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About
What is Reactome ?
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CAK [nucleoplasm]
Stable Identifier
R-DME-69221
Type
Complex
Species
Drosophila melanogaster
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
Cell Cycle (Drosophila melanogaster)
Cell Cycle, Mitotic (Drosophila melanogaster)
Mitotic G1 phase and G1/S transition (Drosophila melanogaster)
G1 Phase (Drosophila melanogaster)
Cyclin D associated events in G1 (Drosophila melanogaster)
CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6 (Drosophila melanogaster)
CAK [nucleoplasm] (Drosophila melanogaster)
G1/S Transition (Drosophila melanogaster)
Cyclin E associated events during G1/S transition (Drosophila melanogaster)
CAK-mediated phosphorylation of Cyclin E:Cdk2 (Drosophila melanogaster)
CAK [nucleoplasm] (Drosophila melanogaster)
Mitotic G2-G2/M phases (Drosophila melanogaster)
G2/M Transition (Drosophila melanogaster)
Cyclin A/B1/B2 associated events during G2/M transition (Drosophila melanogaster)
CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes (Drosophila melanogaster)
CAK [nucleoplasm] (Drosophila melanogaster)
CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes (Drosophila melanogaster)
CAK [nucleoplasm] (Drosophila melanogaster)
S Phase (Drosophila melanogaster)
Cyclin A:Cdk2-associated events at S phase entry (Drosophila melanogaster)
CAK-mediated phosphorylation of Cyclin A:Cdk2 (Drosophila melanogaster)
CAK [nucleoplasm] (Drosophila melanogaster)
DNA Repair (Drosophila melanogaster)
Nucleotide Excision Repair (Drosophila melanogaster)
Global Genome Nucleotide Excision Repair (GG-NER) (Drosophila melanogaster)
Formation of Incision Complex in GG-NER (Drosophila melanogaster)
Recruitment of XPA and release of CAK (Drosophila melanogaster)
CAK [nucleoplasm] (Drosophila melanogaster)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Drosophila melanogaster)
TFIIH [nucleoplasm] (Drosophila melanogaster)
CAK [nucleoplasm] (Drosophila melanogaster)
TFIIH binds GG-NER site to form a verification complex (Drosophila melanogaster)
TFIIH [nucleoplasm] (Drosophila melanogaster)
CAK [nucleoplasm] (Drosophila melanogaster)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Drosophila melanogaster)
TFIIH [nucleoplasm] (Drosophila melanogaster)
CAK [nucleoplasm] (Drosophila melanogaster)
Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Drosophila melanogaster)
Dual incision in TC-NER (Drosophila melanogaster)
5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Drosophila melanogaster)
TC-NER incision complex [nucleoplasm] (Drosophila melanogaster)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Drosophila melanogaster)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Drosophila melanogaster)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Drosophila melanogaster)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Drosophila melanogaster)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Drosophila melanogaster)
TFIIH [nucleoplasm] (Drosophila melanogaster)
CAK [nucleoplasm] (Drosophila melanogaster)
TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Drosophila melanogaster)
TFIIH [nucleoplasm] (Drosophila melanogaster)
CAK [nucleoplasm] (Drosophila melanogaster)
Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Drosophila melanogaster)
