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Ub [cytosol]
Stable Identifier
R-DRE-113595
Type
Set [DefinedSet]
Species
Danio rerio
Compartment
cytosol
Synonyms
ubiquitin
Locations in the PathwayBrowser
Expand all
Autophagy (Danio rerio)
Macroautophagy (Danio rerio)
Selective autophagy (Danio rerio)
Aggrephagy (Danio rerio)
Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub (Danio rerio)
Misfolded proteins:PRKN:UBE2N:UBE2V1:Ub [cytosol] (Danio rerio)
Ub:UBE2N:UBE2V1:PRKN [cytosol] (Danio rerio)
Ub:UBE2N:UBE2V1 [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Ub:UBE2N:UBE2V1:PRKN [cytosol] (Danio rerio)
Ub:UBE2N:UBE2V1 [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Parkin binds Ub:UBE2N:UBE2V1 (Danio rerio)
Ub:UBE2N:UBE2V1 [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Ub:UBE2N:UBE2V1:PRKN [cytosol] (Danio rerio)
Ub:UBE2N:UBE2V1 [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Parkin transfers Ub to misfolded proteins (Danio rerio)
Misfolded proteins:PRKN:UBE2N:UBE2V1:Ub [cytosol] (Danio rerio)
Ub:UBE2N:UBE2V1:PRKN [cytosol] (Danio rerio)
Ub:UBE2N:UBE2V1 [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Ub:Misfolded proteins:PRKN:UBE2N:UBE2V1 [cytosol] (Danio rerio)
Ub-Misfolded Proteins [cytosol] (Danio rerio)
Ub-misfolded nascent CFTR [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
PolyUb-Misfolded Proteins:HDAC6 bind dynein motor (Danio rerio)
PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Danio rerio)
PolyUb-Misfolded Proteins [cytosol] (Danio rerio)
Ub-misfolded nascent CFTR [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
PolyUb-Misfolded Proteins:HDAC6:Dynein complex [cytosol] (Danio rerio)
PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Danio rerio)
PolyUb-Misfolded Proteins [cytosol] (Danio rerio)
Ub-misfolded nascent CFTR [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
PolyUb-Misfolded proteins bind vimentin to form aggresome (Danio rerio)
Poly-vimentin:PolyUb-Misfolded Proteins:HDAC6:Microtubule:Dynein complex [microtubule organizing center] (Danio rerio)
PolyUb-Misfolded Proteins:HDAC6:Microtubule:Dynein complex [microtubule organizing center] (Danio rerio)
PolyUb-Misfolded Proteins:HDAC6:Dynein complex [cytosol] (Danio rerio)
PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Danio rerio)
PolyUb-Misfolded Proteins [cytosol] (Danio rerio)
Ub-misfolded nascent CFTR [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
PolyUb-Misfolded Proteins:HDAC6:Microtubule:Dynein complex [microtubule organizing center] (Danio rerio)
PolyUb-Misfolded Proteins:HDAC6:Dynein complex [cytosol] (Danio rerio)
PolyUb-Misfolded Proteins:HDAC6 [cytosol] (Danio rerio)
PolyUb-Misfolded Proteins [cytosol] (Danio rerio)
Ub-misfolded nascent CFTR [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
PolyUb:misfolded proteins dissociate from PRKN:UBE2N:UBE2V1 (Danio rerio)
PolyUb-Misfolded Proteins [cytosol] (Danio rerio)
Ub-misfolded nascent CFTR [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
PolyUb:Misfolded proteins:PRKN:UBE2N:UBE2V1 [cytosol] (Danio rerio)
PolyUb-Misfolded Proteins [cytosol] (Danio rerio)
Ub-misfolded nascent CFTR [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Ub:misfolded proteins polymerize to PolyUb:misfolded proteins (Danio rerio)
PolyUb:Misfolded proteins:PRKN:UBE2N:UBE2V1 [cytosol] (Danio rerio)
PolyUb-Misfolded Proteins [cytosol] (Danio rerio)
Ub-misfolded nascent CFTR [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Ub:Misfolded proteins:PRKN:UBE2N:UBE2V1 [cytosol] (Danio rerio)
Ub-Misfolded Proteins [cytosol] (Danio rerio)
Ub-misfolded nascent CFTR [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Mitophagy (Danio rerio)
PINK1-PRKN Mediated Mitophagy (Danio rerio)
PRKN ubiquitinates MOM substrates (Danio rerio)
Ub:Ub-UBE2D2,UBE2D3,UBE2N:UBE2V1,UBE2L3 [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Cell Cycle (Danio rerio)
