Reactome | Gbeta13F [cytosol]

Gbeta13F [cytosol]

Stable Identifier

R-DME-6814414

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

cytosol

Synonyms

GNB3, P26308

Locations in the PathwayBrowser

Expand all

Hemostasis (Drosophila melanogaster)

- Platelet activation, signaling and aggregation (Drosophila melanogaster)
  - Signal amplification (Drosophila melanogaster)
    - Thromboxane signalling through TP receptor (Drosophila melanogaster)
      - G13 activation by TP receptor (Drosophila melanogaster)
        
        TP receptor:Thromboxane A2:G-protein G13 (active) [plasma membrane] (Drosophila melanogaster)
        
        Heterotrimeric G-protein G13 (active) [plasma membrane] (Drosophila melanogaster)
        
        G-protein beta-gamma complex [plasma membrane] (Drosophila melanogaster)
        
        G-protein beta subunit [cytosol] (Drosophila melanogaster)
        
        Homologues of GNB3 [cytosol] (Drosophila melanogaster)
        
        Gbeta13F [cytosol] (Drosophila melanogaster)
        
        TP receptor:Thromboxane A2:G-protein G13 (inactive) [plasma membrane] (Drosophila melanogaster)
        
        Heterotrimeric G-protein G13 (inactive) [plasma membrane] (Drosophila melanogaster)
        
        G-protein beta-gamma complex [plasma membrane] (Drosophila melanogaster)
        
        G-protein beta subunit [cytosol] (Drosophila melanogaster)
        
        Homologues of GNB3 [cytosol] (Drosophila melanogaster)
        
        Gbeta13F [cytosol] (Drosophila melanogaster)
      - Gq activation by TP receptor (Drosophila melanogaster)
        
        TP receptor:Thromboxane A2:G-protein Gq (active) [plasma membrane] (Drosophila melanogaster)
        
        Heterotrimeric G-protein Gq (active) [plasma membrane] (Drosophila melanogaster)
        
        G-protein beta-gamma complex [plasma membrane] (Drosophila melanogaster)
        
        G-protein beta subunit [cytosol] (Drosophila melanogaster)
        
        Homologues of GNB3 [cytosol] (Drosophila melanogaster)
        
        Gbeta13F [cytosol] (Drosophila melanogaster)
        
        TP receptor:Thromboxane A2:G-protein Gq (inactive) [plasma membrane] (Drosophila melanogaster)
        
        Heterotrimeric G-protein Gq/11 (inactive) [plasma membrane] (Drosophila melanogaster)
        
        G-protein beta-gamma complex [plasma membrane] (Drosophila melanogaster)
        
        G-protein beta subunit [cytosol] (Drosophila melanogaster)
        
        Homologues of GNB3 [cytosol] (Drosophila melanogaster)
        
        Gbeta13F [cytosol] (Drosophila melanogaster)

Metabolism of proteins (Drosophila melanogaster)

- Protein folding (Drosophila melanogaster)
  - Chaperonin-mediated protein folding (Drosophila melanogaster)
    - Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding (Drosophila melanogaster)
      - ATP binds G-protein beta associated TRiC/CCT (Drosophila melanogaster)
        
        Unfolded G-protein beta subunit:CCT/TRiC:ADP [cytosol] (Drosophila melanogaster)
        
        Unfolded G-protein beta subunit [cytosol] (Drosophila melanogaster)
        
        Homologues of GNB3 [cytosol] (Drosophila melanogaster)
        
        Gbeta13F [cytosol] (Drosophila melanogaster)
        
        Unfolded G-protein beta subunit:CCT/TRiC:ATP [cytosol] (Drosophila melanogaster)
        
        Unfolded G-protein beta subunit [cytosol] (Drosophila melanogaster)
        
        Homologues of GNB3 [cytosol] (Drosophila melanogaster)
        
        Gbeta13F [cytosol] (Drosophila melanogaster)
      - ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT (Drosophila melanogaster)
        
        Unfolded G-protein beta subunit:CCT/TRiC:ADP [cytosol] (Drosophila melanogaster)
        
        Unfolded G-protein beta subunit [cytosol] (Drosophila melanogaster)
        
        Homologues of GNB3 [cytosol] (Drosophila melanogaster)
        
        Gbeta13F [cytosol] (Drosophila melanogaster)
        
        Unfolded G-protein beta subunit:CCT/TRiC:ATP [cytosol] (Drosophila melanogaster)
        
        Unfolded G-protein beta subunit [cytosol] (Drosophila melanogaster)
        
        Homologues of GNB3 [cytosol] (Drosophila melanogaster)
        
        Gbeta13F [cytosol] (Drosophila melanogaster)
      - PDCL binds G-protein beta and TRiC/CCT (Drosophila melanogaster)
        
