Reactome | TfIIFbeta [nucleoplasm]

TfIIFbeta [nucleoplasm]

Stable Identifier

R-DME-65567

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

nucleoplasm

Synonyms

GTF2F2, P41900

Locations in the PathwayBrowser

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Metabolism of RNA (Drosophila melanogaster)

- Processing of Capped Intron-Containing Pre-mRNA (Drosophila melanogaster)
  - Formation of pre-mRNPs (Drosophila melanogaster)
    - capped, methylated pre-mRNA:CBC Complex [nucleoplasm] (Drosophila melanogaster)
      - RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Drosophila melanogaster)
        
        TFIIF [nucleoplasm] (Drosophila melanogaster)
        
        TfIIFbeta [nucleoplasm] (Drosophila melanogaster)
    - capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Drosophila melanogaster)
      - capped, methylated pre-mRNA:CBC Complex [nucleoplasm] (Drosophila melanogaster)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Drosophila melanogaster)
        
        TFIIF [nucleoplasm] (Drosophila melanogaster)
        
        TfIIFbeta [nucleoplasm] (Drosophila melanogaster)
  - Internal Methylation of mRNA (Drosophila melanogaster)
    - capped pre-mRNA:CBC:RNA Pol II (phosphorylated) complex [nucleoplasm] (Drosophila melanogaster)
      - RNA Polymerase II (phosphorylated):TFIIF:capped pre-mRNA [nucleoplasm] (Drosophila melanogaster)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Drosophila melanogaster)
        
        TFIIF [nucleoplasm] (Drosophila melanogaster)
        
        TfIIFbeta [nucleoplasm] (Drosophila melanogaster)
    - capped, methylated pre-mRNA:CBC Complex [nucleoplasm] (Drosophila melanogaster)
      - RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Drosophila melanogaster)
        
        TFIIF [nucleoplasm] (Drosophila melanogaster)
        
        TfIIFbeta [nucleoplasm] (Drosophila melanogaster)
  - mRNA Splicing (Drosophila melanogaster)
    - mRNA Splicing - Major Pathway (Drosophila melanogaster)
      - Formation of the Spliceosomal C* complex (Drosophila melanogaster)
        
        Spliceosomal C complex [nucleoplasm] (Drosophila melanogaster)
        
        mRNA intron lariat, 3'exon:RNA Polymerase II [nucleoplasm] (Drosophila melanogaster)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Drosophila melanogaster)
        
        TFIIF [nucleoplasm] (Drosophila melanogaster)
        
        TfIIFbeta [nucleoplasm] (Drosophila melanogaster)
        
        Spliceosomal C* complex [nucleoplasm] (Drosophila melanogaster)
        
        mRNA intron lariat, 3'exon:RNA Polymerase II [nucleoplasm] (Drosophila melanogaster)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Drosophila melanogaster)
        
        TFIIF [nucleoplasm] (Drosophila melanogaster)
        
        TfIIFbeta [nucleoplasm] (Drosophila melanogaster)
      - Formation of the Spliceosomal P complex and exon ligation (Drosophila melanogaster)
        
        Spliceosomal C* complex [nucleoplasm] (Drosophila melanogaster)
        
        mRNA intron lariat, 3'exon:RNA Polymerase II [nucleoplasm] (Drosophila melanogaster)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Drosophila melanogaster)
        
        TFIIF [nucleoplasm] (Drosophila melanogaster)
        
        TfIIFbeta [nucleoplasm] (Drosophila melanogaster)
        
        Spliceosomal P complex [nucleoplasm] (Drosophila melanogaster)
        
        spliced mRNA:EJC:CBC complex:Alternative splicing factor [nucleoplasm] (Drosophila melanogaster)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Drosophila melanogaster)
        
        TFIIF [nucleoplasm] (Drosophila melanogaster)
        
        TfIIFbeta [nucleoplasm] (Drosophila melanogaster)
    - mRNA Splicing - Minor Pathway (Drosophila melanogaster)
      - ATAC spliceosome mediated Lariat formation,5' splice site cleavage (Drosophila melanogaster)
        
        ATAC C Complex [nucleoplasm] (Drosophila melanogaster)
        
        capped, methylated pre-mRNA:CBC Complex [nucleoplasm] (Drosophila melanogaster)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Drosophila melanogaster)
        