TC-NER incision complex [nucleoplasm] (Drosophila melanogaster)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Drosophila melanogaster)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Drosophila melanogaster)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Drosophila melanogaster)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Drosophila melanogaster)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Drosophila melanogaster)
TFIIH [nucleoplasm] (Drosophila melanogaster)
CAK [nucleoplasm] (Drosophila melanogaster)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Drosophila melanogaster)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Drosophila melanogaster)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Drosophila melanogaster)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Drosophila melanogaster)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Drosophila melanogaster)
TFIIH [nucleoplasm] (Drosophila melanogaster)
CAK [nucleoplasm] (Drosophila melanogaster)
DNA polymerases delta, epsilon or kappa bind the TC-NER site (Drosophila melanogaster)
TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Drosophila melanogaster)
TFIIH [nucleoplasm] (Drosophila melanogaster)
CAK [nucleoplasm] (Drosophila melanogaster)
TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Drosophila melanogaster)
TFIIH [nucleoplasm] (Drosophila melanogaster)
CAK [nucleoplasm] (Drosophila melanogaster)
ERCC2-facilitated RNA Pol II backtracking in TC-NER (Drosophila melanogaster)
TC-NER pre-incision complex [nucleoplasm] (Drosophila melanogaster)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Drosophila melanogaster)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Drosophila melanogaster)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Drosophila melanogaster)
TFIIH [nucleoplasm] (Drosophila melanogaster)
CAK [nucleoplasm] (Drosophila melanogaster)
TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Drosophila melanogaster)
Ubiquitinated,hyperphosphorylated RNA Pol II:Partially open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Drosophila melanogaster)
Ubiquitinated,hyperphosphorylated RNA Pol II:Partially open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Drosophila melanogaster)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Drosophila melanogaster)
TFIIH [nucleoplasm] (Drosophila melanogaster)
CAK [nucleoplasm] (Drosophila melanogaster)
ERCC3-facilitated RNA Pol II backtracking in TC-NER (Drosophila melanogaster)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Drosophila melanogaster)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Drosophila melanogaster)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Drosophila melanogaster)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Drosophila melanogaster)
TFIIH [nucleoplasm] (Drosophila melanogaster)
CAK [nucleoplasm] (Drosophila melanogaster)
TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Drosophila melanogaster)
Ubiquitinated,hyperphosphorylated RNA Pol II:Partially open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Drosophila melanogaster)
Ubiquitinated,hyperphosphorylated RNA Pol II:Partially open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Drosophila melanogaster)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Drosophila melanogaster)
TFIIH [nucleoplasm] (Drosophila melanogaster)
CAK [nucleoplasm] (Drosophila melanogaster)
Formation of TC-NER Pre-Incision Complex (Drosophila melanogaster)
Active RNA Pol II complex transcribes lesion-containing DNA template (Drosophila melanogaster)
Damaged dsDNA with open transcription bubble:Hyperphosphorylated RNA Pol II:TFIIH [nucleoplasm] (Drosophila melanogaster)
TFIIH [nucleoplasm] (Drosophila melanogaster)
