Reactome | Atf-2 [nucleoplasm]

Atf-2 [nucleoplasm]

Stable Identifier

R-DME-450336

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

nucleoplasm

Synonyms

ATF2, Q2PE13

Locations in the PathwayBrowser

Expand all

Immune System (Drosophila melanogaster)

- Cytokine Signaling in Immune system (Drosophila melanogaster)
  - Signaling by Interleukins (Drosophila melanogaster)
    - Interleukin-17 signaling (Drosophila melanogaster)
      - MAP kinase activation (Drosophila melanogaster)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Drosophila melanogaster)
        
        Activation of the AP-1 family of transcription factors (Drosophila melanogaster)
        
        Phosphorylated MAPKs phosphorylate ATF-2 (Drosophila melanogaster)
        
        Atf-2 [nucleoplasm] (Drosophila melanogaster)
- Innate Immune System (Drosophila melanogaster)
  - Toll-like Receptor Cascades (Drosophila melanogaster)
    - Toll Like Receptor 10 (TLR10) Cascade (Drosophila melanogaster)
      - MyD88 cascade initiated on plasma membrane (Drosophila melanogaster)
        
        MAP kinase activation (Drosophila melanogaster)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Drosophila melanogaster)
        
        Activation of the AP-1 family of transcription factors (Drosophila melanogaster)
        
        Phosphorylated MAPKs phosphorylate ATF-2 (Drosophila melanogaster)
        
        Atf-2 [nucleoplasm] (Drosophila melanogaster)
    - Toll Like Receptor 2 (TLR2) Cascade (Drosophila melanogaster)
      - Toll Like Receptor TLR1:TLR2 Cascade (Drosophila melanogaster)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Drosophila melanogaster)
        
        MAP kinase activation (Drosophila melanogaster)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Drosophila melanogaster)
        
        Activation of the AP-1 family of transcription factors (Drosophila melanogaster)
        
        Phosphorylated MAPKs phosphorylate ATF-2 (Drosophila melanogaster)
        
        Atf-2 [nucleoplasm] (Drosophila melanogaster)
      - Toll Like Receptor TLR6:TLR2 Cascade (Drosophila melanogaster)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Drosophila melanogaster)
        
        MAP kinase activation (Drosophila melanogaster)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Drosophila melanogaster)
        
        Activation of the AP-1 family of transcription factors (Drosophila melanogaster)
        
        Phosphorylated MAPKs phosphorylate ATF-2 (Drosophila melanogaster)
        
        Atf-2 [nucleoplasm] (Drosophila melanogaster)
    - Toll Like Receptor 3 (TLR3) Cascade (Drosophila melanogaster)
      - MAP kinase activation (Drosophila melanogaster)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Drosophila melanogaster)
        
        Activation of the AP-1 family of transcription factors (Drosophila melanogaster)
        
        Phosphorylated MAPKs phosphorylate ATF-2 (Drosophila melanogaster)
        
        Atf-2 [nucleoplasm] (Drosophila melanogaster)
    - Toll Like Receptor 4 (TLR4) Cascade (Drosophila melanogaster)
      - MyD88-independent TLR4 cascade (Drosophila melanogaster)
        
        TRIF (TICAM1)-mediated TLR4 signaling (Drosophila melanogaster)
        
        MAP kinase activation (Drosophila melanogaster)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Drosophila melanogaster)
        
        Activation of the AP-1 family of transcription factors (Drosophila melanogaster)
        
        Phosphorylated MAPKs phosphorylate ATF-2 (Drosophila melanogaster)
        
        Atf-2 [nucleoplasm] (Drosophila melanogaster)
      - MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Drosophila melanogaster)
        
        MAP kinase activation (Drosophila melanogaster)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Drosophila melanogaster)
        
        Activation of the AP-1 family of transcription factors (Drosophila melanogaster)
        
        Phosphorylated MAPKs phosphorylate ATF-2 (Drosophila melanogaster)
        
        Atf-2 [nucleoplasm] (Drosophila melanogaster)
    - Toll Like Receptor 5 (TLR5) Cascade (Drosophila melanogaster)
      - MyD88 cascade initiated on plasma membrane (Drosophila melanogaster)
        
        MAP kinase activation (Drosophila melanogaster)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Drosophila melanogaster)
        
        Activation of the AP-1 family of transcription factors (Drosophila melanogaster)
        
        Phosphorylated MAPKs phosphorylate ATF-2 (Drosophila melanogaster)
        
        Atf-2 [nucleoplasm] (Drosophila melanogaster)
    - Toll Like Receptor 7/8 (TLR7/8) Cascade (Drosophila melanogaster)
      - MyD88 dependent cascade initiated on endosome (Drosophila melanogaster)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Drosophila melanogaster)
        
        MAP kinase activation (Drosophila melanogaster)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Drosophila melanogaster)
        
        Activation of the AP-1 family of transcription factors (Drosophila melanogaster)
        
        Phosphorylated MAPKs phosphorylate ATF-2 (Drosophila melanogaster)
        
        Atf-2 [nucleoplasm] (Drosophila melanogaster)
    - Toll Like Receptor 9 (TLR9) Cascade (Drosophila melanogaster)
      - MyD88 dependent cascade initiated on endosome (Drosophila melanogaster)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Drosophila melanogaster)
        
        MAP kinase activation (Drosophila melanogaster)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Drosophila melanogaster)
        
        Activation of the AP-1 family of transcription factors (Drosophila melanogaster)
        
        Phosphorylated MAPKs phosphorylate ATF-2 (Drosophila melanogaster)
        
        Atf-2 [nucleoplasm] (Drosophila melanogaster)

External Reference Information

External Reference

UniProt:Q2PE13

Gene Names

Atf-2

Reference Genes

BioGPS Gene:37978 Atf-2

CTD Gene:37978 Atf-2

ENSEMBL:FBgn0265193

FlyBase:FBgn0265193

KEGG:dme:Dmel_CG44246 Atf-2

Monarch:37978 Atf-2

NCBI Gene:37978 Atf-2

UCSC:Q2PE13 Atf-2

Reference Transcript

RefSeq:NM_001038884.2 Atf-2

Other Identifiers

147896_at

37978

GO:0000792

GO:0000981

GO:0001228

GO:0002376

GO:0002385

GO:0003700

GO:0005634

GO:0005721

GO:0006325

GO:0006355

GO:0006357

GO:0009651

GO:0010369

GO:0010866

GO:0030431

GO:0031507

GO:0034605

GO:0035497

GO:0042803

GO:0043226

GO:0043565

GO:0045814

GO:0045944

GO:0051403

GO:0071470

Participates

as an input of

Phosphorylated MAPKs phosphorylate ATF-2 (Drosophila melanogaster)

Other forms of this molecule

phospho-Atf-2 [nucleoplasm]

Inferred From

ATF2 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_001033973.1

FlyBase

FBgn0265193

Cite Us!