Cytosolic JET binds to CRY, facilitating its ubiquitination

Stable Identifier
R-DME-432593
Type
Reaction [uncertain]
Species
Drosophila melanogaster
Compartment
cytosol
ReviewStatus
5/5
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Cytosolic JET binds to CRY, facilitating its ubiquitination
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After Timeless (TIM) levels drop when it is degraded by the 26S proteasome, the F-box domain containing protein Jetlag (JET) binds to cryptochrome (CRY), facilitating its ubiquitination, marking it for processing by the 26S proteasome. In this model for the Circadian Clock pathway we are assuming that the cytoplasmic and nuclear mechanisms for CRY degradation are the same.
Literature References
PubMed ID Title Journal Year
19185492 Light-dependent interactions between the Drosophila circadian clock factors cryptochrome, jetlag, and timeless

Peschel, N, Chen, KF, Szabo, G, Stanewsky, R

Curr Biol 2009
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Catalyst Activity

ubiquitin-like ligase-substrate adaptor activity of JET [cytosol]

Physical Entity
JET [cytosol] (Drosophila melanogaster)
Activity
ubiquitin-like ligase-substrate adaptor activity (GO:1990756)
Authored
Williams, MG  (2009-08-13)
Reviewed
Edery, I  (2010-07-06)
Created
Williams, MG  (2009-08-14)
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