Reactome | Vha13 [cytosol]

Vha13 [cytosol]

Stable Identifier

R-DME-912578

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

cytosol

Synonyms

ATP6V1G1, Q9XZH6

Locations in the PathwayBrowser

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Cellular responses to stimuli (Drosophila melanogaster)

- Cellular responses to stress (Drosophila melanogaster)
  - Cellular response to starvation (Drosophila melanogaster)
    - Amino acids regulate mTORC1 (Drosophila melanogaster)
      - RRAGA,B exchanges GDP for GTP (Drosophila melanogaster)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane] (Drosophila melanogaster)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Drosophila melanogaster)
        
        v-ATPase:Ragulator [lysosomal membrane] (Drosophila melanogaster)
        
        v-ATPase [lysosomal membrane] (Drosophila melanogaster)
        
        ATP6V1 [cytosol] (Drosophila melanogaster)
        
        ATP6V1G dimer [cytosol] (Drosophila melanogaster)
        
        Vha13 [cytosol] (Drosophila melanogaster)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane] (Drosophila melanogaster)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Drosophila melanogaster)
        
        v-ATPase:Ragulator [lysosomal membrane] (Drosophila melanogaster)
        
        v-ATPase [lysosomal membrane] (Drosophila melanogaster)
        
        ATP6V1 [cytosol] (Drosophila melanogaster)
        
        ATP6V1G dimer [cytosol] (Drosophila melanogaster)
        
        Vha13 [cytosol] (Drosophila melanogaster)
      - RRAGA,B hydrolyzes GTP (Drosophila melanogaster)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Drosophila melanogaster)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Drosophila melanogaster)
        
        v-ATPase:Ragulator [lysosomal membrane] (Drosophila melanogaster)
        
        v-ATPase [lysosomal membrane] (Drosophila melanogaster)
        
        ATP6V1 [cytosol] (Drosophila melanogaster)
        
        ATP6V1G dimer [cytosol] (Drosophila melanogaster)
        
        Vha13 [cytosol] (Drosophila melanogaster)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Drosophila melanogaster)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Drosophila melanogaster)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Drosophila melanogaster)
        
        v-ATPase:Ragulator [lysosomal membrane] (Drosophila melanogaster)
        
        v-ATPase [lysosomal membrane] (Drosophila melanogaster)
        
        ATP6V1 [cytosol] (Drosophila melanogaster)
        
        ATP6V1G dimer [cytosol] (Drosophila melanogaster)
        
        Vha13 [cytosol] (Drosophila melanogaster)
      - RRAGC,D exchanges GTP for GDP (Drosophila melanogaster)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Drosophila melanogaster)
        
        v-ATPase:Ragulator [lysosomal membrane] (Drosophila melanogaster)
        
        v-ATPase [lysosomal membrane] (Drosophila melanogaster)
        
        ATP6V1 [cytosol] (Drosophila melanogaster)
        
        ATP6V1G dimer [cytosol] (Drosophila melanogaster)
        
        Vha13 [cytosol] (Drosophila melanogaster)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GTP [lysosomal membrane] (Drosophila melanogaster)
        
        v-ATPase:Ragulator [lysosomal membrane] (Drosophila melanogaster)
        
        v-ATPase [lysosomal membrane] (Drosophila melanogaster)
        
        ATP6V1 [cytosol] (Drosophila melanogaster)
        
        ATP6V1G dimer [cytosol] (Drosophila melanogaster)
        
        Vha13 [cytosol] (Drosophila melanogaster)
      - RRAGC,D hydrolyzes GTP (Drosophila melanogaster)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Drosophila melanogaster)
        
        v-ATPase:Ragulator [lysosomal membrane] (Drosophila melanogaster)
        
        v-ATPase [lysosomal membrane] (Drosophila melanogaster)
        
        ATP6V1 [cytosol] (Drosophila melanogaster)
        
        ATP6V1G dimer [cytosol] (Drosophila melanogaster)
        
        Vha13 [cytosol] (Drosophila melanogaster)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GTP [lysosomal membrane] (Drosophila melanogaster)
        
        v-ATPase:Ragulator [lysosomal membrane] (Drosophila melanogaster)
        
        v-ATPase [lysosomal membrane] (Drosophila melanogaster)
        
        ATP6V1 [cytosol] (Drosophila melanogaster)
        
        ATP6V1G dimer [cytosol] (Drosophila melanogaster)
        
        Vha13 [cytosol] (Drosophila melanogaster)
      - mTORC1 binds RHEB:GTP (Drosophila melanogaster)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Drosophila melanogaster)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Drosophila melanogaster)
        
        v-ATPase:Ragulator [lysosomal membrane] (Drosophila melanogaster)
        
        v-ATPase [lysosomal membrane] (Drosophila melanogaster)
        
        ATP6V1 [cytosol] (Drosophila melanogaster)
        
        ATP6V1G dimer [cytosol] (Drosophila melanogaster)
        
        Vha13 [cytosol] (Drosophila melanogaster)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Drosophila melanogaster)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Drosophila melanogaster)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Drosophila melanogaster)
        
        v-ATPase:Ragulator [lysosomal membrane] (Drosophila melanogaster)
        
        v-ATPase [lysosomal membrane] (Drosophila melanogaster)
        
        ATP6V1 [cytosol] (Drosophila melanogaster)
        
        ATP6V1G dimer [cytosol] (Drosophila melanogaster)
        
        Vha13 [cytosol] (Drosophila melanogaster)
      - v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 (Drosophila melanogaster)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Drosophila melanogaster)
        
        v-ATPase:Ragulator [lysosomal membrane] (Drosophila melanogaster)
        
        v-ATPase [lysosomal membrane] (Drosophila melanogaster)
        
