Reactome | arrb1 [cytosol]

arrb1 [cytosol]

Stable Identifier

R-DRE-264470

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

cytosol

Synonyms

ARRB1, C3PTE8

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Danio rerio)

- Post-translational protein modification (Danio rerio)
  - Deubiquitination (Danio rerio)
    - Ub-specific processing proteases (Danio rerio)
      - USP33 deubiquitinates CCP110,ARRB (Danio rerio)
        
        USP33:CCP110,ARRB1,ARRB2 [cytosol] (Danio rerio)
        
        CCP110,ARRB2,(ARRB1) [cytosol] (Danio rerio)
        
        arrb1 [cytosol] (Danio rerio)

Signal Transduction (Danio rerio)

- MAPK family signaling cascades (Danio rerio)
  - MAPK1/MAPK3 signaling (Danio rerio)
    - RAF/MAP kinase cascade (Danio rerio)
      - MAP2K and MAPK activation (Danio rerio)
        
        Dual mechanism MAP2K inhibitors bind MAP2Ks (Danio rerio)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Danio rerio)
        
        RAF/MAPK scaffolds [cytosol] (Danio rerio)
        
        arrb1 [cytosol] (Danio rerio)
        
        activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Danio rerio)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Danio rerio)
        
        RAF/MAPK scaffolds [cytosol] (Danio rerio)
        
        arrb1 [cytosol] (Danio rerio)
        
        Dual mechanism MAPK inhibitors bind MAPKs (Danio rerio)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Danio rerio)
        
        RAF/MAPK scaffolds [cytosol] (Danio rerio)
        
        arrb1 [cytosol] (Danio rerio)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Danio rerio)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Danio rerio)
        
        RAF/MAPK scaffolds [cytosol] (Danio rerio)
        
        arrb1 [cytosol] (Danio rerio)
        
        MAP2Ks phosphorylate MAPKs (Danio rerio)
        
        activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Danio rerio)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Danio rerio)
        
        RAF/MAPK scaffolds [cytosol] (Danio rerio)
        
        arrb1 [cytosol] (Danio rerio)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Danio rerio)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Danio rerio)
        
        RAF/MAPK scaffolds [cytosol] (Danio rerio)
        
        arrb1 [cytosol] (Danio rerio)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Danio rerio)
        
        RAF/MAPK scaffolds [cytosol] (Danio rerio)
        
        arrb1 [cytosol] (Danio rerio)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Danio rerio)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Danio rerio)
        
        RAF/MAPK scaffolds [cytosol] (Danio rerio)
        
        arrb1 [cytosol] (Danio rerio)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Danio rerio)
        
        RAF/MAPK scaffolds [cytosol] (Danio rerio)
        
        arrb1 [cytosol] (Danio rerio)
        
        RAF phosphorylates MAP2K dimer (Danio rerio)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Danio rerio)
        
        RAF/MAPK scaffolds [cytosol] (Danio rerio)
        
        arrb1 [cytosol] (Danio rerio)
        
        activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Danio rerio)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Danio rerio)
        
        RAF/MAPK scaffolds [cytosol] (Danio rerio)
        
        arrb1 [cytosol] (Danio rerio)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Danio rerio)
        
        RAF/MAPK scaffolds [cytosol] (Danio rerio)
        
        arrb1 [cytosol] (Danio rerio)
        
        Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Danio rerio)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Danio rerio)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Danio rerio)
        
        RAF/MAPK scaffolds [cytosol] (Danio rerio)
        
        arrb1 [cytosol] (Danio rerio)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Danio rerio)
        
        RAF/MAPK scaffolds [cytosol] (Danio rerio)
        
        arrb1 [cytosol] (Danio rerio)
        
        Single mechanism MAPK inhibitors bind phosphorylated MAPK (Danio rerio)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Danio rerio)
        
        RAF/MAPK scaffolds [cytosol] (Danio rerio)
        
        arrb1 [cytosol] (Danio rerio)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Danio rerio)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Danio rerio)
        
        RAF/MAPK scaffolds [cytosol] (Danio rerio)
        
        arrb1 [cytosol] (Danio rerio)
- Signaling by GPCR (Danio rerio)
  - GPCR downstream signalling (Danio rerio)
    - G alpha (s) signalling events (Danio rerio)
      - ADRB2:Catecholamine binds ARRB1, ARRB2 (Danio rerio)
        
        ARRB [cytosol] (Danio rerio)
        
        arrb1 [cytosol] (Danio rerio)
        
        pS-ADRB2:Catecholamine:ARRB1,ARRB2 [plasma membrane] (Danio rerio)
        
        ARRB [cytosol] (Danio rerio)
        
        arrb1 [cytosol] (Danio rerio)
- Signaling by TGFB family members (Danio rerio)
  - Signaling by TGFBR3 (Danio rerio)
    - TGFBR3 regulates TGF-beta signaling (Danio rerio)
      - Endocytosis of TGFBR3:ARRB complex (Danio rerio)
        
        pTGFBR3-complex:ARRB [plasma membrane] (Danio rerio)
        
        ARRB [cytosol] (Danio rerio)
        
        arrb1 [cytosol] (Danio rerio)
      - TGFBR3 binding to ARRB1/2 (Danio rerio)
        
        ARRB [cytosol] (Danio rerio)
        
        arrb1 [cytosol] (Danio rerio)
        
        pTGFBR3-complex:ARRB [plasma membrane] (Danio rerio)
        
        ARRB [cytosol] (Danio rerio)
        
        arrb1 [cytosol] (Danio rerio)

External Reference Information

External Reference

UniProt:C3PTE8

Gene Names

arrb1

Reference Genes

BioGPS Gene:553266 arrb1

ENSEMBL:ENSDARG00000043241

KEGG:dre:553266 arrb1

Monarch:553266 arrb1

NCBI Gene:553266 arrb1

UCSC:C3PTE8 arrb1

Reference Transcript

RefSeq:NM_001159822.2 arrb1

Other Identifiers

13023594

553266

A_15_P159981

CJ000333

CJ000334

CJ000362

CJ006604

CJ006605

CJ006606

CJ009551

CJ009552

CJ009553

CJ013861

CUST_1799_PI428451953

DRER25485

DRER29385

ENSDART00000063482

ENSDART00000063482_1

ENSDART00000063482_2

GO:0007165

JP000333

JP000334

JP000362

JP007002

JP007003

JP007004

JP009949

JP009950

JP009951

LOLG194

MADDr01002858

Participates

as an input of

as a candidate of

as a component of

F2R:ARRB1 [plasma membrane] (Danio rerio)

as a member of

ARRB [cytosol] (Danio rerio)

Other forms of this molecule

arrb1 [Golgi membrane]

arrb1 [lysosomal membrane]

arrb1 [endocytic vesicle membrane]

arrb1 [cytosol]

Inferred From

ARRB1 [cytosol] (Homo sapiens)

Cross References

ENSEMBL

ENSDARG00000043241, ENSDART00000123839, ENSDARP00000105997

ZFIN

ZDB-GENE-060824-1

Cite Us!