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FYN [cytosol]
Stable Identifier
R-DRE-200917
Type
Protein [EntityWithAccessionedSequence]
Species
Danio rerio
Compartment
cytosol
Synonyms
F1RDG9
Locations in the PathwayBrowser
Expand all
Cell-Cell communication (Danio rerio)
Nephrin family interactions (Danio rerio)
Nephrin binds NCK (Danio rerio)
NEPH1:p-Nephrin:Fyn:NCK [plasma membrane] (Danio rerio)
p-Y1158,Y1176,Y1193,Y1217-NPHS1:KIRREL:FYN [plasma membrane] (Danio rerio)
FYN [cytosol] (Danio rerio)
p-Y1158,Y1176,Y1193,Y1217-NPHS1:KIRREL:FYN [plasma membrane] (Danio rerio)
FYN [cytosol] (Danio rerio)
Nephrin dimer:KIRREL binds FYN (Danio rerio)
FYN [cytosol] (Danio rerio)
NPHS1 dimer:KIRREL:FYN [plasma membrane] (Danio rerio)
FYN [cytosol] (Danio rerio)
Nephrin interacts with Podocin (Danio rerio)
Podocin:p-Nephrin:Fyn:NEPH1 [plasma membrane] (Danio rerio)
p-Y1158,Y1176,Y1193,Y1217-NPHS1:KIRREL:FYN [plasma membrane] (Danio rerio)
FYN [cytosol] (Danio rerio)
p-Y1158,Y1176,Y1193,Y1217-NPHS1:KIRREL:FYN [plasma membrane] (Danio rerio)
FYN [cytosol] (Danio rerio)
Nephrin mediated activation of N-WASP (Danio rerio)
NEPH1:p-Nephrin:Fyn:NCK [plasma membrane] (Danio rerio)
p-Y1158,Y1176,Y1193,Y1217-NPHS1:KIRREL:FYN [plasma membrane] (Danio rerio)
FYN [cytosol] (Danio rerio)
NEPH1:p-Nephrin:Fyn:NCK:N-WASP [plasma membrane] (Danio rerio)
NEPH1:p-Nephrin:Fyn:NCK [plasma membrane] (Danio rerio)
p-Y1158,Y1176,Y1193,Y1217-NPHS1:KIRREL:FYN [plasma membrane] (Danio rerio)
FYN [cytosol] (Danio rerio)
Phosphorylation of nephrin by FYN (Danio rerio)
NPHS1 dimer:KIRREL:FYN [plasma membrane] (Danio rerio)
FYN [cytosol] (Danio rerio)
p-Y1158,Y1176,Y1193,Y1217-NPHS1:KIRREL:FYN [plasma membrane] (Danio rerio)
FYN [cytosol] (Danio rerio)
Developmental Biology (Danio rerio)
Nervous system development (Danio rerio)
Axon guidance (Danio rerio)
EPH-Ephrin signaling (Danio rerio)
EPH-ephrin mediated repulsion of cells (Danio rerio)
SFKs phosphorylate VAV2,3 (Danio rerio)
EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:VAV2,VAV3 [plasma membrane] (Danio rerio)
p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Danio rerio)
SRC,FYN,YES,LYN [cytosol] (Danio rerio)
FYN [cytosol] (Danio rerio)
EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:p-VAV2,VAV3 [plasma membrane] (Danio rerio)
p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Danio rerio)
SRC,FYN,YES,LYN [cytosol] (Danio rerio)
FYN [cytosol] (Danio rerio)
SRC,FYN,YES,LYN [cytosol] (Danio rerio)
FYN [cytosol] (Danio rerio)
TIAM1 exchanges GTP for GDP on RAC1, activating it (Danio rerio)
EFNAs:p-EPHAs:SFKs:TIAM1 [plasma membrane] (Danio rerio)
EFNAs:p-EPHAs:SFKs [plasma membrane] (Danio rerio)
SRC,FYN,YES,LYN [cytosol] (Danio rerio)
FYN [cytosol] (Danio rerio)
VAV exchanges GTP for GDP on RAC1, activating it (Danio rerio)
EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:p-VAV2,VAV3 [plasma membrane] (Danio rerio)
p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Danio rerio)
SRC,FYN,YES,LYN [cytosol] (Danio rerio)
FYN [cytosol] (Danio rerio)
EPHA-mediated growth cone collapse (Danio rerio)
NGEF exchanges GTP for GDP on RHOA (Danio rerio)
