Reactome | anapc2 [cytosol]

anapc2 [cytosol]

Stable Identifier

R-DRE-174229

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

cytosol

Synonyms

ANAPC2, A0A0R4ISV4

Locations in the PathwayBrowser

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Cell Cycle (Danio rerio)

- Cell Cycle Checkpoints (Danio rerio)
  - Mitotic Spindle Checkpoint (Danio rerio)
    - Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components (Danio rerio)
      - Inactivation of APC/C via direct inhibition of the APC/C complex (Danio rerio)
        
        Binding of the MCC complex to the APC/C complex (Danio rerio)
        
        MCC:APC/C complex [cytosol] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Danio rerio)
        
        anapc2 [cytosol] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Danio rerio)
        
        anapc2 [cytosol] (Danio rerio)
- Cell Cycle, Mitotic (Danio rerio)
  - M Phase (Danio rerio)
    - Mitotic Metaphase and Anaphase (Danio rerio)
      - Mitotic Anaphase (Danio rerio)
        
        Separation of Sister Chromatids (Danio rerio)
        
        Association of Securin with Cdc20:APC/C complex (Danio rerio)
        
        CDC20:p-APC/C [cytosol] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Danio rerio)
        
        anapc2 [cytosol] (Danio rerio)
        
        CDC20:p-APC/C:PTTG1 [cytosol] (Danio rerio)
        
        CDC20:p-APC/C [cytosol] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Danio rerio)
        
        anapc2 [cytosol] (Danio rerio)
        
        Degradation of multiubiquitinated Securin (Danio rerio)
        
        CDC20:p-APC/C [cytosol] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Danio rerio)
        
        anapc2 [cytosol] (Danio rerio)
        
        CDC20:pAPC/C:K11polyUb-PTTG1 [cytosol] (Danio rerio)
        
        CDC20:p-APC/C [cytosol] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Danio rerio)
        
        anapc2 [cytosol] (Danio rerio)
        
        Ubiquitination of Securin by phospho-APC/C:Cdc20 complex (Danio rerio)
        
        CDC20:p-APC/C:PTTG1 [cytosol] (Danio rerio)
        
        CDC20:p-APC/C [cytosol] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Danio rerio)
        
        anapc2 [cytosol] (Danio rerio)
        
        CDC20:pAPC/C:K11polyUb-PTTG1 [cytosol] (Danio rerio)
        
        CDC20:p-APC/C [cytosol] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Danio rerio)
        
        anapc2 [cytosol] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Danio rerio)
        
        anapc2 [cytosol] (Danio rerio)
  - Regulation of mitotic cell cycle (Danio rerio)
    - APC/C-mediated degradation of cell cycle proteins (Danio rerio)
      - APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Danio rerio)
        
        Association of cell cycle proteins with the APC/C:Cdh1 complex (Danio rerio)
        
        cell cycle proteins:phospho-APC/C:Cdh1 complex [cytosol] (Danio rerio)
        
        phospho-APC/C:Cdh1 complex [cytosol] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Danio rerio)
        
        anapc2 [cytosol] (Danio rerio)
        
        phospho-APC/C:Cdh1 complex [cytosol] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Danio rerio)
        
        anapc2 [cytosol] (Danio rerio)
        
        Degradation of multiubiquitinated cell cycle proteins (Danio rerio)
        
        multiubiquitinated cell cycle protein:APC/C:Cdh1 complex [cytosol] (Danio rerio)
        
        cell cycle proteins:phospho-APC/C:Cdh1 complex [cytosol] (Danio rerio)
        
        phospho-APC/C:Cdh1 complex [cytosol] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Danio rerio)
        
        anapc2 [cytosol] (Danio rerio)
        
        phospho-APC/C:Cdh1 complex [cytosol] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Danio rerio)
        
        anapc2 [cytosol] (Danio rerio)
        
        Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex (Danio rerio)
        
        cell cycle proteins:phospho-APC/C:Cdh1 complex [cytosol] (Danio rerio)
        
        phospho-APC/C:Cdh1 complex [cytosol] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Danio rerio)
        
        anapc2 [cytosol] (Danio rerio)
        
        multiubiquitinated cell cycle protein:APC/C:Cdh1 complex [cytosol] (Danio rerio)
        
        cell cycle proteins:phospho-APC/C:Cdh1 complex [cytosol] (Danio rerio)
        
        phospho-APC/C:Cdh1 complex [cytosol] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Danio rerio)
        
        anapc2 [cytosol] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Danio rerio)
        
        anapc2 [cytosol] (Danio rerio)
      - Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins (Danio rerio)
        