CAK [nucleoplasm] (Drosophila melanogaster)
Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Drosophila melanogaster)
TFIIH [nucleoplasm] (Drosophila melanogaster)
CAK [nucleoplasm] (Drosophila melanogaster)
ERCC8 (CSA) binds stalled RNA Pol II (Drosophila melanogaster)
Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Drosophila melanogaster)
Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Drosophila melanogaster)
TFIIH [nucleoplasm] (Drosophila melanogaster)
CAK [nucleoplasm] (Drosophila melanogaster)
Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Drosophila melanogaster)
Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Drosophila melanogaster)
Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Drosophila melanogaster)
TFIIH [nucleoplasm] (Drosophila melanogaster)
CAK [nucleoplasm] (Drosophila melanogaster)
ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II (Drosophila melanogaster)
Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Drosophila melanogaster)
Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Drosophila melanogaster)
Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Drosophila melanogaster)
TFIIH [nucleoplasm] (Drosophila melanogaster)
CAK [nucleoplasm] (Drosophila melanogaster)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Drosophila melanogaster)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6 [nucleoplasm] (Drosophila melanogaster)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Drosophila melanogaster)
TFIIH [nucleoplasm] (Drosophila melanogaster)
CAK [nucleoplasm] (Drosophila melanogaster)
RNA Pol II initiates transcription from damaged DNA template (Drosophila melanogaster)
Damaged dsDNA with open transcription bubble:Hyperphosphorylated RNA Pol II:TFIIH [nucleoplasm] (Drosophila melanogaster)
TFIIH [nucleoplasm] (Drosophila melanogaster)
CAK [nucleoplasm] (Drosophila melanogaster)
TFIIH [nucleoplasm] (Drosophila melanogaster)
CAK [nucleoplasm] (Drosophila melanogaster)
UVSSA:USP7 deubiquitinates ERCC6 (Drosophila melanogaster)
TC-NER pre-incision complex [nucleoplasm] (Drosophila melanogaster)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Drosophila melanogaster)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Drosophila melanogaster)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Drosophila melanogaster)
TFIIH [nucleoplasm] (Drosophila melanogaster)
CAK [nucleoplasm] (Drosophila melanogaster)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Drosophila melanogaster)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Drosophila melanogaster)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6 [nucleoplasm] (Drosophila melanogaster)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Drosophila melanogaster)
TFIIH [nucleoplasm] (Drosophila melanogaster)
CAK [nucleoplasm] (Drosophila melanogaster)
Gap-filling DNA repair synthesis and ligation in TC-NER (Drosophila melanogaster)
Ligation of newly synthesized repair patch to incised DNA in TC-NER (Drosophila melanogaster)
TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Drosophila melanogaster)
TFIIH [nucleoplasm] (Drosophila melanogaster)
CAK [nucleoplasm] (Drosophila melanogaster)
TC-NER post-incision complex:dsDNA with transcription bubble [nucleoplasm] (Drosophila melanogaster)
TFIIH [nucleoplasm] (Drosophila melanogaster)
CAK [nucleoplasm] (Drosophila melanogaster)
Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Drosophila melanogaster)
TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Drosophila melanogaster)