EFNAs:p-EPHAs:SFKs:p-Y179-NGEF [plasma membrane] (Danio rerio)
EFNAs:p-EPHAs:SFKs [plasma membrane] (Danio rerio)
SRC,FYN,YES,LYN [cytosol] (Danio rerio)
FYN [cytosol] (Danio rerio)
Ephrin signaling (Danio rerio)
EFNBs bind SFKs (Danio rerio)
EPHBs:EFNBs:SRC,FYN [plasma membrane] (Danio rerio)
SRC,FYN [cytosol] (Danio rerio)
FYN [cytosol] (Danio rerio)
SRC,FYN [cytosol] (Danio rerio)
FYN [cytosol] (Danio rerio)
p-EFNB binds GRB4 (Danio rerio)
EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Danio rerio)
SRC,FYN [cytosol] (Danio rerio)
FYN [cytosol] (Danio rerio)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Danio rerio)
EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Danio rerio)
SRC,FYN [cytosol] (Danio rerio)
FYN [cytosol] (Danio rerio)
Netrin-1 signaling (Danio rerio)
DCC mediated attractive signaling (Danio rerio)
Phosphorylation of DCC by Fyn (Danio rerio)
FYN [cytosol] (Danio rerio)
Semaphorin interactions (Danio rerio)
CRMPs in Sema3A signaling (Danio rerio)
Phosphorylation of CRMPs by Cdk5 (Danio rerio)
Sema3A:Nrp-1:PlexinA:Fyn:Cdk5:pCRMP's [plasma membrane] (Danio rerio)
NRP1:PlexinA1-4:FYN:Cdk5:p53:p-CRMP tetramers [plasma membrane] (Danio rerio)
PlexinA1-4:FYN:Cdk5:p35:p-CRMP tetramers [plasma membrane] (Danio rerio)
Fyn:pCdk5:p35 [plasma membrane] (Danio rerio)
FYN [cytosol] (Danio rerio)
Sema3A:Nrp-1:PlexinA:Fyn:pCdk5 [plasma membrane] (Danio rerio)
NRP1:PlexinA1-4:FYN:pCdk5:p53 [plasma membrane] (Danio rerio)
PlexinA1-4:FYN:pCdk5:p35 [plasma membrane] (Danio rerio)
Fyn:pCdk5:p35 [plasma membrane] (Danio rerio)
FYN [cytosol] (Danio rerio)
Sema3A PAK dependent Axon repulsion (Danio rerio)
Activation of PAK by Rac1 (Danio rerio)
Sema3A:Nrp-1:PlexinA:Rac1-GTP:PAK [plasma membrane] (Danio rerio)
Sema3A:Nrp-1:pPlexinA:Fyn:Fes:Rac-1-GTP [plasma membrane] (Danio rerio)
Sema3A:NRP-1:pPlexin-A:Fyn:Fes [plasma membrane] (Danio rerio)
Sema3A:NRP-1:pPlexin-A:fyn [plasma membrane] (Danio rerio)
NRP1:p-Plexin-A1-4:FYN [plasma membrane] (Danio rerio)
FYN [cytosol] (Danio rerio)
Sema3A:Nrp-1:pPlexinA:Fyn:Fes:Rac-1-GTP [plasma membrane] (Danio rerio)
Sema3A:NRP-1:pPlexin-A:Fyn:Fes [plasma membrane] (Danio rerio)
Sema3A:NRP-1:pPlexin-A:fyn [plasma membrane] (Danio rerio)
NRP1:p-Plexin-A1-4:FYN [plasma membrane] (Danio rerio)
FYN [cytosol] (Danio rerio)
Autophosphorylation of PAK (Danio rerio)
Sema3A:Nrp-1:PlexinA:Rac1-GTP:PAK [plasma membrane] (Danio rerio)
Sema3A:Nrp-1:pPlexinA:Fyn:Fes:Rac-1-GTP [plasma membrane] (Danio rerio)
Sema3A:NRP-1:pPlexin-A:Fyn:Fes [plasma membrane] (Danio rerio)
Sema3A:NRP-1:pPlexin-A:fyn [plasma membrane] (Danio rerio)
NRP1:p-Plexin-A1-4:FYN [plasma membrane] (Danio rerio)
FYN [cytosol] (Danio rerio)
Sema3A:Nrp-1:PlexinA:Rac1-GTP:pPAK [plasma membrane] (Danio rerio)
Sema3A:Nrp-1:pPlexinA:Fyn:Fes:Rac-1-GTP [plasma membrane] (Danio rerio)
Sema3A:NRP-1:pPlexin-A:Fyn:Fes [plasma membrane] (Danio rerio)
Sema3A:NRP-1:pPlexin-A:fyn [plasma membrane] (Danio rerio)
NRP1:p-Plexin-A1-4:FYN [plasma membrane] (Danio rerio)
FYN [cytosol] (Danio rerio)
Phosphorylation of LIMK-1 by PAK (Danio rerio)
Sema3A:Nrp-1:PlexinA:Rac1-GTP:pPAK [plasma membrane] (Danio rerio)
