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STUB1 [cytosol]
Stable Identifier
R-DME-975970
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
cytosol
Synonyms
STUB1, Q9XYW6
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Drosophila melanogaster)
RNA Polymerase II Transcription (Drosophila melanogaster)
Generic Transcription Pathway (Drosophila melanogaster)
Transcriptional regulation by RUNX2 (Drosophila melanogaster)
Regulation of RUNX2 expression and activity (Drosophila melanogaster)
RUNX2 binds STUB1 (Drosophila melanogaster)
RUNX2:STUB1 [cytosol] (Drosophila melanogaster)
STUB1 [cytosol] (Drosophila melanogaster)
STUB1 [cytosol] (Drosophila melanogaster)
STUB1 polyubiquitinates RUNX2 (Drosophila melanogaster)
RUNX2:STUB1 [cytosol] (Drosophila melanogaster)
STUB1 [cytosol] (Drosophila melanogaster)
STUB1 [cytosol] (Drosophila melanogaster)
Immune System (Drosophila melanogaster)
Adaptive Immune System (Drosophila melanogaster)
Class I MHC mediated antigen processing & presentation (Drosophila melanogaster)
Antigen processing: Ubiquitination & Proteasome degradation (Drosophila melanogaster)
Interaction of E3 with substrate and E2-Ub complex (Drosophila melanogaster)
Ag-substrate:E3:E2:Ub [cytosol] (Drosophila melanogaster)
E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
STUB1 [cytosol] (Drosophila melanogaster)
E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
STUB1 [cytosol] (Drosophila melanogaster)
Polyubiquitination of substrate (Drosophila melanogaster)
E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
STUB1 [cytosol] (Drosophila melanogaster)
E3:K48-polyubiquitinated substrate [cytosol] (Drosophila melanogaster)
E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
STUB1 [cytosol] (Drosophila melanogaster)
E3:Ub:substrate [cytosol] (Drosophila melanogaster)
E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
STUB1 [cytosol] (Drosophila melanogaster)
Release of E3 from polyubiquitinated substrate (Drosophila melanogaster)
E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
STUB1 [cytosol] (Drosophila melanogaster)
E3:K48-polyubiquitinated substrate [cytosol] (Drosophila melanogaster)
E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
STUB1 [cytosol] (Drosophila melanogaster)
Transfer of Ub from E2 to substrate and release of E2 (Drosophila melanogaster)
Ag-substrate:E3:E2:Ub [cytosol] (Drosophila melanogaster)
E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
STUB1 [cytosol] (Drosophila melanogaster)
E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
STUB1 [cytosol] (Drosophila melanogaster)
E3:Ub:substrate [cytosol] (Drosophila melanogaster)
E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
STUB1 [cytosol] (Drosophila melanogaster)
Signal Transduction (Drosophila melanogaster)
Intracellular signaling by second messengers (Drosophila melanogaster)
PIP3 activates AKT signaling (Drosophila melanogaster)
PTEN Regulation (Drosophila melanogaster)
Regulation of PTEN stability and activity (Drosophila melanogaster)
NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN (Drosophila melanogaster)
NEDD4,STUB1,WWP2 and XIAP [cytosol] (Drosophila melanogaster)
STUB1 [cytosol] (Drosophila melanogaster)
Signaling by Receptor Tyrosine Kinases (Drosophila melanogaster)
Signaling by ERBB2 (Drosophila melanogaster)
Downregulation of ERBB2 signaling (Drosophila melanogaster)
CHIP (STUB1) mediates ubiquitination of ERBB2 (Drosophila melanogaster)
STUB1 [cytosol] (Drosophila melanogaster)
Signaling by TGFB family members (Drosophila melanogaster)
Signaling by TGF-beta Receptor Complex (Drosophila melanogaster)
TGF-beta receptor signaling activates SMADs (Drosophila melanogaster)
Downregulation of TGF-beta receptor signaling (Drosophila melanogaster)
SMAD3 binds STUB1 (CHIP) (Drosophila melanogaster)
SMAD3:STUB1 [cytosol] (Drosophila melanogaster)
STUB1 [cytosol] (Drosophila melanogaster)
STUB1 [cytosol] (Drosophila melanogaster)
STUB1 (CHIP) ubiquitinates SMAD3 (Drosophila melanogaster)
SMAD3:STUB1 [cytosol] (Drosophila melanogaster)
STUB1 [cytosol] (Drosophila melanogaster)
STUB1 [cytosol] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:Q9XYW6
Gene Names
STUB1
Reference Genes
BioGPS Gene:34433 STUB1
ENSEMBL:FBgn0027052
FlyBase:FBgn0027052
KEGG:dme:Dmel_CG5203 STUB1
Monarch:34433 STUB1
NCBI Gene:34433 STUB1
UCSC:Q9XYW6 STUB1
Reference Transcript
RefSeq:NM_058093.4 STUB1
Other Identifiers
144169_at
1623826_at
34433
GO:0000209
GO:0003824
GO:0004842
GO:0005515
GO:0005737
GO:0006515
GO:0016567
GO:0016740
GO:0030018
GO:0030163
GO:0030544
GO:0030579
GO:0030911
GO:0031398
GO:0031943
GO:0032436
GO:0043161
GO:0045862
GO:0046332
GO:0046627
GO:0051087
GO:0051879
GO:0061630
GO:0071218
GO:0140096
Participates
as an output of
STUB1 polyubiquitinates RUNX2 (Drosophila melanogaster)
STUB1 (CHIP) ubiquitinates SMAD3 (Drosophila melanogaster)
as an input of
RUNX2 binds STUB1 (Drosophila melanogaster)
SMAD3 binds STUB1 (CHIP) (Drosophila melanogaster)
as a component of
RUNX2:STUB1 [cytosol] (Drosophila melanogaster)
STUB1:STUB1 [cytosol] (Drosophila melanogaster)
SMAD3:STUB1 [cytosol] (Drosophila melanogaster)
as a member of
NEDD4,STUB1,WWP2 and XIAP [cytosol] (Drosophila melanogaster)
as a candidate of
E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
Inferred From
STUB1 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_477441.1
ENSEMBL
FBpp0079617
,
FBtr0080027
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9VPX6
2
capt [extracellular region]
(R-DME-350746)
capt [azurophil granule lumen]
(R-DME-6798752)
0.488
2
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