TFIIH [nucleoplasm] (Drosophila melanogaster)
CAK [nucleoplasm] (Drosophila melanogaster)
TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Drosophila melanogaster)
TFIIH [nucleoplasm] (Drosophila melanogaster)
CAK [nucleoplasm] (Drosophila melanogaster)
Gene expression (Transcription) (Drosophila melanogaster)
RNA Polymerase I Transcription (Drosophila melanogaster)
RNA Polymerase I Promoter Clearance (Drosophila melanogaster)
RNA Polymerase I Promoter Escape (Drosophila melanogaster)
Elongation of pre-rRNA transcript (Drosophila melanogaster)
RNA Polymerase I promoter escape complex [nucleoplasm] (Drosophila melanogaster)
TFIIH [nucleoplasm] (Drosophila melanogaster)
CAK [nucleoplasm] (Drosophila melanogaster)
Loss of Rrn3 from RNA Polymerase I promoter escape complex (Drosophila melanogaster)
RNA Polymerase I Transcription Initiation complex [nucleoplasm] (Drosophila melanogaster)
TFIIH [nucleoplasm] (Drosophila melanogaster)
CAK [nucleoplasm] (Drosophila melanogaster)
RNA Polymerase I promoter escape complex [nucleoplasm] (Drosophila melanogaster)
TFIIH [nucleoplasm] (Drosophila melanogaster)
CAK [nucleoplasm] (Drosophila melanogaster)
RNA Polymerase II Transcription (Drosophila melanogaster)
Generic Transcription Pathway (Drosophila melanogaster)
Transcriptional Regulation by TP53 (Drosophila melanogaster)
TP53 Regulates Transcription of DNA Repair Genes (Drosophila melanogaster)
CCNK:CDK12 binds RNA Pol II at DNA repair genes (Drosophila melanogaster)
CCNK:CDK12:Elongation Complex at DNA Repair Genes [nucleoplasm] (Drosophila melanogaster)
Elongation Complex at DNA Repair Genes [nucleoplasm] (Drosophila melanogaster)
TFIIH [nucleoplasm] (Drosophila melanogaster)
CAK [nucleoplasm] (Drosophila melanogaster)
Elongation Complex at DNA Repair Genes [nucleoplasm] (Drosophila melanogaster)
TFIIH [nucleoplasm] (Drosophila melanogaster)
CAK [nucleoplasm] (Drosophila melanogaster)
CDK12 phosphorylates RNA Pol II CTD at DNA repair genes (Drosophila melanogaster)
CCNK:CDK12:CDK12-Phosphorylated Elongation Complex at DNA repair genes [nucleoplasm] (Drosophila melanogaster)
CDK12-Phosphorylated Elongation Complex [nucleoplasm] (Drosophila melanogaster)
TFIIH [nucleoplasm] (Drosophila melanogaster)
CAK [nucleoplasm] (Drosophila melanogaster)
CCNK:CDK12:Elongation Complex at DNA Repair Genes [nucleoplasm] (Drosophila melanogaster)
Elongation Complex at DNA Repair Genes [nucleoplasm] (Drosophila melanogaster)
TFIIH [nucleoplasm] (Drosophila melanogaster)
CAK [nucleoplasm] (Drosophila melanogaster)
Transcriptional regulation by RUNX1 (Drosophila melanogaster)
RUNX1 regulates transcription of genes involved in differentiation of HSCs (Drosophila melanogaster)
RUNX1 binds the core TAL1 complex (Drosophila melanogaster)
CAK [nucleoplasm] (Drosophila melanogaster)
RNA Pol II CTD phosphorylation and interaction with CE (Drosophila melanogaster)
Activation of GT (Drosophila melanogaster)
RNA Pol II with phosphorylated CTD: CE complex [nucleoplasm] (Drosophila melanogaster)
TFIIH [nucleoplasm] (Drosophila melanogaster)
CAK [nucleoplasm] (Drosophila melanogaster)
Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex (Drosophila melanogaster)
Pol II transcription complex containing extruded transcript to +30 [nucleoplasm] (Drosophila melanogaster)
TFIIH [nucleoplasm] (Drosophila melanogaster)
CAK [nucleoplasm] (Drosophila melanogaster)
Phosphorylation (Ser5) of RNA pol II CTD (Drosophila melanogaster)
Pol II transcription complex containing extruded transcript to +30 [nucleoplasm] (Drosophila melanogaster)
