Nuclear CRY is degraded by the 26S proteasome

Stable Identifier
R-DME-432652
Type
Reaction [omitted]
Species
Drosophila melanogaster
Compartment
nucleoplasm
ReviewStatus
5/5
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Nuclear CRY is degraded by the 26S proteasome
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Ubiquitinated cryptochrome (CRY) is degraded by the 26S proteasome.
Literature References
PubMed ID Title Journal Year
11585911 Photic signaling by cryptochrome in the Drosophila circadian system

Lin, FJ, Song, W, Meyer-Bernstein, E, Naidoo, N, Sehgal, A

Mol Cell Biol 2001
15178801 Roles of the two Drosophila CRYPTOCHROME structural domains in circadian photoreception

Busza, A, Emery-Le, M, Rosbash, M, Emery, P

Science 2004
19185492 Light-dependent interactions between the Drosophila circadian clock factors cryptochrome, jetlag, and timeless

Peschel, N, Chen, KF, Szabo, G, Stanewsky, R

Curr Biol 2009
18519643 Identification of novel genes involved in light-dependent CRY degradation through a genome-wide RNAi screen

Sathyanarayanan, S, Zheng, X, Kumar, S, Chen, CH, Chen, D, Hay, B, Sehgal, A

Genes Dev 2008
Participants
Input
Output
Participates
as an event of
Catalyst Activity

endopeptidase activity of 26S proteasome [nucleoplasm]

Physical Entity
26S proteasome [nucleoplasm] (Drosophila melanogaster)
Activity
endopeptidase activity (GO:0004175)
Authored
Williams, MG  (2009-08-13)
Reviewed
Edery, I  (2010-07-06)
Created
Williams, MG  (2009-08-14)
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