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RPA heterotrimer [nucleoplasm]
Stable Identifier
R-DME-68462
Type
Complex
Species
Drosophila melanogaster
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
Cell Cycle (Drosophila melanogaster)
Cell Cycle Checkpoints (Drosophila melanogaster)
G2/M Checkpoints (Drosophila melanogaster)
Activation of ATR in response to replication stress (Drosophila melanogaster)
Binding of ATR-ATRIP to the RPA-ssDNA complex (Drosophila melanogaster)
ATR:ATRIP:RPA:ssDNA signaling complex [nucleoplasm] (Drosophila melanogaster)
RPA complexed to ssDNA [nucleoplasm] (Drosophila melanogaster)
RPA heterotrimer [nucleoplasm] (Drosophila melanogaster)
RPA complexed to ssDNA [nucleoplasm] (Drosophila melanogaster)
RPA heterotrimer [nucleoplasm] (Drosophila melanogaster)
Recruitment of Rad17-RFC complex to DNA (Drosophila melanogaster)
RPA complexed to ssDNA [nucleoplasm] (Drosophila melanogaster)
RPA heterotrimer [nucleoplasm] (Drosophila melanogaster)
Rad17-RFC complex bound to DNA [nucleoplasm] (Drosophila melanogaster)
RPA complexed to ssDNA [nucleoplasm] (Drosophila melanogaster)
RPA heterotrimer [nucleoplasm] (Drosophila melanogaster)
Recruitment of the Rad9-Hus1-Rad1 complex to DNA (Drosophila melanogaster)
Rad17-RFC complex bound to DNA [nucleoplasm] (Drosophila melanogaster)
RPA complexed to ssDNA [nucleoplasm] (Drosophila melanogaster)
RPA heterotrimer [nucleoplasm] (Drosophila melanogaster)
Rad9-Hus1-Rad1 bound to DNA [nucleoplasm] (Drosophila melanogaster)
Rad17-RFC complex bound to DNA [nucleoplasm] (Drosophila melanogaster)
RPA complexed to ssDNA [nucleoplasm] (Drosophila melanogaster)
RPA heterotrimer [nucleoplasm] (Drosophila melanogaster)
Stalling of DNA replication fork and RPA binding (Drosophila melanogaster)
RPA complexed to ssDNA [nucleoplasm] (Drosophila melanogaster)
RPA heterotrimer [nucleoplasm] (Drosophila melanogaster)
RPA heterotrimer [nucleoplasm] (Drosophila melanogaster)
G2/M DNA damage checkpoint (Drosophila melanogaster)
ATR phosphorylates TP53 (Drosophila melanogaster)
ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Drosophila melanogaster)
ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Drosophila melanogaster)
RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Drosophila melanogaster)
RPA heterotrimer [nucleoplasm] (Drosophila melanogaster)
Cell Cycle, Mitotic (Drosophila melanogaster)
S Phase (Drosophila melanogaster)
Synthesis of DNA (Drosophila melanogaster)
DNA strand elongation (Drosophila melanogaster)
Lagging Strand Synthesis (Drosophila melanogaster)
Processive synthesis on the lagging strand (Drosophila melanogaster)
Removal of the Flap Intermediate (Drosophila melanogaster)
RPA binds to the Flap (Drosophila melanogaster)
Processive complex:Okazaki fragment:Flap:RPA heterotrimer [nucleoplasm] (Drosophila melanogaster)
RPA heterotrimer [nucleoplasm] (Drosophila melanogaster)
RPA heterotrimer [nucleoplasm] (Drosophila melanogaster)
Recruitment of Dna2 endonuclease (Drosophila melanogaster)
Processive complex:Okazaki fragment:Flap:RPA heterotrimer [nucleoplasm] (Drosophila melanogaster)
RPA heterotrimer [nucleoplasm] (Drosophila melanogaster)
Processive complex:Okazaki fragment:Flap:RPA heterotrimer:dna2 [nucleoplasm] (Drosophila melanogaster)
Processive complex:Okazaki fragment:Flap:RPA heterotrimer [nucleoplasm] (Drosophila melanogaster)
RPA heterotrimer [nucleoplasm] (Drosophila melanogaster)
Removal of RNA primer and dissociation of RPA and Dna2 (Drosophila melanogaster)
Processive complex:Okazaki fragment:Flap:RPA heterotrimer:dna2 [nucleoplasm] (Drosophila melanogaster)
Processive complex:Okazaki fragment:Flap:RPA heterotrimer [nucleoplasm] (Drosophila melanogaster)
RPA heterotrimer [nucleoplasm] (Drosophila melanogaster)
RPA heterotrimer [nucleoplasm] (Drosophila melanogaster)
Cellular responses to stimuli (Drosophila melanogaster)