TFIIH [nucleoplasm] (Drosophila melanogaster)
CAK [nucleoplasm] (Drosophila melanogaster)
Pol II transcription complex with (ser5) phosphorylated CTD containing extruded transcript to +30 [nucleoplasm] (Drosophila melanogaster)
TFIIH [nucleoplasm] (Drosophila melanogaster)
CAK [nucleoplasm] (Drosophila melanogaster)
RNA Polymerase II CTD (phosphorylated) binds to CE (Drosophila melanogaster)
Pol II transcription complex with (ser5) phosphorylated CTD containing extruded transcript to +30 [nucleoplasm] (Drosophila melanogaster)
TFIIH [nucleoplasm] (Drosophila melanogaster)
CAK [nucleoplasm] (Drosophila melanogaster)
RNA Pol II with phosphorylated CTD: CE complex [nucleoplasm] (Drosophila melanogaster)
TFIIH [nucleoplasm] (Drosophila melanogaster)
CAK [nucleoplasm] (Drosophila melanogaster)
SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Drosophila melanogaster)
CE:Pol II CTD:Spt5 complex [nucleoplasm] (Drosophila melanogaster)
TFIIH [nucleoplasm] (Drosophila melanogaster)
CAK [nucleoplasm] (Drosophila melanogaster)
RNA Pol II with phosphorylated CTD: CE complex [nucleoplasm] (Drosophila melanogaster)
TFIIH [nucleoplasm] (Drosophila melanogaster)
CAK [nucleoplasm] (Drosophila melanogaster)
RNA Polymerase II Pre-transcription Events (Drosophila melanogaster)
Abortive Initiation After Second Transition (Drosophila melanogaster)
TFIIH [nucleoplasm] (Drosophila melanogaster)
CAK [nucleoplasm] (Drosophila melanogaster)
pol II transcription complex containing 4-9 nucleotide long transcript [nucleoplasm] (Drosophila melanogaster)
TFIIH [nucleoplasm] (Drosophila melanogaster)
CAK [nucleoplasm] (Drosophila melanogaster)
Abortive Initiation Before Second Transition (Drosophila melanogaster)
Pol II Promoter Escape Complex [nucleoplasm] (Drosophila melanogaster)
TFIIH [nucleoplasm] (Drosophila melanogaster)
CAK [nucleoplasm] (Drosophila melanogaster)
TFIIH [nucleoplasm] (Drosophila melanogaster)
CAK [nucleoplasm] (Drosophila melanogaster)
Abortive initiation after formation of the first phosphodiester bond (Drosophila melanogaster)
TFIIH [nucleoplasm] (Drosophila melanogaster)
CAK [nucleoplasm] (Drosophila melanogaster)
pol II transcription complex [nucleoplasm] (Drosophila melanogaster)
TFIIH [nucleoplasm] (Drosophila melanogaster)
CAK [nucleoplasm] (Drosophila melanogaster)
Fall Back to Closed Pre-initiation Complex (Drosophila melanogaster)
pol II closed pre-initiation complex [nucleoplasm] (Drosophila melanogaster)
TFIIH [nucleoplasm] (Drosophila melanogaster)
CAK [nucleoplasm] (Drosophila melanogaster)
pol II open pre-initiation complex [nucleoplasm] (Drosophila melanogaster)
TFIIH [nucleoplasm] (Drosophila melanogaster)
CAK [nucleoplasm] (Drosophila melanogaster)
RNA Polymerase II Transcription Elongation (Drosophila melanogaster)
Addition of nucleotides leads to transcript elongation (Drosophila melanogaster)
Elongation complex [nucleoplasm] (Drosophila melanogaster)
TFIIH [nucleoplasm] (Drosophila melanogaster)
CAK [nucleoplasm] (Drosophila melanogaster)
TFIIH [nucleoplasm] (Drosophila melanogaster)
CAK [nucleoplasm] (Drosophila melanogaster)
Formation of RNA Pol II elongation complex (Drosophila melanogaster)
Recruitment of elongation factors to form elongation complex (Drosophila melanogaster)
Elongation complex [nucleoplasm] (Drosophila melanogaster)
TFIIH [nucleoplasm] (Drosophila melanogaster)
CAK [nucleoplasm] (Drosophila melanogaster)
TFIIH [nucleoplasm] (Drosophila melanogaster)
CAK [nucleoplasm] (Drosophila melanogaster)
Formation of the Early Elongation Complex (Drosophila melanogaster)
