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PP1 binds to phosphorylated TIM in complex with PER
Stable Identifier
R-DME-538824
Type
Reaction [binding]
Species
Drosophila melanogaster
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
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Drosophila signaling pathways (Drosophila melanogaster)
Circadian Clock pathway (Drosophila melanogaster)
Dephosphorylation of TIM (Drosophila melanogaster)
PP1 binds to phosphorylated TIM in complex with PER (Drosophila melanogaster)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The protein phosphatase, PP1, binds to Timeless (TIM). The interaction is probably via the RVXF, PP1-binding motif in TIM. This binding motif appears to be absent in the protein Period (PER). The catalytic unit of PP1 could be either of the 4 isoforms which exist in fly: flapwing (FLW), Protein phosphatase 1 at 13C (PP1-13C), Protein phosphatase 1 at 87B (PP1-87B), Protein phosphatase 1alpha at 96A (PP1alpha-96A).
Literature References
PubMed ID
Title
Journal
Year
17575052
Post-translational regulation of the Drosophila circadian clock requires protein phosphatase 1 (PP1)
Fang, Y
,
Sehgal, A
,
Sathyanarayanan, S
Genes Dev
2007
Participants
Input
Phospho TIM:Phospho (multi-site 2) PER:DCO [cytosol]
(Drosophila melanogaster)
PP1 [cytosol]
(Drosophila melanogaster)
Output
PP1:Phospho TIM:Phospho (multi-site 2) PER:DCO [cytosol]
(Drosophila melanogaster)
Participates
as an event of
Dephosphorylation of TIM (Drosophila melanogaster)
Authored
Williams, MG (2010-03-08)
Reviewed
Edery, I (2010-07-06)
Created
Williams, MG (2010-03-08)
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