        APC/C:Cdc20 mediated degradation of mitotic proteins (Danio rerio)
        
        APC/C:Cdc20 mediated degradation of Cyclin B (Danio rerio)
        
        Association of Cyclin B:Cdc2 with Cdc20:APC/C complex (Danio rerio)
        
        CDC20:p-APC/C [cytosol] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Danio rerio)
        
        anapc2 [cytosol] (Danio rerio)
        
        Cdc20:phospho-APC/C:Cyclin B:Cdc2 complex [cytosol] (Danio rerio)
        
        CDC20:p-APC/C [cytosol] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Danio rerio)
        
        anapc2 [cytosol] (Danio rerio)
        
        Degradation of multiubiquitinated Cyclin B (Danio rerio)
        
        CDC20:p-APC/C [cytosol] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Danio rerio)
        
        anapc2 [cytosol] (Danio rerio)
        
        multiubiquitinated Cyclin B:Cdc2:Cdc20:phospho-APC/C complex [cytosol] (Danio rerio)
        
        Cdc20:phospho-APC/C:Cyclin B:Cdc2 complex [cytosol] (Danio rerio)
        
        CDC20:p-APC/C [cytosol] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Danio rerio)
        
        anapc2 [cytosol] (Danio rerio)
        
        Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex (Danio rerio)
        
        Cdc20:phospho-APC/C:Cyclin B:Cdc2 complex [cytosol] (Danio rerio)
        
        CDC20:p-APC/C [cytosol] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Danio rerio)
        
        anapc2 [cytosol] (Danio rerio)
        
        multiubiquitinated Cyclin B:Cdc2:Cdc20:phospho-APC/C complex [cytosol] (Danio rerio)
        
        Cdc20:phospho-APC/C:Cyclin B:Cdc2 complex [cytosol] (Danio rerio)
        
        CDC20:p-APC/C [cytosol] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Danio rerio)
        
        anapc2 [cytosol] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Danio rerio)
        
        anapc2 [cytosol] (Danio rerio)
        
        APC/C:Cdc20 mediated degradation of Securin (Danio rerio)
        
        Association of Securin with Cdc20:APC/C complex (Danio rerio)
        
        CDC20:p-APC/C [cytosol] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Danio rerio)
        
        anapc2 [cytosol] (Danio rerio)
        
        CDC20:p-APC/C:PTTG1 [cytosol] (Danio rerio)
        
        CDC20:p-APC/C [cytosol] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Danio rerio)
        
        anapc2 [cytosol] (Danio rerio)
        
        Degradation of multiubiquitinated Securin (Danio rerio)
        
        CDC20:p-APC/C [cytosol] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Danio rerio)
        
        anapc2 [cytosol] (Danio rerio)
        
        CDC20:pAPC/C:K11polyUb-PTTG1 [cytosol] (Danio rerio)
        
        CDC20:p-APC/C [cytosol] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Danio rerio)
        
        anapc2 [cytosol] (Danio rerio)
        
        Ubiquitination of Securin by phospho-APC/C:Cdc20 complex (Danio rerio)
        
        CDC20:p-APC/C:PTTG1 [cytosol] (Danio rerio)
        
        CDC20:p-APC/C [cytosol] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Danio rerio)
        
        anapc2 [cytosol] (Danio rerio)
        
        CDC20:pAPC/C:K11polyUb-PTTG1 [cytosol] (Danio rerio)
        
        CDC20:p-APC/C [cytosol] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Danio rerio)
        
        anapc2 [cytosol] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Danio rerio)
        
        anapc2 [cytosol] (Danio rerio)
        
        APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint (Danio rerio)
        
        APC-Cdc20 mediated degradation of Nek2A (Danio rerio)
        
        Association of Nek2A with MCC:APC/C (Danio rerio)
        
        MCC:APC/C complex [cytosol] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Danio rerio)
        
        anapc2 [cytosol] (Danio rerio)
        
        Nek2A:MCC:APC/C complex [cytosol] (Danio rerio)
        
        MCC:APC/C complex [cytosol] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Danio rerio)
        
        anapc2 [cytosol] (Danio rerio)
        
        Degradation of multiubiquitinated Nek2A (Danio rerio)
        
