)
Focal Adhesion/Focal contacts [plasma membrane] (Danio rerio)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Danio rerio)
Vinculin bound to PIP2 [plasma membrane] (Danio rerio)
vcla [cytosol] (Danio rerio)
Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Danio rerio)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Danio rerio)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Danio rerio)
RAF/MAPK scaffolds [cytosol] (Danio rerio)
Focal Adhesion/Focal contacts [plasma membrane] (Danio rerio)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Danio rerio)
Vinculin bound to PIP2 [plasma membrane] (Danio rerio)
vcla [cytosol] (Danio rerio)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Danio rerio)
RAF/MAPK scaffolds [cytosol] (Danio rerio)
Focal Adhesion/Focal contacts [plasma membrane] (Danio rerio)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Danio rerio)
Vinculin bound to PIP2 [plasma membrane] (Danio rerio)
vcla [cytosol] (Danio rerio)
Single mechanism MAPK inhibitors bind phosphorylated MAPK (Danio rerio)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Danio rerio)
RAF/MAPK scaffolds [cytosol] (Danio rerio)
Focal Adhesion/Focal contacts [plasma membrane] (Danio rerio)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Danio rerio)
Vinculin bound to PIP2 [plasma membrane] (Danio rerio)
vcla [cytosol] (Danio rerio)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Danio rerio)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Danio rerio)
RAF/MAPK scaffolds [cytosol] (Danio rerio)
Focal Adhesion/Focal contacts [plasma membrane] (Danio rerio)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Danio rerio)
Vinculin bound to PIP2 [plasma membrane] (Danio rerio)
vcla [cytosol] (Danio rerio)
External Reference Information
External Reference
UniProt:B3DI32
Gene Names
vcla
Reference Genes
BioGPS Gene:552980 vcla
CTD Gene:552980 vcla
ENSEMBL:ENSDARG00000044968
KEGG:dre:552980 vcla
Monarch:552980 vcla
NCBI Gene:552980 vcla
UCSC:B3DI32 vcla
Reference Transcript
RefSeq:NM_001128681.1 vcla
Participates
as a member of
Platelet releasate cytosolic proteins [cytosol] (Danio rerio)
as an input of
Calpain2 (m-Calpain, CAPN2:CAPNS:Ca2+) cleaves VCL (Vinculin) (Danio rerio)
CDH1-associated CTNNA1 binds VCL (Danio rerio)
as a component of
Man,Man9GlucNAc2,p-3S-CDH1:CTNNB1,JUP:CTNNA1:CTNND1:F-actin:VCL [plasma membrane] (Danio rerio)
trans-homotypic CDH1 cluster:F-actin:VCL [plasma membrane] (Danio rerio)
Homotypic CDH1 cis-cluster:F-actin:VCL [plasma membrane] (Danio rerio)
Vinculin bound to PIP2 [plasma membrane] (Danio rerio)
Other forms of this molecule
vcla [cytosol]
vcla [secretory granule lumen]
vcla [specific granule lumen]
vcla [extracellular region]
vcla [ficolin-1-rich granule lumen]
Inferred From
VCL [cytosol]
(Homo sapiens)
Cross References
ZFIN
ZDB-GENE-050506-61
© 2026
Reactome
This website requires cookies and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our
Privacy Notice
.
I agree, dismiss this banner
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text