VRI replaces PDP1 as binder to Clk and cry genes

Stable Identifier
R-DME-432607
Type
Reaction [transition]
Species
Drosophila melanogaster
Compartment
nucleoplasm
ReviewStatus
5/5
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VRI replaces PDP1 as binder to Clk and cry genes
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Levels of Vrille (VRI) protein rise in parallel with the rise in vri mRNA transcription. As VRI accumulates in the nucleus between midday and dusk, it binds to the VRI/PAR domain protein-1 (PDP1) binding sites (V/P boxes) to repress transcription of its target genes, Clk and cry. As VRI levels rise, the superior VRI/PDP1 ratio means it competitively replaces PDP1 as the main binder to Clk and cry genes.
Literature References
PubMed ID Title Journal Year
12546820 VRILLE feeds back to control circadian transcription of Clock in the Drosophila circadian oscillator

Glossop, NR, Houl, JH, Zheng, H, Ng, FS, Dudek, SM, Hardin, PE

Neuron 2003
12581523 vrille, Pdp1, and dClock form a second feedback loop in the Drosophila circadian clock

Cyran, SA, Buchsbaum, AM, Reddy, KL, Lin, MC, Glossop, NR, Hardin, PE, Young, MW, Storti, RV, Blau, J

Cell 2003
Participants
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Output
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Authored
Williams, MG  (2009-08-13)
Reviewed
Edery, I  (2010-07-06)
Created
Williams, MG  (2009-08-14)
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