Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
crk [cytosol]
Stable Identifier
R-DRE-2980677
Type
Protein [EntityWithAccessionedSequence]
Species
Danio rerio
Compartment
cytosol
Synonyms
CRK, Q6DEM2
Locations in the PathwayBrowser
Expand all
Immune System (Danio rerio)
Cytokine Signaling in Immune system (Danio rerio)
Signaling by Interleukins (Danio rerio)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Danio rerio)
Regulation of signaling by CBL (Danio rerio)
CBL binds CRK (Danio rerio)
CRK, CRKL [cytosol] (Danio rerio)
crk [cytosol] (Danio rerio)
p(Y700,731,774)-CBL:CRK [cytosol] (Danio rerio)
CRK, CRKL [cytosol] (Danio rerio)
crk [cytosol] (Danio rerio)
Signal Transduction (Danio rerio)
Signaling by Non-Receptor Tyrosine Kinases (Danio rerio)
Signaling by PTK6 (Danio rerio)
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases (Danio rerio)
Activation of RAC1 by the PXN:CRK complex (Danio rerio)
p-Y31,Y118-PXN:CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Danio rerio)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Danio rerio)
crk [cytosol] (Danio rerio)
Phosphorylated PXN recruits the CRK complex (Danio rerio)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Danio rerio)
crk [cytosol] (Danio rerio)
p-Y31,Y118-PXN:CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Danio rerio)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Danio rerio)
crk [cytosol] (Danio rerio)
Signaling by Receptor Tyrosine Kinases (Danio rerio)
Signaling by MET (Danio rerio)
MET promotes cell motility (Danio rerio)
MET activates RAP1 and RAC1 (Danio rerio)
GAB1 recruits CRK,CRKL to MET (Danio rerio)
CRK, CRKL [cytosol] (Danio rerio)
crk [cytosol] (Danio rerio)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Danio rerio)
CRK, CRKL [cytosol] (Danio rerio)
crk [cytosol] (Danio rerio)
MET receptor recycling (Danio rerio)
GGA3 associates with activated MET receptor (Danio rerio)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Danio rerio)
CRK, CRKL [cytosol] (Danio rerio)
crk [cytosol] (Danio rerio)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:GGA3:ARF6:GTP [recycling endosome membrane] (Danio rerio)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Danio rerio)
CRK, CRKL [cytosol] (Danio rerio)
crk [cytosol] (Danio rerio)
RAB4:GTP promotes recycling of activated MET receptor to the plasma membrane (Danio rerio)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:GGA3:ARF6:GTP [recycling endosome membrane] (Danio rerio)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Danio rerio)
CRK, CRKL [cytosol] (Danio rerio)
crk [cytosol] (Danio rerio)
Signaling by NTRKs (Danio rerio)
Signaling by NTRK1 (TRKA) (Danio rerio)
Signalling to ERKs (Danio rerio)
Prolonged ERK activation events (Danio rerio)
ARMS-mediated activation (Danio rerio)
ARMS is phosphorylated by active TrkA receptor (Danio rerio)
Active TrkA receptor:ARMS:Crk complex [plasma membrane] (Danio rerio)
ARMS:Crk [cytosol] (Danio rerio)
crk [cytosol] (Danio rerio)
Active TrkA receptor:Phospho-ARMS:Crk complex [plasma membrane] (Danio rerio)
Phospho-ARMS:Crk [cytosol] (Danio rerio)
crk [cytosol] (Danio rerio)
C3G stimulates nucleotide exchange on Rap1 (Danio rerio)
Active TrkA receptor:Phospho-ARMS:Crk complex [plasma membrane] (Danio rerio)
Phospho-ARMS:Crk [cytosol] (Danio rerio)
crk [cytosol] (Danio rerio)
Crk's SH3 domain engages C3G (Danio rerio)
Active TrkA receptor:Phospho-ARMS:Crk complex [plasma membrane] (Danio rerio)
Phospho-ARMS:Crk [cytosol] (Danio rerio)
crk [cytosol] (Danio rerio)
Signaling by PDGF (Danio rerio)
Downstream signal transduction (Danio rerio)
Crk binds to the active PDGF receptor (Danio rerio)
CRK, CRKL [cytosol] (Danio rerio)
crk [cytosol] (Danio rerio)
PDGF:Phospho-PDGF receptor dimer:Crk [plasma membrane] (Danio rerio)
CRK, CRKL [cytosol] (Danio rerio)
crk [cytosol] (Danio rerio)
Signaling by VEGF (Danio rerio)
VEGFA-VEGFR2 Pathway (Danio rerio)
DOCK180:ELMO binds CRK (Danio rerio)
CRK:DOCK180:ELMO1,ELMO2:VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Danio rerio)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Danio rerio)
crk [cytosol] (Danio rerio)
VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1/p-Y31,Y118-PAX:CRK [plasma membrane] (Danio rerio)
crk [cytosol] (Danio rerio)
DOCK180:ELMO exchanges GTP for GDP, activating RAC1 (Danio rerio)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Danio rerio)
crk [cytosol] (Danio rerio)
CRK:DOCK180:ELMO1,ELMO2:VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Danio rerio)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Danio rerio)
crk [cytosol] (Danio rerio)
External Reference Information
External Reference
UniProt:Q6DEM2
Gene Names
crk
Reference Genes
BioGPS Gene:445234 crk
ENSEMBL:ENSDARG00000055635
KEGG:dre:445234 crk
Monarch:445234 crk
NCBI Gene:445234 crk
UCSC:Q6DEM2 crk
Reference Transcript
RefSeq:NM_001003628.2 crk
Other Identifiers
13020377
445234
A_15_P117920
A_15_P378400
BC077088
CJ006351
CJ006352
CJ006402
CJ006403
CJ006598
CJ006599
CJ007252
CJ007253
CJ009549
CJ009550
CJ012538
CJ012682
CJ013242
CJ013316
CJ013650
CJ013761
CJ014007
CJ014034
DRER11016
Dr.25494.1.A1_at
ENSDART00000078024
ENSDART00000078024_1
ENSDART00000078024_2
GO:0005515
JP006749
JP006750
JP006800
JP006801
JP006996
JP006997
JP007650
JP007651
JP009947
JP009948
LOLS06851
MADDr01009653
OTTDART00000026101
XM_678638
Participates
as a member of
CRK, CRKL [cytosol] (Danio rerio)
as a component of
ARMS:Crk [cytosol] (Danio rerio)
Phospho-ARMS:Crk [cytosol] (Danio rerio)
VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1/p-Y31,Y118-PAX:CRK [plasma membrane] (Danio rerio)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Danio rerio)
Inferred From
CRK [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_001003628.1
ENSEMBL
ENSDART00000188120
,
ENSDART00000181662
,
ENSDARP00000154923
,
ENSDARG00000115801
,
ENSDARP00000153352
,
ENSDARG00000055635
,
ENSDART00000078024
,
ENSDARP00000072488
,
ENSDARG00000109497
ZFIN
ZDB-GENE-040801-148
© 2026
Reactome
This website requires cookies and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our
Privacy Notice
.
I agree, dismiss this banner
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text
