Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
f2 [extracellular region]
Stable Identifier
R-DRE-140598
Type
Protein [EntityWithAccessionedSequence]
Species
Danio rerio
Compartment
extracellular region
Synonyms
F2(315-363), E7FAN5
Locations in the PathwayBrowser
Expand all
Hemostasis (Danio rerio)
Coagulation pathway (Danio rerio)
Amplification and propagation of coagulation cascade (Danio rerio)
factor V -> factor Va + factor V activation peptide (thrombin catalyst) (Danio rerio)
Extracellular thrombin inactivating complexes [extracellular region] (Danio rerio)
activated thrombin (factor IIa):SERPIND1 [extracellular region] (Danio rerio)
activated thrombin (factor IIa) [extracellular region] (Danio rerio)
f2 [extracellular region] (Danio rerio)
thrombin:cleaved SERPINC1 [extracellular region] (Danio rerio)
activated thrombin (factor IIa) [extracellular region] (Danio rerio)
f2 [extracellular region] (Danio rerio)
activated thrombin (factor IIa) [extracellular region] (Danio rerio)
f2 [extracellular region] (Danio rerio)
prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) (Danio rerio)
activated thrombin (factor IIa) [extracellular region] (Danio rerio)
f2 [extracellular region] (Danio rerio)
Fibrin formation (Danio rerio)
factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides (Danio rerio)
Extracellular thrombin inactivating complexes [extracellular region] (Danio rerio)
activated thrombin (factor IIa):SERPIND1 [extracellular region] (Danio rerio)
activated thrombin (factor IIa) [extracellular region] (Danio rerio)
f2 [extracellular region] (Danio rerio)
thrombin:cleaved SERPINC1 [extracellular region] (Danio rerio)
activated thrombin (factor IIa) [extracellular region] (Danio rerio)
f2 [extracellular region] (Danio rerio)
Factor IIa inhibitors:IIa [extracellular region] (Danio rerio)
Factor IIa inhibitors (compounds):IIa [extracellular region] (Danio rerio)
activated thrombin (factor IIa) [extracellular region] (Danio rerio)
f2 [extracellular region] (Danio rerio)
Factor IIa inhibitors (peptide):IIa [extracellular region] (Danio rerio)
activated thrombin (factor IIa) [extracellular region] (Danio rerio)
f2 [extracellular region] (Danio rerio)
activated thrombin (factor IIa) [extracellular region] (Danio rerio)
f2 [extracellular region] (Danio rerio)
fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B (Danio rerio)
Extracellular thrombin inactivating complexes [extracellular region] (Danio rerio)
activated thrombin (factor IIa):SERPIND1 [extracellular region] (Danio rerio)
activated thrombin (factor IIa) [extracellular region] (Danio rerio)
f2 [extracellular region] (Danio rerio)
thrombin:cleaved SERPINC1 [extracellular region] (Danio rerio)
activated thrombin (factor IIa) [extracellular region] (Danio rerio)
f2 [extracellular region] (Danio rerio)
Factor IIa inhibitors:IIa [extracellular region] (Danio rerio)
Factor IIa inhibitors (compounds):IIa [extracellular region] (Danio rerio)
activated thrombin (factor IIa) [extracellular region] (Danio rerio)
f2 [extracellular region] (Danio rerio)
Factor IIa inhibitors (peptide):IIa [extracellular region] (Danio rerio)
activated thrombin (factor IIa) [extracellular region] (Danio rerio)
f2 [extracellular region] (Danio rerio)
activated thrombin (factor IIa) [extracellular region] (Danio rerio)
f2 [extracellular region] (Danio rerio)
Initiation of coagulation cascade (Danio rerio)
factor V -> factor Va intermediate + factor V activation peptide (thrombin catalyst) (Danio rerio)
activated thrombin (factor IIa) [extracellular region] (Danio rerio)
f2 [extracellular region] (Danio rerio)
factor Va intermediate -> factor Va (Danio rerio)
activated thrombin (factor IIa) [extracellular region] (Danio rerio)
f2 [extracellular region] (Danio rerio)
prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst) (Danio rerio)
activated thrombin (factor IIa) [extracellular region] (Danio rerio)
f2 [extracellular region] (Danio rerio)
prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) (Danio rerio)
activated thrombin (factor IIa) [extracellular region] (Danio rerio)
f2 [extracellular region] (Danio rerio)
Regulation of clotting cascade (Danio rerio)
Factor IIa inhibitors (compounds) binds IIa (Danio rerio)
Factor IIa inhibitors (compounds):IIa [extracellular region] (Danio rerio)
activated thrombin (factor IIa) [extracellular region] (Danio rerio)
f2 [extracellular region] (Danio rerio)
activated thrombin (factor IIa) [extracellular region] (Danio rerio)
f2 [extracellular region] (Danio rerio)
Factor IIa inhibitors (peptide) bind IIa (Danio rerio)
Factor IIa inhibitors (peptide):IIa [extracellular region] (Danio rerio)
activated thrombin (factor IIa) [extracellular region] (Danio rerio)
f2 [extracellular region] (Danio rerio)
activated thrombin (factor IIa) [extracellular region] (Danio rerio)
f2 [extracellular region] (Danio rerio)