Hypophosphorylation of RNA Pol II CTD by FCP1P protein (Drosophila melanogaster)
TFIIH [nucleoplasm] (Drosophila melanogaster)
CAK [nucleoplasm] (Drosophila melanogaster)
RNA Polymerase II Transcription Initiation And Promoter Clearance (Drosophila melanogaster)
RNA Polymerase II Promoter Escape (Drosophila melanogaster)
Addition of Nucleotides 5 through 9 on the growing Transcript (Drosophila melanogaster)
pol II transcription complex containing 4 nucleotide long transcript [nucleoplasm] (Drosophila melanogaster)
TFIIH [nucleoplasm] (Drosophila melanogaster)
CAK [nucleoplasm] (Drosophila melanogaster)
pol II transcription complex containing 9 nucleotide long transcript [nucleoplasm] (Drosophila melanogaster)
TFIIH [nucleoplasm] (Drosophila melanogaster)
CAK [nucleoplasm] (Drosophila melanogaster)
Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (Drosophila melanogaster)
pol II transcription complex containing 11 nucleotide long transcript [nucleoplasm] (Drosophila melanogaster)
TFIIH [nucleoplasm] (Drosophila melanogaster)
CAK [nucleoplasm] (Drosophila melanogaster)
pol II transcription complex containing 9 nucleotide long transcript [nucleoplasm] (Drosophila melanogaster)
TFIIH [nucleoplasm] (Drosophila melanogaster)
CAK [nucleoplasm] (Drosophila melanogaster)
Addition of nucleotides between position +11 and +30 (Drosophila melanogaster)
Pol II transcription complex containing extruded transcript to +30 [nucleoplasm] (Drosophila melanogaster)
TFIIH [nucleoplasm] (Drosophila melanogaster)
CAK [nucleoplasm] (Drosophila melanogaster)
pol II transcription complex containing 11 nucleotide long transcript [nucleoplasm] (Drosophila melanogaster)
TFIIH [nucleoplasm] (Drosophila melanogaster)
CAK [nucleoplasm] (Drosophila melanogaster)
Addition of the fourth nucleotide on the Nascent Transcript: Second Transition (Drosophila melanogaster)
pol II transcription complex containing 3 Nucleotide long transcript [nucleoplasm] (Drosophila melanogaster)
TFIIH [nucleoplasm] (Drosophila melanogaster)
CAK [nucleoplasm] (Drosophila melanogaster)
pol II transcription complex containing 4 nucleotide long transcript [nucleoplasm] (Drosophila melanogaster)
TFIIH [nucleoplasm] (Drosophila melanogaster)
CAK [nucleoplasm] (Drosophila melanogaster)
Addition of the third nucleotide on the nascent transcript (Drosophila melanogaster)
pol II transcription complex [nucleoplasm] (Drosophila melanogaster)
TFIIH [nucleoplasm] (Drosophila melanogaster)
CAK [nucleoplasm] (Drosophila melanogaster)
pol II transcription complex containing 3 Nucleotide long transcript [nucleoplasm] (Drosophila melanogaster)
TFIIH [nucleoplasm] (Drosophila melanogaster)
CAK [nucleoplasm] (Drosophila melanogaster)
Unwinding DNA for the nascent transcript (Drosophila melanogaster)
TFIIH [nucleoplasm] (Drosophila melanogaster)
CAK [nucleoplasm] (Drosophila melanogaster)
pol II transcription complex [nucleoplasm] (Drosophila melanogaster)
TFIIH [nucleoplasm] (Drosophila melanogaster)
CAK [nucleoplasm] (Drosophila melanogaster)
Unwinding of DNA for the Nascent Transcript: Second Transition (Drosophila melanogaster)
TFIIH [nucleoplasm] (Drosophila melanogaster)
CAK [nucleoplasm] (Drosophila melanogaster)
pol II transcription complex containing 3 Nucleotide long transcript [nucleoplasm] (Drosophila melanogaster)
TFIIH [nucleoplasm] (Drosophila melanogaster)
CAK [nucleoplasm] (Drosophila melanogaster)
RNA Polymerase II Promoter Opening: First Transition (Drosophila melanogaster)
TFIIH [nucleoplasm] (Drosophila melanogaster)