Cell Cycle Checkpoints (Danio rerio)
G1/S DNA Damage Checkpoints (Danio rerio)
p53-Dependent G1/S DNA damage checkpoint (Danio rerio)
p53-Dependent G1 DNA Damage Response (Danio rerio)
Stabilization of p53 (Danio rerio)
Autodegradation of the E3 ubiquitin ligase COP1 (Danio rerio)
Autoubiquitination of phospho-COP1(Ser-387 ) (Danio rerio)
Ub [cytosol] (Danio rerio)
ubiquitinated phospho-COP1(ser-387) [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Proteasome mediated degradation of COP1 (Danio rerio)
Ub [cytosol] (Danio rerio)
ubiquitinated phospho-COP1(ser-387) [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
G2/M Checkpoints (Danio rerio)
GTSE1 facilitates proteasome-mediated degradation of TP53 (Danio rerio)
Ub [cytosol] (Danio rerio)
Cell Cycle, Mitotic (Danio rerio)
Mitotic G2-G2/M phases (Danio rerio)
G2/M Transition (Danio rerio)
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis (Danio rerio)
Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Danio rerio)
Ub [cytosol] (Danio rerio)
Proteasome-mediated degradation of PolyUb-FBXL7 (Danio rerio)
Ub [cytosol] (Danio rerio)
SCF-FBXL18 ubiquitinates FBXL7 (Danio rerio)
Ub [cytosol] (Danio rerio)
SCF-FBXL7 ubiquitinates AURKA (Danio rerio)
Ub [cytosol] (Danio rerio)
The role of GTSE1 in G2/M progression after G2 checkpoint (Danio rerio)
GTSE1 facilitates proteasome-mediated degradation of TP53 (Danio rerio)
Ub [cytosol] (Danio rerio)
Regulation of mitotic cell cycle (Danio rerio)
APC/C-mediated degradation of cell cycle proteins (Danio rerio)
Regulation of APC/C activators between G1/S and early anaphase (Danio rerio)
SCF-beta-TrCP mediated degradation of Emi1 (Danio rerio)
Ubiquitination of Emi1 by SCF-beta-TrCP (Danio rerio)
SCF-associated multiubiquitinated Emi1complexes [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
S Phase (Danio rerio)
Synthesis of DNA (Danio rerio)
Switching of origins to a post-replicative state (Danio rerio)
CDK-mediated phosphorylation and removal of Cdc6 (Danio rerio)
Ubiquitinated Cdc6 is degraded by the proteasome (Danio rerio)
Ub [cytosol] (Danio rerio)
ubiquitinated Cdc6 [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Ubiquitin-dependent degradation of Cyclin D (Danio rerio)
Proteasome mediated degradation of Cyclin D1 (Danio rerio)
Ub [cytosol] (Danio rerio)
multi-ubiquitinated phospho-(T286) Cyclin D1 [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Cellular responses to stimuli (Danio rerio)
Cellular responses to stress (Danio rerio)
Cellular response to chemical stress (Danio rerio)
KEAP1-NFE2L2 pathway (Danio rerio)
26S proteasome degrades Ub-NFE2L2 (Danio rerio)
Ub [cytosol] (Danio rerio)
CUL3:RBX1 ubiquitinates KEAP1 (Danio rerio)
Ub [cytosol] (Danio rerio)
KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer (Danio rerio)
Ub [cytosol] (Danio rerio)
KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2 (Danio rerio)
Ub [cytosol] (Danio rerio)
MUL1 ubiquitinates UBXN7 (Danio rerio)
Ub [cytosol] (Danio rerio)
TRIM21 ubiquitinates SQSTM1 (Danio rerio)
Ub [cytosol] (Danio rerio)
ub UBXN7 is degraded by the 26S proteasome (Danio rerio)
Ub [cytosol] (Danio rerio)
DNA Replication (Danio rerio)
Synthesis of DNA (Danio rerio)
Switching of origins to a post-replicative state (Danio rerio)
CDK-mediated phosphorylation and removal of Cdc6 (Danio rerio)
Ubiquitinated Cdc6 is degraded by the proteasome (Danio rerio)
Ub [cytosol] (Danio rerio)
ubiquitinated Cdc6 [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Gene expression (Transcription) (Danio rerio)
RNA Polymerase II Transcription (Danio rerio)
Generic Transcription Pathway (Danio rerio)
Transcriptional regulation by RUNX1 (Danio rerio)
RUNX1 regulates transcription of genes involved in differentiation of HSCs (Danio rerio)
26S proteasome degrades TP73 polyubiquitinated by ITCH (Danio rerio)
Ub [cytosol] (Danio rerio)