Sema3A:Nrp-1:pPlexinA:Fyn:Fes:Rac-1-GTP [plasma membrane] (Danio rerio)
Sema3A:NRP-1:pPlexin-A:Fyn:Fes [plasma membrane] (Danio rerio)
Sema3A:NRP-1:pPlexin-A:fyn [plasma membrane] (Danio rerio)
NRP1:p-Plexin-A1-4:FYN [plasma membrane] (Danio rerio)
FYN [cytosol] (Danio rerio)
Immune System (Danio rerio)
Cytokine Signaling in Immune system (Danio rerio)
Signaling by Interleukins (Danio rerio)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Danio rerio)
Regulation of signaling by CBL (Danio rerio)
CBL ubiquitinates PI3K (Danio rerio)
FYN-like kinases:p(Y731)-CBL:GRB2:Ubiquitinated p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
FYN-like kinases [cytosol] (Danio rerio)
FYN [cytosol] (Danio rerio)
FYN-like kinases:p(Y731)-CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
FYN-like kinases [cytosol] (Danio rerio)
FYN [cytosol] (Danio rerio)
CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Danio rerio)
FYN-like kinases [cytosol] (Danio rerio)
FYN [cytosol] (Danio rerio)
FYN-like kinases:CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
FYN-like kinases [cytosol] (Danio rerio)
FYN [cytosol] (Danio rerio)
Innate Immune System (Danio rerio)
C-type lectin receptors (CLRs) (Danio rerio)
Dectin-2 family (Danio rerio)
LYN and FYN phosphorylate FCER1G in CLEC6A:FCERG and CLEC4E:FCERG (Danio rerio)
FYN [cytosol] (Danio rerio)
Signal Transduction (Danio rerio)
Signaling by Receptor Tyrosine Kinases (Danio rerio)
Signaling by SCF-KIT (Danio rerio)
Dimerization of STATs (Danio rerio)
p-JAK2:SFKs:p-KIT complex:p-STAT dimers [plasma membrane] (Danio rerio)
SFKs:p-KIT complex [plasma membrane] (Danio rerio)
Src family tyrosine kinases (SFKs) [cytosol] (Danio rerio)
FYN [cytosol] (Danio rerio)
p-JAK2:SFKs:p-KIT complex:p-STATs [plasma membrane] (Danio rerio)
SFKs:p-KIT complex [plasma membrane] (Danio rerio)
Src family tyrosine kinases (SFKs) [cytosol] (Danio rerio)
FYN [cytosol] (Danio rerio)
Disassociation and translocation of STATs to the nucleus (Danio rerio)
p-JAK2:SFKs:p-KIT complex [plasma membrane] (Danio rerio)
SFKs:p-KIT complex [plasma membrane] (Danio rerio)
Src family tyrosine kinases (SFKs) [cytosol] (Danio rerio)
FYN [cytosol] (Danio rerio)
p-JAK2:SFKs:p-KIT complex:p-STAT dimers [plasma membrane] (Danio rerio)
SFKs:p-KIT complex [plasma membrane] (Danio rerio)
Src family tyrosine kinases (SFKs) [cytosol] (Danio rerio)
FYN [cytosol] (Danio rerio)
GRB2 is indirectly recruited to p-KIT through SHP2 (Danio rerio)
GRB2:p-SHP2:p-KIT complex [plasma membrane] (Danio rerio)
p-SHP2:p-KIT complex [plasma membrane] (Danio rerio)
SFKs:p-KIT complex [plasma membrane] (Danio rerio)
Src family tyrosine kinases (SFKs) [cytosol] (Danio rerio)
FYN [cytosol] (Danio rerio)
p-SHP2:p-KIT complex [plasma membrane] (Danio rerio)
SFKs:p-KIT complex [plasma membrane] (Danio rerio)
Src family tyrosine kinases (SFKs) [cytosol] (Danio rerio)
FYN [cytosol] (Danio rerio)
JAK2 binds to p-KIT (Danio rerio)
JAK2:SFKS:p-KIT complex [plasma membrane] (Danio rerio)
SFKs:p-KIT complex [plasma membrane] (Danio rerio)
Src family tyrosine kinases (SFKs) [cytosol] (Danio rerio)
FYN [cytosol] (Danio rerio)
SFKs:p-KIT complex [plasma membrane] (Danio rerio)