        Unfolded G-protein beta subunit:CCT/TRiC:ADP [cytosol] (Drosophila melanogaster)
        
        Unfolded G-protein beta subunit [cytosol] (Drosophila melanogaster)
        
        Homologues of GNB3 [cytosol] (Drosophila melanogaster)
        
        Gbeta13F [cytosol] (Drosophila melanogaster)
        
        p-S18,S19,S20,S25-PDCL:Partially folded G-protein beta subunit:CCT/TRiC:ADP [cytosol] (Drosophila melanogaster)
        
        Unfolded G-protein beta subunit:CCT/TRiC:ADP [cytosol] (Drosophila melanogaster)
        
        Unfolded G-protein beta subunit [cytosol] (Drosophila melanogaster)
        
        Homologues of GNB3 [cytosol] (Drosophila melanogaster)
        
        Gbeta13F [cytosol] (Drosophila melanogaster)
      - PDCL releases folded G-beta from TRiC/CCT (Drosophila melanogaster)
        
        p-S18,S19,S20,S25-PDCL:G-protein beta 1-4 subunit [cytosol] (Drosophila melanogaster)
        
        G-protein beta 1-4 subunit [cytosol] (Drosophila melanogaster)
        
        Homologues of GNB3 [cytosol] (Drosophila melanogaster)
        
        Gbeta13F [cytosol] (Drosophila melanogaster)
        
        p-S18,S19,S20,S25-PDCL:Partially folded G-protein beta 1-4:CCT/TRiC:ADP [cytosol] (Drosophila melanogaster)
        
        Partially folded G-protein beta 1-4:CCT/TRiC:ADP [cytosol] (Drosophila melanogaster)
        
        G-protein beta 1-4 subunit [cytosol] (Drosophila melanogaster)
        
        Homologues of GNB3 [cytosol] (Drosophila melanogaster)
        
        Gbeta13F [cytosol] (Drosophila melanogaster)
      - TRiC/CCT binds unfolded G-protein beta subunit (Drosophila melanogaster)
        
        Unfolded G-protein beta subunit [cytosol] (Drosophila melanogaster)
        
        Homologues of GNB3 [cytosol] (Drosophila melanogaster)
        
        Gbeta13F [cytosol] (Drosophila melanogaster)
        
        Unfolded G-protein beta subunit:CCT/TRiC:ADP [cytosol] (Drosophila melanogaster)
        
        Unfolded G-protein beta subunit [cytosol] (Drosophila melanogaster)
        
        Homologues of GNB3 [cytosol] (Drosophila melanogaster)
        
        Gbeta13F [cytosol] (Drosophila melanogaster)

Neuronal System (Drosophila melanogaster)

- Potassium Channels (Drosophila melanogaster)
  - Inwardly rectifying K+ channels (Drosophila melanogaster)
    - G protein gated Potassium channels (Drosophila melanogaster)
      - Activation of G protein gated Potassium channels (Drosophila melanogaster)
        
        Activation of GIRK/Kir3 Channels (Drosophila melanogaster)
        
        GABA B receptor G-protein beta-gamma and Kir3 channel complex [plasma membrane] (Drosophila melanogaster)
        
        GABA B receptor G-protein beta-gamma complex [plasma membrane] (Drosophila melanogaster)
        
        G-protein beta-gamma complex [plasma membrane] (Drosophila melanogaster)
        
        G-protein beta subunit [cytosol] (Drosophila melanogaster)
        
        Homologues of GNB3 [cytosol] (Drosophila melanogaster)
        
        Gbeta13F [cytosol] (Drosophila melanogaster)
        
        Binding of Gbeta/gamma to GIRK/Kir3 channels (Drosophila melanogaster)
        
        GABA B receptor G-protein beta-gamma and Kir3 channel complex [plasma membrane] (Drosophila melanogaster)
        
        GABA B receptor G-protein beta-gamma complex [plasma membrane] (Drosophila melanogaster)
        
        G-protein beta-gamma complex [plasma membrane] (Drosophila melanogaster)
        
        G-protein beta subunit [cytosol] (Drosophila melanogaster)
        
        Homologues of GNB3 [cytosol] (Drosophila melanogaster)
        
        Gbeta13F [cytosol] (Drosophila melanogaster)
        
        GABA B receptor G-protein beta-gamma complex [plasma membrane] (Drosophila melanogaster)
        
        G-protein beta-gamma complex [plasma membrane] (Drosophila melanogaster)
        
        G-protein beta subunit [cytosol] (Drosophila melanogaster)
        
        Homologues of GNB3 [cytosol] (Drosophila melanogaster)
        
        Gbeta13F [cytosol] (Drosophila melanogaster)
- Transmission across Chemical Synapses (Drosophila melanogaster)
  - Neurotransmitter receptors and postsynaptic signal transmission (Drosophila melanogaster)
    - GABA receptor activation (Drosophila melanogaster)
      - GABA B receptor activation (Drosophila melanogaster)
        