        ATP6V1 [cytosol] (Drosophila melanogaster)
        
        ATP6V1G dimer [cytosol] (Drosophila melanogaster)
        
        Vha13 [cytosol] (Drosophila melanogaster)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Drosophila melanogaster)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Drosophila melanogaster)
        
        v-ATPase:Ragulator [lysosomal membrane] (Drosophila melanogaster)
        
        v-ATPase [lysosomal membrane] (Drosophila melanogaster)
        
        ATP6V1 [cytosol] (Drosophila melanogaster)
        
        ATP6V1G dimer [cytosol] (Drosophila melanogaster)
        
        Vha13 [cytosol] (Drosophila melanogaster)

Signal Transduction (Drosophila melanogaster)

- Signaling by Receptor Tyrosine Kinases (Drosophila melanogaster)
  - Signaling by Insulin receptor (Drosophila melanogaster)
    - Insulin receptor recycling (Drosophila melanogaster)
      - ATP6AP1 binds V-ATPase (Drosophila melanogaster)
        
        V-ATPase [endosome membrane] (Drosophila melanogaster)
        
        ATP6V1 [cytosol] (Drosophila melanogaster)
        
        ATP6V1G dimer [cytosol] (Drosophila melanogaster)
        
        Vha13 [cytosol] (Drosophila melanogaster)
        
        V-ATPase:ATP6AP1 [endosome membrane] (Drosophila melanogaster)
        
        V-ATPase [endosome membrane] (Drosophila melanogaster)
        
        ATP6V1 [cytosol] (Drosophila melanogaster)
        
        ATP6V1G dimer [cytosol] (Drosophila melanogaster)
        
        Vha13 [cytosol] (Drosophila melanogaster)
      - Endosome acidification (Drosophila melanogaster)
        
        V-ATPase:ATP6AP1 [endosome membrane] (Drosophila melanogaster)
        
        V-ATPase [endosome membrane] (Drosophila melanogaster)
        
        ATP6V1 [cytosol] (Drosophila melanogaster)
        
        ATP6V1G dimer [cytosol] (Drosophila melanogaster)
        
        Vha13 [cytosol] (Drosophila melanogaster)

Transport of small molecules (Drosophila melanogaster)

- Ion channel transport (Drosophila melanogaster)
  - ATP6AP1 binds V-ATPase (Drosophila melanogaster)
    - V-ATPase [endosome membrane] (Drosophila melanogaster)
      - ATP6V1 [cytosol] (Drosophila melanogaster)
        
        ATP6V1G dimer [cytosol] (Drosophila melanogaster)
        
        Vha13 [cytosol] (Drosophila melanogaster)
    - V-ATPase:ATP6AP1 [endosome membrane] (Drosophila melanogaster)
      - V-ATPase [endosome membrane] (Drosophila melanogaster)
        
        ATP6V1 [cytosol] (Drosophila melanogaster)
        
        ATP6V1G dimer [cytosol] (Drosophila melanogaster)
        
        Vha13 [cytosol] (Drosophila melanogaster)
- Iron uptake and transport (Drosophila melanogaster)
  - Transferrin endocytosis and recycling (Drosophila melanogaster)
    - ATP6AP1 binds V-ATPase (Drosophila melanogaster)
      - V-ATPase [endosome membrane] (Drosophila melanogaster)
        
        ATP6V1 [cytosol] (Drosophila melanogaster)
        
        ATP6V1G dimer [cytosol] (Drosophila melanogaster)
        
        Vha13 [cytosol] (Drosophila melanogaster)
      - V-ATPase:ATP6AP1 [endosome membrane] (Drosophila melanogaster)
        
        V-ATPase [endosome membrane] (Drosophila melanogaster)
        
        ATP6V1 [cytosol] (Drosophila melanogaster)
        
        ATP6V1G dimer [cytosol] (Drosophila melanogaster)
        
        Vha13 [cytosol] (Drosophila melanogaster)
    - Acidification of Tf:TfR1 containing endosome (Drosophila melanogaster)
      - V-ATPase:ATP6AP1 [endosome membrane] (Drosophila melanogaster)
        
        V-ATPase [endosome membrane] (Drosophila melanogaster)
        
        ATP6V1 [cytosol] (Drosophila melanogaster)
        
        ATP6V1G dimer [cytosol] (Drosophila melanogaster)
        
        Vha13 [cytosol] (Drosophila melanogaster)

External Reference Information

External Reference

UniProt:Q9XZH6

Gene Names

Vha13

Reference Genes

BioGPS Gene:42341 Vha13

CTD Gene:42341 Vha13

ENSEMBL:FBgn0283536

FlyBase:FBgn0283536

KEGG:dme:Dmel_CG6213 Vha13

Monarch:42341 Vha13

NCBI Gene:42341 Vha13

UCSC:Q9XZH6 Vha13

Reference Transcript

Other Identifiers

144156_at

1627006_at

42341

GO:0000221

GO:0005515

GO:0006811

GO:0007430

GO:0016471

GO:0016787

GO:0016887

GO:0033181

GO:0035002

GO:0046961

GO:0055085

GO:0097401

GO:0098793

GO:1902600

Participates

as a component of

ATP6V1G dimer [cytosol] (Drosophila melanogaster)

Other forms of this molecule

Vha13 [cytosol]

Inferred From

ATP6V1G [cytosol] (Homo sapiens)

ATP6V1G1 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_477437.1, NP_001287407.1

ENSEMBL

FBpp0083214, FBpp0311933, FBgn0283536, FBtr0346100, FBtr0083804

FlyBase

FBgn0283536

PRO

Q9XZH6

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P23647 fu	2	Phospho FU [cytosol] (R-DME-205779) FU [cytosol] (R-DME-205872)	0.553	2

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