Reactome | psma5 [nucleoplasm]

psma5 [nucleoplasm]

Stable Identifier

R-DRE-174340

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

nucleoplasm

Synonyms

PSMA5, Q6TGV6

Locations in the PathwayBrowser

Expand all

Cell Cycle (Danio rerio)

- Cell Cycle Checkpoints (Danio rerio)
  - G1/S DNA Damage Checkpoints (Danio rerio)
    - p53-Independent G1/S DNA Damage Checkpoint (Danio rerio)
      - Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A (Danio rerio)
        
        Proteolytic degradation of ubiquitinated-Cdc25A (Danio rerio)
        
        26S proteasome [nucleoplasm] (Danio rerio)
        
        20S core particle [nucleoplasm] (Danio rerio)
        
        20S CP outer ring [nucleoplasm] (Danio rerio)
        
        psma5 [nucleoplasm] (Danio rerio)
- Cell Cycle, Mitotic (Danio rerio)
  - Mitotic G1 phase and G1/S transition (Danio rerio)
    - G1/S Transition (Danio rerio)
      - Cyclin E associated events during G1/S transition (Danio rerio)
        
        SCF(Skp2)-mediated degradation of p27/p21 (Danio rerio)
        
        Degradation of ubiquitinated p27/p21 by the 26S proteasome (Danio rerio)
        
        26S proteasome [nucleoplasm] (Danio rerio)
        
        20S core particle [nucleoplasm] (Danio rerio)
        
        20S CP outer ring [nucleoplasm] (Danio rerio)
        
        psma5 [nucleoplasm] (Danio rerio)
  - Regulation of mitotic cell cycle (Danio rerio)
    - APC/C-mediated degradation of cell cycle proteins (Danio rerio)
      - APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Danio rerio)
        
        APC/C:Cdh1-mediated degradation of Skp2 (Danio rerio)
        
        26S proteasome [nucleoplasm] (Danio rerio)
        
        20S core particle [nucleoplasm] (Danio rerio)
        
        20S CP outer ring [nucleoplasm] (Danio rerio)
        
        psma5 [nucleoplasm] (Danio rerio)
      - Autodegradation of Cdh1 by Cdh1:APC/C (Danio rerio)
        
        Degradation of multiubiquitinated Cdh1 (Danio rerio)
        
        26S proteasome [nucleoplasm] (Danio rerio)
        
        20S core particle [nucleoplasm] (Danio rerio)
        
        20S CP outer ring [nucleoplasm] (Danio rerio)
        
        psma5 [nucleoplasm] (Danio rerio)
  - S Phase (Danio rerio)
    - Cyclin A:Cdk2-associated events at S phase entry (Danio rerio)
      - SCF(Skp2)-mediated degradation of p27/p21 (Danio rerio)
        
        Degradation of ubiquitinated p27/p21 by the 26S proteasome (Danio rerio)
        
        26S proteasome [nucleoplasm] (Danio rerio)
        
        20S core particle [nucleoplasm] (Danio rerio)
        
        20S CP outer ring [nucleoplasm] (Danio rerio)
        
        psma5 [nucleoplasm] (Danio rerio)

Cellular responses to stimuli (Danio rerio)

- Cellular responses to stress (Danio rerio)
  - Cellular response to chemical stress (Danio rerio)
    - KEAP1-NFE2L2 pathway (Danio rerio)
      - Nuclear events mediated by NFE2L2 (Danio rerio)
        
        GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 (Danio rerio)
        
        Ub,pS335,S338,T NFE2L2 is degraded (Danio rerio)
        
        26S proteasome [nucleoplasm] (Danio rerio)
        
        20S core particle [nucleoplasm] (Danio rerio)
        
        20S CP outer ring [nucleoplasm] (Danio rerio)
        
        psma5 [nucleoplasm] (Danio rerio)

Gene expression (Transcription) (Danio rerio)

- RNA Polymerase II Transcription (Danio rerio)
  - Generic Transcription Pathway (Danio rerio)
    - Transcriptional regulation by RUNX2 (Danio rerio)
      - Regulation of RUNX2 expression and activity (Danio rerio)
        
        26S proteasome degrades PolyUb-RUNX2 (Danio rerio)
        
        26S proteasome [nucleoplasm] (Danio rerio)
        
        20S core particle [nucleoplasm] (Danio rerio)
        
        20S CP outer ring [nucleoplasm] (Danio rerio)
        
        psma5 [nucleoplasm] (Danio rerio)
    - Transcriptional regulation by RUNX3 (Danio rerio)
      - Regulation of RUNX3 expression and activity (Danio rerio)
        
        Polyubiquitinated RUNX3 is degraded by the proteasome (Danio rerio)
        
        26S proteasome [nucleoplasm] (Danio rerio)
        
        20S core particle [nucleoplasm] (Danio rerio)
        
        20S CP outer ring [nucleoplasm] (Danio rerio)
        
        psma5 [nucleoplasm] (Danio rerio)

External Reference Information

External Reference

UniProt:Q6TGV6

Gene Names

psma5

Reference Genes

BioGPS Gene:403011 psma5

ENSEMBL:ENSDARG00000003526

KEGG:dre:403011 psma5

Monarch:403011 psma5

NCBI Gene:403011 psma5

UCSC:Q6TGV6 psma5

Reference Transcript

RefSeq:NM_205708.1 psma5

Other Identifiers

12981147

403011

A_15_P153506

A_15_P493557

A_15_P723351

BC071495

CJ013931

CUST_1512_PI428451953

CUST_1513_PI428451953

DRER02614

DRER40229

DRER44796

Dr.20156.1.S1_at

ENSDART00000020655

ENSDART00000020655_1

ENSDART00000020655_2

GO:0005839

GO:0006511

GO:0019773

GO:0030163

GO:0043161

GO:0051603

LOLS05704

MADDr01009305

NM_205708

OTTDART00000025567

OTTDART00000025568

OTTDART00000025569

XM_679305

Participates

as a component of

20S CP outer ring [nucleoplasm] (Danio rerio)

Other forms of this molecule

psma5 [secretory granule lumen]

psma5 [extracellular region]

psma5 [ficolin-1-rich granule lumen]

psma5 [cytosol]

Inferred From

PSMA5 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_991271.1

ENSEMBL

ENSDARG00000116794, ENSDARG00000003526, ENSDARP00000154466, ENSDART00000185400, ENSDARP00000009133, ENSDART00000020655

ZFIN

ZDB-GENE-040625-96

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