        TFIIF [nucleoplasm] (Drosophila melanogaster)
        
        TfIIFbeta [nucleoplasm] (Drosophila melanogaster)
      - Formation of AT-AC B Complex (Drosophila melanogaster)
        
        ATAC A Complex [nucleoplasm] (Drosophila melanogaster)
        
        capped, methylated pre-mRNA:CBC Complex [nucleoplasm] (Drosophila melanogaster)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Drosophila melanogaster)
        
        TFIIF [nucleoplasm] (Drosophila melanogaster)
        
        TfIIFbeta [nucleoplasm] (Drosophila melanogaster)
        
        ATAC B Complex [nucleoplasm] (Drosophila melanogaster)
        
        ATAC A Complex [nucleoplasm] (Drosophila melanogaster)
        
        capped, methylated pre-mRNA:CBC Complex [nucleoplasm] (Drosophila melanogaster)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Drosophila melanogaster)
        
        TFIIF [nucleoplasm] (Drosophila melanogaster)
        
        TfIIFbeta [nucleoplasm] (Drosophila melanogaster)
      - Formation of AT-AC C complex (Drosophila melanogaster)
        
        ATAC B Complex [nucleoplasm] (Drosophila melanogaster)
        
        ATAC A Complex [nucleoplasm] (Drosophila melanogaster)
        
        capped, methylated pre-mRNA:CBC Complex [nucleoplasm] (Drosophila melanogaster)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Drosophila melanogaster)
        
        TFIIF [nucleoplasm] (Drosophila melanogaster)
        
        TfIIFbeta [nucleoplasm] (Drosophila melanogaster)
        
        ATAC C Complex [nucleoplasm] (Drosophila melanogaster)
        
        capped, methylated pre-mRNA:CBC Complex [nucleoplasm] (Drosophila melanogaster)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Drosophila melanogaster)
        
        TFIIF [nucleoplasm] (Drosophila melanogaster)
        
        TfIIFbeta [nucleoplasm] (Drosophila melanogaster)
- mRNA Capping (Drosophila melanogaster)
  - Activation of GT (Drosophila melanogaster)
    - RNA Pol II with phosphorylated CTD: CE complex [nucleoplasm] (Drosophila melanogaster)
      - RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Drosophila melanogaster)
        
        TFIIF [nucleoplasm] (Drosophila melanogaster)
        
        TfIIFbeta [nucleoplasm] (Drosophila melanogaster)
  - Capping complex formation (Drosophila melanogaster)
    - CE:Pol II CTD:Spt5 complex [nucleoplasm] (Drosophila melanogaster)
      - RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Drosophila melanogaster)
        
        TFIIF [nucleoplasm] (Drosophila melanogaster)
        
        TfIIFbeta [nucleoplasm] (Drosophila melanogaster)
    - Capping complex (initial) [nucleoplasm] (Drosophila melanogaster)
      - CE:Pol II CTD:Spt5 complex [nucleoplasm] (Drosophila melanogaster)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Drosophila melanogaster)
        
        TFIIF [nucleoplasm] (Drosophila melanogaster)
        
        TfIIFbeta [nucleoplasm] (Drosophila melanogaster)
  - Dissociation of transcript with 5'-GMP from GT (Drosophila melanogaster)
    - Capping complex (GpppN..) [nucleoplasm] (Drosophila melanogaster)
      - CE:Pol II CTD:Spt5 complex [nucleoplasm] (Drosophila melanogaster)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Drosophila melanogaster)
        
        TFIIF [nucleoplasm] (Drosophila melanogaster)
        
        TfIIFbeta [nucleoplasm] (Drosophila melanogaster)
    - Capping complex (with freed 5'- GMP) [nucleoplasm] (Drosophila melanogaster)
      - CE:Pol II CTD:Spt5 complex [nucleoplasm] (Drosophila melanogaster)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Drosophila melanogaster)
        
        TFIIF [nucleoplasm] (Drosophila melanogaster)
        
        TfIIFbeta [nucleoplasm] (Drosophila melanogaster)
  - Formation of the CE:GMP intermediate complex (Drosophila melanogaster)
    - Capping complex (intermediate) [nucleoplasm] (Drosophila melanogaster)
      - Covalent CE:GMP intermediate complex [nucleoplasm] (Drosophila melanogaster)
        
