Reactome | nck2b [cytosol]

nck2b [cytosol]

Stable Identifier

R-DRE-204885-2

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

cytosol

Synonyms

NCK2, Q4V9A1

Locations in the PathwayBrowser

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Cell-Cell communication (Danio rerio)

- Nephrin family interactions (Danio rerio)
  - Nephrin binds NCK (Danio rerio)
    - NCK1,NCK2 [cytosol] (Danio rerio)
      - Homologues of NCK2 [cytosol] (Danio rerio)
        
        nck2b [cytosol] (Danio rerio)
    - NEPH1:p-Nephrin:Fyn:NCK [plasma membrane] (Danio rerio)
      - NCK1,NCK2 [cytosol] (Danio rerio)
        
        Homologues of NCK2 [cytosol] (Danio rerio)
        
        nck2b [cytosol] (Danio rerio)
  - Nephrin mediated activation of N-WASP (Danio rerio)
    - NEPH1:p-Nephrin:Fyn:NCK [plasma membrane] (Danio rerio)
      - NCK1,NCK2 [cytosol] (Danio rerio)
        
        Homologues of NCK2 [cytosol] (Danio rerio)
        
        nck2b [cytosol] (Danio rerio)
    - NEPH1:p-Nephrin:Fyn:NCK:N-WASP [plasma membrane] (Danio rerio)
      - NEPH1:p-Nephrin:Fyn:NCK [plasma membrane] (Danio rerio)
        
        NCK1,NCK2 [cytosol] (Danio rerio)
        
        Homologues of NCK2 [cytosol] (Danio rerio)
        
        nck2b [cytosol] (Danio rerio)

Developmental Biology (Danio rerio)

- Nervous system development (Danio rerio)
  - Axon guidance (Danio rerio)
    - EPH-Ephrin signaling (Danio rerio)
      - Ephrin signaling (Danio rerio)
        
        EFNB:GRB4 binds GIT1 (Danio rerio)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Danio rerio)
        
        Homologues of NCK2 [cytosol] (Danio rerio)
        
        nck2b [cytosol] (Danio rerio)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Danio rerio)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Danio rerio)
        
        Homologues of NCK2 [cytosol] (Danio rerio)
        
        nck2b [cytosol] (Danio rerio)
        
        PAKs autophosphorylate (Danio rerio)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:PAK1,3 [plasma membrane] (Danio rerio)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Danio rerio)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Danio rerio)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Danio rerio)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Danio rerio)
        
        Homologues of NCK2 [cytosol] (Danio rerio)
        
        nck2b [cytosol] (Danio rerio)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:p-PAK1,3 [plasma membrane] (Danio rerio)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Danio rerio)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Danio rerio)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Danio rerio)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Danio rerio)
        
        Homologues of NCK2 [cytosol] (Danio rerio)
        
        nck2b [cytosol] (Danio rerio)
        
        PAKs phosphorylate MLC (Danio rerio)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:p-PAK1,3 [plasma membrane] (Danio rerio)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Danio rerio)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Danio rerio)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Danio rerio)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Danio rerio)
        
        Homologues of NCK2 [cytosol] (Danio rerio)
        
        nck2b [cytosol] (Danio rerio)
        
        bPIX exchanges GTP for GDP on RAC, activating it (Danio rerio)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Danio rerio)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Danio rerio)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Danio rerio)
        
        Homologues of NCK2 [cytosol] (Danio rerio)
        
        nck2b [cytosol] (Danio rerio)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Danio rerio)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Danio rerio)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Danio rerio)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Danio rerio)
        
        Homologues of NCK2 [cytosol] (Danio rerio)
        
        nck2b [cytosol] (Danio rerio)
        
        p-EFNB binds GRB4 (Danio rerio)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Danio rerio)
        
        Homologues of NCK2 [cytosol] (Danio rerio)
        
        nck2b [cytosol] (Danio rerio)
        
        Homologues of NCK2 [cytosol] (Danio rerio)
        
        nck2b [cytosol] (Danio rerio)

Signal Transduction (Danio rerio)

- Signaling by Receptor Tyrosine Kinases (Danio rerio)
  - Signaling by PDGF (Danio rerio)
    - Downstream signal transduction (Danio rerio)
      - Nck binds to the active PDGF receptor (Danio rerio)
        
