Reactome | PRKCA [cytosol]

PRKCA [cytosol]

Stable Identifier

R-DME-58196-2

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

cytosol

Synonyms

P13677

Locations in the PathwayBrowser

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Extracellular matrix organization (Drosophila melanogaster)

- Non-integrin membrane-ECM interactions (Drosophila melanogaster)
  - Syndecan interactions (Drosophila melanogaster)
    - Syndecan-4:PI(4,5)P2 binds PKC alpha:DAG (Drosophila melanogaster)
      - Protein Kinase C, alpha type: DAG [plasma membrane] (Drosophila melanogaster)
        
        Homologues of PRKCA [cytosol] (Drosophila melanogaster)
        
        PRKCA [cytosol] (Drosophila melanogaster)
      - Syndecan-4:PI(4,5)P2:Protein kinase C, alpha type:DAG [plasma membrane] (Drosophila melanogaster)
        
        Protein Kinase C, alpha type: DAG [plasma membrane] (Drosophila melanogaster)
        
        Homologues of PRKCA [cytosol] (Drosophila melanogaster)
        
        PRKCA [cytosol] (Drosophila melanogaster)

Signal Transduction (Drosophila melanogaster)

- Intracellular signaling by second messengers (Drosophila melanogaster)
  - DAG and IP3 signaling (Drosophila melanogaster)
    - CaM pathway (Drosophila melanogaster)
      - Calmodulin induced events (Drosophila melanogaster)
        
        GRK2 binds CALM1:4Ca2+ (Drosophila melanogaster)
        
        active PKC (alpha, gamma, delta) [cytosol] (Drosophila melanogaster)
        
        Protein kinase C (alpha, gamma, delta) [cytosol] (Drosophila melanogaster)
        
        Homologues of PRKCA [cytosol] (Drosophila melanogaster)
        
        PRKCA [cytosol] (Drosophila melanogaster)
        
        PKC phosphorylates GRK2 (Drosophila melanogaster)
        
        active PKC (alpha, gamma, delta) [cytosol] (Drosophila melanogaster)
        
        Protein kinase C (alpha, gamma, delta) [cytosol] (Drosophila melanogaster)
        
        Homologues of PRKCA [cytosol] (Drosophila melanogaster)
        
        PRKCA [cytosol] (Drosophila melanogaster)
- Signaling by GPCR (Drosophila melanogaster)
  - GPCR downstream signalling (Drosophila melanogaster)
    - G alpha (i) signalling events (Drosophila melanogaster)
      - Opioid Signalling (Drosophila melanogaster)
        
        G-protein mediated events (Drosophila melanogaster)
        
        PLC beta mediated events (Drosophila melanogaster)
        
        Ca-dependent events (Drosophila melanogaster)
        
        CaM pathway (Drosophila melanogaster)
        
        Calmodulin induced events (Drosophila melanogaster)
        
        GRK2 binds CALM1:4Ca2+ (Drosophila melanogaster)
        
        active PKC (alpha, gamma, delta) [cytosol] (Drosophila melanogaster)
        
        Protein kinase C (alpha, gamma, delta) [cytosol] (Drosophila melanogaster)
        
        Homologues of PRKCA [cytosol] (Drosophila melanogaster)
        
        PRKCA [cytosol] (Drosophila melanogaster)
        
        PKC phosphorylates GRK2 (Drosophila melanogaster)
        
        active PKC (alpha, gamma, delta) [cytosol] (Drosophila melanogaster)
        
        Protein kinase C (alpha, gamma, delta) [cytosol] (Drosophila melanogaster)
        
        Homologues of PRKCA [cytosol] (Drosophila melanogaster)
        
        PRKCA [cytosol] (Drosophila melanogaster)
    - G alpha (q) signalling events (Drosophila melanogaster)
      - Gastrin-CREB signalling pathway via PKC and MAPK (Drosophila melanogaster)
        
        EGFR Transactivation by Gastrin (Drosophila melanogaster)
        