ITCH polyubiquitinates TP73 (Danio rerio)
Ub [cytosol] (Danio rerio)
Transcriptional regulation by RUNX3 (Danio rerio)
Regulation of RUNX3 expression and activity (Danio rerio)
Polyubiquitinated RUNX3 is degraded by the proteasome (Danio rerio)
Ub [cytosol] (Danio rerio)
Immune System (Danio rerio)
Adaptive Immune System (Danio rerio)
Class I MHC mediated antigen processing & presentation (Danio rerio)
Antigen processing: Ubiquitination & Proteasome degradation (Danio rerio)
E1 mediated ubiquitin activation (Danio rerio)
E1 bound ubiquitin [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Interaction of E3 with substrate and E2-Ub complex (Danio rerio)
Ag-substrate:E3:E2:Ub [cytosol] (Danio rerio)
Ubiquitin:E2 conjugating enzymes [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Ubiquitin:E2 conjugating enzymes [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Polyubiquitination of substrate (Danio rerio)
E3:Ub:substrate [cytosol] (Danio rerio)
Ub:substrate [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Ubiquitin:E2 conjugating enzymes [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Proteasomal cleavage of substrate (Danio rerio)
Ub [cytosol] (Danio rerio)
Transfer of Ub from E2 to substrate and release of E2 (Danio rerio)
Ag-substrate:E3:E2:Ub [cytosol] (Danio rerio)
Ubiquitin:E2 conjugating enzymes [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
E3:Ub:substrate [cytosol] (Danio rerio)
Ub:substrate [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Transfer of ubiquitin from E1 to E2 (Danio rerio)
E1 bound ubiquitin [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Ubiquitin:E2 conjugating enzymes [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Innate Immune System (Danio rerio)
Cytosolic sensors of pathogen-associated DNA (Danio rerio)
Regulation of innate immune responses to cytosolic DNA (Danio rerio)
STING ubiquitination by TRIM32 or TRIM56 (Danio rerio)
Ub [cytosol] (Danio rerio)
Metabolism (Danio rerio)
Aerobic respiration and respiratory electron transport (Danio rerio)
Pyruvate metabolism (Danio rerio)
Regulation of pyruvate metabolism (Danio rerio)
CTLH E3 ligase ubiquitinates LDHA (Danio rerio)
Ub [cytosol] (Danio rerio)
CTLH E3 ligase ubiquitinates PKM-1 (Danio rerio)
Ub [cytosol] (Danio rerio)
Metabolism of RNA (Danio rerio)
Regulation of mRNA stability by proteins that bind AU-rich elements (Danio rerio)
AUF1 (hnRNP D0) binds and destabilizes mRNA (Danio rerio)
AUF1 (hnRNP D0) is ubiquitinylated (Danio rerio)
Ub [cytosol] (Danio rerio)
Metabolism of proteins (Danio rerio)
Post-translational protein modification (Danio rerio)
Asparagine N-linked glycosylation (Danio rerio)
N-glycan trimming in the ER and Calnexin/Calreticulin cycle (Danio rerio)
Calnexin/calreticulin cycle (Danio rerio)
ER Quality Control Compartment (ERQC) (Danio rerio)
Ub-unfolded protein:(GlcNAc)2 (Man)9-5 translocates from ERQC to cytosol (Danio rerio)
Ub-unfolded protein:(GlcNAc)2 (Man)9-5 [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Ub-unfolded protein:(GlcNAc)2 (Man)9-5 [endoplasmic reticulum quality control compartment] (Danio rerio)
Ub [cytosol] (Danio rerio)
Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins (Danio rerio)
Ub-unfolded protein:(GlcNAc)2 (Man)9-5 [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5) (Danio rerio)
Ub-unfolded protein:(GlcNAc)2 (Man)9-5 [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Deubiquitination (Danio rerio)
UCH proteinases (Danio rerio)
UCHL1, UCHL3 cleave ubiquitin adducts (Danio rerio)
UCHL1,UCHL3:Ub [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Ub-specific processing proteases (Danio rerio)
USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Danio rerio)
Ub [cytosol] (Danio rerio)
USP5 cleaves polyubiquitin (Danio rerio)
USP5:Ub [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Neddylation (Danio rerio)
26S proteasome degrades HIFalpha (Danio rerio)
