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alpha-Spec [cytosol]
Stable Identifier
R-DME-391563
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
cytosol
Synonyms
SPTA1, P13395
Locations in the PathwayBrowser
Expand all
Developmental Biology (Drosophila melanogaster)
Nervous system development (Drosophila melanogaster)
Axon guidance (Drosophila melanogaster)
L1CAM interactions (Drosophila melanogaster)
Interaction between L1 and Ankyrins (Drosophila melanogaster)
L1 linked to actin cytoskeleton by ankyrin (Drosophila melanogaster)
L1 dimer:Ankyrin:Spectrin:F-actin [plasma membrane] (Drosophila melanogaster)
SPTA:SPTB:F-actin [cytosol] (Drosophila melanogaster)
SPTA:SPTB [cytosol] (Drosophila melanogaster)
alpha-Spec [cytosol] (Drosophila melanogaster)
SPTA:SPTB:F-actin [cytosol] (Drosophila melanogaster)
SPTA:SPTB [cytosol] (Drosophila melanogaster)
alpha-Spec [cytosol] (Drosophila melanogaster)
NCAM signaling for neurite out-growth (Drosophila melanogaster)
NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras (Drosophila melanogaster)
Grb2:Sos:pFAK bound to NCAM1:pFyn [plasma membrane] (Drosophila melanogaster)
NCAM1 complexed with pFyn-Y420 [plasma membrane] (Drosophila melanogaster)
SPTA:SPTB [cytosol] (Drosophila melanogaster)
alpha-Spec [cytosol] (Drosophila melanogaster)
Metabolism of proteins (Drosophila melanogaster)
Post-translational protein modification (Drosophila melanogaster)
Asparagine N-linked glycosylation (Drosophila melanogaster)
Transport to the Golgi and subsequent modification (Drosophila melanogaster)
ER to Golgi Anterograde Transport (Drosophila melanogaster)
COPI-mediated anterograde transport (Drosophila melanogaster)
ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex (Drosophila melanogaster)
RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane] (Drosophila melanogaster)
Spectrin tetramer [cytosol] (Drosophila melanogaster)
SPTA:SPTB [cytosol] (Drosophila melanogaster)
alpha-Spec [cytosol] (Drosophila melanogaster)
Spectrin tetramer [cytosol] (Drosophila melanogaster)
SPTA:SPTB [cytosol] (Drosophila melanogaster)
alpha-Spec [cytosol] (Drosophila melanogaster)
ARFGAPs stimulate ARF GTPase activity (Drosophila melanogaster)
RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane] (Drosophila melanogaster)
Spectrin tetramer [cytosol] (Drosophila melanogaster)
SPTA:SPTB [cytosol] (Drosophila melanogaster)
alpha-Spec [cytosol] (Drosophila melanogaster)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Drosophila melanogaster)
Spectrin tetramer [cytosol] (Drosophila melanogaster)
SPTA:SPTB [cytosol] (Drosophila melanogaster)
alpha-Spec [cytosol] (Drosophila melanogaster)
ERGIC-to-Golgi vesicles bind dynein:dynactin (Drosophila melanogaster)
RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Drosophila melanogaster)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Drosophila melanogaster)
Spectrin tetramer [cytosol] (Drosophila melanogaster)
SPTA:SPTB [cytosol] (Drosophila melanogaster)
alpha-Spec [cytosol] (Drosophila melanogaster)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Drosophila melanogaster)
Spectrin tetramer [cytosol] (Drosophila melanogaster)
SPTA:SPTB [cytosol] (Drosophila melanogaster)
alpha-Spec [cytosol] (Drosophila melanogaster)
cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Drosophila melanogaster)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Drosophila melanogaster)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Drosophila melanogaster)
Spectrin tetramer [cytosol] (Drosophila melanogaster)
SPTA:SPTB [cytosol] (Drosophila melanogaster)
alpha-Spec [cytosol] (Drosophila melanogaster)
RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Drosophila melanogaster)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Drosophila melanogaster)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Drosophila melanogaster)
Spectrin tetramer [cytosol] (Drosophila melanogaster)
SPTA:SPTB [cytosol] (Drosophila melanogaster)
alpha-Spec [cytosol] (Drosophila melanogaster)
Signal Transduction (Drosophila melanogaster)
MAPK family signaling cascades (Drosophila melanogaster)
MAPK1/MAPK3 signaling (Drosophila melanogaster)
RAF/MAP kinase cascade (Drosophila melanogaster)
RAS GEFs promote RAS nucleotide exchange (Drosophila melanogaster)
RAS GEFs [plasma membrane] (Drosophila melanogaster)
Grb2:Sos:pFAK bound to NCAM1:pFyn [plasma membrane] (Drosophila melanogaster)
