Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
Hsc70-4 [cytosol]
Stable Identifier
R-DME-6792602
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
cytosol
Synonyms
HSPA1A, P11147
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Drosophila melanogaster)
Cellular responses to stress (Drosophila melanogaster)
Cellular response to heat stress (Drosophila melanogaster)
Regulation of HSF1-mediated heat shock response (Drosophila melanogaster)
HSP110s exchange ATP for ADP on HSP70s:ADP (Drosophila melanogaster)
HSP70s:ADP [cytosol] (Drosophila melanogaster)
HSPA1A:ADP [cytosol] (Drosophila melanogaster)
Hsc70-4 [cytosol] (Drosophila melanogaster)
HSP70s:ATP [cytosol] (Drosophila melanogaster)
HSPA1A:ATP [cytosol] (Drosophila melanogaster)
Hsc70-4 [cytosol] (Drosophila melanogaster)
HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Drosophila melanogaster)
HSP70s:ADP [cytosol] (Drosophila melanogaster)
HSPA1A:ADP [cytosol] (Drosophila melanogaster)
Hsc70-4 [cytosol] (Drosophila melanogaster)
HSP70s:ATP [cytosol] (Drosophila melanogaster)
HSPA1A:ATP [cytosol] (Drosophila melanogaster)
Hsc70-4 [cytosol] (Drosophila melanogaster)
Hikeshi binds HSP70s:ATP (Drosophila melanogaster)
HSP70s:ATP [cytosol] (Drosophila melanogaster)
HSPA1A:ATP [cytosol] (Drosophila melanogaster)
Hsc70-4 [cytosol] (Drosophila melanogaster)
Hikeshi:HSP70s:ATP [cytosol] (Drosophila melanogaster)
HSP70s:ATP [cytosol] (Drosophila melanogaster)
HSPA1A:ATP [cytosol] (Drosophila melanogaster)
Hsc70-4 [cytosol] (Drosophila melanogaster)
NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm (Drosophila melanogaster)
Hikeshi:HSP70s:ATP [cytosol] (Drosophila melanogaster)
HSP70s:ATP [cytosol] (Drosophila melanogaster)
HSPA1A:ATP [cytosol] (Drosophila melanogaster)
Hsc70-4 [cytosol] (Drosophila melanogaster)
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand (Drosophila melanogaster)
ATP binding to HSP90 triggers conformation change (Drosophila melanogaster)
HSP90:ATP:STIP1:HSP70:nascent protein [cytosol] (Drosophila melanogaster)
HSP70:ADP [cytosol] (Drosophila melanogaster)
HSP70 proteins [cytosol] (Drosophila melanogaster)
Hsc70-4 [cytosol] (Drosophila melanogaster)
HSP90:STIP1:HSP70:nascent protein [cytosol] (Drosophila melanogaster)
HSP70:ADP:nascent protein [cytosol] (Drosophila melanogaster)
HSP70:ADP [cytosol] (Drosophila melanogaster)
HSP70 proteins [cytosol] (Drosophila melanogaster)
Hsc70-4 [cytosol] (Drosophila melanogaster)
ATP hydrolysis by HSP70 (Drosophila melanogaster)
HSP40:HSP70:ADP:nascent protein [cytosol] (Drosophila melanogaster)
HSP70 proteins [cytosol] (Drosophila melanogaster)
Hsc70-4 [cytosol] (Drosophila melanogaster)
HSP40:HSP70:ATP:nascent protein [cytosol] (Drosophila melanogaster)
HSP70 proteins [cytosol] (Drosophila melanogaster)
Hsc70-4 [cytosol] (Drosophila melanogaster)
