Reactome | RpS2 [cytosol]

RpS2 [cytosol]

Stable Identifier

R-DME-72347

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

cytosol

Synonyms

RPS2, P31009

Locations in the PathwayBrowser

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Metabolism of RNA (Drosophila melanogaster)

- Nonsense-Mediated Decay (NMD) (Drosophila melanogaster)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Drosophila melanogaster)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Drosophila melanogaster)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Drosophila melanogaster)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Drosophila melanogaster)
        
        80S ribosome [cytosol] (Drosophila melanogaster)
        
        40S ribosomal complex [cytosol] (Drosophila melanogaster)
        
        RpS2 [cytosol] (Drosophila melanogaster)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Drosophila melanogaster)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Drosophila melanogaster)
        
        80S ribosome [cytosol] (Drosophila melanogaster)
        
        40S ribosomal complex [cytosol] (Drosophila melanogaster)
        
        RpS2 [cytosol] (Drosophila melanogaster)
    - SMG6 hydrolyzes mRNA with premature termination codon (Drosophila melanogaster)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Drosophila melanogaster)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Drosophila melanogaster)
        
        80S ribosome [cytosol] (Drosophila melanogaster)
        
        40S ribosomal complex [cytosol] (Drosophila melanogaster)
        
        RpS2 [cytosol] (Drosophila melanogaster)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Drosophila melanogaster)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Drosophila melanogaster)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Drosophila melanogaster)
        
        80S ribosome [cytosol] (Drosophila melanogaster)
        
        40S ribosomal complex [cytosol] (Drosophila melanogaster)
        
        RpS2 [cytosol] (Drosophila melanogaster)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Drosophila melanogaster)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Drosophila melanogaster)
        
        80S ribosome [cytosol] (Drosophila melanogaster)
        
        40S ribosomal complex [cytosol] (Drosophila melanogaster)
        
        RpS2 [cytosol] (Drosophila melanogaster)
- rRNA processing (Drosophila melanogaster)
  - rRNA processing in the nucleus and cytosol (Drosophila melanogaster)
    - Major pathway of rRNA processing in the nucleolus and cytosol (Drosophila melanogaster)
      - 30S pre-rRNA is nucleolytically processed at site 1 to yield 21S pre-rRNA (Drosophila melanogaster)
        
        RpS2 [cytosol] (Drosophila melanogaster)

External Reference Information

External Reference

UniProt:P31009

Gene Names

RpS2

Reference Genes

BioGPS Gene:34309 RpS2

ENSEMBL:FBgn0004867

FlyBase:FBgn0004867

KEGG:dme:Dmel_CG5920 RpS2

Monarch:34309 RpS2

NCBI Gene:34309 RpS2

UCSC:P31009 RpS2

Other Identifiers

154228_at

1632483_at

34309

GO:0000228

GO:0002181

GO:0003723

GO:0003735

GO:0005198

GO:0005694

GO:0005730

GO:0005737

GO:0005840

GO:0006412

GO:0015935

GO:0022414

GO:0022626

GO:0022627

GO:0030154

GO:0048477

GO:0048856

GO:1990904

Participates

as a component of

as an input of

PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2 (Drosophila melanogaster)

This entity regulates

Positively

30S pre-rRNA is nucleolytically processed at site 1 to yield 21S pre-rRNA (Drosophila melanogaster)

Other forms of this molecule

RpS2 [nucleoplasm]

RpS2 [cytosol]

Inferred From

RPS2 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_476874.1, NP_001260303.1, NP_001285785.1

ENSEMBL

FBtr0079905, FBpp0311561, FBpp0303531, FBgn0004867, FBpp0079500, FBtr0330682, FBtr0345436

FlyBase

FBgn0004867

PRO

P31009

PDB

6XU7, 6XU8, 6XU6, 4V6W

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