Reactome | Spn28Db [endoplasmic reticulum lumen]

Spn28Db [endoplasmic reticulum lumen]

Stable Identifier

R-DME-5689435-10

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

endoplasmic reticulum lumen

Synonyms

(Glc)3(GlcNAc)2(Man)9-SERPINA1, Q9VLV3

Locations in the PathwayBrowser

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Metabolism of proteins (Drosophila melanogaster)

- Post-translational protein modification (Drosophila melanogaster)
  - Asparagine N-linked glycosylation (Drosophila melanogaster)
    - Transport to the Golgi and subsequent modification (Drosophila melanogaster)
      - ER to Golgi Anterograde Transport (Drosophila melanogaster)
        
        COPII-mediated vesicle transport (Drosophila melanogaster)
        
        Inner coat assembly and cargo binding (Drosophila melanogaster)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Drosophila melanogaster)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Drosophila melanogaster)
        
        LMAN receptor:glycosylated cargo [endoplasmic reticulum membrane] (Drosophila melanogaster)
        
        Homologues of (Glc)3(GlcNAc)2(Man)9-SERPINA1 [endoplasmic reticulum lumen] (Drosophila melanogaster)
        
        Spn28Db [endoplasmic reticulum lumen] (Drosophila melanogaster)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Drosophila melanogaster)
        
        LMAN receptor:glycosylated cargo [endoplasmic reticulum membrane] (Drosophila melanogaster)
        
        Homologues of (Glc)3(GlcNAc)2(Man)9-SERPINA1 [endoplasmic reticulum lumen] (Drosophila melanogaster)
        
        Spn28Db [endoplasmic reticulum lumen] (Drosophila melanogaster)
        
        Loss of SAR1B GTPase (Drosophila melanogaster)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Drosophila melanogaster)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Drosophila melanogaster)
        
        LMAN receptor:glycosylated cargo [endoplasmic reticulum membrane] (Drosophila melanogaster)
        
        Homologues of (Glc)3(GlcNAc)2(Man)9-SERPINA1 [endoplasmic reticulum lumen] (Drosophila melanogaster)
        
        Spn28Db [endoplasmic reticulum lumen] (Drosophila melanogaster)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Drosophila melanogaster)
        
        LMAN receptor:glycosylated cargo [endoplasmic reticulum membrane] (Drosophila melanogaster)
        
        Homologues of (Glc)3(GlcNAc)2(Man)9-SERPINA1 [endoplasmic reticulum lumen] (Drosophila melanogaster)
        
        Spn28Db [endoplasmic reticulum lumen] (Drosophila melanogaster)
        
        Cargo concentration in the ER (Drosophila melanogaster)
        
        Inner coat assembly and cargo binding (Drosophila melanogaster)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Drosophila melanogaster)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Drosophila melanogaster)
        
        LMAN receptor:glycosylated cargo [endoplasmic reticulum membrane] (Drosophila melanogaster)
        
        Homologues of (Glc)3(GlcNAc)2(Man)9-SERPINA1 [endoplasmic reticulum lumen] (Drosophila melanogaster)
        
        Spn28Db [endoplasmic reticulum lumen] (Drosophila melanogaster)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Drosophila melanogaster)
        
        LMAN receptor:glycosylated cargo [endoplasmic reticulum membrane] (Drosophila melanogaster)
        
        Homologues of (Glc)3(GlcNAc)2(Man)9-SERPINA1 [endoplasmic reticulum lumen] (Drosophila melanogaster)
        
        Spn28Db [endoplasmic reticulum lumen] (Drosophila melanogaster)
        
        LMAN family proteins bind glycosylated cargo (Drosophila melanogaster)
        
        Homologues of (Glc)3(GlcNAc)2(Man)9-SERPINA1 [endoplasmic reticulum lumen] (Drosophila melanogaster)
        
        Spn28Db [endoplasmic reticulum lumen] (Drosophila melanogaster)
        
        LMAN receptor:glycosylated cargo [endoplasmic reticulum membrane] (Drosophila melanogaster)
        
        Homologues of (Glc)3(GlcNAc)2(Man)9-SERPINA1 [endoplasmic reticulum lumen] (Drosophila melanogaster)
        
        Spn28Db [endoplasmic reticulum lumen] (Drosophila melanogaster)

Vesicle-mediated transport (Drosophila melanogaster)

- Membrane Trafficking (Drosophila melanogaster)
  - ER to Golgi Anterograde Transport (Drosophila melanogaster)
    - COPII-mediated vesicle transport (Drosophila melanogaster)
      - Inner coat assembly and cargo binding (Drosophila melanogaster)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Drosophila melanogaster)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Drosophila melanogaster)
        
        LMAN receptor:glycosylated cargo [endoplasmic reticulum membrane] (Drosophila melanogaster)
        
        Homologues of (Glc)3(GlcNAc)2(Man)9-SERPINA1 [endoplasmic reticulum lumen] (Drosophila melanogaster)
        
        Spn28Db [endoplasmic reticulum lumen] (Drosophila melanogaster)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Drosophila melanogaster)
        
        LMAN receptor:glycosylated cargo [endoplasmic reticulum membrane] (Drosophila melanogaster)
        
        Homologues of (Glc)3(GlcNAc)2(Man)9-SERPINA1 [endoplasmic reticulum lumen] (Drosophila melanogaster)
        
        Spn28Db [endoplasmic reticulum lumen] (Drosophila melanogaster)
      - Loss of SAR1B GTPase (Drosophila melanogaster)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Drosophila melanogaster)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Drosophila melanogaster)
        
