Reactome | SF2 [nucleoplasm]

SF2 [nucleoplasm]

Stable Identifier

R-DME-72037

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

nucleoplasm

Synonyms

SRSF9, Q9V3W7

Locations in the PathwayBrowser

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Metabolism of RNA (Drosophila melanogaster)

- Processing of Capped Intron-Containing Pre-mRNA (Drosophila melanogaster)
  - Formation of pre-mRNPs (Drosophila melanogaster)
    - Alternative Splicing Factors [nucleoplasm] (Drosophila melanogaster)
      - nonshuttling SRSFs [nucleoplasm] (Drosophila melanogaster)
        
        SF2 [nucleoplasm] (Drosophila melanogaster)
    - capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Drosophila melanogaster)
      - Alternative Splicing Factors [nucleoplasm] (Drosophila melanogaster)
        
        nonshuttling SRSFs [nucleoplasm] (Drosophila melanogaster)
        
        SF2 [nucleoplasm] (Drosophila melanogaster)
  - Transport of Mature Transcript to Cytoplasm (Drosophila melanogaster)
    - Transport of Mature mRNA derived from an Intron-Containing Transcript (Drosophila melanogaster)
      - NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B) (Drosophila melanogaster)
        
        NXF1,2:NXT1::polyadenylated, capped mRNA:CBC:EJC:TREX:SRSF proteins [nucleoplasm] (Drosophila melanogaster)
        
        capped mRNA:CBC:EJC:TREX (minus DDX39B) [nucleoplasm] (Drosophila melanogaster)
        
        SF2 [nucleoplasm] (Drosophila melanogaster)
        
        polyadenylated, capped mRNA:CBC:EJC:TREX:SRSF proteins [nucleoplasm] (Drosophila melanogaster)
        
        SF2 [nucleoplasm] (Drosophila melanogaster)
  - mRNA 3'-end processing (Drosophila melanogaster)
    - mRNA Polyadenylation (Drosophila melanogaster)
      - Core CPA complex binds capped pre-mRNA (Drosophila melanogaster)
        
        Core CPA complex:Spliceosomal A complex (uncleaved pre-mRNA) [nucleoplasm] (Drosophila melanogaster)
        
        Spliceosomal A complex (capped, methylated pre-mRNA) [nucleoplasm] (Drosophila melanogaster)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Drosophila melanogaster)
        
        Alternative Splicing Factors [nucleoplasm] (Drosophila melanogaster)
        
        nonshuttling SRSFs [nucleoplasm] (Drosophila melanogaster)
        
        SF2 [nucleoplasm] (Drosophila melanogaster)
        
        Spliceosomal A complex (capped, methylated pre-mRNA) [nucleoplasm] (Drosophila melanogaster)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Drosophila melanogaster)
        
        Alternative Splicing Factors [nucleoplasm] (Drosophila melanogaster)
        
        nonshuttling SRSFs [nucleoplasm] (Drosophila melanogaster)
        
        SF2 [nucleoplasm] (Drosophila melanogaster)
      - PABPN1-stimulated PAPOL synthesizes polyA tail at distal 3'UTR PAS (Drosophila melanogaster)
        
        Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at distal 3'UTR PAS) [nucleoplasm] (Drosophila melanogaster)
        
        Spliceosomal A complex (pre-mRNA polyadenylated at distal 3'UTR PAS) [nucleoplasm] (Drosophila melanogaster)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA polyadenylated at distal 3'UTR PAS) [nucleoplasm] (Drosophila melanogaster)
        
        Alternative Splicing Factors [nucleoplasm] (Drosophila melanogaster)
        
        nonshuttling SRSFs [nucleoplasm] (Drosophila melanogaster)
        
        SF2 [nucleoplasm] (Drosophila melanogaster)
        
        Ub-K63-CPA:Spliceosomal A complex (pre-mRNA cleaved at distal 3'UTR PAS) [nucleoplasm] (Drosophila melanogaster)
        
        Spliceosomal A complex (pre-mRNA cleaved at distal 3'UTR PAS) [nucleoplasm] (Drosophila melanogaster)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA cleaved at distal 3'UTR PAS) [nucleoplasm] (Drosophila melanogaster)
        
        Alternative Splicing Factors [nucleoplasm] (Drosophila melanogaster)
        
        nonshuttling SRSFs [nucleoplasm] (Drosophila melanogaster)
        
        SF2 [nucleoplasm] (Drosophila melanogaster)
      - PABPN1-stimulated PAPOL synthesizes polyA tail at intronic PAS (Drosophila melanogaster)
        
        Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at intronic PAS) [nucleoplasm] (Drosophila melanogaster)
        