        MCC:APC/C complex [cytosol] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Danio rerio)
        
        anapc2 [cytosol] (Danio rerio)
        
        Multiubiquitinated Nek2A [cytosol] (Danio rerio)
        
        Nek2A:MCC:APC/C complex [cytosol] (Danio rerio)
        
        MCC:APC/C complex [cytosol] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Danio rerio)
        
        anapc2 [cytosol] (Danio rerio)
        
        Multiubiquitination of Nek2A (Danio rerio)
        
        Multiubiquitinated Nek2A [cytosol] (Danio rerio)
        
        Nek2A:MCC:APC/C complex [cytosol] (Danio rerio)
        
        MCC:APC/C complex [cytosol] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Danio rerio)
        
        anapc2 [cytosol] (Danio rerio)
        
        Nek2A:MCC:APC/C complex [cytosol] (Danio rerio)
        
        MCC:APC/C complex [cytosol] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Danio rerio)
        
        anapc2 [cytosol] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Danio rerio)
        
        anapc2 [cytosol] (Danio rerio)
        
        Cdc20:Phospho-APC/C mediated degradation of Cyclin A (Danio rerio)
        
        Association of Cyclin A with the APC/C (Danio rerio)
        
        Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Danio rerio)
        
        MCC:APC/C complex [cytosol] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Danio rerio)
        
        anapc2 [cytosol] (Danio rerio)
        
        MCC:APC/C complex [cytosol] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Danio rerio)
        
        anapc2 [cytosol] (Danio rerio)
        
        Degradation multiubiquitinated Cyclin A (Danio rerio)
        
        MCC:APC/C complex [cytosol] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Danio rerio)
        
        anapc2 [cytosol] (Danio rerio)
        
        multiubiquitinated Cyclin A associated with MCC:APC/C complex [cytosol] (Danio rerio)
        
        Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Danio rerio)
        
        MCC:APC/C complex [cytosol] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Danio rerio)
        
        anapc2 [cytosol] (Danio rerio)
        
        Ubiquitination of Cyclin A by APC/C:Cdc20 complex (Danio rerio)
        
        Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Danio rerio)
        
        MCC:APC/C complex [cytosol] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Danio rerio)
        
        anapc2 [cytosol] (Danio rerio)
        
        MCC:APC/C complex [cytosol] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Danio rerio)
        
        anapc2 [cytosol] (Danio rerio)
        
        multiubiquitinated Cyclin A associated with MCC:APC/C complex [cytosol] (Danio rerio)
        
        Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Danio rerio)
        
        MCC:APC/C complex [cytosol] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Danio rerio)
        
        anapc2 [cytosol] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Danio rerio)
        
        anapc2 [cytosol] (Danio rerio)
        
        Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1 (Danio rerio)
        
        CDC20:p-APC/C [cytosol] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Danio rerio)
        
        anapc2 [cytosol] (Danio rerio)
        
        MCC:APC/C complex [cytosol] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Danio rerio)
        
        anapc2 [cytosol] (Danio rerio)
      - Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase (Danio rerio)
        
        Association of Cdh1 with the APC/C (Danio rerio)
        
        phospho-APC/C:Cdh1 complex [cytosol] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Danio rerio)
        
        anapc2 [cytosol] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Danio rerio)
        
        anapc2 [cytosol] (Danio rerio)
        
        Dissociation of Cdc20 from APC/C complex (Danio rerio)
        
        CDC20:p-APC/C [cytosol] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Danio rerio)
        
        anapc2 [cytosol] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Danio rerio)
        
        anapc2 [cytosol] (Danio rerio)
      - Regulation of APC/C activators between G1/S and early anaphase (Danio rerio)
        
        Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components (Danio rerio)
        
        Inactivation of APC/C via direct inhibition of the APC/C complex (Danio rerio)
        
        Binding of the MCC complex to the APC/C complex (Danio rerio)
        
        MCC:APC/C complex [cytosol] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Danio rerio)
        
        anapc2 [cytosol] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Danio rerio)
        
        anapc2 [cytosol] (Danio rerio)
  - S Phase (Danio rerio)
    - Synthesis of DNA (Danio rerio)
      - Switching of origins to a post-replicative state (Danio rerio)
        
        CDK-mediated phosphorylation and removal of Cdc6 (Danio rerio)
        
        Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex (Danio rerio)
        
        phospho-APC/C:Cdh1 complex [cytosol] (Danio rerio)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Danio rerio)
        
        anapc2 [cytosol] (Danio rerio)

