Reactome | RpL8 [cytosol]

RpL8 [cytosol]

Stable Identifier

R-DME-72490

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

cytosol

Synonyms

RPL8, Q9V3G1

Locations in the PathwayBrowser

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Metabolism of RNA (Drosophila melanogaster)

- Nonsense-Mediated Decay (NMD) (Drosophila melanogaster)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Drosophila melanogaster)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Drosophila melanogaster)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Drosophila melanogaster)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Drosophila melanogaster)
        
        80S ribosome [cytosol] (Drosophila melanogaster)
        
        60S ribosomal complex [cytosol] (Drosophila melanogaster)
        
        RpL8 [cytosol] (Drosophila melanogaster)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Drosophila melanogaster)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Drosophila melanogaster)
        
        80S ribosome [cytosol] (Drosophila melanogaster)
        
        60S ribosomal complex [cytosol] (Drosophila melanogaster)
        
        RpL8 [cytosol] (Drosophila melanogaster)
    - SMG6 hydrolyzes mRNA with premature termination codon (Drosophila melanogaster)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Drosophila melanogaster)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Drosophila melanogaster)
        
        80S ribosome [cytosol] (Drosophila melanogaster)
        
        60S ribosomal complex [cytosol] (Drosophila melanogaster)
        
        RpL8 [cytosol] (Drosophila melanogaster)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Drosophila melanogaster)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Drosophila melanogaster)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Drosophila melanogaster)
        
        80S ribosome [cytosol] (Drosophila melanogaster)
        
        60S ribosomal complex [cytosol] (Drosophila melanogaster)
        
        RpL8 [cytosol] (Drosophila melanogaster)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Drosophila melanogaster)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Drosophila melanogaster)
        
        80S ribosome [cytosol] (Drosophila melanogaster)
        
        60S ribosomal complex [cytosol] (Drosophila melanogaster)
        
        RpL8 [cytosol] (Drosophila melanogaster)

External Reference Information

External Reference

UniProt:Q9V3G1

Gene Names

RpL8

Reference Genes

BioGPS Gene:44251 RpL8

ENSEMBL:FBgn0261602

FlyBase:FBgn0261602

KEGG:dme:Dmel_CG1263 RpL8

Monarch:44251 RpL8

NCBI Gene:44251 RpL8

UCSC:Q9V3G1 RpL8

Reference Transcript

Other Identifiers

144032_at

1628775_s_at

44251

GO:0000228

GO:0002181

GO:0003723

GO:0003735

GO:0005198

GO:0005694

GO:0005730

GO:0005737

GO:0005840

GO:0006412

GO:0015934

GO:0019843

GO:0022625

GO:0022626

GO:1990904

Participates

as a component of

Other forms of this molecule

RpL8 [nucleoplasm]

Inferred From

RPL8 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_524726.1, NP_728756.1

ENSEMBL

FBgn0261602, FBtr0072925, FBtr0072924, FBpp0072802, FBpp0072801

FlyBase

FBgn0261602

PRO

Q9V3G1

PDB

6XU8, 6XU7, 6XU6, 4V6W

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