        Activation of GABAB receptors (Drosophila melanogaster)
        
        Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits (Drosophila melanogaster)
        
        Activation of GIRK/Kir3 Channels (Drosophila melanogaster)
        
        GABA B receptor G-protein beta-gamma and Kir3 channel complex [plasma membrane] (Drosophila melanogaster)
        
        GABA B receptor G-protein beta-gamma complex [plasma membrane] (Drosophila melanogaster)
        
        G-protein beta-gamma complex [plasma membrane] (Drosophila melanogaster)
        
        G-protein beta subunit [cytosol] (Drosophila melanogaster)
        
        Homologues of GNB3 [cytosol] (Drosophila melanogaster)
        
        Gbeta13F [cytosol] (Drosophila melanogaster)
        
        Binding of Gbeta/gamma to GIRK/Kir3 channels (Drosophila melanogaster)
        
        GABA B receptor G-protein beta-gamma and Kir3 channel complex [plasma membrane] (Drosophila melanogaster)
        
        GABA B receptor G-protein beta-gamma complex [plasma membrane] (Drosophila melanogaster)
        
        G-protein beta-gamma complex [plasma membrane] (Drosophila melanogaster)
        
        G-protein beta subunit [cytosol] (Drosophila melanogaster)
        
        Homologues of GNB3 [cytosol] (Drosophila melanogaster)
        
        Gbeta13F [cytosol] (Drosophila melanogaster)
        
        GABA B receptor G-protein beta-gamma complex [plasma membrane] (Drosophila melanogaster)
        
        G-protein beta-gamma complex [plasma membrane] (Drosophila melanogaster)
        
        G-protein beta subunit [cytosol] (Drosophila melanogaster)
        
        Homologues of GNB3 [cytosol] (Drosophila melanogaster)
        
        Gbeta13F [cytosol] (Drosophila melanogaster)

Signal Transduction (Drosophila melanogaster)

- Signaling by GPCR (Drosophila melanogaster)
  - GPCR downstream signalling (Drosophila melanogaster)
    - G alpha (i) signalling events (Drosophila melanogaster)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Drosophila melanogaster)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Drosophila melanogaster)
        
        Heterotrimeric G-protein Gi (active) [plasma membrane] (Drosophila melanogaster)
        
        G-protein beta-gamma complex [plasma membrane] (Drosophila melanogaster)
        
        G-protein beta subunit [cytosol] (Drosophila melanogaster)
        
        Homologues of GNB3 [cytosol] (Drosophila melanogaster)
        
        Gbeta13F [cytosol] (Drosophila melanogaster)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Drosophila melanogaster)
        
        Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Drosophila melanogaster)
        
        G-protein beta-gamma complex [plasma membrane] (Drosophila melanogaster)
        
        G-protein beta subunit [cytosol] (Drosophila melanogaster)
        
        Homologues of GNB3 [cytosol] (Drosophila melanogaster)
        
        Gbeta13F [cytosol] (Drosophila melanogaster)
    - G alpha (z) signalling events (Drosophila melanogaster)
      - Liganded Gz-activating GPCR acts as a GEF for Gz (Drosophila melanogaster)
        
        ADRA2A-C:Catecholamine:Heterotrimeric G-protein Gz (active) [plasma membrane] (Drosophila melanogaster)
        
        Heterotrimeric G-protein Gz (active) [plasma membrane] (Drosophila melanogaster)
        
        G-protein beta-gamma complex [plasma membrane] (Drosophila melanogaster)
        
        G-protein beta subunit [cytosol] (Drosophila melanogaster)
        
        Homologues of GNB3 [cytosol] (Drosophila melanogaster)
        
        Gbeta13F [cytosol] (Drosophila melanogaster)
        
        Ligand:GPCR complexes that activate Gz:Heterotrimeric G-protein Gz (inactive) [plasma membrane] (Drosophila melanogaster)
        
        Heterotrimeric G-protein Gz (inactive) [plasma membrane] (Drosophila melanogaster)
        
        G-protein beta-gamma complex [plasma membrane] (Drosophila melanogaster)
        
        G-protein beta subunit [cytosol] (Drosophila melanogaster)
        
        Homologues of GNB3 [cytosol] (Drosophila melanogaster)
        
        Gbeta13F [cytosol] (Drosophila melanogaster)
    - G-protein beta:gamma signalling (Drosophila melanogaster)
      - G beta:gamma signalling through CDC42 (Drosophila melanogaster)
        
        CDC42 binds GNB/GNG:PAK1:ARHGEF6 complex (Drosophila melanogaster)
        
        G-protein beta-gamma complex:Active PAK1:ARHGEF6 [plasma membrane] (Drosophila melanogaster)
        