Src family tyrosine kinases (SFKs) [cytosol] (Danio rerio)
FYN [cytosol] (Danio rerio)
Phosphorylation of JAK2 (Danio rerio)
JAK2:SFKS:p-KIT complex [plasma membrane] (Danio rerio)
SFKs:p-KIT complex [plasma membrane] (Danio rerio)
Src family tyrosine kinases (SFKs) [cytosol] (Danio rerio)
FYN [cytosol] (Danio rerio)
p-JAK2:SFKs:p-KIT complex [plasma membrane] (Danio rerio)
SFKs:p-KIT complex [plasma membrane] (Danio rerio)
Src family tyrosine kinases (SFKs) [cytosol] (Danio rerio)
FYN [cytosol] (Danio rerio)
Phosphorylation of SHP2 by SFKs (Danio rerio)
SHP2:SFKs:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Danio rerio)
SFKs:p-KIT complex [plasma membrane] (Danio rerio)
Src family tyrosine kinases (SFKs) [cytosol] (Danio rerio)
FYN [cytosol] (Danio rerio)
Src family tyrosine kinases (SFKs) [cytosol] (Danio rerio)
FYN [cytosol] (Danio rerio)
p-SHP2:p-KIT complex [plasma membrane] (Danio rerio)
SFKs:p-KIT complex [plasma membrane] (Danio rerio)
Src family tyrosine kinases (SFKs) [cytosol] (Danio rerio)
FYN [cytosol] (Danio rerio)
Phosphorylation of STATs (Danio rerio)
p-JAK2:SFKs:p-KIT complex:STATs [plasma membrane] (Danio rerio)
SFKs:p-KIT complex [plasma membrane] (Danio rerio)
Src family tyrosine kinases (SFKs) [cytosol] (Danio rerio)
FYN [cytosol] (Danio rerio)
p-JAK2:SFKs:p-KIT complex:p-STATs [plasma membrane] (Danio rerio)
SFKs:p-KIT complex [plasma membrane] (Danio rerio)
Src family tyrosine kinases (SFKs) [cytosol] (Danio rerio)
FYN [cytosol] (Danio rerio)
Phosphorylation of p-KIT on Y900 by Src kinases (Danio rerio)
SFKs:p-8Y-KIT:sSCF dimer:p-8Y-KIT [plasma membrane] (Danio rerio)
Src family tyrosine kinases (SFKs) [cytosol] (Danio rerio)
FYN [cytosol] (Danio rerio)
SFKs:p-KIT complex [plasma membrane] (Danio rerio)
Src family tyrosine kinases (SFKs) [cytosol] (Danio rerio)
FYN [cytosol] (Danio rerio)
Src family tyrosine kinases (SFKs) [cytosol] (Danio rerio)
FYN [cytosol] (Danio rerio)
Recruitment of STATs (Danio rerio)
p-JAK2:SFKs:p-KIT complex [plasma membrane] (Danio rerio)
SFKs:p-KIT complex [plasma membrane] (Danio rerio)
Src family tyrosine kinases (SFKs) [cytosol] (Danio rerio)
FYN [cytosol] (Danio rerio)
p-JAK2:SFKs:p-KIT complex:STATs [plasma membrane] (Danio rerio)
SFKs:p-KIT complex [plasma membrane] (Danio rerio)
Src family tyrosine kinases (SFKs) [cytosol] (Danio rerio)
FYN [cytosol] (Danio rerio)
Regulation of KIT signaling (Danio rerio)
Phosphorylation of APS (Danio rerio)
APS dimer:p-c-Kit:SFKs complex [plasma membrane] (Danio rerio)
SFKs:p-KIT complex [plasma membrane] (Danio rerio)
Src family tyrosine kinases (SFKs) [cytosol] (Danio rerio)
FYN [cytosol] (Danio rerio)
Src family tyrosine kinases (SFKs) [cytosol] (Danio rerio)
FYN [cytosol] (Danio rerio)
p-APS dimer:p-KIT complex [plasma membrane] (Danio rerio)
SFKs:p-KIT complex [plasma membrane] (Danio rerio)
Src family tyrosine kinases (SFKs) [cytosol] (Danio rerio)
FYN [cytosol] (Danio rerio)
Recruitment of CBL to KIT (Danio rerio)
CBL:Grb2/p-APS:p-c-Kit complex [plasma membrane] (Danio rerio)
Grb2:SOS:p-c-Kit/p-APS:p-c-Kit complex [plasma membrane] (Danio rerio)
p-APS dimer:p-KIT complex [plasma membrane] (Danio rerio)
