Recruitment of Pak to Dock

Stable Identifier
R-DME-428527
Type
Reaction [binding]
Species
Drosophila melanogaster
Compartment
General
SVG |   | PPTX  | SBGN
Recruitment of Pak to Dock

In Drosophila, Dock bound to Robo1 recruits Pak to specific sites at the growth cone membrane, where Pak, activated by Rac1, regulates the recycling and retrograde flow of actin filaments (Galisteo et al. 1996, Fan et al. 2003).

Literature References
PubMed ID Title Journal Year
14527437 Slit stimulation recruits Dock and Pak to the roundabout receptor and increases Rac activity to regulate axon repulsion at the CNS midline

Fan, X, Labrador, JP, Hing, H, Bashaw, GJ

Neuron 2003
8798379 The adaptor protein Nck links receptor tyrosine kinases with the serine-threonine kinase Pak1

Galisteo, ML, Chernoff, J, Su, YC, Skolnik, EY, Schlessinger, J

J Biol Chem 1996
Participants
Orthologous Events
Authored
Reviewed
Created
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