Reactome | Vha44 [cytosol]

Vha44 [cytosol]

Stable Identifier

R-DME-912586

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

cytosol

Synonyms

ATP6V1C1, Q9V7N5

Locations in the PathwayBrowser

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Cellular responses to stimuli (Drosophila melanogaster)

- Cellular responses to stress (Drosophila melanogaster)
  - Cellular response to starvation (Drosophila melanogaster)
    - Amino acids regulate mTORC1 (Drosophila melanogaster)
      - RRAGA,B exchanges GDP for GTP (Drosophila melanogaster)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane] (Drosophila melanogaster)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Drosophila melanogaster)
        
        v-ATPase:Ragulator [lysosomal membrane] (Drosophila melanogaster)
        
        v-ATPase [lysosomal membrane] (Drosophila melanogaster)
        
        ATP6V1 [cytosol] (Drosophila melanogaster)
        
        Vha44 [cytosol] (Drosophila melanogaster)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane] (Drosophila melanogaster)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Drosophila melanogaster)
        
        v-ATPase:Ragulator [lysosomal membrane] (Drosophila melanogaster)
        
        v-ATPase [lysosomal membrane] (Drosophila melanogaster)
        
        ATP6V1 [cytosol] (Drosophila melanogaster)
        
        Vha44 [cytosol] (Drosophila melanogaster)
      - RRAGA,B hydrolyzes GTP (Drosophila melanogaster)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Drosophila melanogaster)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Drosophila melanogaster)
        
        v-ATPase:Ragulator [lysosomal membrane] (Drosophila melanogaster)
        
        v-ATPase [lysosomal membrane] (Drosophila melanogaster)
        
        ATP6V1 [cytosol] (Drosophila melanogaster)
        
        Vha44 [cytosol] (Drosophila melanogaster)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Drosophila melanogaster)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Drosophila melanogaster)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Drosophila melanogaster)
        
        v-ATPase:Ragulator [lysosomal membrane] (Drosophila melanogaster)
        
        v-ATPase [lysosomal membrane] (Drosophila melanogaster)
        
        ATP6V1 [cytosol] (Drosophila melanogaster)
        
        Vha44 [cytosol] (Drosophila melanogaster)
      - RRAGC,D exchanges GTP for GDP (Drosophila melanogaster)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Drosophila melanogaster)
        
        v-ATPase:Ragulator [lysosomal membrane] (Drosophila melanogaster)
        
        v-ATPase [lysosomal membrane] (Drosophila melanogaster)
        
        ATP6V1 [cytosol] (Drosophila melanogaster)
        
        Vha44 [cytosol] (Drosophila melanogaster)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GTP [lysosomal membrane] (Drosophila melanogaster)
        
        v-ATPase:Ragulator [lysosomal membrane] (Drosophila melanogaster)
        
        v-ATPase [lysosomal membrane] (Drosophila melanogaster)
        
        ATP6V1 [cytosol] (Drosophila melanogaster)
        
        Vha44 [cytosol] (Drosophila melanogaster)
      - RRAGC,D hydrolyzes GTP (Drosophila melanogaster)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Drosophila melanogaster)
        
        v-ATPase:Ragulator [lysosomal membrane] (Drosophila melanogaster)
        
        v-ATPase [lysosomal membrane] (Drosophila melanogaster)
        
        ATP6V1 [cytosol] (Drosophila melanogaster)
        
        Vha44 [cytosol] (Drosophila melanogaster)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GTP [lysosomal membrane] (Drosophila melanogaster)
        
        v-ATPase:Ragulator [lysosomal membrane] (Drosophila melanogaster)
        
        v-ATPase [lysosomal membrane] (Drosophila melanogaster)
        
        ATP6V1 [cytosol] (Drosophila melanogaster)
        
