ROK phosphorylates SQH

Stable Identifier
R-DME-350444
Type
Reaction [transition]
Species
Drosophila melanogaster
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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ROK phosphorylates SQH
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Myosin regulatory light chain (MRLC) orthologue Spaghetti Squash (SQH) is phosphorylated at Thr20 and Ser21 by Rho-kinase (ROK). Zipper (ZIP) the myosin heavy chain orthologue would be expected to have it’s conformation modified and catalytic ativity elevated upon SQH phosphorylation. This leads to cytoskeletal organisation and correct pre-hair orientation.
Literature References
PubMed ID Title Journal Year
15269282 The essential role of PP1beta in Drosophila is to regulate nonmuscle myosin

Vereshchagina, N, Bennett, D, Szöor, B, Kirchner, J, Gross, SR, Vissi, E, White-Cooper, H, Alphey, L

Mol Biol Cell 2004
11301004 Drosophila Rho-associated kinase (Drok) links Frizzled-mediated planar cell polarity signaling to the actin cytoskeleton

Winter, CG, Wang, B, Ballew, A, Royou, A, Karess, R, Axelrod, JD, Luo, L

Cell 2001
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein serine/threonine kinase activity of PK:VANG:STAN dimer:FZ:DSH:DGO:DAAM:RHO1:GTP:ROK [plasma membrane]

Physical Entity
PK:VANG:STAN dimer:FZ:DSH:DGO:DAAM:RHO1:GTP:ROK [plasma membrane] (Drosophila melanogaster)
Activity
protein serine/threonine kinase activity (GO:0004674)
Authored
Williams, MG  (2008-05-20)
Reviewed
Axelrod, JD  (2009-11-19)
Created
Williams, MG  (2008-05-19)
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