Reactome | mAChR-A [plasma membrane]

mAChR-A [plasma membrane]

Stable Identifier

R-DME-390654

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

plasma membrane

Synonyms

CHRM2, P16395

Locations in the PathwayBrowser

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Vesicle-mediated transport (Drosophila melanogaster)

- Membrane Trafficking (Drosophila melanogaster)
  - Clathrin-mediated endocytosis (Drosophila melanogaster)
    - BAR domain proteins recruit dynamin (Drosophila melanogaster)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Drosophila melanogaster)
        
        ARRB-binding GPCRs [plasma membrane] (Drosophila melanogaster)
        
        mAChR-A [plasma membrane] (Drosophila melanogaster)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Drosophila melanogaster)
        
        ARRB-binding GPCRs [plasma membrane] (Drosophila melanogaster)
        
        mAChR-A [plasma membrane] (Drosophila melanogaster)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Drosophila melanogaster)
      - CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Drosophila melanogaster)
        
        ARRB-binding GPCRs [plasma membrane] (Drosophila melanogaster)
        
        mAChR-A [plasma membrane] (Drosophila melanogaster)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Drosophila melanogaster)
        
        ARRB-binding GPCRs [plasma membrane] (Drosophila melanogaster)
        
        mAChR-A [plasma membrane] (Drosophila melanogaster)
    - Cargo recognition for clathrin-mediated endocytosis (Drosophila melanogaster)
      - ARBB recruits GPCRs into clathrin-coated pits (Drosophila melanogaster)
        
        ARBBs:ARBB-binding GPCRs:clathrin-coated pit [plasma membrane] (Drosophila melanogaster)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Drosophila melanogaster)
        
        ARRB-binding GPCRs [plasma membrane] (Drosophila melanogaster)
        
        mAChR-A [plasma membrane] (Drosophila melanogaster)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Drosophila melanogaster)
        
        ARRB-binding GPCRs [plasma membrane] (Drosophila melanogaster)
        
        mAChR-A [plasma membrane] (Drosophila melanogaster)
      - ARRB bind GPCRs (Drosophila melanogaster)
        
        ARRB-binding GPCRs [plasma membrane] (Drosophila melanogaster)
        
        mAChR-A [plasma membrane] (Drosophila melanogaster)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Drosophila melanogaster)
        
        ARRB-binding GPCRs [plasma membrane] (Drosophila melanogaster)
        
        mAChR-A [plasma membrane] (Drosophila melanogaster)
    - Clathrin recruits PIK3C2A (Drosophila melanogaster)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Drosophila melanogaster)
        
        ARRB-binding GPCRs [plasma membrane] (Drosophila melanogaster)
        
        mAChR-A [plasma membrane] (Drosophila melanogaster)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Drosophila melanogaster)
        
        ARRB-binding GPCRs [plasma membrane] (Drosophila melanogaster)
        
        mAChR-A [plasma membrane] (Drosophila melanogaster)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Drosophila melanogaster)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Drosophila melanogaster)
        
        ARRB-binding GPCRs [plasma membrane] (Drosophila melanogaster)
        
        mAChR-A [plasma membrane] (Drosophila melanogaster)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Drosophila melanogaster)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Drosophila melanogaster)
        
        ARRB-binding GPCRs [plasma membrane] (Drosophila melanogaster)
        
        mAChR-A [plasma membrane] (Drosophila melanogaster)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Drosophila melanogaster)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Drosophila melanogaster)
        
        ARRB-binding GPCRs [plasma membrane] (Drosophila melanogaster)
        
        mAChR-A [plasma membrane] (Drosophila melanogaster)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Drosophila melanogaster)
        
        ARRB-binding GPCRs [plasma membrane] (Drosophila melanogaster)
        
        mAChR-A [plasma membrane] (Drosophila melanogaster)
    - F- and N- BAR domain proteins bind the clathrin-coated pit (Drosophila melanogaster)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Drosophila melanogaster)
        
        ARRB-binding GPCRs [plasma membrane] (Drosophila melanogaster)
        
        mAChR-A [plasma membrane] (Drosophila melanogaster)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Drosophila melanogaster)
        
        ARRB-binding GPCRs [plasma membrane] (Drosophila melanogaster)
        
        mAChR-A [plasma membrane] (Drosophila melanogaster)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Drosophila melanogaster)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Drosophila melanogaster)
        
        ARRB-binding GPCRs [plasma membrane] (Drosophila melanogaster)
        
        mAChR-A [plasma membrane] (Drosophila melanogaster)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Drosophila melanogaster)
        
        ARRB-binding GPCRs [plasma membrane] (Drosophila melanogaster)
        
        mAChR-A [plasma membrane] (Drosophila melanogaster)

External Reference Information

External Reference

UniProt:P16395

Gene Names

mAChR-A

Reference Genes

BioGPS Gene:37892 mAChR-A

ENSEMBL:FBgn0000037

FlyBase:FBgn0000037

KEGG Gene (Drosophila melanogaster):Dmel_CG4356 mAChR-A

Monarch:37892 mAChR-A

NCBI Gene:37892 mAChR-A

Reference Transcript

Other Identifiers

143057_at

1624833_a_at

37892

GO:0004930

GO:0004993

GO:0005886

GO:0007165

GO:0007186

GO:0007187

GO:0007197

GO:0007200

GO:0007213

GO:0007268

GO:0008227

GO:0016020

GO:0016907

GO:0023052

GO:0030425

GO:0030594

GO:0045202

GO:0045211

GO:0060089

GO:0098664

Participates

as a member of

ARRB-binding GPCRs [plasma membrane] (Drosophila melanogaster)

as an input of

as a component of

Other forms of this molecule

mAChR-A [clathrin-coated endocytic vesicle membrane]

mAChR-A [plasma membrane]

Inferred From

CHRM2,CHRM4 [plasma membrane] (Homo sapiens)

CHRM2 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_726440.1, NP_523844.2

ZINC - Investigational

ACM1_DROME

ZINC - Metabolites

ACM1_DROME

Flybase

FBgn0000037

ZINC - World Drugs

ACM1_DROME

ZINC - FDA approved

ACM1_DROME

ZINC - Substances

ACM1_DROME

ZINC - Biogenic

ACM1_DROME

ZINC target

P16395

PRO

P16395

ZINC - Predictions - Purchasable

ACM1_DROME

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