HSP70 proteins [cytosol] (Drosophila melanogaster)
Hsc70-4 [cytosol] (Drosophila melanogaster)
FKBP4 binds HSP90:ATP:STIP1:HSP70:nascent protein (Drosophila melanogaster)
HSP90:ATP:FKBP4:STIP1:HSP70:nascent protein [cytosol] (Drosophila melanogaster)
HSP90:ATP:STIP1:HSP70:nascent protein [cytosol] (Drosophila melanogaster)
HSP70:ADP [cytosol] (Drosophila melanogaster)
HSP70 proteins [cytosol] (Drosophila melanogaster)
Hsc70-4 [cytosol] (Drosophila melanogaster)
HSP90:ATP:STIP1:HSP70:nascent protein [cytosol] (Drosophila melanogaster)
HSP70:ADP [cytosol] (Drosophila melanogaster)
HSP70 proteins [cytosol] (Drosophila melanogaster)
Hsc70-4 [cytosol] (Drosophila melanogaster)
FKBP5 binds HSP90:ATP:STIP1:HSP70:nascent protein (Drosophila melanogaster)
HSP90:ATP:FKBP5:STIP1:HSP70:nascent protein [cytosol] (Drosophila melanogaster)
HSP90:ATP:STIP1:HSP70:nascent protein [cytosol] (Drosophila melanogaster)
HSP70:ADP [cytosol] (Drosophila melanogaster)
HSP70 proteins [cytosol] (Drosophila melanogaster)
Hsc70-4 [cytosol] (Drosophila melanogaster)
HSP90:ATP:STIP1:HSP70:nascent protein [cytosol] (Drosophila melanogaster)
HSP70:ADP [cytosol] (Drosophila melanogaster)
HSP70 proteins [cytosol] (Drosophila melanogaster)
Hsc70-4 [cytosol] (Drosophila melanogaster)
HSP70 binds to HSP40:nascent protein (Drosophila melanogaster)
HSP40:HSP70:ATP:nascent protein [cytosol] (Drosophila melanogaster)
HSP70 proteins [cytosol] (Drosophila melanogaster)
Hsc70-4 [cytosol] (Drosophila melanogaster)
HSP70:ATP [cytosol] (Drosophila melanogaster)
HSP70 proteins [cytosol] (Drosophila melanogaster)
Hsc70-4 [cytosol] (Drosophila melanogaster)
STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein (Drosophila melanogaster)
HSP40:HSP70:ADP:nascent protein [cytosol] (Drosophila melanogaster)
HSP70 proteins [cytosol] (Drosophila melanogaster)
Hsc70-4 [cytosol] (Drosophila melanogaster)
HSP90:STIP1:HSP70:nascent protein [cytosol] (Drosophila melanogaster)
HSP70:ADP:nascent protein [cytosol] (Drosophila melanogaster)
HSP70:ADP [cytosol] (Drosophila melanogaster)
HSP70 proteins [cytosol] (Drosophila melanogaster)
Hsc70-4 [cytosol] (Drosophila melanogaster)
p23 (PTGES3) binds HSP90:ATP:FKBP4:nascent protein (Drosophila melanogaster)
HSP70:ATP [cytosol] (Drosophila melanogaster)
HSP70 proteins [cytosol] (Drosophila melanogaster)
Hsc70-4 [cytosol] (Drosophila melanogaster)
HSP90:ATP:FKBP4:STIP1:HSP70:nascent protein [cytosol] (Drosophila melanogaster)
HSP90:ATP:STIP1:HSP70:nascent protein [cytosol] (Drosophila melanogaster)
HSP70:ADP [cytosol] (Drosophila melanogaster)
HSP70 proteins [cytosol] (Drosophila melanogaster)
Hsc70-4 [cytosol] (Drosophila melanogaster)
p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein (Drosophila melanogaster)
HSP70:ATP [cytosol] (Drosophila melanogaster)
HSP70 proteins [cytosol] (Drosophila melanogaster)
Hsc70-4 [cytosol] (Drosophila melanogaster)