NCAM1 complexed with pFyn-Y420 [plasma membrane] (Drosophila melanogaster)
SPTA:SPTB [cytosol] (Drosophila melanogaster)
alpha-Spec [cytosol] (Drosophila melanogaster)
Vesicle-mediated transport (Drosophila melanogaster)
Membrane Trafficking (Drosophila melanogaster)
ER to Golgi Anterograde Transport (Drosophila melanogaster)
COPI-mediated anterograde transport (Drosophila melanogaster)
ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex (Drosophila melanogaster)
RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane] (Drosophila melanogaster)
Spectrin tetramer [cytosol] (Drosophila melanogaster)
SPTA:SPTB [cytosol] (Drosophila melanogaster)
alpha-Spec [cytosol] (Drosophila melanogaster)
Spectrin tetramer [cytosol] (Drosophila melanogaster)
SPTA:SPTB [cytosol] (Drosophila melanogaster)
alpha-Spec [cytosol] (Drosophila melanogaster)
ARFGAPs stimulate ARF GTPase activity (Drosophila melanogaster)
RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane] (Drosophila melanogaster)
Spectrin tetramer [cytosol] (Drosophila melanogaster)
SPTA:SPTB [cytosol] (Drosophila melanogaster)
alpha-Spec [cytosol] (Drosophila melanogaster)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Drosophila melanogaster)
Spectrin tetramer [cytosol] (Drosophila melanogaster)
SPTA:SPTB [cytosol] (Drosophila melanogaster)
alpha-Spec [cytosol] (Drosophila melanogaster)
ERGIC-to-Golgi vesicles bind dynein:dynactin (Drosophila melanogaster)
RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Drosophila melanogaster)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Drosophila melanogaster)
Spectrin tetramer [cytosol] (Drosophila melanogaster)
SPTA:SPTB [cytosol] (Drosophila melanogaster)
alpha-Spec [cytosol] (Drosophila melanogaster)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Drosophila melanogaster)
Spectrin tetramer [cytosol] (Drosophila melanogaster)
SPTA:SPTB [cytosol] (Drosophila melanogaster)
alpha-Spec [cytosol] (Drosophila melanogaster)
cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Drosophila melanogaster)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Drosophila melanogaster)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Drosophila melanogaster)
Spectrin tetramer [cytosol] (Drosophila melanogaster)
SPTA:SPTB [cytosol] (Drosophila melanogaster)
alpha-Spec [cytosol] (Drosophila melanogaster)
RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Drosophila melanogaster)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Drosophila melanogaster)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Drosophila melanogaster)
Spectrin tetramer [cytosol] (Drosophila melanogaster)
SPTA:SPTB [cytosol] (Drosophila melanogaster)
alpha-Spec [cytosol] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:P13395
Gene Names
alpha-Spec
Reference Genes
BioGPS Gene:38231 alpha-Spec
CTD Gene:38231 alpha-Spec
ENSEMBL:FBgn0250789
FlyBase:FBgn0250789
KEGG:dme:Dmel_CG1977 alpha-Spec
Monarch:38231 alpha-Spec
NCBI Gene:38231 alpha-Spec
UCSC:P13395 alpha-Spec
Reference Transcript
RefSeq:NM_057391.4 alpha-Spec
Other Identifiers
1626349_at
38231
GO:0003779
GO:0005509
GO:0005515
GO:0005516
GO:0005737
GO:0005794
GO:0005856
GO:0005886
GO:0005929
GO:0005938
GO:0007009
GO:0007010
GO:0007026
GO:0007274
GO:0007294
GO:0007308
GO:0007417
GO:0008017
GO:0008092
GO:0008360
GO:0009653
GO:0016199
GO:0016323
GO:0016324
GO:0016328
GO:0022414
GO:0030036
GO:0030054
GO:0030723
GO:0030727
GO:0030864
GO:0031514
GO:0031594
GO:0034330
GO:0035332
GO:0042062
GO:0042995
GO:0043226
GO:0045169
GO:0045170
GO:0045478
GO:0046872
GO:0048790
GO:0048856
GO:0050807
GO:0051015
GO:0051693
GO:0061024
Participates
as a component of
SPTA:SPTB [cytosol] (Drosophila melanogaster)
Other forms of this molecule
alpha-Spec [specific granule lumen]
alpha-Spec [extracellular region]
alpha-Spec [tertiary granule lumen]
alpha-Spec [cytosol]
alpha-Spec [cytosol]
alpha-Spec [cytosol]
Inferred From
Spectrin alpha chain [cytosol]
(Homo sapiens)
SPTA1 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_476739.1
ENSEMBL
FBpp0072672
,
FBtr0072789
,
FBgn0250789
FlyBase
FBgn0250789
PRO
P13395
PDB
2SPC
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q00963
4
beta-Spec [cytosol]
(R-DME-420044)
beta-Spec [cytosol]
(R-DME-391565)
beta-Spec [cytosol]
(R-DME-420049)
beta-Spec [cytosol]
(R-DME-420048)
0.508
2
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