        CE:Pol II CTD:Spt5 complex [nucleoplasm] (Drosophila melanogaster)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Drosophila melanogaster)
        
        TFIIF [nucleoplasm] (Drosophila melanogaster)
        
        TfIIFbeta [nucleoplasm] (Drosophila melanogaster)
    - Capping complex (hydrolyzed) [nucleoplasm] (Drosophila melanogaster)
      - CE:Pol II CTD:Spt5 complex [nucleoplasm] (Drosophila melanogaster)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Drosophila melanogaster)
        
        TFIIF [nucleoplasm] (Drosophila melanogaster)
        
        TfIIFbeta [nucleoplasm] (Drosophila melanogaster)
  - Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme (Drosophila melanogaster)
    - Capping complex (hydrolyzed) [nucleoplasm] (Drosophila melanogaster)
      - CE:Pol II CTD:Spt5 complex [nucleoplasm] (Drosophila melanogaster)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Drosophila melanogaster)
        
        TFIIF [nucleoplasm] (Drosophila melanogaster)
        
        TfIIFbeta [nucleoplasm] (Drosophila melanogaster)
    - Capping complex (initial) [nucleoplasm] (Drosophila melanogaster)
      - CE:Pol II CTD:Spt5 complex [nucleoplasm] (Drosophila melanogaster)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Drosophila melanogaster)
        
        TFIIF [nucleoplasm] (Drosophila melanogaster)
        
        TfIIFbeta [nucleoplasm] (Drosophila melanogaster)
  - Methylation of GMP-cap by RNA Methyltransferase (Drosophila melanogaster)
    - Capping complex (with freed 5'- GMP) [nucleoplasm] (Drosophila melanogaster)
      - CE:Pol II CTD:Spt5 complex [nucleoplasm] (Drosophila melanogaster)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Drosophila melanogaster)
        
        TFIIF [nucleoplasm] (Drosophila melanogaster)
        
        TfIIFbeta [nucleoplasm] (Drosophila melanogaster)
    - RNA Polymerase II (phosphorylated):TFIIF:capped pre-mRNA [nucleoplasm] (Drosophila melanogaster)
      - RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Drosophila melanogaster)
        
        TFIIF [nucleoplasm] (Drosophila melanogaster)
        
        TfIIFbeta [nucleoplasm] (Drosophila melanogaster)
  - RNA Polymerase II CTD (phosphorylated) binds to CE (Drosophila melanogaster)
    - Pol II transcription complex with (ser5) phosphorylated CTD containing extruded transcript to +30 [nucleoplasm] (Drosophila melanogaster)
      - RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Drosophila melanogaster)
        
        TFIIF [nucleoplasm] (Drosophila melanogaster)
        
        TfIIFbeta [nucleoplasm] (Drosophila melanogaster)
    - RNA Pol II with phosphorylated CTD: CE complex [nucleoplasm] (Drosophila melanogaster)
      - RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Drosophila melanogaster)
        
        TFIIF [nucleoplasm] (Drosophila melanogaster)
        
        TfIIFbeta [nucleoplasm] (Drosophila melanogaster)
  - Recognition and binding of the mRNA cap by the cap-binding complex (Drosophila melanogaster)
    - RNA Polymerase II (phosphorylated):TFIIF:capped pre-mRNA [nucleoplasm] (Drosophila melanogaster)
      - RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Drosophila melanogaster)
        
        TFIIF [nucleoplasm] (Drosophila melanogaster)
        
        TfIIFbeta [nucleoplasm] (Drosophila melanogaster)
    - capped pre-mRNA:CBC:RNA Pol II (phosphorylated) complex [nucleoplasm] (Drosophila melanogaster)
      - RNA Polymerase II (phosphorylated):TFIIF:capped pre-mRNA [nucleoplasm] (Drosophila melanogaster)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Drosophila melanogaster)
        
        TFIIF [nucleoplasm] (Drosophila melanogaster)
        
        TfIIFbeta [nucleoplasm] (Drosophila melanogaster)
  - SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Drosophila melanogaster)
    - CE:Pol II CTD:Spt5 complex [nucleoplasm] (Drosophila melanogaster)
      - RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Drosophila melanogaster)
        
        TFIIF [nucleoplasm] (Drosophila melanogaster)
        