Ub [cytosol] (Danio rerio)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:NEDD8-CUL2:RBX1:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Danio rerio)
ub-hydroxyPro-HIF-alpha [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
26S proteasome degrades Ub-NFE2L2 (Danio rerio)
Ub [cytosol] (Danio rerio)
KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2 (Danio rerio)
Ub [cytosol] (Danio rerio)
MUL1 ubiquitinates UBXN7 (Danio rerio)
Ub [cytosol] (Danio rerio)
VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha (Danio rerio)
UBE2D1,2,3:Ubiquitin [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:NEDD8-CUL2:RBX1:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Danio rerio)
ub-hydroxyPro-HIF-alpha [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
ub UBXN7 is degraded by the 26S proteasome (Danio rerio)
Ub [cytosol] (Danio rerio)
Protein ubiquitination (Danio rerio)
E3 ubiquitin ligases ubiquitinate target proteins (Danio rerio)
RNF152 binds RRAGA:GDP and Ubiquitin:UBE2D3 (Danio rerio)
RNF152:RRAGA:GDP:Ub:UBE2N [lysosomal membrane] (Danio rerio)
Ub:UBE2N [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Ub:UBE2N [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
RNF152 polyubiquitinates RRAGA (Danio rerio)
RNF152:RRAGA:GDP:Ub:UBE2N [lysosomal membrane] (Danio rerio)
Ub:UBE2N [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Ub:UBE2N [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Synthesis of active ubiquitin: roles of E1 and E2 enzymes (Danio rerio)
UBA1 adenylates ubiquitin in the cytosol (Danio rerio)
Ub [cytosol] (Danio rerio)
UBA1 conjugates ubiquitin to UBA1 in the cytosol (Danio rerio)
Ub-Cys632-UBA1 [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
UBA1 conjugates ubiquitin to cytosolic E2 enzymes (Danio rerio)
Ub-Cys632-UBA1:ubiquitin adenylate [cytosol] (Danio rerio)
Ub-Cys632-UBA1 [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Ub:E2 (UBA1 substrate) [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol (Danio rerio)
Ub [cytosol] (Danio rerio)
Ub-Cys632-UBA1 [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Ub-Cys632-UBA1:ubiquitin adenylate [cytosol] (Danio rerio)
Ub-Cys632-UBA1 [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Signal Transduction (Danio rerio)
Death Receptor Signaling (Danio rerio)
TNF signaling (Danio rerio)
Regulation of TNFR1 signaling (Danio rerio)
K63polyUb-RIPK1 is deubiquitinated (Danio rerio)
Ub [cytosol] (Danio rerio)
MIB2 binds CFLAR (Danio rerio)
CFLAR:MIB2:Ub:UBE2D1 [cytosol] (Danio rerio)
Ub:UBE2D1 [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Ub:UBE2D1 [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
MIB2 binds CYLD (Danio rerio)
MIB2:CYLD:UBE2D2 [cytosol] (Danio rerio)
Ub:UBE2D2 [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Ub:UBE2D2 [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
MIB2 binds RIPK1 within TNF-α:TNFR1:TRADD:RIPK1:TRAF2 (Danio rerio)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2:MIB2:Ub:UBE2D1 [plasma membrane] (Danio rerio)
Ub:UBE2D1 [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Ub:UBE2D1 [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
MIB2 ubiquitinates CFLAR (Danio rerio)
CFLAR:MIB2:Ub:UBE2D1 [cytosol] (Danio rerio)
Ub:UBE2D1 [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
MIB2 ubiquitinates CYLD at K338, K530 (Danio rerio)
MIB2:CYLD:UBE2D2 [cytosol] (Danio rerio)
Ub:UBE2D2 [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
MIB2 ubiquitinates RIPK1 at K377, K604, K634 (Danio rerio)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2:MIB2:Ub:UBE2D1 [plasma membrane] (Danio rerio)
Ub:UBE2D1 [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
p75 NTR receptor-mediated signalling (Danio rerio)
p75NTR signals via NF-kB (Danio rerio)
NF-kB is activated and signals survival (Danio rerio)
IkB is ubiquitinated and degraded (Danio rerio)
