Reactome | Orc6 [nucleoplasm]

Orc6 [nucleoplasm]

Stable Identifier

R-DME-68539

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

nucleoplasm

Synonyms

ORC6, Q9Y1B2

Locations in the PathwayBrowser

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Cell Cycle (Drosophila melanogaster)

- Cell Cycle, Mitotic (Drosophila melanogaster)
  - S Phase (Drosophila melanogaster)
    - Synthesis of DNA (Drosophila melanogaster)
      - Switching of origins to a post-replicative state (Drosophila melanogaster)
        
        Orc1 removal from chromatin (Drosophila melanogaster)
        
        Orc1 is phosphorylated by cyclin A/CDK2 (Drosophila melanogaster)
        
        pre-replicative complex (Orc1-minus) [nucleoplasm] (Drosophila melanogaster)
        
        Orc6 [nucleoplasm] (Drosophila melanogaster)

External Reference Information

External Reference

UniProt:Q9Y1B2

Gene Names

Orc6

Reference Genes

BioGPS Gene:36017 Orc6

ENSEMBL:FBgn0023180

FlyBase:FBgn0023180

KEGG:dme:Dmel_CG1584 Orc6

Monarch:36017 Orc6

NCBI Gene:36017 Orc6

UCSC:Q9Y1B2 Orc6

Reference Transcript

RefSeq:NM_057971.6 Orc6

Other Identifiers

142854_at

1627090_at

36017

GO:0000278

GO:0000808

GO:0003677

GO:0005096

GO:0005515

GO:0005634

GO:0005664

GO:0005856

GO:0005886

GO:0006260

GO:0006270

GO:0007010

GO:0032156

GO:0032185

GO:0042803

GO:0098772

Participates

as a component of

pre-replicative complex (Orc1-minus) [nucleoplasm] (Drosophila melanogaster)

Other forms of this molecule

Orc6 [cytosol]

phospho-Orc6 [cytosol]

phospho-Orc6 [nucleoplasm]

Inferred From

ORC6 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_477319.1

ENSEMBL

FBtr0088482, FBpp0087566, FBgn0023180

FlyBase

FBgn0023180

PRO

Q9Y1B2

PDB

7JGS, 7JK5, 4XGC, 7JK2, 7JK3, 7JGR, 7JK6, 7JK4

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O16810	5	phospho-PolyUb,p-S,T-ORC1 [cytosol] (R-DME-9032195) phospho-PolyUb,p-S,T-ORC1 [nucleoplasm] (R-DME-9032189) phospho-p-S,T-ORC1 [nucleoplasm] (R-DME-68943) ORC1 [cytosol] (R-DME-113840) ORC1 [nucleoplasm] (R-DME-68522)	0.61	4
UniProt:Q7K2L1	1	Orc3 [nucleoplasm] (R-DME-68513)	0.609	2

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