Reactome | phospho-Atf3 [nucleoplasm]

phospho-Atf3 [nucleoplasm]

Stable Identifier

R-DME-450283-2

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

nucleoplasm

Synonyms

p-T325,T331,S362,S374-FOS, Q9XZS8

Locations in the PathwayBrowser

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Immune System (Drosophila melanogaster)

- Cytokine Signaling in Immune system (Drosophila melanogaster)
  - Signaling by Interleukins (Drosophila melanogaster)
    - Interleukin-17 signaling (Drosophila melanogaster)
      - MAP kinase activation (Drosophila melanogaster)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Drosophila melanogaster)
        
        Activation of the AP-1 family of transcription factors (Drosophila melanogaster)
        
        c-FOS activation by phospho ERK1/2 (Drosophila melanogaster)
        
        Homologues of p-T325,T331,S362,S374-FOS [nucleoplasm] (Drosophila melanogaster)
        
        phospho-Atf3 [nucleoplasm] (Drosophila melanogaster)
- Innate Immune System (Drosophila melanogaster)
  - Fc epsilon receptor (FCERI) signaling (Drosophila melanogaster)
    - FCERI mediated MAPK activation (Drosophila melanogaster)
      - c-FOS activation by phospho ERK1/2 (Drosophila melanogaster)
        
        Homologues of p-T325,T331,S362,S374-FOS [nucleoplasm] (Drosophila melanogaster)
        
        phospho-Atf3 [nucleoplasm] (Drosophila melanogaster)
  - Toll-like Receptor Cascades (Drosophila melanogaster)
    - Toll Like Receptor 10 (TLR10) Cascade (Drosophila melanogaster)
      - MyD88 cascade initiated on plasma membrane (Drosophila melanogaster)
        
        MAP kinase activation (Drosophila melanogaster)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Drosophila melanogaster)
        
        Activation of the AP-1 family of transcription factors (Drosophila melanogaster)
        
        c-FOS activation by phospho ERK1/2 (Drosophila melanogaster)
        
        Homologues of p-T325,T331,S362,S374-FOS [nucleoplasm] (Drosophila melanogaster)
        
        phospho-Atf3 [nucleoplasm] (Drosophila melanogaster)
    - Toll Like Receptor 2 (TLR2) Cascade (Drosophila melanogaster)
      - Toll Like Receptor TLR1:TLR2 Cascade (Drosophila melanogaster)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Drosophila melanogaster)
        
        MAP kinase activation (Drosophila melanogaster)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Drosophila melanogaster)
        
        Activation of the AP-1 family of transcription factors (Drosophila melanogaster)
        
        c-FOS activation by phospho ERK1/2 (Drosophila melanogaster)
        
        Homologues of p-T325,T331,S362,S374-FOS [nucleoplasm] (Drosophila melanogaster)
        
        phospho-Atf3 [nucleoplasm] (Drosophila melanogaster)
      - Toll Like Receptor TLR6:TLR2 Cascade (Drosophila melanogaster)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Drosophila melanogaster)
        
        MAP kinase activation (Drosophila melanogaster)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Drosophila melanogaster)
        
        Activation of the AP-1 family of transcription factors (Drosophila melanogaster)
        
        c-FOS activation by phospho ERK1/2 (Drosophila melanogaster)
        
        Homologues of p-T325,T331,S362,S374-FOS [nucleoplasm] (Drosophila melanogaster)
        
        phospho-Atf3 [nucleoplasm] (Drosophila melanogaster)
    - Toll Like Receptor 3 (TLR3) Cascade (Drosophila melanogaster)
      - MAP kinase activation (Drosophila melanogaster)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Drosophila melanogaster)
        
        Activation of the AP-1 family of transcription factors (Drosophila melanogaster)
        
        c-FOS activation by phospho ERK1/2 (Drosophila melanogaster)
        
        Homologues of p-T325,T331,S362,S374-FOS [nucleoplasm] (Drosophila melanogaster)
        
        phospho-Atf3 [nucleoplasm] (Drosophila melanogaster)
    - Toll Like Receptor 4 (TLR4) Cascade (Drosophila melanogaster)
      - MyD88-independent TLR4 cascade (Drosophila melanogaster)
        
        TRIF (TICAM1)-mediated TLR4 signaling (Drosophila melanogaster)
        
        MAP kinase activation (Drosophila melanogaster)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Drosophila melanogaster)
        
