Reactome | mapkap1 [cytosol]

mapkap1 [cytosol]

Stable Identifier

R-DRE-3006620

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

cytosol

Synonyms

MAPKAP1, E7EZP2

Locations in the PathwayBrowser

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Cellular responses to stimuli (Danio rerio)

- Cellular responses to mechanical stimuli (Danio rerio)
  - Response of endothelial cells to shear stress (Danio rerio)
    - High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells (Danio rerio)
      - mTORC2 phosphorylates AKT1 on serine-473 (Danio rerio)
        
        mTORC2:PIP3 [plasma membrane] (Danio rerio)
        
        MAPKAP1:PIP3 [plasma membrane] (Danio rerio)
        
        mapkap1 [cytosol] (Danio rerio)

Gene expression (Transcription) (Danio rerio)

- RNA Polymerase II Transcription (Danio rerio)
  - Generic Transcription Pathway (Danio rerio)
    - Transcriptional Regulation by TP53 (Danio rerio)
      - Regulation of TP53 Activity (Danio rerio)
        
        Regulation of TP53 Expression and Degradation (Danio rerio)
        
        Regulation of TP53 Degradation (Danio rerio)
        
        mTORC2 phosphorylates SGK1 (Danio rerio)
        
        mTORC2:PIP3 [plasma membrane] (Danio rerio)
        
        MAPKAP1:PIP3 [plasma membrane] (Danio rerio)
        
        mapkap1 [cytosol] (Danio rerio)

Immune System (Danio rerio)

- Adaptive Immune System (Danio rerio)
  - Regulation of T cell activation by CD28 family (Danio rerio)
    - Co-stimulation by CD28 (Danio rerio)
      - CD28 dependent PI3K/Akt signaling (Danio rerio)
        
        mTORC2 phosphorylates AKT at S473 (Danio rerio)
        
        mTORC2:PIP3 [plasma membrane] (Danio rerio)
        
        MAPKAP1:PIP3 [plasma membrane] (Danio rerio)
        
        mapkap1 [cytosol] (Danio rerio)

External Reference Information

External Reference

UniProt:E7EZP2

Gene Names

mapkap1

Reference Genes

BioGPS Gene:100537196 mapkap1

ENSEMBL:ENSDARG00000091777

KEGG:dre:100537196 mapkap1

Monarch:100537196 mapkap1

NCBI Gene:100537196 mapkap1

UCSC:E7EZP2 mapkap1

Reference Transcript

RefSeq:XM_003198574.6 mapkap1

Other Identifiers

100537196

13192287

A_15_P147436

A_15_P244326

CUST_10926_PI428451953

CUST_10927_PI428451953

DRER25601

DRER38496

ENSDART00000038507

ENSDART00000038507_1

ENSDART00000038507_2

GO:0031932

GT_Spec_XM_003198574.2_378845

XM_689755

Participates

as a component of

MAPKAP1:PIP3 [plasma membrane] (Danio rerio)

Inferred From

MAPKAP1 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_003198622.1

ENSEMBL

ENSDARG00000091777, ENSDART00000124022, ENSDARP00000111582

ZFIN

ZDB-GENE-041111-178

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