        NCK1,NCK2 [cytosol] (Danio rerio)
        
        Homologues of NCK2 [cytosol] (Danio rerio)
        
        nck2b [cytosol] (Danio rerio)
        
        PDGF:Phospho-PDGFR receptor dimer:Nck [plasma membrane] (Danio rerio)
        
        NCK1,NCK2 [cytosol] (Danio rerio)
        
        Homologues of NCK2 [cytosol] (Danio rerio)
        
        nck2b [cytosol] (Danio rerio)
  - Signaling by VEGF (Danio rerio)
    - VEGFA-VEGFR2 Pathway (Danio rerio)
      - CDC42:GTP binds PAK2 (Danio rerio)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN:PAK2 [plasma membrane] (Danio rerio)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Danio rerio)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Danio rerio)
        
        NCK1,NCK2 [cytosol] (Danio rerio)
        
        Homologues of NCK2 [cytosol] (Danio rerio)
        
        nck2b [cytosol] (Danio rerio)
        
        VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:PAK2:CDC42:GTP [plasma membrane] (Danio rerio)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Danio rerio)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Danio rerio)
        
        NCK1,NCK2 [cytosol] (Danio rerio)
        
        Homologues of NCK2 [cytosol] (Danio rerio)
        
        nck2b [cytosol] (Danio rerio)
      - FYN autophosphorylates (Danio rerio)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:FYN [plasma membrane] (Danio rerio)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Danio rerio)
        
        NCK1,NCK2 [cytosol] (Danio rerio)
        
        Homologues of NCK2 [cytosol] (Danio rerio)
        
        nck2b [cytosol] (Danio rerio)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-Y420-FYN [plasma membrane] (Danio rerio)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Danio rerio)
        
        NCK1,NCK2 [cytosol] (Danio rerio)
        
        Homologues of NCK2 [cytosol] (Danio rerio)
        
        nck2b [cytosol] (Danio rerio)
      - FYN phosphorylates PAK2 (Danio rerio)
        
        VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:p-2Y-PAK2:CDC42:GTP [plasma membrane] (Danio rerio)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Danio rerio)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Danio rerio)
        
        NCK1,NCK2 [cytosol] (Danio rerio)
        
        Homologues of NCK2 [cytosol] (Danio rerio)
        
        nck2b [cytosol] (Danio rerio)
        
        VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:p-3Y-PAK2:CDC42:GTP [plasma membrane] (Danio rerio)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Danio rerio)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Danio rerio)
        
        NCK1,NCK2 [cytosol] (Danio rerio)
        
        Homologues of NCK2 [cytosol] (Danio rerio)
        
        nck2b [cytosol] (Danio rerio)
      - PAK2 autophorylates (Danio rerio)
        
        VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:PAK2:CDC42:GTP [plasma membrane] (Danio rerio)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Danio rerio)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Danio rerio)
        
        NCK1,NCK2 [cytosol] (Danio rerio)
        
        Homologues of NCK2 [cytosol] (Danio rerio)
        
        nck2b [cytosol] (Danio rerio)
        
        VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:p-2Y-PAK2:CDC42:GTP [plasma membrane] (Danio rerio)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Danio rerio)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Danio rerio)
        
        NCK1,NCK2 [cytosol] (Danio rerio)
        
        Homologues of NCK2 [cytosol] (Danio rerio)
        
        nck2b [cytosol] (Danio rerio)
      - PAK2 binds NCK (Danio rerio)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Danio rerio)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Danio rerio)
        
        NCK1,NCK2 [cytosol] (Danio rerio)
        
        Homologues of NCK2 [cytosol] (Danio rerio)
        
        nck2b [cytosol] (Danio rerio)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN:PAK2 [plasma membrane] (Danio rerio)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Danio rerio)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Danio rerio)
        
        NCK1,NCK2 [cytosol] (Danio rerio)
        
        Homologues of NCK2 [cytosol] (Danio rerio)
        
        nck2b [cytosol] (Danio rerio)
      - p-6Y-VEGFR2 binds FYN (Danio rerio)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Danio rerio)
        
        NCK1,NCK2 [cytosol] (Danio rerio)
        
        Homologues of NCK2 [cytosol] (Danio rerio)
        
        nck2b [cytosol] (Danio rerio)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:FYN [plasma membrane] (Danio rerio)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Danio rerio)
        
