Reactome | Dimeric TGFB1 [extracellular region]

Dimeric TGFB1 [extracellular region]

Stable Identifier

R-DRE-170852

Type

Complex

Species

Danio rerio

Compartment

extracellular region

Locations in the PathwayBrowser

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General

This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Participants

components

x 2 tgfb1a [extracellular region] (Danio rerio)

Participates

as a component of

TGFB1:LAP1 [extracellular region] (Danio rerio)
Dimeric TGFB1:TGFBR2 homodimer [plasma membrane] (Danio rerio)
TGFB1:TGFBR2:TGFBR1 [plasma membrane] (Danio rerio)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Danio rerio)
TGFB1:p-TGFBR:ZFYVE9:SMAD2/3 [early endosome membrane] (Danio rerio)
TGFB1:p-TGFBR:ZFYVE9 [early endosome membrane] (Danio rerio)
TGFB1:p-TGFBR:ZFYVE9:p-2S-SMAD2,3 [early endosome membrane] (Danio rerio)

as an input of

Dimeric TGF-beta-1 binds to the receptor (Danio rerio)

This entity regulates

Positively

RUNX3 binds ZFHX3 (Danio rerio)
RUNX3 translocates to the nucleus (Danio rerio)

Inferred From

Dimeric TGFB1 [extracellular region] (Homo sapiens)