SFKs:p-KIT complex [plasma membrane] (Danio rerio)
Src family tyrosine kinases (SFKs) [cytosol] (Danio rerio)
FYN [cytosol] (Danio rerio)
Grb2:SOS:p-c-Kit/p-APS:p-c-Kit complex [plasma membrane] (Danio rerio)
p-APS dimer:p-KIT complex [plasma membrane] (Danio rerio)
SFKs:p-KIT complex [plasma membrane] (Danio rerio)
Src family tyrosine kinases (SFKs) [cytosol] (Danio rerio)
FYN [cytosol] (Danio rerio)
Synthesis of PIP3 from PIP2 by PI3K (Danio rerio)
PI3K:p-KIT:sSCF dimer:p-KIT,PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Danio rerio)
PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Danio rerio)
GRB2:p-SHP2:p-KIT complex [plasma membrane] (Danio rerio)
p-SHP2:p-KIT complex [plasma membrane] (Danio rerio)
SFKs:p-KIT complex [plasma membrane] (Danio rerio)
Src family tyrosine kinases (SFKs) [cytosol] (Danio rerio)
FYN [cytosol] (Danio rerio)
Signaling by VEGF (Danio rerio)
VEGFA-VEGFR2 Pathway (Danio rerio)
FYN autophosphorylates (Danio rerio)
FYN [cytosol] (Danio rerio)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:FYN [plasma membrane] (Danio rerio)
FYN [cytosol] (Danio rerio)
p-6Y-VEGFR2 binds FYN (Danio rerio)
FYN [cytosol] (Danio rerio)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:FYN [plasma membrane] (Danio rerio)
FYN [cytosol] (Danio rerio)
External Reference Information
External Reference
UniProt:F1RDG9
Reference Genes
BioGPS Gene:574422
CTD Gene:574422
ENSEMBL:ENSDARG00000025319
KEGG Gene (Danio rerio):574422
Monarch:574422
NCBI Gene:574422
Reference Transcript
RefSeq:NM_001029969.1
RefSeq:XM_005160302.3
Other Identifiers
13093613
13278662
574422
A_15_P205101
CJ007107
CJ007108
CJ009745
CJ009746
CJ009919
CJ009920
CJ009972
CJ009973
CJ010546
CJ010547
CUST_6743_PI428451953
DRER04447
ENSDART00000036635
ENSDART00000036635_1
ENSDART00000036635_2
JP007505
JP007506
JP010143
JP010144
JP010317
JP010318
JP010370
JP010371
JP010944
JP010945
MADDr01001606
MADDr01009604
NM_001029969
Participates
as a member of
SRC,FYN [cytosol] (Danio rerio)
SRC,FYN,YES,LYN [cytosol] (Danio rerio)
FYN-like kinases [cytosol] (Danio rerio)
Src family tyrosine kinases (SFKs) [cytosol] (Danio rerio)
as an input of
Nephrin dimer:KIRREL binds FYN (Danio rerio)
p-6Y-VEGFR2 binds FYN (Danio rerio)
as a component of
NPHS1 dimer:KIRREL:FYN [plasma membrane] (Danio rerio)
p-Y1158,Y1176,Y1193,Y1217-NPHS1:KIRREL:FYN [plasma membrane] (Danio rerio)
Fyn:pCdk5:p35 [plasma membrane] (Danio rerio)
Plexin-A1-4:FYN [plasma membrane] (Danio rerio)
NRP1:Plexin-A1-4:FYN [plasma membrane] (Danio rerio)
NRP1:p-Plexin-A1-4:FYN [plasma membrane] (Danio rerio)
VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:FYN [plasma membrane] (Danio rerio)
Other forms of this molecule
phospho-p-S21,Y420-FYN [cytosol]
phospho-p-Y420-FYN [cytosol]
phospho-MyrG-p-Y420-FYN-1 [plasma membrane]
Inferred From
FYN, LYN [cytosol]
(Homo sapiens)
FYN [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_001025140.1
,
XP_005160359.1
ZFIN
ZDB-GENE-050706-89
Ensembl
ENSDARP00000133954
,
ENSDART00000169407
,
ENSDARP00000037198
,
ENSDART00000036635
,
ENSDARG00000025319
PRO
F1RDG9
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