Reactome | ACTN2 [cytosol]

ACTN2 [cytosol]

Stable Identifier

R-DME-390562

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

cytosol

Synonyms

P18091

Locations in the PathwayBrowser

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Neuronal System (Drosophila melanogaster)

- Transmission across Chemical Synapses (Drosophila melanogaster)
  - Neurotransmitter receptors and postsynaptic signal transmission (Drosophila melanogaster)
    - Activation of NMDA receptors and postsynaptic events (Drosophila melanogaster)
      - Unblocking of NMDA receptors, glutamate binding and activation (Drosophila melanogaster)
        
        Ca2+ influx into the post-synaptic cell (Drosophila melanogaster)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2 NMDA receptors [plasma membrane] (Drosophila melanogaster)
        
        GRIN1:GRIN2 NMDA receptors:PSD proteins [plasma membrane] (Drosophila melanogaster)
        
        GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:ACTN2 [plasma membrane] (Drosophila melanogaster)
        
        ACTN2 homodimer [cytosol] (Drosophila melanogaster)
        
        ACTN2 [cytosol] (Drosophila melanogaster)
        
        Membrane depolarization upon activation of Ca impermeable AMPA receptors (Drosophila melanogaster)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors:p-T286-CaMKII dodecamer:CALM1:4xCa2+ [plasma membrane] (Drosophila melanogaster)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors [plasma membrane] (Drosophila melanogaster)
        
        GRIN1:GRIN2B NMDA receptors:PSD proteins [plasma membrane] (Drosophila melanogaster)
        
        GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:ACTN2 [plasma membrane] (Drosophila melanogaster)
        
        ACTN2 homodimer [cytosol] (Drosophila melanogaster)
        
        ACTN2 [cytosol] (Drosophila melanogaster)

External Reference Information

External Reference

UniProt:P18091

Reference Genes

BioGPS Gene:31166

CTD Gene:31166

ENSEMBL:FBgn0000667

FlyBase:FBgn0000667

KEGG:dme:Dmel_CG4376

Monarch:31166

NCBI Gene:31166

UCSC:P18091

Reference Transcript

Other Identifiers

154816_at

1635252_a_at

31166

GO:0003779

GO:0005509

GO:0005515

GO:0005737

GO:0008092

GO:0009653

GO:0044877

GO:0046872

Participates

as a component of

ACTN2 homodimer [cytosol] (Drosophila melanogaster)

Other forms of this molecule

ACTN1 [cytosol]

ACTN1 [extracellular region]

ACTN2 [extracellular region]

ACTN4 [extracellular region]

ACTN2 [platelet alpha granule lumen]

ACTN1 [platelet alpha granule lumen]

ACTN4 [platelet alpha granule lumen]

Inferred From

ACTN2 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_477484.2, NP_477485.1, NP_001188532.1, NP_001188533.1, NP_726784.1, NP_001259165.1, NP_001259166.1, NP_001259167.1

ENSEMBL

FBpp0070331, FBtr0070345, FBgn0000667

FlyBase

FBgn0000667

PRO

P18091

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P46150	5	Moe [cytosol] (R-DME-9020826) phospho-Moe [cytosol] (R-DME-374559) phospho-Moe [cytosol] (R-DME-374572) Moe [cytosol] (R-DME-437348) Moe [cytosol] (R-DME-437350)	0.547	2

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