Heparin cofactor 2 (SERPIND1) binds activated thrombin (factor IIa) (Danio rerio)
activated thrombin (factor IIa) [extracellular region] (Danio rerio)
f2 [extracellular region] (Danio rerio)
activated thrombin (factor IIa):SERPIND1 [extracellular region] (Danio rerio)
activated thrombin (factor IIa) [extracellular region] (Danio rerio)
f2 [extracellular region] (Danio rerio)
activated thrombin (factor IIa) + antithrombin III:heparan sulfate -> thrombin:antithrombin III:heparan sulfate (Danio rerio)
activated thrombin (factor IIa) [extracellular region] (Danio rerio)
f2 [extracellular region] (Danio rerio)
thrombin:cleaved SERPINC1:HSPGs-> thrombin:cleaved SERPINC1 + HSPGs (Danio rerio)
thrombin:cleaved SERPINC1 [extracellular region] (Danio rerio)
activated thrombin (factor IIa) [extracellular region] (Danio rerio)
f2 [extracellular region] (Danio rerio)
Platelet activation, signaling and aggregation (Danio rerio)
Thrombin signalling through proteinase activated receptors (PARs) (Danio rerio)
Activated thrombin (factor IIa) cleaves F2R (PAR1), activating it (Danio rerio)
activated thrombin (factor IIa) [extracellular region] (Danio rerio)
f2 [extracellular region] (Danio rerio)
Activated thrombin (factor IIa) cleaves PAR3,4, activating them (Danio rerio)
activated thrombin (factor IIa) [extracellular region] (Danio rerio)
f2 [extracellular region] (Danio rerio)
Immune System (Danio rerio)
Innate Immune System (Danio rerio)
Complement cascade (Danio rerio)
Regulation of Complement cascade (Danio rerio)
Thrombin, ELANE cleave C5 (Danio rerio)
activated thrombin (factor IIa) [extracellular region] (Danio rerio)
f2 [extracellular region] (Danio rerio)
Metabolism of proteins (Danio rerio)
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) (Danio rerio)
Thrombin proteolyzes IGF:IGFBP3:ALS (Danio rerio)
activated thrombin (factor IIa) [extracellular region] (Danio rerio)
f2 [extracellular region] (Danio rerio)
Signal Transduction (Danio rerio)
Signaling by GPCR (Danio rerio)
GPCR downstream signalling (Danio rerio)
G alpha (q) signalling events (Danio rerio)
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Danio rerio)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Danio rerio)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Danio rerio)
Thrombin:Proteinase-activated receptors [plasma membrane] (Danio rerio)
activated thrombin (factor IIa) [extracellular region] (Danio rerio)
f2 [extracellular region] (Danio rerio)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Danio rerio)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Danio rerio)
Thrombin:Proteinase-activated receptors [plasma membrane] (Danio rerio)
activated thrombin (factor IIa) [extracellular region] (Danio rerio)
f2 [extracellular region] (Danio rerio)
GPCR ligand binding (Danio rerio)
Class A/1 (Rhodopsin-like receptors) (Danio rerio)
Peptide ligand-binding receptors (Danio rerio)
Proteinase-activated receptors can bind thrombin (Danio rerio)
Thrombin:Proteinase-activated receptors [plasma membrane] (Danio rerio)
activated thrombin (factor IIa) [extracellular region] (Danio rerio)
f2 [extracellular region] (Danio rerio)
activated thrombin (factor IIa) [extracellular region] (Danio rerio)
f2 [extracellular region] (Danio rerio)
External Reference Information
External Reference
UniProt:E7FAN5
Gene Names
f2
Reference Genes
BioGPS Gene:325881 f2
ENSEMBL:ENSDARG00000036041
Monarch:325881 f2
NCBI Gene:325881 f2
UCSC:E7FAN5 f2
Reference Transcript
RefSeq:XM_005168965.5 f2
Other Identifiers
13229973
13280476
325881
A_15_P111944
A_15_P112672
A_15_P113614
A_15_P113734
A_15_P271876
A_15_P362785
A_15_P380390
A_15_P578152
A_15_P724726
A_15_P727546
A_15_P750501
CJ006724
CJ006725
CUST_17524_PI428451953
CUST_17525_PI428451953
CUST_1827_PI428451958
DRER06463
DRER20649
DRER31197
DRER32781
DRER36192
DRER45193
ENSDART00000052325_1
ENSDART00000052325_2
ENSDART00000114238
GO:0004252
GO:0005509
GO:0005576
GO:0006508
GO:0007596
GO:0016787
GT_Spec_XM_005168965.1_403185
GT_Xhyb_NM_213390.1_135656
JP007122
JP007123
LOLS15793
MADDr01007281
NM_213390
OTTDART00000025192
OTTDART00000025193
Participates
as a component of
activated thrombin (factor IIa) [extracellular region] (Danio rerio)
Other forms of this molecule
f2 [Golgi lumen]
f2 [Golgi lumen]
f2 [Golgi lumen]
f2 [endoplasmic reticulum lumen]
f2 [endoplasmic reticulum lumen]
f2 [plasma membrane]
f2 [plasma membrane]
f2 [extracellular region]
f2 [extracellular region]
f2 [extracellular region]
Inferred From
F2(315-363) [extracellular region]
(Homo sapiens)
Cross References
RefSeq
XP_005169022.1
ENSEMBL
ENSDARP00000052324
,
ENSDARG00000036041
,
ENSDART00000052325
ZFIN
ZDB-GENE-030131-4606
© 2026
Reactome
This website requires cookies and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our
Privacy Notice
.
I agree, dismiss this banner
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text