Cellular responses to stress (Drosophila melanogaster)
Cellular response to heat stress (Drosophila melanogaster)
Regulation of HSF1-mediated heat shock response (Drosophila melanogaster)
RPA1 binds HSF1 (Drosophila melanogaster)
HSF1:RPA [nucleoplasm] (Drosophila melanogaster)
RPA heterotrimer [nucleoplasm] (Drosophila melanogaster)
RPA heterotrimer [nucleoplasm] (Drosophila melanogaster)
DNA Repair (Drosophila melanogaster)
Base Excision Repair (Drosophila melanogaster)
Resolution of Abasic Sites (AP sites) (Drosophila melanogaster)
Resolution of AP sites via the multiple-nucleotide patch replacement pathway (Drosophila melanogaster)
PCNA-Dependent Long Patch Base Excision Repair (Drosophila melanogaster)
LIG1 binds APEX1 and PCNA at SSB (Drosophila melanogaster)
APEX1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP)-dsDNA [nucleoplasm] (Drosophila melanogaster)
PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Drosophila melanogaster)
RPA heterotrimer [nucleoplasm] (Drosophila melanogaster)
LIG1:APEX1:PCNA:POLD,POLE:RPA:RFC:SSB:(3'poly-dNMP)-dsDNA [nucleoplasm] (Drosophila melanogaster)
APEX1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP)-dsDNA [nucleoplasm] (Drosophila melanogaster)
PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Drosophila melanogaster)
RPA heterotrimer [nucleoplasm] (Drosophila melanogaster)
LIG1 bound to APEX1 and PCNA ligates SSB (Drosophila melanogaster)
LIG1:APEX1:PCNA:POLD,POLE:RPA:RFC:SSB:(3'poly-dNMP)-dsDNA [nucleoplasm] (Drosophila melanogaster)
APEX1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP)-dsDNA [nucleoplasm] (Drosophila melanogaster)
PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Drosophila melanogaster)
RPA heterotrimer [nucleoplasm] (Drosophila melanogaster)
LIG1:APEX1:PCNA:POLD,POLE:RPA:RFC:dsDNA [nucleoplasm] (Drosophila melanogaster)
PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Drosophila melanogaster)
RPA heterotrimer [nucleoplasm] (Drosophila melanogaster)
POLD,POLE-mediated DNA strand displacement synthesis (Drosophila melanogaster)
APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Drosophila melanogaster)
PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Drosophila melanogaster)
RPA heterotrimer [nucleoplasm] (Drosophila melanogaster)
APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP-displaced 5'ddRP flap)-dsDNA [nucleoplasm] (Drosophila melanogaster)
PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Drosophila melanogaster)
RPA heterotrimer [nucleoplasm] (Drosophila melanogaster)
DNA Damage Bypass (Drosophila melanogaster)
Recognition of DNA damage by PCNA-containing replication complex (Drosophila melanogaster)
RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA (Drosophila melanogaster)
MonoUb:K164-PCNA:RPA:RFC:Damaged DNA Template [nucleoplasm] (Drosophila melanogaster)
MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Drosophila melanogaster)
RPA heterotrimer [nucleoplasm] (Drosophila melanogaster)
RAD18:UBE2B,RBX1:CUL4:DDB1:DTL:PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] (Drosophila melanogaster)
PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] (Drosophila melanogaster)
PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Drosophila melanogaster)
RPA heterotrimer [nucleoplasm] (Drosophila melanogaster)
RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA (Drosophila melanogaster)
PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] (Drosophila melanogaster)
PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Drosophila melanogaster)
RPA heterotrimer [nucleoplasm] (Drosophila melanogaster)
RAD18:UBE2B,RBX1:CUL4:DDB1:DTL:PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] (Drosophila melanogaster)
PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] (Drosophila melanogaster)
PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Drosophila melanogaster)
