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Hem [cytosol]
Stable Identifier
R-DME-5694031
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
cytosol
Synonyms
NCKAP1L, P55162
Locations in the PathwayBrowser
Expand all
Immune System (Drosophila melanogaster)
Innate Immune System (Drosophila melanogaster)
Fcgamma receptor (FCGR) dependent phagocytosis (Drosophila melanogaster)
Regulation of actin dynamics for phagocytic cup formation (Drosophila melanogaster)
(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Drosophila melanogaster)
Mother filament:branching complex [cytosol] (Drosophila melanogaster)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Drosophila melanogaster)
WAVE2, WASP, N-WASP [plasma membrane] (Drosophila melanogaster)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Drosophila melanogaster)
p-Y,S,T-WRC [cytosol] (Drosophila melanogaster)
Hem [cytosol] (Drosophila melanogaster)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Drosophila melanogaster)
p-Y-WRC [cytosol] (Drosophila melanogaster)
Hem [cytosol] (Drosophila melanogaster)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Drosophila melanogaster)
WAVE2, WASP, N-WASP [plasma membrane] (Drosophila melanogaster)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Drosophila melanogaster)
p-Y,S,T-WRC [cytosol] (Drosophila melanogaster)
Hem [cytosol] (Drosophila melanogaster)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Drosophila melanogaster)
p-Y-WRC [cytosol] (Drosophila melanogaster)
Hem [cytosol] (Drosophila melanogaster)
ABL phosphorylates WAVEs (Drosophila melanogaster)
WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Drosophila melanogaster)
WAVE Regulatory Complex [cytosol] (Drosophila melanogaster)
Hem [cytosol] (Drosophila melanogaster)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Drosophila melanogaster)
p-Y-WRC [cytosol] (Drosophila melanogaster)
Hem [cytosol] (Drosophila melanogaster)
Detachment of WASP/WAVE (Drosophila melanogaster)
Mother filament:branching complex [cytosol] (Drosophila melanogaster)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Drosophila melanogaster)
WAVE2, WASP, N-WASP [plasma membrane] (Drosophila melanogaster)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Drosophila melanogaster)
p-Y,S,T-WRC [cytosol] (Drosophila melanogaster)
Hem [cytosol] (Drosophila melanogaster)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Drosophila melanogaster)
p-Y-WRC [cytosol] (Drosophila melanogaster)
Hem [cytosol] (Drosophila melanogaster)
WAVE2, WASP, N-WASP [plasma membrane] (Drosophila melanogaster)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Drosophila melanogaster)
p-Y,S,T-WRC [cytosol] (Drosophila melanogaster)
Hem [cytosol] (Drosophila melanogaster)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Drosophila melanogaster)
p-Y-WRC [cytosol] (Drosophila melanogaster)
Hem [cytosol] (Drosophila melanogaster)
RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Drosophila melanogaster)
WAVE Regulatory Complex [cytosol] (Drosophila melanogaster)
Hem [cytosol] (Drosophila melanogaster)
WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Drosophila melanogaster)
WAVE Regulatory Complex [cytosol] (Drosophila melanogaster)
Hem [cytosol] (Drosophila melanogaster)
p-ERK phosphorylates WAVEs and ABI (Drosophila melanogaster)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Drosophila melanogaster)
p-Y,S,T-WRC [cytosol] (Drosophila melanogaster)
Hem [cytosol] (Drosophila melanogaster)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Drosophila melanogaster)
p-Y-WRC [cytosol] (Drosophila melanogaster)
Hem [cytosol] (Drosophila melanogaster)
Signal Transduction (Drosophila melanogaster)
Signaling by Receptor Tyrosine Kinases (Drosophila melanogaster)
Signaling by VEGF (Drosophila melanogaster)
VEGFA-VEGFR2 Pathway (Drosophila melanogaster)
RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Drosophila melanogaster)
WAVE Regulatory Complex [cytosol] (Drosophila melanogaster)
Hem [cytosol] (Drosophila melanogaster)
WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Drosophila melanogaster)
WAVE Regulatory Complex [cytosol] (Drosophila melanogaster)
Hem [cytosol] (Drosophila melanogaster)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Drosophila melanogaster)
Signaling by Rho GTPases (Drosophila melanogaster)
RHO GTPase Effectors (Drosophila melanogaster)
RHO GTPases Activate WASPs and WAVEs (Drosophila melanogaster)
(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Drosophila melanogaster)
Mother filament:branching complex [cytosol] (Drosophila melanogaster)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Drosophila melanogaster)
WAVE2, WASP, N-WASP [plasma membrane] (Drosophila melanogaster)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Drosophila melanogaster)
p-Y,S,T-WRC [cytosol] (Drosophila melanogaster)
Hem [cytosol] (Drosophila melanogaster)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Drosophila melanogaster)
p-Y-WRC [cytosol] (Drosophila melanogaster)
Hem [cytosol] (Drosophila melanogaster)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Drosophila melanogaster)
WAVE2, WASP, N-WASP [plasma membrane] (Drosophila melanogaster)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Drosophila melanogaster)