        Spliceosomal A complex (pre-mRNA polyadenylated at intronic PAS) [nucleoplasm] (Drosophila melanogaster)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA polyadenylated at intronic PAS) [nucleoplasm] (Drosophila melanogaster)
        
        Alternative Splicing Factors [nucleoplasm] (Drosophila melanogaster)
        
        nonshuttling SRSFs [nucleoplasm] (Drosophila melanogaster)
        
        SF2 [nucleoplasm] (Drosophila melanogaster)
        
        Ub-K63-CPA:Spliceosomal A complex (pre-mRNA cleaved at intronic PAS) [nucleoplasm] (Drosophila melanogaster)
        
        Spliceosomal A complex (pre-mRNA cleaved at intronal PAS) [nucleoplasm] (Drosophila melanogaster)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA cleaved at intronic PAS) [nucleoplasm] (Drosophila melanogaster)
        
        Alternative Splicing Factors [nucleoplasm] (Drosophila melanogaster)
        
        nonshuttling SRSFs [nucleoplasm] (Drosophila melanogaster)
        
        SF2 [nucleoplasm] (Drosophila melanogaster)
      - PABPN1-stimulated PAPOL synthesizes polyA tail at proximal 3'UTR PAS (Drosophila melanogaster)
        
        Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at proximal 3'UTR PAS) [nucleoplasm] (Drosophila melanogaster)
        
        Spliceosomal A complex (pre-mRNA polyadenylated at proximal 3'UTR PAS) [nucleoplasm] (Drosophila melanogaster)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA polyadenylated at proximal 3'UTR PAS) [nucleoplasm] (Drosophila melanogaster)
        
        Alternative Splicing Factors [nucleoplasm] (Drosophila melanogaster)
        
        nonshuttling SRSFs [nucleoplasm] (Drosophila melanogaster)
        
        SF2 [nucleoplasm] (Drosophila melanogaster)
        
        Ub-K63-CPA:Spliceosomal A complex (pre-mRNA cleaved at proximal 3'UTR PAS) [nucleoplasm] (Drosophila melanogaster)
        
        Spliceosomal A complex (pre-mRNA cleaved at proximal 3'UTR PAS) [nucleoplasm] (Drosophila melanogaster)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA cleaved at proximal 3'UTR PAS) [nucleoplasm] (Drosophila melanogaster)
        
        Alternative Splicing Factors [nucleoplasm] (Drosophila melanogaster)
        
        nonshuttling SRSFs [nucleoplasm] (Drosophila melanogaster)
        
        SF2 [nucleoplasm] (Drosophila melanogaster)
      - PP1 dephosphorylates RNA Pol II (Drosophila melanogaster)
        
        CPA:Spliceosomal A complex (uncleaved pre-mRNA) [nucleoplasm] (Drosophila melanogaster)
        
        Spliceosomal A complex (capped, methylated pre-mRNA) [nucleoplasm] (Drosophila melanogaster)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Drosophila melanogaster)
        
        Alternative Splicing Factors [nucleoplasm] (Drosophila melanogaster)
        
        nonshuttling SRSFs [nucleoplasm] (Drosophila melanogaster)
        
        SF2 [nucleoplasm] (Drosophila melanogaster)
        
        CPA:Spliceosomal A complex (uncleaved pre-mRNA, RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Drosophila melanogaster)
        
        Spliceosomal A complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Drosophila melanogaster)
        
        capped, methylated pre-mRNP:CBC complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Drosophila melanogaster)
        
        Alternative Splicing Factors [nucleoplasm] (Drosophila melanogaster)
        
        nonshuttling SRSFs [nucleoplasm] (Drosophila melanogaster)
        
        SF2 [nucleoplasm] (Drosophila melanogaster)
      - RBBP6 activates CPSF complex (Drosophila melanogaster)
        
        CPA:Spliceosomal A complex (uncleaved pre-mRNA, RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Drosophila melanogaster)
        
        Spliceosomal A complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Drosophila melanogaster)
        
        capped, methylated pre-mRNP:CBC complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Drosophila melanogaster)
        
        Alternative Splicing Factors [nucleoplasm] (Drosophila melanogaster)
        
        nonshuttling SRSFs [nucleoplasm] (Drosophila melanogaster)
        
        SF2 [nucleoplasm] (Drosophila melanogaster)
        
        Ub-K63-CPA:Spliceosomal A complex (uncleaved pre-mRNA, RNA Pol II Ser2 dephosphorylated) [nucleoplasm] (Drosophila melanogaster)
        
        Spliceosomal A complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Drosophila melanogaster)
        
        capped, methylated pre-mRNP:CBC complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Drosophila melanogaster)
        
        Alternative Splicing Factors [nucleoplasm] (Drosophila melanogaster)
        
        nonshuttling SRSFs [nucleoplasm] (Drosophila melanogaster)
        