RPA heterotrimer [nucleoplasm] (Drosophila melanogaster)
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template (Drosophila melanogaster)
Termination of translesion DNA synthesis (Drosophila melanogaster)
POLD,POLE binds deISGylated PCNA after TLS (Drosophila melanogaster)
PCNA:POLD,POLE:RPA:RFC:TLS-DNA Template [nucleoplasm] (Drosophila melanogaster)
PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm] (Drosophila melanogaster)
RPA heterotrimer [nucleoplasm] (Drosophila melanogaster)
PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm] (Drosophila melanogaster)
RPA heterotrimer [nucleoplasm] (Drosophila melanogaster)
USP43 binds ISG:K164,ISG:K168-PCNA (Drosophila melanogaster)
ISG:K164,ISG:K168-PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm] (Drosophila melanogaster)
RPA heterotrimer [nucleoplasm] (Drosophila melanogaster)
USP43:ISG:K164,ISG:K168-PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm] (Drosophila melanogaster)
ISG:K164,ISG:K168-PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm] (Drosophila melanogaster)
RPA heterotrimer [nucleoplasm] (Drosophila melanogaster)
USP43 deISGylates ISG:K164,ISG:K168-PCNA (Drosophila melanogaster)
PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm] (Drosophila melanogaster)
RPA heterotrimer [nucleoplasm] (Drosophila melanogaster)
USP43:ISG:K164,ISG:K168-PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm] (Drosophila melanogaster)
ISG:K164,ISG:K168-PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm] (Drosophila melanogaster)
RPA heterotrimer [nucleoplasm] (Drosophila melanogaster)
Translesion Synthesis by POLH (Drosophila melanogaster)
Elongation by POLH (Drosophila melanogaster)
POLH:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA)-DNA Template [nucleoplasm] (Drosophila melanogaster)
MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA)-DNA Template [nucleoplasm] (Drosophila melanogaster)
RPA heterotrimer [nucleoplasm] (Drosophila melanogaster)
POLH:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-DNA Template [nucleoplasm] (Drosophila melanogaster)
MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Drosophila melanogaster)
RPA heterotrimer [nucleoplasm] (Drosophila melanogaster)
Insertion of correct bases opposite the lesion by POLH (Drosophila melanogaster)
POLH:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA)-DNA Template [nucleoplasm] (Drosophila melanogaster)
MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA)-DNA Template [nucleoplasm] (Drosophila melanogaster)
RPA heterotrimer [nucleoplasm] (Drosophila melanogaster)
POLH:MonoUb:K164-PCNA:RPA:RFC:TT-CPD-DNA Template [nucleoplasm] (Drosophila melanogaster)
MonoUb:K164-PCNA:RPA:RFC:TT-CPD-DNA Template [nucleoplasm] (Drosophila melanogaster)
MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Drosophila melanogaster)
RPA heterotrimer [nucleoplasm] (Drosophila melanogaster)
POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template (Drosophila melanogaster)
MonoUb:K164-PCNA:RPA:RFC:TT-CPD-DNA Template [nucleoplasm] (Drosophila melanogaster)
MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Drosophila melanogaster)
RPA heterotrimer [nucleoplasm] (Drosophila melanogaster)
POLH:MonoUb:K164-PCNA:RPA:RFC:TT-CPD-DNA Template [nucleoplasm] (Drosophila melanogaster)
MonoUb:K164-PCNA:RPA:RFC:TT-CPD-DNA Template [nucleoplasm] (Drosophila melanogaster)
MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Drosophila melanogaster)
RPA heterotrimer [nucleoplasm] (Drosophila melanogaster)
SPRTN binds monoUb:K164-PCNA associated with POLH (Drosophila melanogaster)
POLH:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-DNA Template [nucleoplasm] (Drosophila melanogaster)
MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Drosophila melanogaster)
RPA heterotrimer [nucleoplasm] (Drosophila melanogaster)