Immune System (Danio rerio)

- Adaptive Immune System (Danio rerio)
  - Class I MHC mediated antigen processing & presentation (Danio rerio)
    - Antigen processing: Ubiquitination & Proteasome degradation (Danio rerio)
      - Interaction of E3 with substrate and E2-Ub complex (Danio rerio)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Danio rerio)
        
        E3 ligases in proteasomal degradation [cytosol] (Danio rerio)
        
        APC/C E3 ligase complex [cytosol] (Danio rerio)
        
        anapc2 [cytosol] (Danio rerio)
        
        E3 ligases in proteasomal degradation [cytosol] (Danio rerio)
        
        APC/C E3 ligase complex [cytosol] (Danio rerio)
        
        anapc2 [cytosol] (Danio rerio)
      - Polyubiquitination of substrate (Danio rerio)
        
        E3 ligases in proteasomal degradation [cytosol] (Danio rerio)
        
        APC/C E3 ligase complex [cytosol] (Danio rerio)
        
        anapc2 [cytosol] (Danio rerio)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Danio rerio)
        
        E3 ligases in proteasomal degradation [cytosol] (Danio rerio)
        
        APC/C E3 ligase complex [cytosol] (Danio rerio)
        
        anapc2 [cytosol] (Danio rerio)
        
        E3:Ub:substrate [cytosol] (Danio rerio)
        
        E3 ligases in proteasomal degradation [cytosol] (Danio rerio)
        
        APC/C E3 ligase complex [cytosol] (Danio rerio)
        
        anapc2 [cytosol] (Danio rerio)
      - Release of E3 from polyubiquitinated substrate (Danio rerio)
        
        E3 ligases in proteasomal degradation [cytosol] (Danio rerio)
        
        APC/C E3 ligase complex [cytosol] (Danio rerio)
        
        anapc2 [cytosol] (Danio rerio)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Danio rerio)
        
        E3 ligases in proteasomal degradation [cytosol] (Danio rerio)
        
        APC/C E3 ligase complex [cytosol] (Danio rerio)
        
        anapc2 [cytosol] (Danio rerio)
      - Transfer of Ub from E2 to substrate and release of E2 (Danio rerio)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Danio rerio)
        
        E3 ligases in proteasomal degradation [cytosol] (Danio rerio)
        
        APC/C E3 ligase complex [cytosol] (Danio rerio)
        
        anapc2 [cytosol] (Danio rerio)
        
        E3 ligases in proteasomal degradation [cytosol] (Danio rerio)
        
        APC/C E3 ligase complex [cytosol] (Danio rerio)
        
        anapc2 [cytosol] (Danio rerio)
        
        E3:Ub:substrate [cytosol] (Danio rerio)
        
        E3 ligases in proteasomal degradation [cytosol] (Danio rerio)
        
        APC/C E3 ligase complex [cytosol] (Danio rerio)
        
        anapc2 [cytosol] (Danio rerio)

External Reference Information

External Reference

UniProt:A0A0R4ISV4

Gene Names

anapc2

Reference Genes

BioGPS Gene:100318335 anapc2

ENSEMBL:ENSDARG00000105035

KEGG:dre:100318335 anapc2

Monarch:100318335 anapc2

NCBI Gene:100318335 anapc2

UCSC:A0A0R4ISV4 anapc2

Reference Transcript

RefSeq:NM_001256746.2 anapc2

Other Identifiers

100318335

13208876

A_15_P155886

CJ012065

CUST_153_PI424165973

CUST_154_PI424165973

CUST_155_PI424165973

CUST_156_PI424165973

CUST_157_PI424165973

CUST_158_PI424165973

CUST_159_PI424165973

CUST_160_PI424165973

CUST_28698_PI428451953

CUST_28699_PI428451953

DRER03575

DRER33234

Dr.24066.1.S1_at

ENSDART00000027796

ENSDART00000027796_1

ENSDART00000027796_2

GO:0006511

GO:0031625

GT_Spec_NM_001256746.1_276915

XM_684458

ZV700S00004087

Participates

as a component of

Other forms of this molecule

anapc2 [nucleoplasm]

Inferred From

ANAPC2 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001243675.1

ENSEMBL

ENSDART00000171159, ENSDARP00000139310, ENSDARG00000105035

ZFIN

ZDB-GENE-081104-256

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