CAK [nucleoplasm] (Drosophila melanogaster)
pol II closed pre-initiation complex [nucleoplasm] (Drosophila melanogaster)
TFIIH [nucleoplasm] (Drosophila melanogaster)
CAK [nucleoplasm] (Drosophila melanogaster)
pol II open pre-initiation complex [nucleoplasm] (Drosophila melanogaster)
TFIIH [nucleoplasm] (Drosophila melanogaster)
CAK [nucleoplasm] (Drosophila melanogaster)
RNA Polymerase II Transcription Initiation (Drosophila melanogaster)
NTP Binds Active Site of RNA Polymerase II (Drosophila melanogaster)
Pol II initiation complex [nucleoplasm] (Drosophila melanogaster)
RNA Polymearse II:NTP:TFIIF complex [nucleoplasm] (Drosophila melanogaster)
TFIIH [nucleoplasm] (Drosophila melanogaster)
CAK [nucleoplasm] (Drosophila melanogaster)
pol II open pre-initiation complex [nucleoplasm] (Drosophila melanogaster)
TFIIH [nucleoplasm] (Drosophila melanogaster)
CAK [nucleoplasm] (Drosophila melanogaster)
Newly Formed Phosphodiester Bond Stabilized and PPi Released (Drosophila melanogaster)
Pol II Initiation complex with phosphodiester-PPi intermediate [nucleoplasm] (Drosophila melanogaster)
TFIIH [nucleoplasm] (Drosophila melanogaster)
CAK [nucleoplasm] (Drosophila melanogaster)
pol II transcription complex [nucleoplasm] (Drosophila melanogaster)
TFIIH [nucleoplasm] (Drosophila melanogaster)
CAK [nucleoplasm] (Drosophila melanogaster)
Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP (Drosophila melanogaster)
Pol II Initiation complex with phosphodiester-PPi intermediate [nucleoplasm] (Drosophila melanogaster)
TFIIH [nucleoplasm] (Drosophila melanogaster)
CAK [nucleoplasm] (Drosophila melanogaster)
Pol II initiation complex [nucleoplasm] (Drosophila melanogaster)
RNA Polymearse II:NTP:TFIIF complex [nucleoplasm] (Drosophila melanogaster)
TFIIH [nucleoplasm] (Drosophila melanogaster)
CAK [nucleoplasm] (Drosophila melanogaster)
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening (Drosophila melanogaster)
Formation of the closed pre-initiation complex (Drosophila melanogaster)
TFIIH [nucleoplasm] (Drosophila melanogaster)
CAK [nucleoplasm] (Drosophila melanogaster)
pol II closed pre-initiation complex [nucleoplasm] (Drosophila melanogaster)
TFIIH [nucleoplasm] (Drosophila melanogaster)
CAK [nucleoplasm] (Drosophila melanogaster)
Metabolism of RNA (Drosophila melanogaster)
mRNA Capping (Drosophila melanogaster)
Activation of GT (Drosophila melanogaster)
RNA Pol II with phosphorylated CTD: CE complex [nucleoplasm] (Drosophila melanogaster)
TFIIH [nucleoplasm] (Drosophila melanogaster)
CAK [nucleoplasm] (Drosophila melanogaster)
Capping complex formation (Drosophila melanogaster)
CE:Pol II CTD:Spt5 complex [nucleoplasm] (Drosophila melanogaster)
TFIIH [nucleoplasm] (Drosophila melanogaster)
CAK [nucleoplasm] (Drosophila melanogaster)
Capping complex (initial) [nucleoplasm] (Drosophila melanogaster)
CE:Pol II CTD:Spt5 complex [nucleoplasm] (Drosophila melanogaster)
TFIIH [nucleoplasm] (Drosophila melanogaster)
CAK [nucleoplasm] (Drosophila melanogaster)
Dissociation of transcript with 5'-GMP from GT (Drosophila melanogaster)
Capping complex (GpppN..) [nucleoplasm] (Drosophila melanogaster)
CE:Pol II CTD:Spt5 complex [nucleoplasm] (Drosophila melanogaster)
TFIIH [nucleoplasm] (Drosophila melanogaster)
CAK [nucleoplasm] (Drosophila melanogaster)
Capping complex (with freed 5'- GMP) [nucleoplasm] (Drosophila melanogaster)
CE:Pol II CTD:Spt5 complex [nucleoplasm] (Drosophila melanogaster)
TFIIH [nucleoplasm] (Drosophila melanogaster)
CAK [nucleoplasm] (Drosophila melanogaster)