p-Y,S,T-WRC [cytosol] (Drosophila melanogaster)
Hem [cytosol] (Drosophila melanogaster)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Drosophila melanogaster)
p-Y-WRC [cytosol] (Drosophila melanogaster)
Hem [cytosol] (Drosophila melanogaster)
ABL phosphorylates WAVEs (Drosophila melanogaster)
WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Drosophila melanogaster)
WAVE Regulatory Complex [cytosol] (Drosophila melanogaster)
Hem [cytosol] (Drosophila melanogaster)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Drosophila melanogaster)
p-Y-WRC [cytosol] (Drosophila melanogaster)
Hem [cytosol] (Drosophila melanogaster)
Detachment of WASP/WAVE (Drosophila melanogaster)
Mother filament:branching complex [cytosol] (Drosophila melanogaster)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Drosophila melanogaster)
WAVE2, WASP, N-WASP [plasma membrane] (Drosophila melanogaster)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Drosophila melanogaster)
p-Y,S,T-WRC [cytosol] (Drosophila melanogaster)
Hem [cytosol] (Drosophila melanogaster)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Drosophila melanogaster)
p-Y-WRC [cytosol] (Drosophila melanogaster)
Hem [cytosol] (Drosophila melanogaster)
WAVE2, WASP, N-WASP [plasma membrane] (Drosophila melanogaster)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Drosophila melanogaster)
p-Y,S,T-WRC [cytosol] (Drosophila melanogaster)
Hem [cytosol] (Drosophila melanogaster)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Drosophila melanogaster)
p-Y-WRC [cytosol] (Drosophila melanogaster)
Hem [cytosol] (Drosophila melanogaster)
RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Drosophila melanogaster)
WAVE Regulatory Complex [cytosol] (Drosophila melanogaster)
Hem [cytosol] (Drosophila melanogaster)
WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Drosophila melanogaster)
WAVE Regulatory Complex [cytosol] (Drosophila melanogaster)
Hem [cytosol] (Drosophila melanogaster)
p-ERK phosphorylates WAVEs and ABI (Drosophila melanogaster)
p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Drosophila melanogaster)
p-Y,S,T-WRC [cytosol] (Drosophila melanogaster)
Hem [cytosol] (Drosophila melanogaster)
p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Drosophila melanogaster)
p-Y-WRC [cytosol] (Drosophila melanogaster)
Hem [cytosol] (Drosophila melanogaster)
RHO GTPase cycle (Drosophila melanogaster)
RAC1 GTPase cycle (Drosophila melanogaster)
RAC1 binds effectors at the plasma membrane (Drosophila melanogaster)
RAC1 effectors [cytosol] (Drosophila melanogaster)
WAVE Regulatory Complex [cytosol] (Drosophila melanogaster)
Hem [cytosol] (Drosophila melanogaster)
RAC1:GTP:RAC1 effectors [plasma membrane] (Drosophila melanogaster)
RAC1 effectors [cytosol] (Drosophila melanogaster)
WAVE Regulatory Complex [cytosol] (Drosophila melanogaster)
Hem [cytosol] (Drosophila melanogaster)
RAC2 GTPase cycle (Drosophila melanogaster)
RAC2 binds effectors at the plasma membrane (Drosophila melanogaster)
RAC2 plasma membrane effectors [cytosol] (Drosophila melanogaster)
WAVE2 Regulatory Complex [cytosol] (Drosophila melanogaster)
Hem [cytosol] (Drosophila melanogaster)
RAC2:GTP:RAC2 cytosolic effectors [plasma membrane] (Drosophila melanogaster)
RAC2 plasma membrane effectors [cytosol] (Drosophila melanogaster)
WAVE2 Regulatory Complex [cytosol] (Drosophila melanogaster)
Hem [cytosol] (Drosophila melanogaster)
RAC3 GTPase cycle (Drosophila melanogaster)
RAC3 binds effectors at the plasma membrane (Drosophila melanogaster)
RAC3 effectors [cytosol] (Drosophila melanogaster)
WAVE1 Regulatory Complex [cytosol] (Drosophila melanogaster)
Hem [cytosol] (Drosophila melanogaster)
WAVE2 Regulatory Complex [cytosol] (Drosophila melanogaster)
Hem [cytosol] (Drosophila melanogaster)
RAC3:GTP:RAC3 effectors [plasma membrane] (Drosophila melanogaster)
RAC3 effectors [cytosol] (Drosophila melanogaster)
WAVE1 Regulatory Complex [cytosol] (Drosophila melanogaster)
Hem [cytosol] (Drosophila melanogaster)
WAVE2 Regulatory Complex [cytosol] (Drosophila melanogaster)
Hem [cytosol] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:P55162
Gene Names
Hem
Reference Genes
BioGPS Gene:40462 Hem
CTD Gene:40462 Hem
ENSEMBL:FBgn0011771
FlyBase:FBgn0011771
KEGG:dme:Dmel_CG5837 Hem
Monarch:40462 Hem
NCBI Gene:40462 Hem
UCSC:P55162 Hem
Reference Transcript
RefSeq:NM_079490.4 Hem
Other Identifiers
155022_at
1630271_at
40462
GO:0000902
GO:0001764
GO:0005515
GO:0005886
GO:0007010
GO:0007155
GO:0007409
GO:0007417
GO:0007520
GO:0007528
GO:0008360
GO:0008407
GO:0016477
GO:0030031
GO:0030036
GO:0030866
GO:0031209
GO:0031594
GO:0033627
GO:0034315
GO:0034330
GO:0048812
GO:0048856
GO:0048870
GO:0050807
Participates
as a component of
WAVE1 Regulatory Complex [cytosol] (Drosophila melanogaster)
WAVE2 Regulatory Complex [cytosol] (Drosophila melanogaster)
p-Y,S,T-WRC [cytosol] (Drosophila melanogaster)
p-Y-WRC [cytosol] (Drosophila melanogaster)
WAVE Regulatory Complex [cytosol] (Drosophila melanogaster)
Other forms of this molecule
Hem [secretory granule membrane]
Hem [plasma membrane]
Hem [ficolin-1-rich granule membrane]
Hem [cytosol]
Inferred From
NCKAP1L [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_524214.1
ENSEMBL
FBpp0078162
,
FBtr0078510
PRO
P55162
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