ROK phosphorylates MBS

Stable Identifier
R-DME-350362
Type
Reaction [transition]
Species
Drosophila melanogaster
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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ROK phosphorylates MBS
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Myosin binding subunit (MBS) of Myosin phosphatase is phosphorylated at Thr594 by activated Rho-kinase (ROK). Myosin phosphatase is subsequently deactivated.
Literature References
PubMed ID Title Journal Year
10570971 Identification and characterization of Drosophila homolog of Rho-kinase

Mizuno, T, Amano, M, Kaibuchi, K, Nishida, Y

Gene 1999
11874917 Drosophila myosin phosphatase and its role in dorsal closure

Mizuno, T, Tsutsui, K, Nishida, Y

Development 2002
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein serine/threonine kinase activity of PK:VANG:STAN dimer:FZ:DSH:DGO:DAAM:RHO1:GTP:ROK [plasma membrane]

Physical Entity
PK:VANG:STAN dimer:FZ:DSH:DGO:DAAM:RHO1:GTP:ROK [plasma membrane] (Drosophila melanogaster)
Activity
protein serine/threonine kinase activity (GO:0004674)
Authored
Williams, MG  (2008-05-20)
Reviewed
Axelrod, JD  (2009-11-19)
Created
Williams, MG  (2008-05-19)
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