        TfIIFbeta [nucleoplasm] (Drosophila melanogaster)
    - RNA Pol II with phosphorylated CTD: CE complex [nucleoplasm] (Drosophila melanogaster)
      - RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Drosophila melanogaster)
        
        TFIIF [nucleoplasm] (Drosophila melanogaster)
        
        TfIIFbeta [nucleoplasm] (Drosophila melanogaster)
  - Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA (Drosophila melanogaster)
    - Capping complex (intermediate) [nucleoplasm] (Drosophila melanogaster)
      - Covalent CE:GMP intermediate complex [nucleoplasm] (Drosophila melanogaster)
        
        CE:Pol II CTD:Spt5 complex [nucleoplasm] (Drosophila melanogaster)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Drosophila melanogaster)
        
        TFIIF [nucleoplasm] (Drosophila melanogaster)
        
        TfIIFbeta [nucleoplasm] (Drosophila melanogaster)
    - Capping complex (GpppN..) [nucleoplasm] (Drosophila melanogaster)
      - CE:Pol II CTD:Spt5 complex [nucleoplasm] (Drosophila melanogaster)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Drosophila melanogaster)
        
        TFIIF [nucleoplasm] (Drosophila melanogaster)
        
        TfIIFbeta [nucleoplasm] (Drosophila melanogaster)

Signal Transduction (Drosophila melanogaster)

- Signaling by Nuclear Receptors (Drosophila melanogaster)
  - ESR-mediated signaling (Drosophila melanogaster)
    - Estrogen-dependent gene expression (Drosophila melanogaster)
      - ESR1:ESTG:P-TEFb recruited to paused RNA polymerase II on MYB gene (Drosophila melanogaster)
        
        MYB gene:hypophosphorylated RNA polymerase II:TFIIF [nucleoplasm] (Drosophila melanogaster)
        
        RNA Polymerase II holoenzyme complex (hypophosphorylated):TFIIF complex [nucleoplasm] (Drosophila melanogaster)
        
        TFIIF [nucleoplasm] (Drosophila melanogaster)
        
        TfIIFbeta [nucleoplasm] (Drosophila melanogaster)
        
        MYB gene:hypophosphorylated RNA polymerase II:TFIIF:ESR1:ESTG:P-TEFb [nucleoplasm] (Drosophila melanogaster)
        
        RNA Polymerase II holoenzyme complex (hypophosphorylated):TFIIF complex [nucleoplasm] (Drosophila melanogaster)
        
        TFIIF [nucleoplasm] (Drosophila melanogaster)
        
        TfIIFbeta [nucleoplasm] (Drosophila melanogaster)
      - p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Drosophila melanogaster)
        
        MYB gene:hyperphosphorylated RNA polymerase II:TFIIF:ESR1:ESTG:P-TEFb [nucleoplasm] (Drosophila melanogaster)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Drosophila melanogaster)
        
        TFIIF [nucleoplasm] (Drosophila melanogaster)
        
        TfIIFbeta [nucleoplasm] (Drosophila melanogaster)
        
        MYB gene:hypophosphorylated RNA polymerase II:TFIIF:ESR1:ESTG:P-TEFb [nucleoplasm] (Drosophila melanogaster)
        
        RNA Polymerase II holoenzyme complex (hypophosphorylated):TFIIF complex [nucleoplasm] (Drosophila melanogaster)
        
        TFIIF [nucleoplasm] (Drosophila melanogaster)
        
        TfIIFbeta [nucleoplasm] (Drosophila melanogaster)

External Reference Information

External Reference

UniProt:P41900

Gene Names

TfIIFbeta

Reference Genes

BioGPS Gene:41290 TfIIFbeta

ENSEMBL:FBgn0010421

Flybase:FBgn0010421

KEGG Gene (Drosophila melanogaster):Dmel_CG6538 TfIIFbeta

Monarch:41290 TfIIFbeta

NCBI Gene:41290 TfIIFbeta

Reference Transcript

RefSeq:NM_079581.4 TfIIFbeta

Other Identifiers

142514_at

1633349_at

41290

GO:0001096

GO:0003677

GO:0005634

GO:0005654

GO:0005674

GO:0006351

GO:0006366

GO:0006367

GO:0006368

GO:0043226

Participates

as a component of

TFIIF [nucleoplasm] (Drosophila melanogaster)

Inferred From

GTF2F2 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_524305.2

Flybase

FBgn0010421

PRO

P41900

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