        Activation of the AP-1 family of transcription factors (Drosophila melanogaster)
        
        c-FOS activation by phospho ERK1/2 (Drosophila melanogaster)
        
        Homologues of p-T325,T331,S362,S374-FOS [nucleoplasm] (Drosophila melanogaster)
        
        phospho-Atf3 [nucleoplasm] (Drosophila melanogaster)
      - MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Drosophila melanogaster)
        
        MAP kinase activation (Drosophila melanogaster)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Drosophila melanogaster)
        
        Activation of the AP-1 family of transcription factors (Drosophila melanogaster)
        
        c-FOS activation by phospho ERK1/2 (Drosophila melanogaster)
        
        Homologues of p-T325,T331,S362,S374-FOS [nucleoplasm] (Drosophila melanogaster)
        
        phospho-Atf3 [nucleoplasm] (Drosophila melanogaster)
    - Toll Like Receptor 5 (TLR5) Cascade (Drosophila melanogaster)
      - MyD88 cascade initiated on plasma membrane (Drosophila melanogaster)
        
        MAP kinase activation (Drosophila melanogaster)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Drosophila melanogaster)
        
        Activation of the AP-1 family of transcription factors (Drosophila melanogaster)
        
        c-FOS activation by phospho ERK1/2 (Drosophila melanogaster)
        
        Homologues of p-T325,T331,S362,S374-FOS [nucleoplasm] (Drosophila melanogaster)
        
        phospho-Atf3 [nucleoplasm] (Drosophila melanogaster)
    - Toll Like Receptor 7/8 (TLR7/8) Cascade (Drosophila melanogaster)
      - MyD88 dependent cascade initiated on endosome (Drosophila melanogaster)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Drosophila melanogaster)
        
        MAP kinase activation (Drosophila melanogaster)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Drosophila melanogaster)
        
        Activation of the AP-1 family of transcription factors (Drosophila melanogaster)
        
        c-FOS activation by phospho ERK1/2 (Drosophila melanogaster)
        
        Homologues of p-T325,T331,S362,S374-FOS [nucleoplasm] (Drosophila melanogaster)
        
        phospho-Atf3 [nucleoplasm] (Drosophila melanogaster)
    - Toll Like Receptor 9 (TLR9) Cascade (Drosophila melanogaster)
      - MyD88 dependent cascade initiated on endosome (Drosophila melanogaster)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Drosophila melanogaster)
        
        MAP kinase activation (Drosophila melanogaster)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Drosophila melanogaster)
        
        Activation of the AP-1 family of transcription factors (Drosophila melanogaster)
        
        c-FOS activation by phospho ERK1/2 (Drosophila melanogaster)
        
        Homologues of p-T325,T331,S362,S374-FOS [nucleoplasm] (Drosophila melanogaster)
        
        phospho-Atf3 [nucleoplasm] (Drosophila melanogaster)

External Reference Information

External Reference

UniProt:Q9XZS8

Gene Names

Atf3

Reference Genes

BioGPS Gene:43867 Atf3

ENSEMBL:FBgn0028550

FlyBase:FBgn0028550

KEGG:dme:Dmel_CG11405 Atf3

Monarch:43867 Atf3

NCBI Gene:43867 Atf3

UCSC:Q9XZS8 Atf3

Reference Transcript

Other Identifiers

144236_at

1637792_at

43867

GO:0000978

GO:0000981

GO:0002376

GO:0003677

GO:0003700

GO:0005515

GO:0005634

GO:0006355

GO:0006357

GO:0006955

GO:0010883

GO:0043565

GO:0055088

Participates

as a member of

Homologues of p-T325,T331,S362,S374-FOS [nucleoplasm] (Drosophila melanogaster)

Other forms of this molecule

Atf3 [nucleoplasm]

Inferred From

p-T325,T331,S362,S374-FOS [nucleoplasm] (Homo sapiens)

Modified Residues

Name

O-phospho-L-serine at 362 (in Homo sapiens)

Coordinate

362

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 374 (in Homo sapiens)

Coordinate

374

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-threonine at 325 (in Homo sapiens)

Coordinate

325

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Name

O-phospho-L-threonine at 331 (in Homo sapiens)

Coordinate

331

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Cross References

RefSeq

NP_620473.1, NP_001284769.1

ENSEMBL

FBtr0070244, FBgn0028550, FBpp0070234, FBtr0345507, FBpp0311616

FlyBase

FBgn0028550

PRO

Q9XZS8

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