SPRTN:POLH:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-DNA Template [nucleoplasm] (Drosophila melanogaster)
POLH:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-DNA Template [nucleoplasm] (Drosophila melanogaster)
MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Drosophila melanogaster)
RPA heterotrimer [nucleoplasm] (Drosophila melanogaster)
SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH (Drosophila melanogaster)
NPLOC4:UFD1L:VCP:SPRTN:POLH:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-DNA Template [nucleoplasm] (Drosophila melanogaster)
SPRTN:POLH:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-DNA Template [nucleoplasm] (Drosophila melanogaster)
POLH:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-DNA Template [nucleoplasm] (Drosophila melanogaster)
MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Drosophila melanogaster)
RPA heterotrimer [nucleoplasm] (Drosophila melanogaster)
SPRTN:POLH:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-DNA Template [nucleoplasm] (Drosophila melanogaster)
POLH:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-DNA Template [nucleoplasm] (Drosophila melanogaster)
MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Drosophila melanogaster)
RPA heterotrimer [nucleoplasm] (Drosophila melanogaster)
SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA (Drosophila melanogaster)
NPLOC4:UFD1L:VCP:SPRTN:POLH:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-DNA Template [nucleoplasm] (Drosophila melanogaster)
SPRTN:POLH:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-DNA Template [nucleoplasm] (Drosophila melanogaster)
POLH:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-DNA Template [nucleoplasm] (Drosophila melanogaster)
MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Drosophila melanogaster)
RPA heterotrimer [nucleoplasm] (Drosophila melanogaster)
NPLOC4:UFD1L:VPC:SPRTN:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-Template DNA [nucleoplasm] (Drosophila melanogaster)
MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Drosophila melanogaster)
RPA heterotrimer [nucleoplasm] (Drosophila melanogaster)
Translesion synthesis by POLI (Drosophila melanogaster)
POLI incorporates dNMP opposite to damaged DNA base (Drosophila melanogaster)
POLI:REV1:POLZ:MonoUb:K164-PCNA:RPA:RFC:(EtAD:T)-DNA Template,(Gamma-HOPdG:C)-DNA Template [nucleoplasm] (Drosophila melanogaster)
MonoUb:K164-PCNA:RPA:RFC:(EtAD:T)-DNA Template,(Gamma-HOPdG:C)-DNA Template [nucleoplasm] (Drosophila melanogaster)
MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Drosophila melanogaster)
RPA heterotrimer [nucleoplasm] (Drosophila melanogaster)
POLI:REV1:POLZ:MonoUb:K164-PCNA:RPA:RFC:EtAD-DNA Template,Gamma-HOPdG-DNA Template [nucleoplasm] (Drosophila melanogaster)
MonoUb:K164-PCNA:RPA:RFC:EtAD-DNA Template,Gamma-HOPdG-DNA Template [nucleoplasm] (Drosophila melanogaster)
MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Drosophila melanogaster)
RPA heterotrimer [nucleoplasm] (Drosophila melanogaster)
POLI simultaneously binds REV1 and monoUb:K164-PCNA at damaged DNA (Drosophila melanogaster)
MonoUb:K164-PCNA:RPA:RFC:EtAD-DNA Template,Gamma-HOPdG-DNA Template [nucleoplasm] (Drosophila melanogaster)
MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Drosophila melanogaster)
RPA heterotrimer [nucleoplasm] (Drosophila melanogaster)
POLI:REV1:POLZ:MonoUb:K164-PCNA:RPA:RFC:EtAD-DNA Template,Gamma-HOPdG-DNA Template [nucleoplasm] (Drosophila melanogaster)
MonoUb:K164-PCNA:RPA:RFC:EtAD-DNA Template,Gamma-HOPdG-DNA Template [nucleoplasm] (Drosophila melanogaster)
MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Drosophila melanogaster)
RPA heterotrimer [nucleoplasm] (Drosophila melanogaster)
POLZ elongates POLI-incorporated dNMP (Drosophila melanogaster)
POLI:MonoUb:K164-PCNA:RPA:RFC:(EtAD:T-mispaireddNMPs)-DNA Template,(Gamma-HOPdG:C-mispaireddNMPs)-DNA Template [nucleoplasm] (Drosophila melanogaster)