Ub [cytosol] (Danio rerio)
Ubiquitinated phospho-IkB [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
p75NTR recruits signalling complexes (Danio rerio)
TRAF6 is auto-ubiquitinated (Danio rerio)
Ub [cytosol] (Danio rerio)
Intracellular signaling by second messengers (Danio rerio)
PIP3 activates AKT signaling (Danio rerio)
PTEN Regulation (Danio rerio)
Regulation of PTEN localization (Danio rerio)
PTEN undergoes monoubiquitination (Danio rerio)
Ub [cytosol] (Danio rerio)
Regulation of PTEN stability and activity (Danio rerio)
MKRN1 polyubiquitinates PTEN (Danio rerio)
Ub [cytosol] (Danio rerio)
NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN (Danio rerio)
Ub [cytosol] (Danio rerio)
Proteasome degrades polyubiquitinated PTEN (Danio rerio)
Ub [cytosol] (Danio rerio)
RNF146 polyubiquitinates PARylated PTEN (Danio rerio)
Ub [cytosol] (Danio rerio)
TRIM27 polyubiquitinates PTEN (Danio rerio)
Ub [cytosol] (Danio rerio)
USP13 and OTUD3 deubiquitinate PTEN (Danio rerio)
Ub [cytosol] (Danio rerio)
MAPK family signaling cascades (Danio rerio)
MAPK1/MAPK3 signaling (Danio rerio)
RAF/MAP kinase cascade (Danio rerio)
Negative regulation of MAPK pathway (Danio rerio)
BRAP autoubiquitinates (Danio rerio)
Ub [cytosol] (Danio rerio)
MAPK6/MAPK4 signaling (Danio rerio)
MAPK6 is degraded by the 26S proteasome (Danio rerio)
Ub [cytosol] (Danio rerio)
Signaling by Hedgehog (Danio rerio)
Hedgehog 'off' state (Danio rerio)
GLI3 is processed to GLI3R by the proteasome (Danio rerio)
SCF(beta-TrCP) ubiquitinates p-GLI3 (Danio rerio)
Ub [cytosol] (Danio rerio)
Hedgehog ligand biogenesis (Danio rerio)
Hh C-terminal fragments are degraded by the proteasome (Danio rerio)
Ub [cytosol] (Danio rerio)
SYVN1 ubiquitinates Hh C-terminal fragments (Danio rerio)
Ub [cytosol] (Danio rerio)
Signaling by NOTCH (Danio rerio)
Signaling by NOTCH1 (Danio rerio)
Activated NOTCH1 Transmits Signal to the Nucleus (Danio rerio)
ITCH ubiquitinates DTX (Danio rerio)
Ub [cytosol] (Danio rerio)
Ub-DTX:ITCH [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Signaling by Non-Receptor Tyrosine Kinases (Danio rerio)
Signaling by PTK6 (Danio rerio)
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 (Danio rerio)
CBL autoubiquitinates (Danio rerio)
Ub [cytosol] (Danio rerio)
Signaling by Receptor Tyrosine Kinases (Danio rerio)
Signaling by EGFR (Danio rerio)
EGFR downregulation (Danio rerio)
CBL binds and ubiquitinates phosphorylated Sprouty (Danio rerio)
EGF-like ligands:p-6Y-EGFR:CBL:Ub-p-Y53/55-SPRY1/2 [plasma membrane] (Danio rerio)
Ub-p-Y53/55-SPRY1/2 [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
CBL ubiquitinates Sprouty (Danio rerio)
EGF-like ligands:p-6Y-EGFR:CBL:Ub-p-Y53/55-SPRY1/2 [plasma membrane] (Danio rerio)
Ub-p-Y53/55-SPRY1/2 [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Ubiquitination of stimulated EGFR (CBL) (Danio rerio)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL [plasma membrane] (Danio rerio)
Ub [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Ubiquitination of stimulated EGFR (CBL:GRB2) (Danio rerio)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Danio rerio)
Ub [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Signaling by ERBB2 (Danio rerio)
Downregulation of ERBB2 signaling (Danio rerio)
CUL5 mediates ubiquitination of ERBB2 (Danio rerio)
Ub [cytosol] (Danio rerio)
Ub-ERBB2:ERBIN:HSP90:CDC37 [plasma membrane] (Danio rerio)
Ub [cytosol] (Danio rerio)
Downregulation of ERBB2:ERBB3 signaling (Danio rerio)
RNF41 ubiquitinates ERBB3 (Danio rerio)
Ub [cytosol] (Danio rerio)
Ub-ERBB3 [plasma membrane] (Danio rerio)
Ub [cytosol] (Danio rerio)
RNF41 ubiquitinates activated ERBB3 (Danio rerio)
NRG1/2:Ub-p-10Y-ERBB3:p-ERBB2 [plasma membrane] (Danio rerio)
Ub [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Self-ubiquitination of RNF41 (Danio rerio)
Ub [cytosol] (Danio rerio)