        NCK1,NCK2 [cytosol] (Danio rerio)
        
        Homologues of NCK2 [cytosol] (Danio rerio)
        
        nck2b [cytosol] (Danio rerio)
      - p-6Y-VEGFR2 binds NCK (Danio rerio)
        
        NCK1,NCK2 [cytosol] (Danio rerio)
        
        Homologues of NCK2 [cytosol] (Danio rerio)
        
        nck2b [cytosol] (Danio rerio)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Danio rerio)
        
        NCK1,NCK2 [cytosol] (Danio rerio)
        
        Homologues of NCK2 [cytosol] (Danio rerio)
        
        nck2b [cytosol] (Danio rerio)
      - p-Y420-FYN is phosphorylated on S21 (Danio rerio)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Danio rerio)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Danio rerio)
        
        NCK1,NCK2 [cytosol] (Danio rerio)
        
        Homologues of NCK2 [cytosol] (Danio rerio)
        
        nck2b [cytosol] (Danio rerio)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-Y420-FYN [plasma membrane] (Danio rerio)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Danio rerio)
        
        NCK1,NCK2 [cytosol] (Danio rerio)
        
        Homologues of NCK2 [cytosol] (Danio rerio)
        
        nck2b [cytosol] (Danio rerio)
      - p38 MAPK activation by VEGFR (Danio rerio)
        
        VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:p-3Y-PAK2:CDC42:GTP [plasma membrane] (Danio rerio)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane] (Danio rerio)
        
        VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane] (Danio rerio)
        
        NCK1,NCK2 [cytosol] (Danio rerio)
        
        Homologues of NCK2 [cytosol] (Danio rerio)
        
        nck2b [cytosol] (Danio rerio)
- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Danio rerio)
  - Signaling by Rho GTPases (Danio rerio)
    - RHO GTPase cycle (Danio rerio)
      - RHOU GTPase cycle (Danio rerio)
        
        RHOU binds effectors at the plasma membrane (Danio rerio)
        
        RHOU effectors [cytosol] (Danio rerio)
        
        Homologues of NCK2 [cytosol] (Danio rerio)
        
        nck2b [cytosol] (Danio rerio)
        
        RHOU:GTP:RHOU effectors [plasma membrane] (Danio rerio)
        
        RHOU effectors [cytosol] (Danio rerio)
        
        Homologues of NCK2 [cytosol] (Danio rerio)
        
        nck2b [cytosol] (Danio rerio)
      - RHOV GTPase cycle (Danio rerio)
        
        RHOV binds effectors at the plasma membrane (Danio rerio)
        
        RHOV effectors [cytosol] (Danio rerio)
        
        Homologues of NCK2 [cytosol] (Danio rerio)
        
        nck2b [cytosol] (Danio rerio)
        
        RHOV:GTP:RHOV effectors [plasma membrane] (Danio rerio)
        
        RHOV effectors [cytosol] (Danio rerio)
        
        Homologues of NCK2 [cytosol] (Danio rerio)
        
        nck2b [cytosol] (Danio rerio)

External Reference Information

External Reference

UniProt:Q4V9A1

Gene Names

nck2b

Reference Genes

BioGPS Gene:445098 nck2b

CTD Gene:445098 nck2b

ENSEMBL:ENSDARG00000043361

Monarch:445098 nck2b

NCBI Gene:445098 nck2b

UCSC:Q4V9A1 nck2b

Reference Transcript

Other Identifiers

13212675

445098

A_15_P115046

BC096988

CJ012700

CUST_11831_PI428451958

DRER08853

Dr.19787.1.S1_a_at

Dr.2658.1.A1_at

ENSDART00000063648

ENSDART00000063648_1

ENSDART00000063648_2

GO:0005515

GT_Spec_NM_001003492.2_263295

LOLS02112

MADDr01002876

NM_001003492

ZV700S00003198

ZV700S00004849

Participates

as a member of

Homologues of NCK2 [cytosol] (Danio rerio)

Inferred From

NCK2 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001003492.2, XP_073808925.1

ENSEMBL

ENSDARP00000155059, ENSDARP00000063647, ENSDART00000186232, ENSDARG00000043361, ENSDART00000063648

ZFIN

ZDB-GENE-040801-235

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