Formation of the CE:GMP intermediate complex (Drosophila melanogaster)
Capping complex (intermediate) [nucleoplasm] (Drosophila melanogaster)
Covalent CE:GMP intermediate complex [nucleoplasm] (Drosophila melanogaster)
CE:Pol II CTD:Spt5 complex [nucleoplasm] (Drosophila melanogaster)
TFIIH [nucleoplasm] (Drosophila melanogaster)
CAK [nucleoplasm] (Drosophila melanogaster)
Capping complex (hydrolyzed) [nucleoplasm] (Drosophila melanogaster)
CE:Pol II CTD:Spt5 complex [nucleoplasm] (Drosophila melanogaster)
TFIIH [nucleoplasm] (Drosophila melanogaster)
CAK [nucleoplasm] (Drosophila melanogaster)
Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme (Drosophila melanogaster)
Capping complex (hydrolyzed) [nucleoplasm] (Drosophila melanogaster)
CE:Pol II CTD:Spt5 complex [nucleoplasm] (Drosophila melanogaster)
TFIIH [nucleoplasm] (Drosophila melanogaster)
CAK [nucleoplasm] (Drosophila melanogaster)
Capping complex (initial) [nucleoplasm] (Drosophila melanogaster)
CE:Pol II CTD:Spt5 complex [nucleoplasm] (Drosophila melanogaster)
TFIIH [nucleoplasm] (Drosophila melanogaster)
CAK [nucleoplasm] (Drosophila melanogaster)
Methylation of GMP-cap by RNA Methyltransferase (Drosophila melanogaster)
Capping complex (with freed 5'- GMP) [nucleoplasm] (Drosophila melanogaster)
CE:Pol II CTD:Spt5 complex [nucleoplasm] (Drosophila melanogaster)
TFIIH [nucleoplasm] (Drosophila melanogaster)
CAK [nucleoplasm] (Drosophila melanogaster)
TFIIH [nucleoplasm] (Drosophila melanogaster)
CAK [nucleoplasm] (Drosophila melanogaster)
RNA Polymerase II CTD (phosphorylated) binds to CE (Drosophila melanogaster)
Pol II transcription complex with (ser5) phosphorylated CTD containing extruded transcript to +30 [nucleoplasm] (Drosophila melanogaster)
TFIIH [nucleoplasm] (Drosophila melanogaster)
CAK [nucleoplasm] (Drosophila melanogaster)
RNA Pol II with phosphorylated CTD: CE complex [nucleoplasm] (Drosophila melanogaster)
TFIIH [nucleoplasm] (Drosophila melanogaster)
CAK [nucleoplasm] (Drosophila melanogaster)
SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Drosophila melanogaster)
CE:Pol II CTD:Spt5 complex [nucleoplasm] (Drosophila melanogaster)
TFIIH [nucleoplasm] (Drosophila melanogaster)
CAK [nucleoplasm] (Drosophila melanogaster)
RNA Pol II with phosphorylated CTD: CE complex [nucleoplasm] (Drosophila melanogaster)
TFIIH [nucleoplasm] (Drosophila melanogaster)
CAK [nucleoplasm] (Drosophila melanogaster)
Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA (Drosophila melanogaster)
Capping complex (intermediate) [nucleoplasm] (Drosophila melanogaster)
Covalent CE:GMP intermediate complex [nucleoplasm] (Drosophila melanogaster)
CE:Pol II CTD:Spt5 complex [nucleoplasm] (Drosophila melanogaster)
TFIIH [nucleoplasm] (Drosophila melanogaster)
CAK [nucleoplasm] (Drosophila melanogaster)
Capping complex (GpppN..) [nucleoplasm] (Drosophila melanogaster)
CE:Pol II CTD:Spt5 complex [nucleoplasm] (Drosophila melanogaster)
TFIIH [nucleoplasm] (Drosophila melanogaster)
CAK [nucleoplasm] (Drosophila melanogaster)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
CDK7 [nucleoplasm]
(Drosophila melanogaster)
CycH [nucleoplasm]
(Drosophila melanogaster)
Mat1 [nucleoplasm]
(Drosophila melanogaster)
Participates
as an output of
Recruitment of XPA and release of CAK (Drosophila melanogaster)
as a component of
TFIIH [nucleoplasm] (Drosophila melanogaster)
This entity regulates
Positively
RUNX1 binds the core TAL1 complex
(Drosophila melanogaster)
Inferred From
CAK [nucleoplasm]
(Homo sapiens)
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