Reactome | col1a1a [extracellular region]

col1a1a [extracellular region]

Stable Identifier

R-DRE-2127352-2

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

extracellular region

Synonyms

GlcGalHyl-COL3A1(154-1241), Q6U1J5

Locations in the PathwayBrowser

Expand all

Extracellular matrix organization (Danio rerio)

- Collagen formation (Danio rerio)
  - Assembly of collagen fibrils and other multimeric structures (Danio rerio)
    - Formation of collagen fibres (Danio rerio)
      - Collagen fibres [extracellular region] (Danio rerio)
        
        Collagen type III fibre [extracellular region] (Danio rerio)
        
        Collagen type III fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type III [extracellular region] (Danio rerio)
        
        Collagen alpha-1(III) chains [extracellular region] (Danio rerio)
        
        Homologues of GlcGalHyl-COL3A1(154-1241) [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
      - Collagen fibrils [extracellular region] (Danio rerio)
        
        Collagen type III fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type III [extracellular region] (Danio rerio)
        
        Collagen alpha-1(III) chains [extracellular region] (Danio rerio)
        
        Homologues of GlcGalHyl-COL3A1(154-1241) [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
    - Formation of collagen fibrils (Danio rerio)
      - Collagen fibrils [extracellular region] (Danio rerio)
        
        Collagen type III fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type III [extracellular region] (Danio rerio)
        
        Collagen alpha-1(III) chains [extracellular region] (Danio rerio)
        
        Homologues of GlcGalHyl-COL3A1(154-1241) [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
      - Tropocollagens [extracellular region] (Danio rerio)
        
        Tropocollagen type III [extracellular region] (Danio rerio)
        
        Collagen alpha-1(III) chains [extracellular region] (Danio rerio)
        
        Homologues of GlcGalHyl-COL3A1(154-1241) [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
  - Collagen biosynthesis and modifying enzymes (Danio rerio)
    - Removal of fibrillar collagen C-propeptides (Danio rerio)
      - Tropocollagens [extracellular region] (Danio rerio)
        
        Tropocollagen type III [extracellular region] (Danio rerio)
        
        Collagen alpha-1(III) chains [extracellular region] (Danio rerio)
        
        Homologues of GlcGalHyl-COL3A1(154-1241) [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
- Degradation of the extracellular matrix (Danio rerio)
  - Collagen degradation (Danio rerio)
    - Collagen type III degradation by MMP1,8,9,13 (Danio rerio)
      - Collagen type III fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type III [extracellular region] (Danio rerio)
        
        Collagen alpha-1(III) chains [extracellular region] (Danio rerio)
        
        Homologues of GlcGalHyl-COL3A1(154-1241) [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
    - Collagen type III degradation by MMP14 (Danio rerio)
      - Collagen type III fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type III [extracellular region] (Danio rerio)
        
        Collagen alpha-1(III) chains [extracellular region] (Danio rerio)
        
        Homologues of GlcGalHyl-COL3A1(154-1241) [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
    - Collagen type III degradation by MMP15 (Danio rerio)
      - Collagen type III fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type III [extracellular region] (Danio rerio)
        
        Collagen alpha-1(III) chains [extracellular region] (Danio rerio)
        
        Homologues of GlcGalHyl-COL3A1(154-1241) [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
- ECM proteoglycans (Danio rerio)
  - VTN binds collagens II, III and V (Danio rerio)
    - Collagens [extracellular region] (Danio rerio)
      - Collagen type III fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type III [extracellular region] (Danio rerio)
        
        Collagen alpha-1(III) chains [extracellular region] (Danio rerio)
        
        Homologues of GlcGalHyl-COL3A1(154-1241) [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
    - VTN:Collagen types II,III,V [extracellular region] (Danio rerio)
      - Collagens [extracellular region] (Danio rerio)
        
        Collagen type III fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type III [extracellular region] (Danio rerio)
        
        Collagen alpha-1(III) chains [extracellular region] (Danio rerio)
        
        Homologues of GlcGalHyl-COL3A1(154-1241) [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
- Non-integrin membrane-ECM interactions (Danio rerio)
  - DDR2 binds collagen type I, II, III, V, X fibrils (Danio rerio)
    - Collagens [extracellular region] (Danio rerio)
      - Collagen type III fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type III [extracellular region] (Danio rerio)
        
        Collagen alpha-1(III) chains [extracellular region] (Danio rerio)
        
        Homologues of GlcGalHyl-COL3A1(154-1241) [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
    - DDR2 dimer:Collagen type I, II, III, V, X fibrils [plasma membrane] (Danio rerio)
      - Collagens [extracellular region] (Danio rerio)
        
        Collagen type III fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type III [extracellular region] (Danio rerio)
        
        Collagen alpha-1(III) chains [extracellular region] (Danio rerio)
        
        Homologues of GlcGalHyl-COL3A1(154-1241) [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)

Signal Transduction (Danio rerio)

- Signaling by Receptor Tyrosine Kinases (Danio rerio)
  - Signaling by PDGF (Danio rerio)
    - PDGF binds to extracellular matrix proteins (Danio rerio)
      - Extracellular matrix ligands [extracellular region] (Danio rerio)
        
        Collagens [extracellular region] (Danio rerio)
        
        Collagen type III fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type III [extracellular region] (Danio rerio)
        
        Collagen alpha-1(III) chains [extracellular region] (Danio rerio)
        
        Homologues of GlcGalHyl-COL3A1(154-1241) [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)
      - PDGF A and B chains:ECM complex [extracellular region] (Danio rerio)
        
        Extracellular matrix ligands [extracellular region] (Danio rerio)
        
        Collagens [extracellular region] (Danio rerio)
        
        Collagen type III fibril [extracellular region] (Danio rerio)
        
        Tropocollagen type III [extracellular region] (Danio rerio)
        
        Collagen alpha-1(III) chains [extracellular region] (Danio rerio)
        
        Homologues of GlcGalHyl-COL3A1(154-1241) [extracellular region] (Danio rerio)
        
        col1a1a [extracellular region] (Danio rerio)

External Reference Information

External Reference

UniProt:Q6U1J5

Gene Names

col1a1a

Reference Genes

BioGPS Gene:337158 col1a1a

CTD Gene:337158 col1a1a

ENSEMBL:ENSDARG00000012405

KEGG:dre:337158 col1a1a

Monarch:337158 col1a1a

NCBI Gene:337158 col1a1a

UCSC:Q6U1J5 col1a1a

Reference Transcript

RefSeq:NM_199214.1 col1a1a

Participates

as a member of

Homologues of GlcGalHyl-COL3A1(154-1241) [extracellular region] (Danio rerio)

Other forms of this molecule

col1a1a [endoplasmic reticulum lumen]

col1a1a [extracellular region]

Inferred From

GlcGalHyl-COL3A1(154-1241) [extracellular region] (Homo sapiens)

Modified Residues

Name

O5-glucosylgalactosyl-L-hydroxylysine at unknown position

PsiMod Name

O5-glucosylgalactosyl-L-hydroxylysine

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to O5-glucosylgalactosyl-L-hydroxylysine.

Cross References

RefSeq

NP_954684.1

ZFIN

ZDB-GENE-030131-9102

Cite Us!