Ub-RNF41 [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Signaling by ERBB4 (Danio rerio)
Downregulation of ERBB4 signaling (Danio rerio)
ERBB4 ubiquitination by WWP1/ITCH (Danio rerio)
Ub [cytosol] (Danio rerio)
Ub-ERBB4:WWP1/ITCH [plasma membrane] (Danio rerio)
Ub [cytosol] (Danio rerio)
NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer (Danio rerio)
Ub [cytosol] (Danio rerio)
Ub-ERBB4jmAcyt1s80:NEDD4 [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Signaling by FGFR (Danio rerio)
Signaling by FGFR1 (Danio rerio)
Negative regulation of FGFR1 signaling (Danio rerio)
Spry regulation of FGF signaling (Danio rerio)
CBL dissociates from ubiquitinated p-SPRY2 (Danio rerio)
Ub-(Y55/Y227)p-SPRY2 [plasma membrane] (Danio rerio)
Ub [cytosol] (Danio rerio)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Danio rerio)
Ub [cytosol] (Danio rerio)
Phosphorylated SPRY2 is ubiquitinated by CBL (Danio rerio)
Ub [cytosol] (Danio rerio)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Danio rerio)
Ub [cytosol] (Danio rerio)
Signaling by FGFR2 (Danio rerio)
Negative regulation of FGFR2 signaling (Danio rerio)
Spry regulation of FGF signaling (Danio rerio)
CBL dissociates from ubiquitinated p-SPRY2 (Danio rerio)
Ub-(Y55/Y227)p-SPRY2 [plasma membrane] (Danio rerio)
Ub [cytosol] (Danio rerio)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Danio rerio)
Ub [cytosol] (Danio rerio)
Phosphorylated SPRY2 is ubiquitinated by CBL (Danio rerio)
Ub [cytosol] (Danio rerio)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Danio rerio)
Ub [cytosol] (Danio rerio)
Signaling by FGFR3 (Danio rerio)
Negative regulation of FGFR3 signaling (Danio rerio)
Spry regulation of FGF signaling (Danio rerio)
CBL dissociates from ubiquitinated p-SPRY2 (Danio rerio)
Ub-(Y55/Y227)p-SPRY2 [plasma membrane] (Danio rerio)
Ub [cytosol] (Danio rerio)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Danio rerio)
Ub [cytosol] (Danio rerio)
Phosphorylated SPRY2 is ubiquitinated by CBL (Danio rerio)
Ub [cytosol] (Danio rerio)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Danio rerio)
Ub [cytosol] (Danio rerio)
Signaling by FGFR4 (Danio rerio)
Negative regulation of FGFR4 signaling (Danio rerio)
Spry regulation of FGF signaling (Danio rerio)
CBL dissociates from ubiquitinated p-SPRY2 (Danio rerio)
Ub-(Y55/Y227)p-SPRY2 [plasma membrane] (Danio rerio)
Ub [cytosol] (Danio rerio)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Danio rerio)
Ub [cytosol] (Danio rerio)
Phosphorylated SPRY2 is ubiquitinated by CBL (Danio rerio)
Ub [cytosol] (Danio rerio)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Danio rerio)
Ub [cytosol] (Danio rerio)
Signaling by MET (Danio rerio)
Negative regulation of MET activity (Danio rerio)
CBL monoubiquitinates activated MET (Danio rerio)
Ub [cytosol] (Danio rerio)
Signaling by TGFB family members (Danio rerio)
Signaling by TGF-beta Receptor Complex (Danio rerio)
TGF-beta receptor signaling activates SMADs (Danio rerio)
Downregulation of TGF-beta receptor signaling (Danio rerio)
Degradation of TGF-beta receptor complex (Danio rerio)
TGFB1:TGFBR2:Ub-p-TGFBR1:Ub-SMAD7 [plasma membrane] (Danio rerio)
Ub [cytosol] (Danio rerio)
Degradation of ubiquitinated SMAD2 (Danio rerio)
Ub-SMAD2 [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Degradation of ubiquitinated SMAD3 (Danio rerio)
Ub-SMAD3 [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
SMURF2 ubiquitinates SMAD2 (Danio rerio)
Ub [cytosol] (Danio rerio)
Ub-SMAD2 [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) (Danio rerio)
Disassembly of tight junctions (Danio rerio)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:Ub-RHOA:SMURF1 [cell junction] (Danio rerio)
Ub [cytosol] (Danio rerio)
SMURF1 ubiquitinates RHOA (Danio rerio)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:Ub-RHOA:SMURF1 [cell junction] (Danio rerio)