        LMAN receptor:glycosylated cargo [endoplasmic reticulum membrane] (Drosophila melanogaster)
        
        Homologues of (Glc)3(GlcNAc)2(Man)9-SERPINA1 [endoplasmic reticulum lumen] (Drosophila melanogaster)
        
        Spn28Db [endoplasmic reticulum lumen] (Drosophila melanogaster)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Drosophila melanogaster)
        
        LMAN receptor:glycosylated cargo [endoplasmic reticulum membrane] (Drosophila melanogaster)
        
        Homologues of (Glc)3(GlcNAc)2(Man)9-SERPINA1 [endoplasmic reticulum lumen] (Drosophila melanogaster)
        
        Spn28Db [endoplasmic reticulum lumen] (Drosophila melanogaster)
    - Cargo concentration in the ER (Drosophila melanogaster)
      - Inner coat assembly and cargo binding (Drosophila melanogaster)
        
        COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Drosophila melanogaster)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Drosophila melanogaster)
        
        LMAN receptor:glycosylated cargo [endoplasmic reticulum membrane] (Drosophila melanogaster)
        
        Homologues of (Glc)3(GlcNAc)2(Man)9-SERPINA1 [endoplasmic reticulum lumen] (Drosophila melanogaster)
        
        Spn28Db [endoplasmic reticulum lumen] (Drosophila melanogaster)
        
        COPII cargo:receptors [endoplasmic reticulum membrane] (Drosophila melanogaster)
        
        LMAN receptor:glycosylated cargo [endoplasmic reticulum membrane] (Drosophila melanogaster)
        
        Homologues of (Glc)3(GlcNAc)2(Man)9-SERPINA1 [endoplasmic reticulum lumen] (Drosophila melanogaster)
        
        Spn28Db [endoplasmic reticulum lumen] (Drosophila melanogaster)
      - LMAN family proteins bind glycosylated cargo (Drosophila melanogaster)
        
        Homologues of (Glc)3(GlcNAc)2(Man)9-SERPINA1 [endoplasmic reticulum lumen] (Drosophila melanogaster)
        
        Spn28Db [endoplasmic reticulum lumen] (Drosophila melanogaster)
        
        LMAN receptor:glycosylated cargo [endoplasmic reticulum membrane] (Drosophila melanogaster)
        
        Homologues of (Glc)3(GlcNAc)2(Man)9-SERPINA1 [endoplasmic reticulum lumen] (Drosophila melanogaster)
        
        Spn28Db [endoplasmic reticulum lumen] (Drosophila melanogaster)

External Reference Information

External Reference

UniProt:Q9VLV3

Gene Names

Spn28Db

Reference Genes

BioGPS Gene:326261 Spn28Db

ENSEMBL:FBgn0053121

FlyBase:FBgn0053121

KEGG:dme:Dmel_CG33121 Spn28Db

Monarch:326261 Spn28Db

NCBI Gene:326261 Spn28Db

UCSC:Q9VLV3 Spn28Db

Reference Transcript

RefSeq:NM_001370007.1 Spn28Db

Other Identifiers

1631727_at

326261

GO:0004867

GO:0005615

GO:0019953

GO:0022414

GO:0098772

Participates

as a member of

Homologues of (Glc)3(GlcNAc)2(Man)9-SERPINA1 [endoplasmic reticulum lumen] (Drosophila melanogaster)

Other forms of this molecule

Spn28Db [extracellular region]

Spn28Db [plasma membrane]

Spn28Db [extracellular region]

Spn28Db [platelet dense granule lumen]

Spn28Db [endoplasmic reticulum-Golgi intermediate compartment membrane]

Spn28Db [COPII-coated ER to Golgi transport vesicle]

Spn28Db [secretory granule lumen]

Spn28Db [ficolin-1-rich granule lumen]

Spn28Db [azurophil granule lumen]

phospho-Spn28Db [endoplasmic reticulum lumen]

Spn28Db [endoplasmic reticulum lumen]

Spn28Db [extracellular region]

Spn28Db [platelet alpha granule lumen]

Spn28Db [extracellular region]

Inferred From

(Glc)3(GlcNAc)2(Man)9-SERPINA1 [endoplasmic reticulum lumen] (Homo sapiens)

Modified Residues

Name

N4-(N-acetylamino)glucosyl-L-asparagine (N-{alpha-Glc-(1->2)-alpha-Glc-(1->3)-alpha-Glc-(1->3)-alpha-Man-(1->2)-alpha-Man-(1->2)-alpha-Man-(1->3)-(alpha-Man-(1->2)-alpha-Man-(1->3)-(alpha-Man-(1->2)-alpha-Man-(1->6))-alpha-Man-(1->6))-beta-Man-(1->4)-beta-GlcNAc-(1->4)-beta-GlcNAc}-L-Asn residue (ChEBI:59084)) at unknown position

Modification

N-{alpha-Glc-(1->2)-alpha-Glc-(1->3)-alpha-Glc-(1->3)-alpha-Man-(1->2)-alpha-Man-(1->2)-alpha-Man-(1->3)-(alpha-Man-(1->2)-alpha-Man-(1->3)-(alpha-Man-(1->2)-alpha-Man-(1->6))-alpha-Man-(1->6))-beta-Man-(1->4)-beta-GlcNAc-(1->4)-beta-GlcNAc}-yl group (ChEBI:59084)

PsiMod Name

N4-(N-acetylamino)glucosyl-L-asparagine

PsiMod Definition

A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.

Cross References

RefSeq

NP_001356884.1

FlyBase

FBgn0053121

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