        Vha44 [cytosol] (Drosophila melanogaster)
      - mTORC1 binds RHEB:GTP (Drosophila melanogaster)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Drosophila melanogaster)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Drosophila melanogaster)
        
        v-ATPase:Ragulator [lysosomal membrane] (Drosophila melanogaster)
        
        v-ATPase [lysosomal membrane] (Drosophila melanogaster)
        
        ATP6V1 [cytosol] (Drosophila melanogaster)
        
        Vha44 [cytosol] (Drosophila melanogaster)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Drosophila melanogaster)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Drosophila melanogaster)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Drosophila melanogaster)
        
        v-ATPase:Ragulator [lysosomal membrane] (Drosophila melanogaster)
        
        v-ATPase [lysosomal membrane] (Drosophila melanogaster)
        
        ATP6V1 [cytosol] (Drosophila melanogaster)
        
        Vha44 [cytosol] (Drosophila melanogaster)
      - v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 (Drosophila melanogaster)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Drosophila melanogaster)
        
        v-ATPase:Ragulator [lysosomal membrane] (Drosophila melanogaster)
        
        v-ATPase [lysosomal membrane] (Drosophila melanogaster)
        
        ATP6V1 [cytosol] (Drosophila melanogaster)
        
        Vha44 [cytosol] (Drosophila melanogaster)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Drosophila melanogaster)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Drosophila melanogaster)
        
        v-ATPase:Ragulator [lysosomal membrane] (Drosophila melanogaster)
        
        v-ATPase [lysosomal membrane] (Drosophila melanogaster)
        
        ATP6V1 [cytosol] (Drosophila melanogaster)
        
        Vha44 [cytosol] (Drosophila melanogaster)

Signal Transduction (Drosophila melanogaster)

- Signaling by Receptor Tyrosine Kinases (Drosophila melanogaster)
  - Signaling by Insulin receptor (Drosophila melanogaster)
    - Insulin receptor recycling (Drosophila melanogaster)
      - ATP6AP1 binds V-ATPase (Drosophila melanogaster)
        
        V-ATPase [endosome membrane] (Drosophila melanogaster)
        
        ATP6V1 [cytosol] (Drosophila melanogaster)
        
        Vha44 [cytosol] (Drosophila melanogaster)
        
        V-ATPase:ATP6AP1 [endosome membrane] (Drosophila melanogaster)
        
        V-ATPase [endosome membrane] (Drosophila melanogaster)
        
        ATP6V1 [cytosol] (Drosophila melanogaster)
        
        Vha44 [cytosol] (Drosophila melanogaster)
      - Endosome acidification (Drosophila melanogaster)
        
        V-ATPase:ATP6AP1 [endosome membrane] (Drosophila melanogaster)
        
        V-ATPase [endosome membrane] (Drosophila melanogaster)
        
        ATP6V1 [cytosol] (Drosophila melanogaster)
        
        Vha44 [cytosol] (Drosophila melanogaster)

External Reference Information

External Reference

UniProt:Q9V7N5

Gene Names

Vha44

Reference Genes

BioGPS Gene:36826 Vha44

CTD Gene:36826 Vha44

ENSEMBL:FBgn0287825

Flybase:FBgn0287825

KEGG Gene (Drosophila melanogaster):Dmel_CG8048 Vha44

Monarch:36826 Vha44

NCBI Gene:36826 Vha44

Reference Transcript

Other Identifiers

153422_at

1635352_s_at

36826

GO:0000221

GO:0005215

GO:0005773

GO:0005886

GO:0006811

GO:0015078

GO:0033180

GO:0033181

GO:0043226

GO:0046961

GO:0055085

GO:0140657

GO:1902600

Participates

as a component of

ATP6V1 [cytosol] (Drosophila melanogaster)

Other forms of this molecule

Vha44 [cytosol]

Inferred From

ATP6V1C [cytosol] (Homo sapiens)

ATP6V1C1 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001137679.1, NP_725565.3, NP_477266.1, NP_725564.1, NP_599140.1

Flybase

FBgn0287825

PRO

Q9V7N5

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