MonoUb:K164-PCNA:RPA:RFC:(EtAD:T-mispaireddNMPs)-DNA Template,(Gamma-HOPdG:C-mispaireddNMPs)-DNA Template [nucleoplasm] (Drosophila melanogaster)
MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Drosophila melanogaster)
RPA heterotrimer [nucleoplasm] (Drosophila melanogaster)
POLI:REV1:POLZ:MonoUb:K164-PCNA:RPA:RFC:(EtAD:T)-DNA Template,(Gamma-HOPdG:C)-DNA Template [nucleoplasm] (Drosophila melanogaster)
MonoUb:K164-PCNA:RPA:RFC:(EtAD:T)-DNA Template,(Gamma-HOPdG:C)-DNA Template [nucleoplasm] (Drosophila melanogaster)
MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Drosophila melanogaster)
RPA heterotrimer [nucleoplasm] (Drosophila melanogaster)
Translesion synthesis by POLK (Drosophila melanogaster)
POLK and POLZ cooperate in elongation of mispaired primer termini (Drosophila melanogaster)
POLK:MonoUb:K164-PCNA:RPA:RFC:(Tg:A-mispaireddNMPs)-DNA Template,(OGUA:A-mispaireddNMPs)-DNA Template,(BPDE-G:C-mispaireddNMPs)-DNA Template [nucleoplasm] (Drosophila melanogaster)
MonoUb:K164-PCNA:RPA:RFC:(Tg:A-mispaireddNMPs)-DNA Template,(OGUA:A-mispaireddNMPs)-DNA Template,(BPDE-G:C-mispaireddNMPs)-DNA Template [nucleoplasm] (Drosophila melanogaster)
MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Drosophila melanogaster)
RPA heterotrimer [nucleoplasm] (Drosophila melanogaster)
POLK:REV1:POLZ:MonoUb:K164-PCNA:RPA:RFC:(Tg:A)-DNA Template,(OGUA:A)-DNA Template,(BPDE-G:C)-DNA Template [nucleoplasm] (Drosophila melanogaster)
MonoUb:K164-PCNA:RPA:RFC:(Tg:A)-DNA Template,(OGUA:A)-DNA Template,(BPDE-G:C)-DNA Template [nucleoplasm] (Drosophila melanogaster)
MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Drosophila melanogaster)
RPA heterotrimer [nucleoplasm] (Drosophila melanogaster)
POLK incorporates dNMP opposite to damaged DNA base (Drosophila melanogaster)
POLK:REV1:POLZ:MonoUb:K164-PCNA:RPA:RFC:(Tg:A)-DNA Template,(OGUA:A)-DNA Template,(BPDE-G:C)-DNA Template [nucleoplasm] (Drosophila melanogaster)
MonoUb:K164-PCNA:RPA:RFC:(Tg:A)-DNA Template,(OGUA:A)-DNA Template,(BPDE-G:C)-DNA Template [nucleoplasm] (Drosophila melanogaster)
MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Drosophila melanogaster)
RPA heterotrimer [nucleoplasm] (Drosophila melanogaster)
POLK:REV1:POLZ:MonoUb:K164-PCNA:RPA:RFC:Tg-DNA Template,OGUA-DNA Template,BPDE-G-DNA Template [nucleoplasm] (Drosophila melanogaster)
MonoUb:K164-PCNA:RPA:RFC:Tg-DNA Template,OGUA-DNA Template,BPDE-G-DNA Template [nucleoplasm] (Drosophila melanogaster)
MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Drosophila melanogaster)
RPA heterotrimer [nucleoplasm] (Drosophila melanogaster)
Translesion synthesis by REV1 (Drosophila melanogaster)
POLZ extends translesion synthesis (Drosophila melanogaster)
POLZ:REV1:MonoUb:K164-PCNA:RPA:RFC:(AP:Cyt)-DNA Template [nucleoplasm] (Drosophila melanogaster)
REV1:MonoUb:K164-PCNA:RPA:RFC:(AP:Cyt)-DNA Template [nucleoplasm] (Drosophila melanogaster)
MonoUb:K164-PCNA:RPA:RFC:(AP:Cyt)-dsDNA [nucleoplasm] (Drosophila melanogaster)
MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Drosophila melanogaster)
RPA heterotrimer [nucleoplasm] (Drosophila melanogaster)
REV1:MonoUb:K164-PCNA:RPA:RFC:(AP:Cyt-mispairedPolydNMP)-DNA Template [nucleoplasm] (Drosophila melanogaster)
MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Drosophila melanogaster)
RPA heterotrimer [nucleoplasm] (Drosophila melanogaster)
REV1 binds AP-dsDNA (Drosophila melanogaster)
MonoUb:K164-PCNA:RPA:RFC:AP-DNA Template [nucleoplasm] (Drosophila melanogaster)
MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Drosophila melanogaster)
RPA heterotrimer [nucleoplasm] (Drosophila melanogaster)
REV1:MonoUb:K164-PCNA:RPA:RFC:AP-DNA Template [nucleoplasm] (Drosophila melanogaster)
MonoUb:K164-PCNA:RPA:RFC:AP-DNA Template [nucleoplasm] (Drosophila melanogaster)
MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Drosophila melanogaster)