HSP90:ATP:FKBP5:STIP1:HSP70:nascent protein [cytosol] (Drosophila melanogaster)
HSP90:ATP:STIP1:HSP70:nascent protein [cytosol] (Drosophila melanogaster)
HSP70:ADP [cytosol] (Drosophila melanogaster)
HSP70 proteins [cytosol] (Drosophila melanogaster)
Hsc70-4 [cytosol] (Drosophila melanogaster)
Mitochondrial unfolded protein response (UPRmt) (Drosophila melanogaster)
Oxidized DNAJA1 binds HSPA1A,B (HSP70) displacing HSF1 (Drosophila melanogaster)
HSF1:HSPA1A,B [cytosol] (Drosophila melanogaster)
Hsc70-4 [cytosol] (Drosophila melanogaster)
HSPA1A,B:ox-C149,C150-DNAJA1 [cytosol] (Drosophila melanogaster)
Hsc70-4 [cytosol] (Drosophila melanogaster)
Metabolism of RNA (Drosophila melanogaster)
Regulation of mRNA stability by proteins that bind AU-rich elements (Drosophila melanogaster)
AUF1 (hnRNP D0) binds and destabilizes mRNA (Drosophila melanogaster)
AUF1 (hnRNP D0) is ubiquitinylated (Drosophila melanogaster)
AUF1 Complexed with Translation and Heat Shock Proteins [cytosol] (Drosophila melanogaster)
Hsc70-4 [cytosol] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:P11147
Gene Names
Hsc70-4
Reference Genes
ENSEMBL:FBgn0266599
FlyBase:FBgn0266599
UCSC:P11147 Hsc70-4
Other Identifiers
143194_at
1630637_s_at
41840
GO:0000166
GO:0000398
GO:0005515
GO:0005524
GO:0005634
GO:0005737
GO:0005829
GO:0005886
GO:0006457
GO:0006914
GO:0006950
GO:0007269
GO:0007399
GO:0007411
GO:0007413
GO:0016071
GO:0016192
GO:0016787
GO:0016887
GO:0030707
GO:0031047
GO:0031072
GO:0035194
GO:0035967
GO:0042026
GO:0044183
GO:0048471
GO:0048856
GO:0051085
GO:0051087
GO:0061024
GO:0061077
GO:0061738
GO:0065003
GO:0070922
GO:0071011
GO:0071013
GO:0097753
GO:0098793
GO:0140662
Participates
as a component of
AUF1 Complexed with Translation and Heat Shock Proteins [cytosol] (Drosophila melanogaster)
HSPA1A:ADP [cytosol] (Drosophila melanogaster)
HSPA1A:ATP [cytosol] (Drosophila melanogaster)
HSPA1A,B:ox-C149,C150-DNAJA1 [cytosol] (Drosophila melanogaster)
HSF1:HSPA1A,B [cytosol] (Drosophila melanogaster)
as a member of
HSP70 proteins [cytosol] (Drosophila melanogaster)
Other forms of this molecule
Hsc70-4 [nucleoplasm]
Hsc70-4 [extracellular region]
Hsc70-4 [ficolin-1-rich granule lumen]
Hsc70-4 [cytosol]
Hsc70-4 [nucleoplasm]
Inferred From
HSPA1A,B [cytosol]
(Homo sapiens)
HSPA1A [cytosol]
(Homo sapiens)
HSPA1B [cytosol]
(Homo sapiens)
Cross References
ENSEMBL
FBgn0266599
,
FBpp0307982
,
FBpp0082518
,
FBpp0082515
,
FBpp0082519
,
FBtr0083060
,
FBtr0337053
,
FBtr0083059
,
FBtr0083058
,
FBtr0083055
,
FBpp0082516
,
FBtr0083057
,
FBtr0083056
,
FBpp0082517
,
FBpp0082514
FlyBase
FBgn0266599
PRO
P11147
GlyGen
P11147
© 2026
Reactome
This website requires cookies and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our
Privacy Notice
.
I agree, dismiss this banner
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text