        G-protein beta-gamma complex [plasma membrane] (Drosophila melanogaster)
        
        G-protein beta subunit [cytosol] (Drosophila melanogaster)
        
        Homologues of GNB3 [cytosol] (Drosophila melanogaster)
        
        Gbeta13F [cytosol] (Drosophila melanogaster)
        
        G-protein beta-gamma complex:PAK1:ARHGEF6:CDC42 [plasma membrane] (Drosophila melanogaster)
        
        G-protein beta-gamma complex:Active PAK1:ARHGEF6 [plasma membrane] (Drosophila melanogaster)
        
        G-protein beta-gamma complex [plasma membrane] (Drosophila melanogaster)
        
        G-protein beta subunit [cytosol] (Drosophila melanogaster)
        
        Homologues of GNB3 [cytosol] (Drosophila melanogaster)
        
        Gbeta13F [cytosol] (Drosophila melanogaster)
        
        CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated (Drosophila melanogaster)
        
        G-protein beta-gamma complex:Active PAK1:ARHGEF6:Active CDC42 [plasma membrane] (Drosophila melanogaster)
        
        G-protein beta-gamma complex:Active PAK1:ARHGEF6 [plasma membrane] (Drosophila melanogaster)
        
        G-protein beta-gamma complex [plasma membrane] (Drosophila melanogaster)
        
        G-protein beta subunit [cytosol] (Drosophila melanogaster)
        
        Homologues of GNB3 [cytosol] (Drosophila melanogaster)
        
        Gbeta13F [cytosol] (Drosophila melanogaster)
        
        G-protein beta-gamma complex:PAK1:ARHGEF6:CDC42 [plasma membrane] (Drosophila melanogaster)
        
        G-protein beta-gamma complex:Active PAK1:ARHGEF6 [plasma membrane] (Drosophila melanogaster)
        
        G-protein beta-gamma complex [plasma membrane] (Drosophila melanogaster)
        
        G-protein beta subunit [cytosol] (Drosophila melanogaster)
        
        Homologues of GNB3 [cytosol] (Drosophila melanogaster)
        
        Gbeta13F [cytosol] (Drosophila melanogaster)
        
        PAK1 in GNB/GNG:PAK1:ARHGEF6:Active CDC42 is activated (Drosophila melanogaster)
        
        G-protein beta-gamma complex:Active PAK1:ARHGEF6:Active CDC42 [plasma membrane] (Drosophila melanogaster)
        
        G-protein beta-gamma complex:Active PAK1:ARHGEF6 [plasma membrane] (Drosophila melanogaster)
        
        G-protein beta-gamma complex [plasma membrane] (Drosophila melanogaster)
        
        G-protein beta subunit [cytosol] (Drosophila melanogaster)
        
        Homologues of GNB3 [cytosol] (Drosophila melanogaster)
        
        Gbeta13F [cytosol] (Drosophila melanogaster)

External Reference Information

External Reference

UniProt:P26308

Gene Names

Gbeta13F

Reference Genes

BioGPS Gene:32544 Gbeta13F

CTD Gene:32544 Gbeta13F

ENSEMBL:FBgn0001105

FlyBase:FBgn0001105

KEGG:dme:Dmel_CG10545 Gbeta13F

Monarch:32544 Gbeta13F

NCBI Gene:32544 Gbeta13F

UCSC:P26308 Gbeta13F

Reference Transcript

Other Identifiers

143175_at

154331_at

1627398_a_at

1627915_a_at

1632667_s_at

32544

AFFX-Dros-GAPDH_3_at

AFFX-Dros-GAPDH_5_at

AFFX-Dros-GAPDH_M_at

GO:0003380

GO:0003674

GO:0005515

GO:0005737

GO:0005834

GO:0005886

GO:0007010

GO:0007155

GO:0007163

GO:0007165

GO:0007186

GO:0010470

GO:0030159

GO:0043519

GO:0045176

GO:0045879

GO:0048383

GO:0048856

GO:0055059

GO:0060027

GO:0060090

GO:0061343

Participates

as a member of

Homologues of GNB3 [cytosol] (Drosophila melanogaster)

Other forms of this molecule

Gbeta13F [cytosol]

Inferred From

Unfolded GNB3 [cytosol] (Homo sapiens)

Partially folded GNB3 [cytosol] (Homo sapiens)

GNB3 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_996459.1, NP_996460.1, NP_001303567.1, NP_525090.1, NP_996462.1, NP_996461.1

ENSEMBL

FBpp0312372, FBtr0074111, FBgn0001105, FBtr0074108, FBtr0074107, FBtr0331597, FBpp0089185, FBtr0074110, FBpp0073921, FBpp0089184, FBpp0089182, FBtr0346794, FBpp0303987

FlyBase

FBgn0001105

PRO

P26308

Cite Us!