Reactome | dusp4 [nucleoplasm]

dusp4 [nucleoplasm]

Stable Identifier

R-DRE-203794

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

nucleoplasm

Synonyms

DUSP4, Q7SZF3

Locations in the PathwayBrowser

Expand all

Immune System (Danio rerio)

- Cytokine Signaling in Immune system (Danio rerio)
  - Signaling by Interleukins (Danio rerio)
    - Interleukin-17 signaling (Danio rerio)
      - MAP kinase activation (Danio rerio)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Danio rerio)
        
        ERK/MAPK targets (Danio rerio)
        
        ERKs are inactivated (Danio rerio)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Danio rerio)
        
        ERK-specific DUSP [nucleoplasm] (Danio rerio)
        
        dusp4 [nucleoplasm] (Danio rerio)
- Innate Immune System (Danio rerio)
  - Toll-like Receptor Cascades (Danio rerio)
    - Toll Like Receptor 10 (TLR10) Cascade (Danio rerio)
      - MyD88 cascade initiated on plasma membrane (Danio rerio)
        
        MAP kinase activation (Danio rerio)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Danio rerio)
        
        ERK/MAPK targets (Danio rerio)
        
        ERKs are inactivated (Danio rerio)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Danio rerio)
        
        ERK-specific DUSP [nucleoplasm] (Danio rerio)
        
        dusp4 [nucleoplasm] (Danio rerio)
    - Toll Like Receptor 2 (TLR2) Cascade (Danio rerio)
      - Toll Like Receptor TLR1:TLR2 Cascade (Danio rerio)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Danio rerio)
        
        MAP kinase activation (Danio rerio)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Danio rerio)
        
        ERK/MAPK targets (Danio rerio)
        
        ERKs are inactivated (Danio rerio)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Danio rerio)
        
        ERK-specific DUSP [nucleoplasm] (Danio rerio)
        
        dusp4 [nucleoplasm] (Danio rerio)
      - Toll Like Receptor TLR6:TLR2 Cascade (Danio rerio)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Danio rerio)
        
        MAP kinase activation (Danio rerio)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Danio rerio)
        
        ERK/MAPK targets (Danio rerio)
        
        ERKs are inactivated (Danio rerio)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Danio rerio)
        
        ERK-specific DUSP [nucleoplasm] (Danio rerio)
        
        dusp4 [nucleoplasm] (Danio rerio)
    - Toll Like Receptor 3 (TLR3) Cascade (Danio rerio)
      - MAP kinase activation (Danio rerio)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Danio rerio)
        
        ERK/MAPK targets (Danio rerio)
        
        ERKs are inactivated (Danio rerio)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Danio rerio)
        
        ERK-specific DUSP [nucleoplasm] (Danio rerio)
        
        dusp4 [nucleoplasm] (Danio rerio)
    - Toll Like Receptor 4 (TLR4) Cascade (Danio rerio)
      - MyD88-independent TLR4 cascade (Danio rerio)
        
        TRIF (TICAM1)-mediated TLR4 signaling (Danio rerio)
        
        MAP kinase activation (Danio rerio)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Danio rerio)
        
        ERK/MAPK targets (Danio rerio)
        
        ERKs are inactivated (Danio rerio)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Danio rerio)
        
        ERK-specific DUSP [nucleoplasm] (Danio rerio)
        
        dusp4 [nucleoplasm] (Danio rerio)
      - MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Danio rerio)
        
        MAP kinase activation (Danio rerio)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Danio rerio)
        
        ERK/MAPK targets (Danio rerio)
        
        ERKs are inactivated (Danio rerio)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Danio rerio)
        
        ERK-specific DUSP [nucleoplasm] (Danio rerio)
        
        dusp4 [nucleoplasm] (Danio rerio)
    - Toll Like Receptor 5 (TLR5) Cascade (Danio rerio)
      - MyD88 cascade initiated on plasma membrane (Danio rerio)
        
        MAP kinase activation (Danio rerio)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Danio rerio)
        
        ERK/MAPK targets (Danio rerio)
        
        ERKs are inactivated (Danio rerio)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Danio rerio)
        
        ERK-specific DUSP [nucleoplasm] (Danio rerio)
        
        dusp4 [nucleoplasm] (Danio rerio)
    - Toll Like Receptor 7/8 (TLR7/8) Cascade (Danio rerio)
      - MyD88 dependent cascade initiated on endosome (Danio rerio)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Danio rerio)
        
        MAP kinase activation (Danio rerio)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Danio rerio)
        
        ERK/MAPK targets (Danio rerio)
        
        ERKs are inactivated (Danio rerio)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Danio rerio)
        
        ERK-specific DUSP [nucleoplasm] (Danio rerio)
        
        dusp4 [nucleoplasm] (Danio rerio)
    - Toll Like Receptor 9 (TLR9) Cascade (Danio rerio)
      - MyD88 dependent cascade initiated on endosome (Danio rerio)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Danio rerio)
        
        MAP kinase activation (Danio rerio)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Danio rerio)
        
        ERK/MAPK targets (Danio rerio)
        
        ERKs are inactivated (Danio rerio)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Danio rerio)
        
        ERK-specific DUSP [nucleoplasm] (Danio rerio)
        
        dusp4 [nucleoplasm] (Danio rerio)

External Reference Information

External Reference

UniProt:Q7SZF3

Gene Names

dusp4

Reference Genes

BioGPS Gene:394146 dusp4

ENSEMBL:ENSDARG00000044688

KEGG:dre:394146 dusp4

Monarch:394146 dusp4

NCBI Gene:394146 dusp4

UCSC:Q7SZF3 dusp4

Reference Transcript

RefSeq:NM_201171.1 dusp4

Other Identifiers

13115197

394146

A_15_P107952

A_15_P116617

A_15_P627626

CJ012627

CJ012946

CJ013838

CUST_11906_PI428451958

DRER09315

Dr.9304.1.S1_at

ENSDART00000065664

ENSDART00000065664_1

ENSDART00000065664_2

ENSDART00000097118_y_1

ENSDART00000097118_y_2

GO:0006470

GO:0016311

GO:0017017

GT_Spec_NM_201171.1_83453

LOLS15303

MADDr01009050

NM_201171

OTTDART00000029337

XM_679650

XM_697376

XM_702536

XM_702537

ZV700S00006581

Participates

as a candidate of

nuclear MAPK DUSPs [nucleoplasm] (Danio rerio)

as a member of

ERK-specific DUSP [nucleoplasm] (Danio rerio)

Inferred From

DUSP4 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_957465.1

ENSEMBL

ENSDART00000065664, ENSDARG00000116379, ENSDARP00000065663, ENSDARP00000151096, ENSDARG00000044688, ENSDART00000189462

ZFIN

ZDB-GENE-040426-709

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