Ub [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Signaling by WNT (Danio rerio)
Beta-catenin independent WNT signaling (Danio rerio)
PCP/CE pathway (Danio rerio)
Asymmetric localization of PCP proteins (Danio rerio)
SMURF1/2 ubiquitinates PRICKLE1 (Danio rerio)
Ub [cytosol] (Danio rerio)
TCF dependent signaling in response to WNT (Danio rerio)
Degradation of AXIN (Danio rerio)
AXIN is ubiquitinated by SMURF2 (Danio rerio)
Ub [cytosol] (Danio rerio)
Ubiquitinated AXIN is degraded by the proteasome (Danio rerio)
Ub [cytosol] (Danio rerio)
Degradation of DVL (Danio rerio)
DVL is ubiquitinated by CUL3:KLHL12:RBX1 (Danio rerio)
Ub [cytosol] (Danio rerio)
Ubiquitinated DVL is degraded by the proteasome (Danio rerio)
Ub [cytosol] (Danio rerio)
Regulation of FZD by ubiquitination (Danio rerio)
ZNRF3 autoubiquitinates to promote its internalization (Danio rerio)
Ub [cytosol] (Danio rerio)
ZNRF3 ubiquitinates FZD to promote its downregulation (Danio rerio)
Ub [cytosol] (Danio rerio)
Transport of small molecules (Danio rerio)
ABC-family proteins mediated transport (Danio rerio)
RNF5 and RNF185 ubiquitinate misfolded CFTR (Danio rerio)
Ub [cytosol] (Danio rerio)
Ub-misfolded nascent CFTR:ERAD complex [endoplasmic reticulum membrane] (Danio rerio)
Ub-misfolded nascent CFTR [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
misfolded CFTR is degraded by the 26S proteasome (Danio rerio)
Ub [cytosol] (Danio rerio)
Ub-misfolded nascent CFTR [cytosol] (Danio rerio)
Ub [cytosol] (Danio rerio)
Participants
members
rps27a [cytosol]
(Danio rerio)
uba52 [cytosol]
(Danio rerio)
Participates
as a component of
USP5:Ub [cytosol] (Danio rerio)
UCHL1,UCHL3:Ub [cytosol] (Danio rerio)
Ub:E2 (UBA1 substrate) [cytosol] (Danio rerio)
Ub-Cys632-UBA1 [cytosol] (Danio rerio)
Ub:UBE2D1,UBE2D2,UBE2D3, UBE2E1,UBE2N [cytosol] (Danio rerio)
Ub:UBE2N [cytosol] (Danio rerio)
Ub-DTX:ITCH [cytosol] (Danio rerio)
Ub-unfolded protein:(GlcNAc)2 (Man)9-5 [cytosol] (Danio rerio)
Ub-unfolded protein:(GlcNAc)2 (Man)9-5 [endoplasmic reticulum quality control compartment] (Danio rerio)
ub-hydroxyPro-HIF-alpha [cytosol] (Danio rerio)
Ub:UBE2D1 [cytosol] (Danio rerio)
Ub:UBE2D2 [cytosol] (Danio rerio)
ubiquitinated phospho-COP1(ser-387) [cytosol] (Danio rerio)
Ub-p-Y53/55-SPRY1/2 [cytosol] (Danio rerio)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Danio rerio)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL [plasma membrane] (Danio rerio)
NFKB1:RELA:p-S32,S36-NFKBIA:Ub [cytosol] (Danio rerio)
ubiquitinated Cdc6 [cytosol] (Danio rerio)
Ub-p-S252,S497,T501-BORA [cytosol] (Danio rerio)
multi-ubiquitinated phospho-(T286) Cyclin D1 [cytosol] (Danio rerio)
K63 linked polyubiquitin chain [cytosol] (Danio rerio)
Ubiquitinated phospho-IkB [cytosol] (Danio rerio)
Ub-misfolded nascent CFTR [cytosol] (Danio rerio)
Ub:UBE2N:UBE2V1 [cytosol] (Danio rerio)
Ub:Ub-UBE2D2,UBE2D3,UBE2N:UBE2V1,UBE2L3 [cytosol] (Danio rerio)
SCF-associated multiubiquitinated Emi1complexes [cytosol] (Danio rerio)
Ub-SMAD3 [cytosol] (Danio rerio)
Ub-SMAD2 [cytosol] (Danio rerio)
TGFB1:TGFBR2:Ub-p-TGFBR1:Ub-SMAD7 [plasma membrane] (Danio rerio)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:Ub-RHOA:SMURF1 [cell junction] (Danio rerio)
Ub:substrate [cytosol] (Danio rerio)
Ubiquitin:E2 conjugating enzymes [cytosol] (Danio rerio)
E1 bound ubiquitin [cytosol] (Danio rerio)
UBE2D1,2,3:Ubiquitin [cytosol] (Danio rerio)
Ub:UBE2L3 [cytosol] (Danio rerio)
Ub-ERBB4jmAcyt1s80:NEDD4 [cytosol] (Danio rerio)
Ub-ERBB4:WWP1/ITCH [plasma membrane] (Danio rerio)
Ub-ERBB2:ERBIN:Ub-HSP90:CDC37 [plasma membrane] (Danio rerio)
Ub-RNF41 [cytosol] (Danio rerio)
Ub-ERBB3 [plasma membrane] (Danio rerio)
NRG1/2:Ub-p-10Y-ERBB3:p-ERBB2 [plasma membrane] (Danio rerio)
Ub-ERBB2:ERBIN:HSP90:CDC37 [plasma membrane] (Danio rerio)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Danio rerio)
Ub-(Y55/Y227)p-SPRY2 [plasma membrane] (Danio rerio)
as an input of