        SF2 [nucleoplasm] (Drosophila melanogaster)
  - mRNA Splicing (Drosophila melanogaster)
    - mRNA Splicing - Major Pathway (Drosophila melanogaster)
      - Formation of the Spliceosomal B* complex (Drosophila melanogaster)
        
        Spliceosomal B* complex [nucleoplasm] (Drosophila melanogaster)
        
        capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Drosophila melanogaster)
        
        Alternative Splicing Factors [nucleoplasm] (Drosophila melanogaster)
        
        nonshuttling SRSFs [nucleoplasm] (Drosophila melanogaster)
        
        SF2 [nucleoplasm] (Drosophila melanogaster)
        
        Spliceosomal Bact complex [nucleoplasm] (Drosophila melanogaster)
        
        capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Drosophila melanogaster)
        
        Alternative Splicing Factors [nucleoplasm] (Drosophila melanogaster)
        
        nonshuttling SRSFs [nucleoplasm] (Drosophila melanogaster)
        
        SF2 [nucleoplasm] (Drosophila melanogaster)
      - Formation of the Spliceosomal C complex containing intron lariat (Drosophila melanogaster)
        
        Spliceosomal B* complex [nucleoplasm] (Drosophila melanogaster)
        
        capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Drosophila melanogaster)
        
        Alternative Splicing Factors [nucleoplasm] (Drosophila melanogaster)
        
        nonshuttling SRSFs [nucleoplasm] (Drosophila melanogaster)
        
        SF2 [nucleoplasm] (Drosophila melanogaster)
        
        Spliceosomal C complex [nucleoplasm] (Drosophila melanogaster)
        
        Alternative Splicing Factors [nucleoplasm] (Drosophila melanogaster)
        
        nonshuttling SRSFs [nucleoplasm] (Drosophila melanogaster)
        
        SF2 [nucleoplasm] (Drosophila melanogaster)
      - Formation of the Spliceosomal C* complex (Drosophila melanogaster)
        
        Spliceosomal C complex [nucleoplasm] (Drosophila melanogaster)
        
        Alternative Splicing Factors [nucleoplasm] (Drosophila melanogaster)
        
        nonshuttling SRSFs [nucleoplasm] (Drosophila melanogaster)
        
        SF2 [nucleoplasm] (Drosophila melanogaster)
        
        Spliceosomal C* complex [nucleoplasm] (Drosophila melanogaster)
        
        Alternative Splicing Factors [nucleoplasm] (Drosophila melanogaster)
        
        nonshuttling SRSFs [nucleoplasm] (Drosophila melanogaster)
        
        SF2 [nucleoplasm] (Drosophila melanogaster)
      - Formation of the Spliceosomal P complex and exon ligation (Drosophila melanogaster)
        
        Spliceosomal C* complex [nucleoplasm] (Drosophila melanogaster)
        
        Alternative Splicing Factors [nucleoplasm] (Drosophila melanogaster)
        
        nonshuttling SRSFs [nucleoplasm] (Drosophila melanogaster)
        
        SF2 [nucleoplasm] (Drosophila melanogaster)
        
        Spliceosomal P complex [nucleoplasm] (Drosophila melanogaster)
        
        spliced mRNA:EJC:CBC complex:Alternative splicing factor [nucleoplasm] (Drosophila melanogaster)
        
        Alternative Splicing Factors [nucleoplasm] (Drosophila melanogaster)
        
        nonshuttling SRSFs [nucleoplasm] (Drosophila melanogaster)
        
        SF2 [nucleoplasm] (Drosophila melanogaster)

External Reference Information

External Reference

UniProt:Q9V3W7

Gene Names

SF2

Reference Genes

BioGPS Gene:53443 SF2

CTD Gene:53443 SF2

ENSEMBL:FBgn0283477

FlyBase:FBgn0283477

KEGG:dme:Dmel_CG6987 SF2

Monarch:53443 SF2

NCBI Gene:53443 SF2

UCSC:Q9V3W7 SF2

Reference Transcript

Other Identifiers

154911_at

1629409_s_at

1634975_at

53443

GO:0000380

GO:0000381

GO:0000398

GO:0001178

GO:0003676

GO:0003677

GO:0003723

GO:0003729

GO:0005515

GO:0005634

GO:0006355

GO:0006397

GO:0006405

GO:0006913

GO:0008380

GO:0010468

GO:0016071

GO:0016607

GO:0031440

GO:0071011

GO:0071013

Participates

as a member of

nonshuttling SRSFs [nucleoplasm] (Drosophila melanogaster)

as a component of

Other forms of this molecule

SF2 [nucleoplasm]

Inferred From

SRSF9 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_001247139.1, NP_652611.1

FlyBase

FBgn0283477

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