RPA heterotrimer [nucleoplasm] (Drosophila melanogaster)
REV1 inserts dCMP opposite to AP sites in DNA (Drosophila melanogaster)
REV1:MonoUb:K164-PCNA:RPA:RFC:(AP:Cyt)-DNA Template [nucleoplasm] (Drosophila melanogaster)
MonoUb:K164-PCNA:RPA:RFC:(AP:Cyt)-dsDNA [nucleoplasm] (Drosophila melanogaster)
MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Drosophila melanogaster)
RPA heterotrimer [nucleoplasm] (Drosophila melanogaster)
REV1:MonoUb:K164-PCNA:RPA:RFC:AP-DNA Template [nucleoplasm] (Drosophila melanogaster)
MonoUb:K164-PCNA:RPA:RFC:AP-DNA Template [nucleoplasm] (Drosophila melanogaster)
MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Drosophila melanogaster)
RPA heterotrimer [nucleoplasm] (Drosophila melanogaster)
REV1 recruits POLZ to (AP:Cyt)-DNA Template (Drosophila melanogaster)
POLZ:REV1:MonoUb:K164-PCNA:RPA:RFC:(AP:Cyt)-DNA Template [nucleoplasm] (Drosophila melanogaster)
REV1:MonoUb:K164-PCNA:RPA:RFC:(AP:Cyt)-DNA Template [nucleoplasm] (Drosophila melanogaster)
MonoUb:K164-PCNA:RPA:RFC:(AP:Cyt)-dsDNA [nucleoplasm] (Drosophila melanogaster)
MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Drosophila melanogaster)
RPA heterotrimer [nucleoplasm] (Drosophila melanogaster)
REV1:MonoUb:K164-PCNA:RPA:RFC:(AP:Cyt)-DNA Template [nucleoplasm] (Drosophila melanogaster)
MonoUb:K164-PCNA:RPA:RFC:(AP:Cyt)-dsDNA [nucleoplasm] (Drosophila melanogaster)
MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Drosophila melanogaster)
RPA heterotrimer [nucleoplasm] (Drosophila melanogaster)
DNA Double-Strand Break Repair (Drosophila melanogaster)
Homology Directed Repair (Drosophila melanogaster)
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Drosophila melanogaster)
Processing of DNA double-strand break ends (Drosophila melanogaster)
ATR phosphorylates RPA2 (Drosophila melanogaster)
ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Drosophila melanogaster)
ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Drosophila melanogaster)
RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Drosophila melanogaster)
RPA heterotrimer [nucleoplasm] (Drosophila melanogaster)
PPP4C:PPP4R2 dephosphorylates RPA2 (Drosophila melanogaster)
RPA heterotrimer [nucleoplasm] (Drosophila melanogaster)
Mismatch Repair (Drosophila melanogaster)
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) (Drosophila melanogaster)
EXO1 interacting with MSH2:MSH6 excises single strand DNA containing a mismatch (Drosophila melanogaster)
RPA heterotrimer [nucleoplasm] (Drosophila melanogaster)
RPA:DNA containing single strand gap [nucleoplasm] (Drosophila melanogaster)
RPA heterotrimer [nucleoplasm] (Drosophila melanogaster)
Nucleotide Excision Repair (Drosophila melanogaster)
Global Genome Nucleotide Excision Repair (GG-NER) (Drosophila melanogaster)
Dual Incision in GG-NER (Drosophila melanogaster)
5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Drosophila melanogaster)
GG-NER incision complex:5'-incised damaged DNA [nucleoplasm] (Drosophila melanogaster)
RPA heterotrimer [nucleoplasm] (Drosophila melanogaster)
GG-NER incision complex:Open bubble dsDNA [nucleoplasm] (Drosophila melanogaster)
GG-NER pre-incision complex:Open bubble-dsDNA [nucleoplasm] (Drosophila melanogaster)
RPA heterotrimer [nucleoplasm] (Drosophila melanogaster)
DNA polymerases delta, epsilon or kappa bind the GG-NER site (Drosophila melanogaster)
GG-NER incision complex:5'-incised damaged DNA [nucleoplasm] (Drosophila melanogaster)
RPA heterotrimer [nucleoplasm] (Drosophila melanogaster)
GG-NER incision complex:5'-incised damaged DNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Drosophila melanogaster)
(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Drosophila melanogaster)
RPA heterotrimer [nucleoplasm] (Drosophila melanogaster)
Formation of Incision Complex in GG-NER (Drosophila melanogaster)
Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER (Drosophila melanogaster)
GG-NER incision complex:Open bubble dsDNA [nucleoplasm] (Drosophila melanogaster)
GG-NER pre-incision complex:Open bubble-dsDNA [nucleoplasm] (Drosophila melanogaster)
RPA heterotrimer [nucleoplasm] (Drosophila melanogaster)
GG-NER pre-incision complex:Open bubble-dsDNA [nucleoplasm] (Drosophila melanogaster)
RPA heterotrimer [nucleoplasm] (Drosophila melanogaster)
Gap-filling DNA repair synthesis and ligation in GG-NER (Drosophila melanogaster)
Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER (Drosophila melanogaster)
(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC:Incised DNA without lesion [nucleoplasm] (Drosophila melanogaster)
(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Drosophila melanogaster)
RPA heterotrimer [nucleoplasm] (Drosophila melanogaster)
(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC:SSB-dsDNA [nucleoplasm] (Drosophila melanogaster)
(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Drosophila melanogaster)
RPA heterotrimer [nucleoplasm] (Drosophila melanogaster)
Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Drosophila melanogaster)
Dual incision in TC-NER (Drosophila melanogaster)
5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Drosophila melanogaster)
TC-NER incision complex [nucleoplasm] (Drosophila melanogaster)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Drosophila melanogaster)
RPA heterotrimer [nucleoplasm] (Drosophila melanogaster)
TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Drosophila melanogaster)
RPA heterotrimer [nucleoplasm] (Drosophila melanogaster)
Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Drosophila melanogaster)
TC-NER incision complex [nucleoplasm] (Drosophila melanogaster)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Drosophila melanogaster)
RPA heterotrimer [nucleoplasm] (Drosophila melanogaster)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Drosophila melanogaster)
RPA heterotrimer [nucleoplasm] (Drosophila melanogaster)
DNA polymerases delta, epsilon or kappa bind the TC-NER site (Drosophila melanogaster)
TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Drosophila melanogaster)
(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Drosophila melanogaster)
RPA heterotrimer [nucleoplasm] (Drosophila melanogaster)
TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Drosophila melanogaster)
RPA heterotrimer [nucleoplasm] (Drosophila melanogaster)
Gap-filling DNA repair synthesis and ligation in TC-NER (Drosophila melanogaster)
Ligation of newly synthesized repair patch to incised DNA in TC-NER (Drosophila melanogaster)
(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Drosophila melanogaster)
RPA heterotrimer [nucleoplasm] (Drosophila melanogaster)
TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Drosophila melanogaster)
(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Drosophila melanogaster)
RPA heterotrimer [nucleoplasm] (Drosophila melanogaster)
Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Drosophila melanogaster)
TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Drosophila melanogaster)
(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Drosophila melanogaster)
RPA heterotrimer [nucleoplasm] (Drosophila melanogaster)
TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Drosophila melanogaster)
(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Drosophila melanogaster)
RPA heterotrimer [nucleoplasm] (Drosophila melanogaster)
DNA Replication (Drosophila melanogaster)
Synthesis of DNA (Drosophila melanogaster)
DNA strand elongation (Drosophila melanogaster)
Lagging Strand Synthesis (Drosophila melanogaster)
Processive synthesis on the lagging strand (Drosophila melanogaster)
Removal of the Flap Intermediate (Drosophila melanogaster)
RPA binds to the Flap (Drosophila melanogaster)