AUF1 (hnRNP D0) is ubiquitinylated (Danio rerio)
Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol (Danio rerio)
UBA1 adenylates ubiquitin in the cytosol (Danio rerio)
SYVN1 ubiquitinates Hh C-terminal fragments (Danio rerio)
TRIM21 ubiquitinates SQSTM1 (Danio rerio)
MUL1 ubiquitinates UBXN7 (Danio rerio)
RNF5 and RNF185 ubiquitinate misfolded CFTR (Danio rerio)
CUL3:RBX1 ubiquitinates KEAP1 (Danio rerio)
KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer (Danio rerio)
KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2 (Danio rerio)
ITCH polyubiquitinates TP73 (Danio rerio)
SCF(beta-TrCP) ubiquitinates p-GLI3 (Danio rerio)
ITCH ubiquitinates DTX (Danio rerio)
STING ubiquitination by TRIM32 or TRIM56 (Danio rerio)
CTLH E3 ligase ubiquitinates LDHA (Danio rerio)
CTLH E3 ligase ubiquitinates PKM-1 (Danio rerio)
AXIN is ubiquitinated by SMURF2 (Danio rerio)
SMURF1/2 ubiquitinates PRICKLE1 (Danio rerio)
DVL is ubiquitinated by CUL3:KLHL12:RBX1 (Danio rerio)
ZNRF3 autoubiquitinates to promote its internalization (Danio rerio)
ZNRF3 ubiquitinates FZD to promote its downregulation (Danio rerio)
Autoubiquitination of phospho-COP1(Ser-387 ) (Danio rerio)
CBL ubiquitinates Sprouty (Danio rerio)
CBL binds and ubiquitinates phosphorylated Sprouty (Danio rerio)
Ubiquitination of stimulated EGFR (CBL:GRB2) (Danio rerio)
Ubiquitination of stimulated EGFR (CBL) (Danio rerio)
SCF-FBXL7 ubiquitinates AURKA (Danio rerio)
SCF-FBXL18 ubiquitinates FBXL7 (Danio rerio)
CBL autoubiquitinates (Danio rerio)
IkB is ubiquitinated and degraded (Danio rerio)
TRAF6 is auto-ubiquitinated (Danio rerio)
Ubiquitination of Emi1 by SCF-beta-TrCP (Danio rerio)
SMURF2 ubiquitinates SMAD2 (Danio rerio)
SMURF1 ubiquitinates RHOA (Danio rerio)
E1 mediated ubiquitin activation (Danio rerio)
PTEN undergoes monoubiquitination (Danio rerio)
NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN (Danio rerio)
TRIM27 polyubiquitinates PTEN (Danio rerio)
RNF146 polyubiquitinates PARylated PTEN (Danio rerio)
MKRN1 polyubiquitinates PTEN (Danio rerio)
BRAP autoubiquitinates (Danio rerio)
CBL monoubiquitinates activated MET (Danio rerio)
NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer (Danio rerio)
ERBB4 ubiquitination by WWP1/ITCH (Danio rerio)
Self-ubiquitination of RNF41 (Danio rerio)
RNF41 ubiquitinates activated ERBB3 (Danio rerio)
RNF41 ubiquitinates ERBB3 (Danio rerio)
CUL5 mediates ubiquitination of ERBB2 (Danio rerio)
Phosphorylated SPRY2 is ubiquitinated by CBL (Danio rerio)
as an output of
MAPK6 is degraded by the 26S proteasome (Danio rerio)
USP5 cleaves polyubiquitin (Danio rerio)
USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Danio rerio)
26S proteasome degrades HIFalpha (Danio rerio)
Hh C-terminal fragments are degraded by the proteasome (Danio rerio)
ub UBXN7 is degraded by the 26S proteasome (Danio rerio)
misfolded CFTR is degraded by the 26S proteasome (Danio rerio)
26S proteasome degrades Ub-NFE2L2 (Danio rerio)
26S proteasome degrades TP73 polyubiquitinated by ITCH (Danio rerio)
Polyubiquitinated RUNX3 is degraded by the proteasome (Danio rerio)
K63polyUb-RIPK1 is deubiquitinated (Danio rerio)
Ubiquitinated AXIN is degraded by the proteasome (Danio rerio)
Ubiquitinated DVL is degraded by the proteasome (Danio rerio)
Proteasome mediated degradation of COP1 (Danio rerio)
Ubiquitinated Cdc6 is degraded by the proteasome (Danio rerio)
Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Danio rerio)
Proteasome-mediated degradation of PolyUb-FBXL7 (Danio rerio)
Proteasome mediated degradation of Cyclin D1 (Danio rerio)
GTSE1 facilitates proteasome-mediated degradation of TP53 (Danio rerio)
Proteasomal cleavage of substrate (Danio rerio)
USP13 and OTUD3 deubiquitinate PTEN (Danio rerio)
Proteasome degrades polyubiquitinated PTEN (Danio rerio)
Inferred From
Ub [cytosol]
(Homo sapiens)
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