        Activated PKC-alpha activate MMP3 (Drosophila melanogaster)
        
        Protein Kinase C, alpha type: DAG [plasma membrane] (Drosophila melanogaster)
        
        Homologues of PRKCA [cytosol] (Drosophila melanogaster)
        
        PRKCA [cytosol] (Drosophila melanogaster)
        
        Diacylgycerol activates Protein kinase C, alpha type (Drosophila melanogaster)
        
        Homologues of PRKCA [cytosol] (Drosophila melanogaster)
        
        PRKCA [cytosol] (Drosophila melanogaster)
        
        Protein Kinase C, alpha type: DAG [plasma membrane] (Drosophila melanogaster)
        
        Homologues of PRKCA [cytosol] (Drosophila melanogaster)
        
        PRKCA [cytosol] (Drosophila melanogaster)
- Signaling by Receptor Tyrosine Kinases (Drosophila melanogaster)
  - Signaling by SCF-KIT (Drosophila melanogaster)
    - Regulation of KIT signaling (Drosophila melanogaster)
      - PKC alpha interacts with and phosphorylates KIT (Drosophila melanogaster)
        
        Homologues of PRKCA [cytosol] (Drosophila melanogaster)
        
        PRKCA [cytosol] (Drosophila melanogaster)
        
        p-KIT (S741,746):PKC alpha [plasma membrane] (Drosophila melanogaster)
        
        Homologues of PRKCA [cytosol] (Drosophila melanogaster)
        
        PRKCA [cytosol] (Drosophila melanogaster)
  - Signaling by VEGF (Drosophila melanogaster)
    - VEGFA-VEGFR2 Pathway (Drosophila melanogaster)
      - VEGFR2 mediated cell proliferation (Drosophila melanogaster)
        
        PDK1 phosphorylates PKC (Drosophila melanogaster)
        
        PKCA,PKCB,PKCD,PKCZ [cytosol] (Drosophila melanogaster)
        
        Homologues of PRKCA [cytosol] (Drosophila melanogaster)
        
        PRKCA [cytosol] (Drosophila melanogaster)

External Reference Information

External Reference

UniProt:P13677

Reference Genes

BioGPS Gene:36897

CTD Gene:36897

ENSEMBL:FBgn0004784

FlyBase:FBgn0004784

KEGG:dme:Dmel_CG6518

Monarch:36897

NCBI Gene:36897

UCSC:P13677

Reference Transcript

RefSeq:NM_057515.3

Other Identifiers

152951_at

1637807_at

36897

GO:0000166

GO:0003824

GO:0004672

GO:0004674

GO:0004697

GO:0004698

GO:0005515

GO:0005524

GO:0005768

GO:0006468

GO:0007601

GO:0007602

GO:0008270

GO:0008585

GO:0009416

GO:0016027

GO:0016028

GO:0016059

GO:0016301

GO:0016477

GO:0016740

GO:0019722

GO:0030845

GO:0035556

GO:0045471

GO:0046872

GO:0048870

GO:0050877

GO:0050962

GO:0106310

GO:0140096

GO:2000370

Participates

as a member of

Homologues of PRKCA [cytosol] (Drosophila melanogaster)

Other forms of this molecule

PRKCA [nucleoplasm]

phospho-p-T497,T638,S657-PRKCA [nucleoplasm]

phospho-p-T500,T642,S661-PRKCB [nucleoplasm]

PRKCB [cytosol]

phospho-p-T500-PRKCB [cytosol]

phospho-p-T497-PRKCA [cytosol]

phospho-p-T500,T642,S661-PRKCB [cytosol]

PRKCB [plasma membrane]

PRKCA [plasma membrane]

phospho-p-T497,T638,S657-PRKCA [cytosol]

phospho-pT497,T638,S657-PRKCA [plasma membrane]

Inferred From

PRKCA [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_476863.1

ENSEMBL

FBgn0004784, FBtr0087047, FBpp0086196

IntEnz

2.7.11.13

FlyBase

FBgn0004784

PRO

P13677

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