Processive complex:Okazaki fragment:Flap:RPA heterotrimer [nucleoplasm] (Drosophila melanogaster)
RPA heterotrimer [nucleoplasm] (Drosophila melanogaster)
RPA heterotrimer [nucleoplasm] (Drosophila melanogaster)
Recruitment of Dna2 endonuclease (Drosophila melanogaster)
Processive complex:Okazaki fragment:Flap:RPA heterotrimer [nucleoplasm] (Drosophila melanogaster)
RPA heterotrimer [nucleoplasm] (Drosophila melanogaster)
Processive complex:Okazaki fragment:Flap:RPA heterotrimer:dna2 [nucleoplasm] (Drosophila melanogaster)
Processive complex:Okazaki fragment:Flap:RPA heterotrimer [nucleoplasm] (Drosophila melanogaster)
RPA heterotrimer [nucleoplasm] (Drosophila melanogaster)
Removal of RNA primer and dissociation of RPA and Dna2 (Drosophila melanogaster)
Processive complex:Okazaki fragment:Flap:RPA heterotrimer:dna2 [nucleoplasm] (Drosophila melanogaster)
Processive complex:Okazaki fragment:Flap:RPA heterotrimer [nucleoplasm] (Drosophila melanogaster)
RPA heterotrimer [nucleoplasm] (Drosophila melanogaster)
RPA heterotrimer [nucleoplasm] (Drosophila melanogaster)
Gene expression (Transcription) (Drosophila melanogaster)
RNA Polymerase II Transcription (Drosophila melanogaster)
Generic Transcription Pathway (Drosophila melanogaster)
Transcriptional Regulation by TP53 (Drosophila melanogaster)
Regulation of TP53 Activity (Drosophila melanogaster)
Regulation of TP53 Activity through Phosphorylation (Drosophila melanogaster)
ATR phosphorylates TP53 (Drosophila melanogaster)
ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Drosophila melanogaster)
ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Drosophila melanogaster)
RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Drosophila melanogaster)
RPA heterotrimer [nucleoplasm] (Drosophila melanogaster)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
RPA1 [nucleoplasm]
(Drosophila melanogaster)
RPA2 [nucleoplasm]
(Drosophila melanogaster)
RPA3 [nucleoplasm]
(Drosophila melanogaster)
Participates
as a component of
PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm] (Drosophila melanogaster)
ISG:K164,ISG:K168-PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm] (Drosophila melanogaster)
DNA polymerase Y:MonoUb:K164,ISG:K164,ISG:K168-PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm] (Drosophila melanogaster)
MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA)-DNA Template [nucleoplasm] (Drosophila melanogaster)
HSF1:RPA [nucleoplasm] (Drosophila melanogaster)
TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Drosophila melanogaster)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Drosophila melanogaster)
(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Drosophila melanogaster)
GG-NER incision complex:5'-incised damaged DNA [nucleoplasm] (Drosophila melanogaster)
GG-NER pre-incision complex:Open bubble-dsDNA [nucleoplasm] (Drosophila melanogaster)
RPA:DNA containing single strand gap [nucleoplasm] (Drosophila melanogaster)
Processive complex:Okazaki fragment:Flap:RPA heterotrimer [nucleoplasm] (Drosophila melanogaster)
RPA complexed to ssDNA [nucleoplasm] (Drosophila melanogaster)
MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Drosophila melanogaster)
PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Drosophila melanogaster)
RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Drosophila melanogaster)
as an input of
RPA1 binds HSF1 (Drosophila melanogaster)
EXO1 interacting with MSH2:MSH6 excises single strand DNA containing a mismatch (Drosophila melanogaster)
RPA binds to the Flap (Drosophila melanogaster)
Stalling of DNA replication fork and RPA binding (Drosophila melanogaster)
as an output of
Removal of RNA primer and dissociation of RPA and Dna2 (Drosophila melanogaster)
PPP4C:PPP4R2 dephosphorylates RPA2 (Drosophila melanogaster)
Inferred From
RPA heterotrimer [nucleoplasm]
(Homo sapiens)
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